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Gene: HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) Homo sapiens
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Symbol: HMGCS2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
Description: Predicted to have hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Localizes to the mitochondrion. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial; mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase; testicular tissue protein Li 88
Orthologs:
Mus musculus (house mouse) : Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Canis lupus familiaris (dog) : HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Sus scrofa (pig) : LOC110260333 (hydroxymethylglutaryl-CoA synthase, mitochondrial-like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,747,996 - 119,768,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,290,619 - 120,311,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,092,525 - 120,113,041 (-)NCBINCBI36hg18NCBI36
Build 341120,003,046 - 120,023,560NCBI
Celera1118,521,355 - 118,542,283 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,149,159 - 118,170,093 (-)NCBIHuRef
CHM1_11120,406,161 - 120,427,088 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HMGCS2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737571
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.