Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) - Rat Genome Database

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Gene: Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) Ictidomys tridecemlineatus
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Symbol: Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
RGD ID: 12536955
Description: ENCODES a protein that exhibits 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); acetyl-CoA C-acyltransferase activity (ortholog); enoyl-CoA hydratase activity (ortholog); INVOLVED IN cardiolipin acyl-chain remodeling (ortholog); fatty acid beta-oxidation (ortholog); response to drug (ortholog); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN mitochondrial fatty acid beta-oxidation multienzyme complex (ortholog); mitochondrial nucleoid (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; trifunctional enzyme subunit alpha, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBI
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Genomics

Comparative Map Data
Hadha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBI
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl226,190,635 - 26,244,672 (-)EnsemblGRCh38hg38GRCh38
GRCh38226,190,635 - 26,244,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37226,413,504 - 26,467,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,267,008 - 26,321,098 (-)NCBINCBI36hg18NCBI36
Build 34226,325,159 - 26,379,140NCBI
Celera226,253,733 - 26,307,825 (-)NCBI
Cytogenetic Map2p23.3NCBI
HuRef226,149,287 - 26,203,382 (-)NCBIHuRef
CHM1_1226,343,424 - 26,397,498 (-)NCBICHM1_1
Hadha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,324,421 - 30,359,978 (-)NCBIGRCm39mm39
GRCm39 Ensembl530,323,302 - 30,360,160 (-)Ensembl
GRCm38530,119,423 - 30,154,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,118,304 - 30,155,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,444,844 - 30,481,520 (-)NCBIGRCm37mm9NCBIm37
MGSCv36530,449,091 - 30,485,767 (-)NCBImm8
Celera527,635,841 - 27,672,518 (-)NCBICelera
Cytogenetic Map5B1NCBI
Hadha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2626,187,969 - 26,227,605 (+)NCBI
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0627,589,840 - 27,628,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0637,400,511 - 37,439,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,173,798 - 26,191,433 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,176,752 - 26,194,387NCBI
Celera625,664,847 - 25,704,584 (+)NCBICelera
Cytogenetic Map6q14NCBI
Hadha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,183,945 - 8,233,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,183,945 - 8,233,869 (-)NCBIChiLan1.0ChiLan1.0
HADHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A26,279,761 - 26,334,068 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,279,995 - 26,334,068 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A26,185,938 - 26,240,229 (-)NCBIMhudiblu_PPA_v0panPan3
HADHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,307,207 - 20,355,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,307,226 - 20,355,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,202,960 - 20,251,371 (-)NCBI
ROS_Cfam_1.01720,629,967 - 20,678,383 (-)NCBI
UMICH_Zoey_3.11720,316,604 - 20,365,079 (-)NCBI
UNSW_CanFamBas_1.01720,326,338 - 20,376,047 (-)NCBI
UU_Cfam_GSD_1.01720,374,308 - 20,422,731 (-)NCBI
HADHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,752,865 - 112,797,735 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,690,643 - 119,782,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HADHA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,411,620 - 81,468,415 (+)NCBI
ChlSab1.1 Ensembl1481,411,648 - 81,472,257 (+)Ensembl
Hadha
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247388,338,250 - 8,384,701 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005322566   ⟹   XP_005322623
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBI
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322623 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005322623   ⟸   XM_005322566
- UniProtKB: I3LYV4 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
3HCDH   3HCDH_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001593 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000001425 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000020773 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001594 UniProtKB/TrEMBL
  ENSSTOT00000030104 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1040.10 UniProtKB/TrEMBL
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/TrEMBL
  6PGD_dom2 UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/TrEMBL
  Crotonase_core_superfam UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/TrEMBL
  Fa_ox_alpha_mit UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene Hadha ENTREZGENE
Pfam 3HCDH UniProtKB/TrEMBL
  3HCDH_N UniProtKB/TrEMBL
  ECH_1 UniProtKB/TrEMBL
PROSITE 3HCDH UniProtKB/TrEMBL
  ENOYL_COA_HYDRATASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48179 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52096 UniProtKB/TrEMBL
TIGRFAMs fa_ox_alpha_mit UniProtKB/TrEMBL
UniProt I3LYV4 ENTREZGENE, UniProtKB/TrEMBL
  I3N8S7_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-26 Hadha  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  Symbol and/or name change 5135510 APPROVED