HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) - Rat Genome Database

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Gene: HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) Homo sapiens
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Symbol: HADHA
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
RGD ID: 733877
HGNC Page HGNC:4801
Description: Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in cardiolipin acyl-chain remodeling and fatty acid beta-oxidation. Located in mitochondrial inner membrane and mitochondrial nucleoid. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Implicated in mitochondrial trifunctional protein deficiency 1 and steatotic liver disease. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit; 3-oxoacyl-CoA thiolase; 78 kDa gastrin-binding protein; ECHA; gastrin-binding protein; GBP; HADH; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-coenzyme a dehydrogenase/3-ketoacyl-coenzyme a hiolase/enoyl-coenzyme a hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; LCEH; LCHAD; long-chain 2-enoyl-CoA hydratase; long-chain-3-hydroxyacyl-CoA dehydrogenase; MGC1728; mitochondrial long-chain 2-enoyl-Coenzyme A (CoA) hydratase, alpha subunit; mitochondrial long-chain L-3-hydroxyacyl-Coenzyme A (CoA) dehydrogenase, alpha subunit; mitochondrial trifunctional enzyme, alpha subunit; mitochondrial trifunctional protein, alpha subunit; monolysocardiolipin acyltransferase; MTPA; TP-ALPHA; trifunctional enzyme subunit alpha, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: HADHAP1   HADHAP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,190,635 - 26,244,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,190,635 - 26,244,672 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,413,504 - 26,467,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,267,008 - 26,321,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,325,159 - 26,379,140NCBI
Celera226,253,733 - 26,307,825 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,149,287 - 26,203,382 (-)NCBIHuRef
CHM1_1226,343,424 - 26,397,498 (-)NCBICHM1_1
T2T-CHM13v2.0226,225,960 - 26,279,973 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
HADHAHumanAlzheimer's disease  IEP 10047114protein:decreased expression:brainRGD 
HADHAHumanCOVID-19  HEP 28912744mRNA:increased expression:peripheral blood mononuclear cell (human)RGD 
HADHAHumanExperimental Diabetes Mellitus  ISORGD:155275710047114protein:decreased expression:brainRGD 
HADHAHumanFetal Growth Retardation  ISORGD:6205121599884mRNA:decreased expressionRGD 
HADHAHumanmetabolic dysfunction-associated steatotic liver disease  ISORGD:62051214694831protein:decreased expression:liverRGD 
HADHAHumansteatotic liver disease  IAGP 1599882DNA:point mutations: ;1132C>T,1528G>C;LCHAD deficiency,OMIM:609015RGD 
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HADHAHumangenetic disease  IAGPRGD:1533034298554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
HADHAHumangenetic disease  IAGPRGD:14394188|RGD:156295888|RGD:156309973|RGD:156331924|RGD:329389498|RGD:401724728|RGD:401768553|RGD:401866736|RGD:401881676|RGD:401891564|RGD:405788497|RGD:405788509|RGD:405788516|RGD:405788522|RGD:405788526|RGD:405788532|RGD:405788538|RGD:407504702|RGD:407504705|RGD:407514008|RGD:407514009|RGD:597662780|RGD:5976902118554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
HADHAHumangenetic disease  IAGPRGD:127297639|RGD:13515497|RGD:13531082|RGD:14729819|RGD:151739850|RGD:151742645|RGD:151791653|RGD:151857533|RGD:151873321|RGD:155932567|RGD:155995061|RGD:156003438|RGD:156018294|RGD:156139242|RGD:156150374|RGD:156316356|RGD:26895404|RGD:26898172|RGD:288962978554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
HADHAHumangenetic disease  IAGPRGD:11587746|RGD:126746936|RGD:126747047|RGD:12837836|RGD:1504148888554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
HADHAHumangenetic disease  IAGPRGD:100588008554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532|PMID:30682426|PMID:33638202
HADHAHumangenetic disease  IAGPRGD:85980268554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10352164|PMID:10518281|PMID:11773547|PMID:14630990|PMID:15902556|PMID:18408953|PMID:19852779|PMID:20583174|PMID:20814823|PMID:21103935|PMID:21549624|PMID:23430857|PMID:23868323|PMID:24033266|PMID:25741868|PMID:25888220|PMID:26024122|PMID:26109258|PMID:26653362|PMID:27117294|PMID:27491397|PMID:28492532|PMID:7811722|PMID:7846063|PMID:8739956|PMID:8770876|PMID:9003853|PMID:9266371
HADHAHumangenetic disease  IAGPRGD:85980328554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10352164|PMID:14630990|PMID:14694500|PMID:21103935|PMID:21549624|PMID:22459206|PMID:23798014|PMID:25741868|PMID:28492532|PMID:37184518|PMID:7738175|PMID:9739053
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:85606678554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:17576681|PMID:23868323|PMID:25741868|PMID:26109258|PMID:27491397|PMID:28492532|PMID:7738175|PMID:9536098
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:10050143|RGD:10056213|RGD:10056215|RGD:11584296|RGD:11585195|RGD:11587746|RGD:11590939|RGD:126746936|RGD:126747047|RGD:12837836|RGD:12913704|RGD:13474588|RGD:13520477|RGD:13617219|RGD:13815092|RGD:150413789|RGD:150414888|RGD:15112482|RGD:15141205|RGD:151766339|RGD:156212598|RGD:156363396|RGD:156370677|RGD:38488246|RGD:8639520|RGD:8639521|RGD:86912748554872ClinVar Annotator: match by term: HADHA-related disorder | ClinVar Annotator: match by term: Long chain more ...ClinVarPMID:25741868|PMID:28492532
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:1559963308554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:14630990|PMID:16199547|PMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:26905333|RGD:401943054|RGD:405005165|RGD:4050693998554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:16199547|PMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:137870888554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:21103935|PMID:25741868|PMID:30934865|PMID:33638202|PMID:35433174
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:10056212|RGD:10056214|RGD:11583942|RGD:11584298|RGD:11584571|RGD:11585467|RGD:11586398|RGD:11586535|RGD:11588241|RGD:11588382|RGD:11588803|RGD:11591174|RGD:126734998|RGD:126735011|RGD:126908290|RGD:127325421|RGD:12841034|RGD:13495825|RGD:13515497|RGD:13526751|RGD:13531082|RGD:13532390|RGD:13537243|RGD:13538627|RGD:13538906|RGD:13706213|RGD:13783698|RGD:14715543|RGD:14721935|RGD:14729819|RGD:150425517|RGD:150459896|RGD:15101821|RGD:15101909|RGD:15104390|RGD:15109514|RGD:15110111|RGD:15112904|RGD:15128731|RGD:15132367|RGD:15132557|RGD:15140266|RGD:15141090|RGD:15144717|RGD:15148406|RGD:15159280|RGD:15170996|RGD:15181137|RGD:151857533|RGD:15187946|RGD:15196608|RGD:152032804|RGD:152056857|RGD:152155049|RGD:156287460|RGD:26895404|RGD:26898172|RGD:26904276|RGD:26905915|RGD:26919597|RGD:28888827|RGD:28896297|RGD:28896301|RGD:38464046|RGD:38467155|RGD:405003747|RGD:40905500|RGD:86302758554872ClinVar Annotator: match by term: HADHA-related disorder | ClinVar Annotator: match by term: Long chain more ...ClinVarPMID:28492532
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:5978320398554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868|PMID:3487815
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:10058801|RGD:12738932|RGD:12739720|RGD:13488779|RGD:13791931|RGD:14703608|RGD:151815822|RGD:155726325|RGD:156016389|RGD:156124213|RGD:156225138|RGD:156228283|RGD:156331739|RGD:26898010|RGD:329952074|RGD:401943018|RGD:405012313|RGD:5976368478554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:11583308|RGD:11583805|RGD:11590551|RGD:11593749|RGD:11665583|RGD:11666346|RGD:126729909|RGD:127286067|RGD:127293957|RGD:127293962|RGD:127293966|RGD:127293969|RGD:127293974|RGD:13520493|RGD:13783781|RGD:13787929|RGD:14730134|RGD:14730136|RGD:14730142|RGD:150429537|RGD:150534192|RGD:150545765|RGD:155735467|RGD:401941400|RGD:401941401|RGD:401941402|RGD:401941403|RGD:401941404|RGD:401941405|RGD:401943014|RGD:401943022|RGD:401943030|RGD:401943042|RGD:401943049|RGD:401943058|RGD:401943061|RGD:401943907|RGD:405869058|RGD:405869067|RGD:405869070|RGD:405869075|RGD:405869079|RGD:405869083|RGD:405869087|RGD:407429168|RGD:597636835|RGD:597636852|RGD:597636857|RGD:597636862|RGD:597636876|RGD:597636880|RGD:597636885|RGD:5976368908554872ClinVar Annotator: match by term: HADHA-related disorder | ClinVar Annotator: match by term: Long chain more ...ClinVarPMID:25741868
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:10048836|RGD:10056216|RGD:11585982|RGD:11588065|RGD:11591691|RGD:11597644|RGD:11645637|RGD:11649007|RGD:11649719|RGD:11650466|RGD:11654087|RGD:11658062|RGD:11665835|RGD:12739219|RGD:12739311|RGD:12739653|RGD:12739712|RGD:12740023|RGD:12740422|RGD:12740553|RGD:13782874|RGD:13783046|RGD:13783157|RGD:13784210|RGD:13784285|RGD:13784596|RGD:13784883|RGD:13786311|RGD:13786687|RGD:13787062|RGD:13789143|RGD:13790490|RGD:13791740|RGD:13791924|RGD:13792244|RGD:14394188|RGD:150496581|RGD:153345962|RGD:28886636|RGD:28886642|RGD:28887004|RGD:28887011|RGD:28887017|RGD:28888481|RGD:28888486|RGD:28888491|RGD:28893406|RGD:28895451|RGD:28895698|RGD:28900316|RGD:28900320|RGD:28900824|RGD:40905501|RGD:5969220818554872ClinVar Annotator: match by term: HADHA-related disorder | ClinVar Annotator: match by term: Long chain more ...ClinVar 
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:5969429518554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:34578803
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:100562188554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:26109258|PMID:35383965
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGPRGD:100588008554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868|PMID:28492532|PMID:30682426|PMID:33638202
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HADHAHumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25226513
HADHAHumanmitochondrial trifunctional protein deficiency  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
HADHAHumanMyocardial Ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
HADHAHumanosteoarthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066
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Original Reference(s)
HADHAHumanLong-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency  IAGP 7240710 OMIM 
HADHAHumanmitochondrial trifunctional protein deficiency 1  IAGP 7240710 OMIM 

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HADHAHuman(+)-dexrazoxane decreases expressionISORGD:15527576480464Dexrazoxane results in decreased expression of HADHA mRNACTDPMID:26873546
HADHAHuman(+)-schisandrin B multiple interactionsISORGD:6205126480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HADHA mRNA]CTDPMID:31150632
HADHAHuman(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein]CTDPMID:32478940
HADHAHuman1,2-dimethylhydrazine decreases expressionISORGD:155275764804641,2-Dimethylhydrazine results in decreased expression of HADHA mRNACTDPMID:22206623
HADHAHuman1,2-dimethylhydrazine multiple interactionsISORGD:15527576480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HADHA mRNACTDPMID:22206623
HADHAHuman1,4-benzoquinone decreases expressionEXP 6480464quinone results in decreased expression of HADHA mRNA; quinone results in decreased expression of HADHA more ...CTDPMID:32478940
HADHAHuman1,4-benzoquinone multiple interactionsEXP 6480464Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein]CTDPMID:32478940
HADHAHuman1-chloro-2,4-dinitrobenzene affects bindingEXP 6480464Dinitrochlorobenzene binds to HADHA proteinCTDPMID:32991956
HADHAHuman1-naphthyl isothiocyanate multiple interactionsISORGD:15527576480464[1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of HADHA mRNA; Allopurinol inhibits the more ...CTDPMID:33749747
HADHAHuman1-naphthyl isothiocyanate decreases expressionISORGD:155275764804641-Naphthylisothiocyanate results in decreased expression of HADHA mRNACTDPMID:33749747
HADHAHuman17alpha-ethynylestradiol increases expressionISORGD:6205126480464Ethinyl Estradiol results in increased expression of HADHA mRNACTDPMID:16174780
HADHAHuman17beta-estradiol decreases expressionISORGD:6205126480464Estradiol results in decreased expression of HADHA proteinCTDPMID:32145629
HADHAHuman17beta-estradiol increases expressionISORGD:15527576480464Estradiol results in increased expression of HADHA mRNACTDPMID:39298647
HADHAHuman2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:155275764804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HADHA mRNACTDPMID:38040069
HADHAHuman2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HADHA proteinCTDPMID:31675489
HADHAHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:6205126480464Tetrachlorodibenzodioxin results in decreased expression of HADHA mRNACTDPMID:20959002
HADHAHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:6205126480464Tetrachlorodibenzodioxin results in increased expression of HADHA mRNACTDPMID:34747641
HADHAHuman2,4,6-tribromophenol decreases expressionEXP 64804642,4,6-tribromophenol results in decreased expression of HADHA mRNACTDPMID:31675489
HADHAHuman2,4,6-trinitrotoluene affects expressionISORGD:6205126480464Trinitrotoluene affects the expression of HADHA mRNACTDPMID:21346803
HADHAHuman2,6-dimethoxyphenol multiple interactionsEXP 6480464[pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization more ...CTDPMID:38598786

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Biological Process
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HADHAHumancardiolipin acyl-chain remodeling involved_inIMP 150520179 PMID:31604922UniProtPMID:31604922
HADHAHumancardiolipin acyl-chain remodeling involved_inIDA 150520179 PMID:23152787UniProtPMID:23152787
HADHAHumanfatty acid beta-oxidation acts_upstream_of_or_withinIEAUniProtKB:Q8BMS1|ensembl:ENSMUSP00000120976150520179 EnsemblGO_REF:0000107
HADHAHumanfatty acid beta-oxidation involved_inIBAFB:FBgn0028479|MGI:2135593|PANTHER:PTN000592895|RGD:620512|UniProtKB:P21177|UniProtKB:P40939|UniProtKB:P77399150520179 GO_CentralGO_REF:0000033
HADHAHumanfatty acid beta-oxidation involved_inIMP 150520179 PMID:31604922UniProtPMID:31604922
HADHAHumanfatty acid beta-oxidation involved_inIEAARBA:ARBA00028692150520179 UniProtGO_REF:0000117
HADHAHumanfatty acid beta-oxidation involved_inIDA 150520179 PMID:29915090ComplexPortalPMID:29915090
HADHAHumanfatty acid beta-oxidation involved_inIEAInterPro:IPR012803150520179 InterProGO_REF:0000002
HADHAHumanfatty acid beta-oxidation involved_inIEAUniPathway:UPA00659150520179 UniProtGO_REF:0000041
HADHAHumanfatty acid beta-oxidation  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHumanfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-0276150520179 UniProtGO_REF:0000043
HADHAHumanfatty acid metabolic process involved_inIEAInterPro:IPR006108|InterPro:IPR006176|InterPro:IPR006180150520179 InterProGO_REF:0000002
HADHAHumanlipid metabolic process involved_inIEAUniProtKB-KW:KW-0443150520179 UniProtGO_REF:0000043
HADHAHumanorganic acid catabolic process involved_inIEAARBA:ARBA00028831150520179 UniProtGO_REF:0000117
HADHAHumanresponse to insulin acts_upstream_of_or_withinIEAUniProtKB:Q8BMS1|ensembl:ENSMUSP00000120976150520179 EnsemblGO_REF:0000107
HADHAHumanresponse to xenobiotic stimulus  ISORGD:6205129068941 RGDPMID:12176671|REF_RGD_ID:1599883
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Cellular Component
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HADHAHumanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
HADHAHumanmitochondrial fatty acid beta-oxidation multienzyme complex  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHumanmitochondrial fatty acid beta-oxidation multienzyme complex part_ofIBAPANTHER:PTN000592780|RGD:620512|UniProtKB:P40939150520179 GO_CentralGO_REF:0000033
HADHAHumanmitochondrial fatty acid beta-oxidation multienzyme complex part_ofIEAInterPro:IPR012803150520179 InterProGO_REF:0000002
HADHAHumanmitochondrial fatty acid beta-oxidation multienzyme complex part_ofIPI 150520179 PMID:29915090ComplexPortalPMID:29915090
HADHAHumanmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
HADHAHumanmitochondrial inner membrane located_inIDA 150520179 PMID:29915090ComplexPortalPMID:29915090
HADHAHumanmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
HADHAHumanmitochondrial inner membrane located_inTAS 150520179 ReactomeReactome:R-HSA-1482775|Reactome:R-HSA-77271|Reactome:R-HSA-77277|Reactome:R-HSA-77283|Reactome:R-HSA-77301|Reactome:R-HSA-77303|Reactome:R-HSA-77304|Reactome:R-HSA-77309|Reactome:R-HSA-77321|Reactome:R-HSA-77329|Reactome:R-HSA-77340
HADHAHumanmitochondrial nucleoid located_inIDA 150520179 PMID:18063578BHF-UCLPMID:18063578
HADHAHumanmitochondrion located_inHDA 150520179 PMID:20833797UniProtPMID:20833797
HADHAHumanmitochondrion located_inIEAUniProtKB-SubCell:SL-0173150520179 UniProtGO_REF:0000044
HADHAHumanmitochondrion located_inIEAInterPro:IPR012803150520179 InterProGO_REF:0000002
HADHAHumanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
HADHAHumanmitochondrion located_inHTP 150520179 PMID:34800366FlyBasePMID:34800366
HADHAHumanmitochondrion located_inIDA 150520179 PMID:23152787HPAGO_REF:0000052|PMID:23152787
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Molecular Function
1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HADHAHuman3-hydroxyacyl-CoA dehydratase activity  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHuman3-hydroxyacyl-CoA dehydrogenase activity  ISORGD:6205129068941 RGDPMID:1730633|PMID:8253773|REF_RGD_ID:1600572|REF_RGD_ID:632874
HADHAHuman3-hydroxyacyl-CoA dehydrogenase activity enablesIEAARBA:ARBA00043364150520179 UniProtGO_REF:0000117
HADHAHuman3-hydroxyacyl-CoA dehydrogenase activity enablesIEAInterPro:IPR012803150520179 InterProGO_REF:0000002
HADHAHuman3-hydroxyacyl-CoA dehydrogenase activity enablesTAS 150520179 PMID:8135828PINCPMID:8135828
HADHAHumanacetyl-CoA C-acetyltransferase activity enablesTAS 150520179 PMID:8135828PINCPMID:8135828
HADHAHumanacetyl-CoA C-acyltransferase activity  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHumancatalytic activity enablesIEAInterPro:IPR018376150520179 InterProGO_REF:0000002
HADHAHumancatalytic activity enablesIEAUniProtKB-KW:KW-0511150520179 UniProtGO_REF:0000043
HADHAHumanenoyl-CoA hydratase activity  ISORGD:6205129068941 RGDPMID:1730633|PMID:8253773|REF_RGD_ID:1600572|REF_RGD_ID:632874
HADHAHumanenoyl-CoA hydratase activity enablesIBAPANTHER:PTN000592895|RGD:620512|UniProtKB:P21177|UniProtKB:P77399150520179 GO_CentralGO_REF:0000033
HADHAHumanenoyl-CoA hydratase activity enablesIEAEC:4.2.1.17150520179 UniProtGO_REF:0000003
HADHAHumanenoyl-CoA hydratase activity enablesIEAInterPro:IPR012803150520179 InterProGO_REF:0000002
HADHAHumanenoyl-CoA hydratase activity enablesTAS 150520179 PMID:8135828PINCPMID:8135828
HADHAHumanenoyl-CoA hydratase activity enablesIEARHEA:16105|RHEA:20724150520179 RHEAGO_REF:0000116
HADHAHumanfatty-acyl-CoA binding  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHumanlong-chain fatty acyl-CoA hydrolase activity enablesIDA 150520179 PMID:22586271UniProtPMID:22586271
HADHAHumanlong-chain-3-hydroxyacyl-CoA dehydrogenase activity  ISORGD:6205129068941 RGDPMID:1730633|REF_RGD_ID:1600572
HADHAHumanlong-chain-3-hydroxyacyl-CoA dehydrogenase activity enablesIEAUniProtKB:Q8BMS1|ensembl:ENSMUSP00000120976150520179 EnsemblGO_REF:0000107
HADHAHumanlong-chain-3-hydroxyacyl-CoA dehydrogenase activity enablesIBAMGI:2135593|PANTHER:PTN000592895|RGD:620512150520179 GO_CentralGO_REF:0000033
1 to 20 of 33 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HADHAHumanfatty acid beta degradation pathway   TAS 2317625 RGD 
HADHAHumanfatty acid metabolic pathway  ISORGD:6205121600572 RGD 

Imported Annotations - SMPDB

1 to 12 of 12 rows
1 to 12 of 12 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HADHAHumanbeta-alanine metabolic pathway  IEA 6907045 KEGGhsa:00410
HADHAHumanbutanoate metabolic pathway  IEA 6907045 KEGGhsa:00650
HADHAHumanlysine degradation pathway  IEA 6907045 KEGGhsa:00310
HADHAHumanpropanoate metabolic pathway  IEA 6907045 KEGGhsa:00640
HADHAHumantryptophan metabolic pathway  IEA 6907045 KEGGhsa:00380
HADHAHumanvaline, leucine and isoleucine degradation pathway  IEA 6907045 KEGGhsa:00280
1 to 20 of 87 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HADHAHumanAbnormal chorioretinal morphology  IAGP 8699517 HPOORPHA:5
HADHAHumanAbnormal electroretinogram  IAGP 8699517 HPOORPHA:5
HADHAHumanAbnormality of metabolism/homeostasis  IAGP 8699517 HPOORPHA:5
HADHAHumanAbnormality of retinal pigmentation  IAGP 8699517 HPOORPHA:5
HADHAHumanAbnormality of the amniotic fluid  IAGP 8699517 HPOMIM:609015
HADHAHumanAreflexia  IAGP 8699517 HPOMIM:609015|PMID:12838198|ORPHA:746
HADHAHumanArrhythmia  IAGP 8699517 HPOMIM:609015|PMID:12838198|ORPHA:746
HADHAHumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:609015|MIM:609016
HADHAHumanBabinski sign  IAGP 8699517 HPOORPHA:746
HADHAHumanCardiomyopathy  IAGP 8699517 HPOMIM:609016|ORPHA:746
HADHAHumanCholestasis  IAGP 8699517 HPOMIM:609015|PMID:12838198|ORPHA:746
HADHAHumanCholestatic liver disease  IAGP 8699517 HPOORPHA:5
HADHAHumanChorioretinal atrophy  IAGP 8699517 HPOORPHA:5
HADHAHumanChronic hepatic failure  IAGP 8699517 HPOORPHA:746
HADHAHumanComa  IAGP 8699517 HPOORPHA:746
HADHAHumanCongestive heart failure  IAGP 8699517 HPOMIM:609015|ORPHA:746
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGP 8699517 HPOMIM:609016
HADHAHumanDecreased patellar reflex  IAGP 8699517 HPOORPHA:746
HADHAHumanDifficulty climbing stairs  IAGP 8699517 HPOORPHA:746
HADHAHumanDiffuse hepatic steatosis  IAGP 8699517 HPOORPHA:746
1 to 20 of 87 rows
1 to 20 of 926 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:1559918948554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:28492532
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368768554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368858554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368358554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368908554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:1559963308554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:14630990|PMID:16199547|PMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:1561242138554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:1563706778554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868|PMID:28492532
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368808554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:137870888554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:21103935|PMID:25741868|PMID:30934865|PMID:33638202|PMID:35433174
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368578554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:3299520748554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:4050693998554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:16199547|PMID:21103935|PMID:21549624|PMID:22459206|PMID:25741868|PMID:28492532|PMID:7738175
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368528554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5976368628554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:5969429518554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:34578803
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:4050037478554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:28492532
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:1560087228554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868|PMID:28492532
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:151129048554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:28492532
HADHAHumanDecreased 3-hydroxyacyl-CoA dehydrogenase level  IAGPRGD:116663468554872ClinVar Annotator: match by term: Long chain 3-hydroxyacyl-CoA dehydrogenase deficiencyClinVarPMID:25741868
1 to 20 of 926 rows

1 to 14 of 14 rows
#
Reference Title
Reference Citation
1. Potential roles of PINK1 for increased PGC-1alpha-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes. Choi J, etal., Mitochondrion. 2014 Sep;18:41-8. doi: 10.1016/j.mito.2014.09.005. Epub 2014 Sep 23.
2. The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon? Eaton S, etal., Biochem Soc Trans. 2000 Feb;28(2):177-82.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Lane RH, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Jan;280(1):R183-90.
5. Proteomic analysis of liver mitochondria from rats with nonalcoholic steatohepatitis. Li L, etal., World J Gastroenterol. 2014 Apr 28;20(16):4778-86. doi: 10.3748/wjg.v20.i16.4778.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
12. The molecular basis of pediatric long chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with maternal acute fatty liver of pregnancy. Sims HF, etal., Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):841-5.
13. Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. Uchida Y, etal., J Biol Chem. 1992 Jan 15;267(2):1034-41.
14. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
1 to 14 of 14 rows
1 to 10 of 27 rows
PMID:1550553   PMID:7738175   PMID:7811722   PMID:7918661   PMID:7958339   PMID:8135828   PMID:8163672   PMID:8770876   PMID:8865274   PMID:8921383   PMID:9003853   PMID:9266371  
PMID:9605857   PMID:9739053   PMID:10075708   PMID:11978893   PMID:12118083   PMID:12413376   PMID:12477932   PMID:12601813   PMID:12754706   PMID:12971430   PMID:14630990   PMID:14743216  
PMID:15146197   PMID:15161933   PMID:15347768   PMID:15489334   PMID:15952740   PMID:16055720   PMID:16176262   PMID:16196087   PMID:17081983   PMID:17143551   PMID:17199921   PMID:17313315  
PMID:17353931   PMID:18029348   PMID:18031367   PMID:18045290   PMID:18063578   PMID:18485779   PMID:18676680   PMID:19064571   PMID:19170196   PMID:19615732   PMID:19625176   PMID:19692168  
PMID:19737925   PMID:19738201   PMID:19765186   PMID:20186120   PMID:20305087   PMID:20360068   PMID:20532202   PMID:20562859   PMID:20589231   PMID:20736409   PMID:20814823   PMID:20825197  
PMID:20833797   PMID:20877624   PMID:21080425   PMID:21081666   PMID:21145461   PMID:21319273   PMID:21549624   PMID:21565611   PMID:21654808   PMID:21873635   PMID:21901101   PMID:21988832  
PMID:22000755   PMID:22190034   PMID:22304920   PMID:22325456   PMID:22471497   PMID:22496890   PMID:22583932   PMID:22586271   PMID:22586326   PMID:22746996   PMID:22751105   PMID:22939629  
PMID:23152787   PMID:23181366   PMID:23211419   PMID:23253803   PMID:23398456   PMID:23443559   PMID:23455922   PMID:23473034   PMID:23858473   PMID:23874603   PMID:23979707   PMID:24067654  
PMID:24105666   PMID:24255178   PMID:24550385   PMID:24657165   PMID:24711643   PMID:24980433   PMID:24981860   PMID:25281560   PMID:25315684   PMID:25437307   PMID:25478839   PMID:25593309  
PMID:25670202   PMID:25673715   PMID:25720964   PMID:25816318   PMID:25921289   PMID:25963833   PMID:26043024   PMID:26109258   PMID:26344197   PMID:26367179   PMID:26446488   PMID:26496610  
1 to 10 of 27 rows



HADHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,190,635 - 26,244,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,190,635 - 26,244,672 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,413,504 - 26,467,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,267,008 - 26,321,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,325,159 - 26,379,140NCBI
Celera226,253,733 - 26,307,825 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,149,287 - 26,203,382 (-)NCBIHuRef
CHM1_1226,343,424 - 26,397,498 (-)NCBICHM1_1
T2T-CHM13v2.0226,225,960 - 26,279,973 (-)NCBIT2T-CHM13v2.0
Hadha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,324,421 - 30,359,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,323,302 - 30,360,160 (-)EnsemblGRCm39 Ensembl
GRCm38530,119,423 - 30,154,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,118,304 - 30,155,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,444,844 - 30,481,520 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,449,091 - 30,485,767 (-)NCBIMGSCv36mm8
Celera527,635,841 - 27,672,518 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.95NCBI
Hadha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,907,801 - 31,947,434 (+)NCBIGRCr8
mRatBN7.2626,187,969 - 26,227,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,187,956 - 26,227,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,480,604 - 26,520,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,796,486 - 26,836,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,275,476 - 26,314,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,589,840 - 27,628,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,400,511 - 37,439,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,173,798 - 26,191,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,176,752 - 26,194,387NCBI
Celera625,664,847 - 25,704,584 (+)NCBICelera
Cytogenetic Map6q14NCBI
Hadha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,183,945 - 8,233,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,183,945 - 8,233,869 (-)NCBIChiLan1.0ChiLan1.0
HADHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,273,366 - 100,327,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,277,338 - 100,331,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,185,938 - 26,240,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,279,761 - 26,334,068 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,279,995 - 26,334,068 (-)Ensemblpanpan1.1panPan2
HADHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,307,207 - 20,355,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,307,226 - 20,355,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,202,960 - 20,251,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,629,967 - 20,678,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,629,967 - 20,678,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,316,604 - 20,365,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,326,338 - 20,376,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,374,308 - 20,422,731 (-)NCBIUU_Cfam_GSD_1.0
Hadha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,182,261 - 6,224,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,690,643 - 119,782,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HADHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,411,620 - 81,468,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,411,648 - 81,472,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,689,160 - 30,746,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,338,250 - 8,384,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,338,250 - 8,384,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in HADHA
996 total Variants

Predicted Target Of
Summary Value
Count of predictions:1128
Count of miRNA genes:716
Interacting mature miRNAs:811
Transcripts:ENST00000380649, ENST00000457468, ENST00000461025, ENST00000471743, ENST00000492433
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597318162GWAS1414236_H3-hydroxydecanoate measurement QTL GWAS1414236 (human)0.00000053-hydroxydecanoate measurement22619518426195185Human
597317696GWAS1413770_HX-16580 measurement QTL GWAS1413770 (human)2e-12X-16580 measurement22619518426195185Human
597276293GWAS1372367_HAlzheimer disease, polygenic risk score QTL GWAS1372367 (human)2e-08Alzheimer disease, polygenic risk score22622883126228832Human
597318165GWAS1414239_H3-hydroxylaurate measurement QTL GWAS1414239 (human)9e-103-hydroxylaurate measurement22619518426195185Human

D2S158  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,452,164 - 26,452,434UniSTSGRCh37
Build 36226,305,668 - 26,305,938RGDNCBI36
Celera226,292,392 - 26,292,666RGD
Cytogenetic Map2p23UniSTS
HuRef226,187,946 - 26,188,216UniSTS
Marshfield Genetic Map245.83RGD
Marshfield Genetic Map245.83UniSTS
Genethon Genetic Map250.1UniSTS
deCODE Assembly Map249.47UniSTS
Whitehead-YAC Contig Map2 UniSTS
SHGC-945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,452,157 - 26,452,328UniSTSGRCh37
Build 36226,305,661 - 26,305,832RGDNCBI36
Celera226,292,385 - 26,292,560RGD
Cytogenetic Map2p23UniSTS
HuRef226,187,939 - 26,188,110UniSTS
TNG Radiation Hybrid Map219313.0UniSTS
RH17550  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37128,787,532 - 8,787,807UniSTSGRCh37
GRCh374166,326,677 - 166,326,951UniSTSGRCh37
Build 364166,546,127 - 166,546,401RGDNCBI36
Celera1210,325,117 - 10,325,392UniSTS
Celera4163,662,108 - 163,662,382RGD
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p23UniSTS
HuRef4162,078,476 - 162,078,750UniSTS
HuRef128,569,571 - 8,569,846UniSTS
RH103795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,420,275 - 26,420,453UniSTSGRCh37
Build 36226,273,779 - 26,273,957RGDNCBI36
Celera226,260,504 - 26,260,682RGD
Cytogenetic Map2p23UniSTS
HuRef226,156,057 - 26,156,235UniSTS
GeneMap99-GB4 RH Map289.92UniSTS
D2S1548E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,414,365 - 26,414,496UniSTSGRCh37
Build 36226,267,869 - 26,268,000RGDNCBI36
Celera226,254,594 - 26,254,725RGD
Cytogenetic Map2p23UniSTS
HuRef226,150,148 - 26,150,279UniSTS
D12S1229E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,417,968 - 26,418,090UniSTSGRCh37
GRCh37128,789,407 - 8,789,530UniSTSGRCh37
Build 36226,271,472 - 26,271,594RGDNCBI36
Celera226,258,197 - 26,258,319RGD
Celera1210,326,992 - 10,327,115UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map2p23UniSTS
HuRef226,153,750 - 26,153,872UniSTS
HuRef128,571,446 - 8,571,569UniSTS
GDB:451574  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,413,843 - 26,413,963UniSTSGRCh37
GRCh37128,790,369 - 8,790,493UniSTSGRCh37
Build 36226,267,347 - 26,267,467RGDNCBI36
Celera226,254,072 - 26,254,192RGD
Celera1210,327,954 - 10,328,078UniSTS
Cytogenetic Map2p23UniSTS
Cytogenetic Map12p13.31UniSTS
HuRef226,149,626 - 26,149,746UniSTS
HuRef128,572,408 - 8,572,532UniSTS
HADHA-I16  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,417,307 - 26,417,671UniSTSGRCh37
Build 36226,270,811 - 26,271,175RGDNCBI36
Celera226,257,536 - 26,257,900RGD
HuRef226,153,089 - 26,153,453UniSTS
RH47828  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,437,603 - 26,437,728UniSTSGRCh37
Build 36226,291,107 - 26,291,232RGDNCBI36
Celera226,277,830 - 26,277,955RGD
Cytogenetic Map2p23UniSTS
HuRef226,173,384 - 26,173,509UniSTS
GeneMap99-GB4 RH Map297.79UniSTS
A002C23  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,413,930 - 26,414,048UniSTSGRCh37
Build 36226,267,434 - 26,267,552RGDNCBI36
Celera226,254,159 - 26,254,277RGD
Cytogenetic Map2p23UniSTS
HuRef226,149,713 - 26,149,831UniSTS
GeneMap99-GB4 RH Map289.92UniSTS
SHGC-34066  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374166,326,678 - 166,326,802UniSTSGRCh37
GRCh37226,437,387 - 26,438,002UniSTSGRCh37
Build 364166,546,128 - 166,546,252RGDNCBI36
Celera226,277,614 - 26,278,229UniSTS
Celera4163,662,109 - 163,662,233RGD
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map2p23UniSTS
Cytogenetic Map4q32UniSTS
HuRef4162,078,477 - 162,078,601UniSTS
HuRef226,173,168 - 26,173,783UniSTS
Whitehead-RH Map2147.7UniSTS
GeneMap99-G3 RH Map12567.0UniSTS
RH1478  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,413,825 - 26,414,005UniSTSGRCh37
Build 36226,267,329 - 26,267,509RGDNCBI36
Celera226,254,054 - 26,254,234RGD
Cytogenetic Map2p23UniSTS
HuRef226,149,608 - 26,149,788UniSTS
SHGC-31508  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,413,893 - 26,414,102UniSTSGRCh37
Build 36226,267,397 - 26,267,606RGDNCBI36
Celera226,254,122 - 26,254,331RGD
Cytogenetic Map2p23UniSTS
HuRef226,149,676 - 26,149,885UniSTS
TNG Radiation Hybrid Map219307.0UniSTS
GeneMap99-GB4 RH Map290.12UniSTS
Whitehead-RH Map2156.8UniSTS
GeneMap99-G3 RH Map25896.0UniSTS
G19975  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,413,930 - 26,414,048UniSTSGRCh37
Build 36226,267,434 - 26,267,552RGDNCBI36
Celera226,254,159 - 26,254,277RGD
Cytogenetic Map2p23UniSTS
HuRef226,149,713 - 26,149,831UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2436 2788 2252 4969 1726 2348 6 623 1951 464 2269 7298 6468 53 3730 849 1740 1614 175 1


1 to 19 of 19 rows
RefSeq Transcripts NG_007121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC010896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI972144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN264228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ626228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU727642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENST00000380649   ⟹   ENSP00000370023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,635 - 26,244,632 (-)Ensembl
Ensembl Acc Id: ENST00000461025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,232,202 - 26,235,304 (-)Ensembl
Ensembl Acc Id: ENST00000471743
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,211,937 - 26,244,607 (-)Ensembl
Ensembl Acc Id: ENST00000492433   ⟹   ENSP00000438039
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,655 - 26,244,604 (-)Ensembl
Ensembl Acc Id: ENST00000643057   ⟹   ENSP00000493761
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,671 - 26,244,610 (-)Ensembl
Ensembl Acc Id: ENST00000643063   ⟹   ENSP00000495353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,922 - 26,244,604 (-)Ensembl
Ensembl Acc Id: ENST00000643233   ⟹   ENSP00000493880
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,889 - 26,244,626 (-)Ensembl
Ensembl Acc Id: ENST00000644428   ⟹   ENSP00000495560
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,655 - 26,244,672 (-)Ensembl
Ensembl Acc Id: ENST00000645274   ⟹   ENSP00000493996
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,190,881 - 26,244,616 (-)Ensembl
Ensembl Acc Id: ENST00000646031   ⟹   ENSP00000493956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,191,059 - 26,214,449 (-)Ensembl
Ensembl Acc Id: ENST00000646483   ⟹   ENSP00000496185
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,191,250 - 26,244,596 (-)Ensembl
RefSeq Acc Id: NM_000182   ⟹   NP_000173
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38226,190,635 - 26,244,632 (-)NCBI
GRCh37226,413,504 - 26,467,665 (-)NCBI
Build 36226,267,008 - 26,321,098 (-)NCBI Archive
HuRef226,149,287 - 26,203,382 (-)ENTREZGENE
CHM1_1226,343,424 - 26,397,498 (-)NCBI
T2T-CHM13v2.0226,225,960 - 26,279,973 (-)NCBI
Sequence:
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_000173   ⟸   NM_000182
- Peptide Label: precursor
- UniProtKB: Q96GT7 (UniProtKB/Swiss-Prot),   Q53TA2 (UniProtKB/Swiss-Prot),   Q53T69 (UniProtKB/Swiss-Prot),   Q16679 (UniProtKB/Swiss-Prot),   B4DYP2 (UniProtKB/Swiss-Prot),   B2R7L4 (UniProtKB/Swiss-Prot),   Q9UQC5 (UniProtKB/Swiss-Prot),   P40939 (UniProtKB/Swiss-Prot),   E9KL44 (UniProtKB/TrEMBL),   H0YFD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000438039   ⟸   ENST00000492433
Ensembl Acc Id: ENSP00000493880   ⟸   ENST00000643233
Ensembl Acc Id: ENSP00000495353   ⟸   ENST00000643063
Ensembl Acc Id: ENSP00000493761   ⟸   ENST00000643057
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding

Name Modeler Protein Id AA Range Protein Structure
AF-P40939-F1-model_v2 AlphaFold P40939 1-763 view protein structure

RGD ID:6859828
Promoter ID:EPDNEW_H3078
Type:initiation region
Name:HADHA_1
Description:hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoAhydratase , alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38226,244,610 - 26,244,670EPDNEW
RGD ID:6797555
Promoter ID:HG_KWN:31856
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_000182,   OTTHUMT00000214050,   OTTHUMT00000324480,   OTTHUMT00000324481,   OTTHUMT00000324482,   UC002RHA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36226,320,516 - 26,322,222 (+)MPROMDB
RGD ID:6851952
Promoter ID:EP73782
Type:initiation region
Name:HS_HADHA
Description:Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme Athiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alphasubunit.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36226,320,998 - 26,321,058EPD


1 to 40 of 58 rows
Database
Acc Id
Source(s)
COSMIC HADHA COSMIC
Ensembl Genes ENSG00000084754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000380649 ENTREZGENE
  ENST00000380649.8 UniProtKB/Swiss-Prot
  ENST00000646483.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1040.50 UniProtKB/Swiss-Prot
  2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
GTEx ENSG00000084754 GTEx
HGNC ID HGNC:4801 ENTREZGENE
Human Proteome Map HADHA Human Proteome Map
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot
  3HC_DH_C UniProtKB/Swiss-Prot
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot
  Fa_ox_alpha_mit UniProtKB/Swiss-Prot
  FA_oxidation_alpha_subunit UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3030 UniProtKB/Swiss-Prot
NCBI Gene 3030 ENTREZGENE
OMIM 600890 OMIM
PANTHER TRIFUNCTIONAL ENZYME SUBUNIT ALPHA UniProtKB/Swiss-Prot
  TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam 3HCDH UniProtKB/Swiss-Prot
  3HCDH_N UniProtKB/Swiss-Prot
  ECH_1 UniProtKB/Swiss-Prot
PharmGKB PA29175 PharmGKB
PROSITE 3HCDH UniProtKB/Swiss-Prot
  ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
  SSF52096 UniProtKB/Swiss-Prot
UniProt A0A2R8Y4E0_HUMAN UniProtKB/TrEMBL
  A0A2R8Y4F5_HUMAN UniProtKB/TrEMBL
  A0A2R8Y688_HUMAN UniProtKB/TrEMBL
  A0A2R8YDM1_HUMAN UniProtKB/TrEMBL
  A0A2R8YG21_HUMAN UniProtKB/TrEMBL
1 to 40 of 58 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-26 HADHA  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha  HADHA  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  Symbol and/or name change 5135510 APPROVED
2011-07-27 HADHA  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  HADHA  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit  Symbol and/or name change 5135510 APPROVED