VDAC1 (voltage dependent anion channel 1) - Rat Genome Database
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Gene: VDAC1 (voltage dependent anion channel 1) Homo sapiens
Analyze
Symbol: VDAC1
Name: voltage dependent anion channel 1
RGD ID: 732557
Description: Exhibits several functions, including cholesterol binding activity; ion channel binding activity; and phosphatidylcholine binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of calcium import into the mitochondrion; and positive regulation of mitophagy. Localizes to mitochondrion and plasma membrane. Implicated in prostate cancer. Biomarker of Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hVDAC1; MGC111064; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin; porin 31HL; porin 31HM; porin-31-HL; sperm binding protein 1a; VDAC-1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1
Orthologs:
Mus musculus (house mouse) : Vdac1 (voltage-dependent anion channel 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vdac1 (voltage-dependent anion channel 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vdac1 (voltage dependent anion channel 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VDAC1 (voltage dependent anion channel 1)
Canis lupus familiaris (dog) : VDAC1 (voltage dependent anion channel 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vdac1 (voltage dependent anion channel 1)
Sus scrofa (pig) : VDAC1 (voltage dependent anion channel 1)
Chlorocebus sabaeus (African green monkey) : VDAC1 (voltage dependent anion channel 1)
Heterocephalus glaber (naked mole-rat) : Vdac1 (voltage dependent anion channel 1)
more info ...
Related Pseudogenes: LOC644169   VDAC1P1   VDAC1P10   VDAC1P11   VDAC1P12   VDAC1P13   VDAC1P2   VDAC1P3   VDAC1P4   VDAC1P5   VDAC1P6   VDAC1P7   VDAC1P8   VDAC1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5133,971,871 - 134,004,975 (-)EnsemblGRCh38hg38GRCh38
GRCh385133,971,871 - 134,070,987 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375133,307,566 - 133,341,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,335,506 - 133,368,332 (-)NCBINCBI36hg18NCBI36
Build 345133,335,505 - 133,368,332NCBI
Celera5129,431,292 - 129,464,120 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5128,492,511 - 128,525,784 (-)NCBIHuRef
CHM1_15132,740,167 - 132,773,436 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B2  (EXP)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
ATP  (EXP)
bafilomycin A1  (ISO)
benzo[a]pyrene  (EXP)
betulinic acid  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
bortezomib  (EXP)
Brodifacoum  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carnosic acid  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper(II) chloride  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
dopamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
efavirenz  (EXP)
emodin  (EXP)
Erythropoietin  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (EXP)
josamycin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melphalan  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methyl methanesulfonate  (EXP)
microcystin-LR  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethylmaleimide  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP)
oxybenzone  (ISO)
p-menthan-3-ol  (EXP)
p-toluidine  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (ISO)
phenethyl caffeate  (ISO)
phosphoramide mustard  (ISO)
pirinixic acid  (ISO)
Propiverine  (ISO)
pyrazinecarboxamide  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (EXP)
SB 431542  (EXP)
simvastatin  (ISO)
sodium fluoride  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1373486   PMID:1602151   PMID:1657034   PMID:2559745   PMID:7517385   PMID:7525559   PMID:7539795   PMID:7685903   PMID:8420959   PMID:9119086   PMID:9644232   PMID:9843949  
PMID:9874241   PMID:10049775   PMID:10365962   PMID:10501981   PMID:10620603   PMID:10639121   PMID:10661876   PMID:10737788   PMID:10772903   PMID:10922061   PMID:10978502   PMID:11039896  
PMID:11091140   PMID:11181702   PMID:11602586   PMID:11845315   PMID:12009301   PMID:12079506   PMID:12087096   PMID:12118373   PMID:12243190   PMID:12477932   PMID:12663490   PMID:12698369  
PMID:12736244   PMID:12767928   PMID:14573604   PMID:14647451   PMID:14702039   PMID:15033708   PMID:15047060   PMID:15082785   PMID:15302935   PMID:15372022   PMID:15489334   PMID:15592455  
PMID:15630200   PMID:15635413   PMID:15637055   PMID:15644312   PMID:15952740   PMID:16185087   PMID:16196087   PMID:16201016   PMID:16236267   PMID:16344560   PMID:16565220   PMID:16585511  
PMID:17008324   PMID:17081983   PMID:17209561   PMID:17254575   PMID:17336328   PMID:17353931   PMID:17500595   PMID:17828567   PMID:18022941   PMID:18063578   PMID:18250166   PMID:18308720  
PMID:18362892   PMID:18381814   PMID:18568384   PMID:18607100   PMID:18614564   PMID:18690523   PMID:18755977   PMID:18832158   PMID:19049977   PMID:19056867   PMID:19094960   PMID:19130895  
PMID:19595769   PMID:19640993   PMID:19668262   PMID:19669810   PMID:19706527   PMID:19717555   PMID:19738201   PMID:19847302   PMID:20080789   PMID:20098416   PMID:20117113   PMID:20132430  
PMID:20186120   PMID:20192921   PMID:20230784   PMID:20237496   PMID:20347420   PMID:20360068   PMID:20404552   PMID:20434446   PMID:20435015   PMID:20458337   PMID:20833797   PMID:20846459  
PMID:20877624   PMID:20890124   PMID:20937774   PMID:21081666   PMID:21139048   PMID:21148773   PMID:21281574   PMID:21281575   PMID:21319273   PMID:21370995   PMID:21442216   PMID:21492153  
PMID:21630459   PMID:21720385   PMID:21873635   PMID:21890473   PMID:21900206   PMID:21906983   PMID:21963094   PMID:21987572   PMID:22117062   PMID:22119785   PMID:22159995   PMID:22164227  
PMID:22190034   PMID:22304920   PMID:22315232   PMID:22325275   PMID:22389449   PMID:22397371   PMID:22435461   PMID:22505724   PMID:22586326   PMID:22589539   PMID:22616995   PMID:22658674  
PMID:22841291   PMID:22926141   PMID:22939629   PMID:22990118   PMID:23000965   PMID:23055042   PMID:23060438   PMID:23068103   PMID:23161549   PMID:23182705   PMID:23254330   PMID:23376485  
PMID:23503661   PMID:23533145   PMID:23555273   PMID:23824909   PMID:23874603   PMID:24063855   PMID:24211404   PMID:24272356   PMID:24324700   PMID:24337577   PMID:24561123   PMID:24625528  
PMID:24654937   PMID:24668813   PMID:24704533   PMID:24728177   PMID:24816145   PMID:24886575   PMID:24947355   PMID:24960163   PMID:24999758   PMID:25015289   PMID:25147182   PMID:25244949  
PMID:25281560   PMID:25296756   PMID:25341036   PMID:25436615   PMID:25448878   PMID:25459681   PMID:25502766   PMID:25545271   PMID:25556234   PMID:25681439   PMID:25691661   PMID:25874870  
PMID:25921289   PMID:25959826   PMID:26055708   PMID:26186194   PMID:26191154   PMID:26217791   PMID:26320552   PMID:26344197   PMID:26387735   PMID:26462148   PMID:26472185   PMID:26496610  
PMID:26542804   PMID:26631732   PMID:26641092   PMID:26646027   PMID:26655341   PMID:26716410   PMID:26801612   PMID:26816005   PMID:26831666   PMID:26947058   PMID:26972000   PMID:27021164  
PMID:27025967   PMID:27080741   PMID:27173435   PMID:27179829   PMID:27304056   PMID:27342126   PMID:27419626   PMID:27544294   PMID:27641616   PMID:27653481   PMID:27721436   PMID:27738100  
PMID:27751915   PMID:27761954   PMID:27779201   PMID:27898307   PMID:27941998   PMID:28319114   PMID:28339833   PMID:28396346   PMID:28443643   PMID:28514442   PMID:28515276   PMID:28608415  
PMID:28685749   PMID:28712289   PMID:28760928   PMID:28765557   PMID:28977666   PMID:29128334   PMID:29229926   PMID:29298432   PMID:29507755   PMID:29509190   PMID:29509794   PMID:29551631  
PMID:29568061   PMID:29594867   PMID:29596470   PMID:29676259   PMID:29715546   PMID:29954845   PMID:30009671   PMID:30021884   PMID:30097533   PMID:30154076   PMID:30188326   PMID:30352685  
PMID:30528266   PMID:30575818   PMID:30833792   PMID:30912129   PMID:30945288   PMID:30948266   PMID:30997501   PMID:31015432   PMID:31046837   PMID:31073040   PMID:31091453   PMID:31180492  
PMID:31206022   PMID:31300519   PMID:31527235   PMID:31536960   PMID:31586073   PMID:31605013   PMID:31767755   PMID:31914671   PMID:31935366   PMID:31980649   PMID:32021252   PMID:32047033  
PMID:32203420   PMID:32694731   PMID:32829673   PMID:32877691  


Genomics

Comparative Map Data
VDAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5133,971,871 - 134,004,975 (-)EnsemblGRCh38hg38GRCh38
GRCh385133,971,871 - 134,070,987 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375133,307,566 - 133,341,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,335,506 - 133,368,332 (-)NCBINCBI36hg18NCBI36
Build 345133,335,505 - 133,368,332NCBI
Celera5129,431,292 - 129,464,120 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5128,492,511 - 128,525,784 (-)NCBIHuRef
CHM1_15132,740,167 - 132,773,436 (-)NCBICHM1_1
Vdac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,251,678 - 52,280,224 (+)NCBI
GRCm381152,360,851 - 52,389,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,360,860 - 52,389,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,174,617 - 52,202,898 (+)NCBIGRCm37mm9NCBIm37
MGSCv361152,204,538 - 52,232,819 (+)NCBImm8
Celera1156,932,845 - 56,961,186 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Vdac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01037,724,915 - 37,752,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,724,915 - 37,752,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,498,352 - 37,525,819 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,795,721 - 37,823,253 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11037,802,150 - 37,829,682 (+)NCBI
Celera1035,886,487 - 35,913,291 (+)NCBICelera
Cytogenetic Map10q22NCBI
Vdac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554085,260,444 - 5,275,972 (-)NCBIChiLan1.0ChiLan1.0
VDAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15135,529,173 - 135,663,570 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,529,173 - 135,560,005 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05129,375,267 - 129,408,230 (-)NCBIMhudiblu_PPA_v0panPan3
VDAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1122,197,949 - 22,212,924 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11122,197,814 - 22,212,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Vdac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366471,220,075 - 1,249,579 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VDAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,302,192 - 136,413,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,302,188 - 136,334,461 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,876,797 - 141,909,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VDAC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,783,670 - 36,817,071 (-)NCBI
Vdac1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473338,183,376 - 38,210,368 (+)NCBI

Position Markers
D5S1995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371355,239,061 - 55,240,618UniSTSGRCh37
GRCh375133,320,049 - 133,320,229UniSTSGRCh37
Build 365133,347,948 - 133,348,128RGDNCBI36
Celera1336,225,618 - 36,227,171UniSTS
Celera5129,443,735 - 129,443,915RGD
Cytogenetic Map5q31UniSTS
HuRef5128,504,999 - 128,505,183UniSTS
HuRef1335,953,195 - 35,954,748UniSTS
Marshfield Genetic Map5137.95UniSTS
Marshfield Genetic Map5137.95RGD
Genethon Genetic Map5137.9UniSTS
deCODE Assembly Map5135.81UniSTS
Stanford-G3 RH Map55034.0UniSTS
Whitehead-YAC Contig Map5 UniSTS
GeneMap99-G3 RH Map55122.0UniSTS
D8S1135  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37816,065,453 - 16,065,790UniSTSGRCh37
Build 36816,109,824 - 16,110,161RGDNCBI36
Celera815,029,985 - 15,030,314RGD
Cytogenetic Map5q31UniSTS
HuRef814,610,034 - 14,610,363UniSTS
HuRef5128,514,287 - 128,515,559UniSTS
Whitehead-RH Map859.5UniSTS
Whitehead-YAC Contig Map8 UniSTS
NCBI RH Map8169.0UniSTS
D5S2665  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375133,316,771 - 133,316,901UniSTSGRCh37
Build 365133,344,670 - 133,344,800RGDNCBI36
Celera5129,440,457 - 129,440,587RGD
Cytogenetic Map5q31UniSTS
HuRef5128,501,721 - 128,501,851UniSTS
D17S2116  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375133,310,821 - 133,310,930UniSTSGRCh37
Build 365133,338,720 - 133,338,829RGDNCBI36
Celera5129,434,506 - 129,434,615RGD
Cytogenetic Map5q31UniSTS
HuRef5128,495,766 - 128,495,875UniSTS
DXS1261  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31UniSTS
WI-7287  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31UniSTS
Whitehead-YAC Contig MapX UniSTS
RH38718  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1952
Count of miRNA genes:670
Interacting mature miRNAs:762
Transcripts:ENST00000265333, ENST00000395044, ENST00000395047, ENST00000425992, ENST00000466080, ENST00000489906, ENST00000492324
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1 11
Medium 2431 2856 1722 622 1842 464 4354 2169 3701 416 1437 1607 171 1204 2788 4
Low 5 133 1 1 107 1 1 27 16 1 3 2 2 1
Below cutoff 1 3 1 1 15 1 8 3 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_036624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_036625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005272075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA072915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB475162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM035071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265333   ⟹   ENSP00000265333
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,971,871 - 134,004,975 (-)Ensembl
RefSeq Acc Id: ENST00000395044   ⟹   ENSP00000378484
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,971,915 - 134,004,742 (-)Ensembl
RefSeq Acc Id: ENST00000395047   ⟹   ENSP00000378487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,971,952 - 134,004,842 (-)Ensembl
RefSeq Acc Id: ENST00000425992   ⟹   ENSP00000390129
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,980,729 - 134,004,635 (-)Ensembl
RefSeq Acc Id: ENST00000466080
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,988,788 - 134,004,692 (-)Ensembl
RefSeq Acc Id: ENST00000489906
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,972,726 - 133,976,369 (-)Ensembl
RefSeq Acc Id: ENST00000492324
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,972,726 - 133,981,017 (-)Ensembl
RefSeq Acc Id: NM_003374   ⟹   NP_003365
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,871 - 134,004,975 (-)NCBI
GRCh375133,307,566 - 133,341,300 (-)NCBI
Build 365133,335,506 - 133,368,332 (-)NCBI Archive
HuRef5128,492,511 - 128,525,784 (-)ENTREZGENE
CHM1_15132,740,167 - 132,773,436 (-)NCBI
Sequence:
RefSeq Acc Id: NR_036624
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,871 - 134,004,768 (-)NCBI
GRCh375133,307,566 - 133,341,300 (-)NCBI
HuRef5128,492,511 - 128,525,784 (-)ENTREZGENE
CHM1_15132,740,167 - 132,773,269 (-)NCBI
Sequence:
RefSeq Acc Id: NR_036625
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,871 - 134,004,768 (-)NCBI
GRCh375133,307,566 - 133,341,300 (-)NCBI
HuRef5128,492,511 - 128,525,784 (-)ENTREZGENE
CHM1_15132,740,167 - 132,773,269 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005272075   ⟹   XP_005272132
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,915 - 134,005,133 (-)NCBI
GRCh375133,307,566 - 133,341,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009821   ⟹   XP_016865310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,915 - 134,004,653 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009822   ⟹   XP_016865311
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,915 - 134,070,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009823   ⟹   XP_016865312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,971,915 - 134,004,658 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003365   ⟸   NM_003374
- UniProtKB: P21796 (UniProtKB/Swiss-Prot),   B3KTS5 (UniProtKB/TrEMBL),   A0A1L1UHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005272132   ⟸   XM_005272075
- Peptide Label: isoform X1
- UniProtKB: P21796 (UniProtKB/Swiss-Prot),   A0A1L1UHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865311   ⟸   XM_017009822
- Peptide Label: isoform X1
- UniProtKB: P21796 (UniProtKB/Swiss-Prot),   A0A1L1UHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865312   ⟸   XM_017009823
- Peptide Label: isoform X1
- UniProtKB: P21796 (UniProtKB/Swiss-Prot),   A0A1L1UHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865310   ⟸   XM_017009821
- Peptide Label: isoform X1
- UniProtKB: P21796 (UniProtKB/Swiss-Prot),   A0A1L1UHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000390129   ⟸   ENST00000425992
RefSeq Acc Id: ENSP00000378487   ⟸   ENST00000395047
RefSeq Acc Id: ENSP00000378484   ⟸   ENST00000395044
RefSeq Acc Id: ENSP00000265333   ⟸   ENST00000265333

Promoters
RGD ID:6803699
Promoter ID:HG_KWN:51103
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000259213
Position:
Human AssemblyChrPosition (strand)Source
Build 365133,340,654 - 133,341,154 (-)MPROMDB
RGD ID:6803697
Promoter ID:HG_KWN:51104
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000259212
Position:
Human AssemblyChrPosition (strand)Source
Build 365133,345,156 - 133,345,656 (-)MPROMDB
RGD ID:6852336
Promoter ID:EP73975
Type:initiation region
Name:HS_VDAC1
Description:Voltage-dependent anion channel 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 365133,368,301 - 133,368,361EPD
RGD ID:6803698
Promoter ID:HG_KWN:51105
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000265333,   OTTHUMT00000259209,   OTTHUMT00000259210,   OTTHUMT00000259211,   UC003KYQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365133,368,341 - 133,369,642 (-)MPROMDB
RGD ID:6870578
Promoter ID:EPDNEW_H8454
Type:initiation region
Name:VDAC1_1
Description:voltage dependent anion channel 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385134,004,739 - 134,004,799EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1(chr5:132816203-135383158)x1 copy number loss See cases [RCV000052113] Chr5:132816203..135383158 [GRCh38]
Chr5:132151895..134718848 [GRCh37]
Chr5:132179794..134746747 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2
pathogenic
GRCh38/hg38 5q31.1(chr5:133531234-134847678)x1 copy number loss See cases [RCV000052115] Chr5:133531234..134847678 [GRCh38]
Chr5:132866925..134183368 [GRCh37]
Chr5:132894824..134211267 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132301874-134187817)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|See cases [RCV000053312] Chr5:132301874..134187817 [GRCh38]
Chr5:131637567..133523508 [GRCh37]
Chr5:131665466..133551407 [NCBI36]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12669 AgrOrtholog
COSMIC VDAC1 COSMIC
Ensembl Genes ENSG00000213585 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000265333 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378484 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378487 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390129 UniProtKB/TrEMBL
Ensembl Transcript ENST00000265333 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395044 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000425992 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000213585 GTEx
HGNC ID HGNC:12669 ENTREZGENE
Human Proteome Map VDAC1 Human Proteome Map
InterPro Porin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDAC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7416 ENTREZGENE
OMIM 604492 OMIM
PANTHER PTHR11743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11743:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Porin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37292 PharmGKB
PRINTS EUKARYTPORIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EUKARYOTIC_PORIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.519320 ENTREZGENE
UniProt A0A1L1UHR1 ENTREZGENE, UniProtKB/TrEMBL
  B3KTS5 ENTREZGENE, UniProtKB/TrEMBL
  C9JI87_HUMAN UniProtKB/TrEMBL
  L8ECA2_HUMAN UniProtKB/TrEMBL
  P21796 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B3KVK4 UniProtKB/Swiss-Prot
  D3DQ93 UniProtKB/Swiss-Prot
  Q5FVE7 UniProtKB/Swiss-Prot
  Q9UIQ5 UniProtKB/Swiss-Prot
  Q9UPL0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 VDAC1  voltage dependent anion channel 1    voltage-dependent anion channel 1  Symbol and/or name change 5135510 APPROVED