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Gene: AQP9 (aquaporin 9) Homo sapiens

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Symbol:

AQP9

Name:

aquaporin 9

RGD ID:

735505

HGNC Page

HGNC:643

Description:

Enables channel activity. Involved in several processes, including cellular response to cAMP; glycerol transmembrane transport; and urea transmembrane transport. Located in intracellular membrane-bounded organelle. Is active in plasma membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

AQP-9; aquaglyceroporin-9; aquaporin-9; HsT17287; small solute channel 1; SSC1; T17287

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Aqp9 (aquaporin 9)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Aqp9 (aquaporin 9)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):	Aqp9 (aquaporin 9)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	AQP9 (aquaporin 9)	NCBI	Ortholog
Canis lupus familiaris (dog):	AQP9 (aquaporin 9)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aqp9 (aquaporin 9)	NCBI	Ortholog
Sus scrofa (pig):	AQP9 (aquaporin 9)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	AQP9 (aquaporin 9)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Aqp9 (aquaporin 9)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Aqp9 (aquaporin 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aqp9 (aquaporin 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aqp9a (aquaporin 9a)	Alliance	DIOPT (ZFIN)
Danio rerio (zebrafish):	aqp9b (aquaporin 9b)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	AQY3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aqp-1	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FPS1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-3	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-8	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	aqp9.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	aqp9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	58,138,169 - 58,185,911 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	58,138,169 - 58,185,911 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	58,430,368 - 58,478,110 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	56,217,700 - 56,265,402 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	56,217,770 - 56,265,401	NCBI
Celera	15	35,319,964 - 35,368,212 (+)	NCBI		Celera
Cytogenetic Map	15	q21.3	NCBI
HuRef	15	35,253,376 - 35,301,102 (+)	NCBI		HuRef
CHM1_1	15	58,548,384 - 58,596,089 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	55,940,466 - 55,988,212 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	Neuralgia	ameliorates	ISO	RGD:68433	152995474		RGD
AQP9	Human	Optic Nerve Injuries		ISO	RGD:68433	2326035		RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	Bloom syndrome		IAGP	RGD:126736038	8554872	ClinVar Annotator: match by term: Bloom syndrome	ClinVar	PMID:28492532
AQP9	Human	colorectal cancer		IAGP	RGD:126736038	8554872	ClinVar Annotator: match by term: Familial colorectal cancer	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	acute myeloid leukemia		EXP		11554173	CTD Direct Evidence: therapeutic	CTD	PMID:16968895
AQP9	Human	acute promyelocytic leukemia		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23563754
AQP9	Human	Arsenic Poisoning		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19805235
AQP9	Human	autism spectrum disorder		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:35663546
AQP9	Human	juvenile rheumatoid arthritis		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19565504
AQP9	Human	leukemia		EXP		11554173	CTD Direct Evidence: therapeutic	CTD	PMID:15336539
AQP9	Human	MPTP Poisoning		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29566083

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	(+)-schisandrin B	multiple interactions	ISO	RGD:68433	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AQP9 mRNA]	CTD	PMID:31150632
AQP9	Human	(-)-demecolcine	increases expression	EXP		6480464	Demecolcine results in increased expression of AQP9 mRNA	CTD	PMID:23649840
AQP9	Human	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:68648	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AQP9 mRNA	CTD	PMID:36331819
AQP9	Human	17alpha-ethynylestradiol	increases expression	ISO	RGD:68433	6480464	Ethinyl Estradiol results in increased expression of AQP9 mRNA	CTD	PMID:17108234
AQP9	Human	17beta-estradiol	multiple interactions	ISO	RGD:68433	6480464	[Estradiol results in decreased expression of AQP9 mRNA] which results in decreased uptake of Glycerol; more ...	CTD	PMID:20381596\|PMID:22114114
AQP9	Human	17beta-estradiol	increases expression	ISO	RGD:68648	6480464	Estradiol results in increased expression of AQP9 mRNA	CTD	PMID:39298647
AQP9	Human	17beta-estradiol	decreases expression	ISO	RGD:68433	6480464	Estradiol results in decreased expression of AQP9 mRNA	CTD	PMID:22114114
AQP9	Human	17beta-estradiol	increases expression	ISO	RGD:68433	6480464	Estradiol results in increased expression of AQP9 mRNA; Estradiol results in increased expression of AQP9 more ...	CTD	PMID:17026757\|PMID:20381596
AQP9	Human	17beta-hydroxy-5alpha-androstan-3-one	increases expression	ISO	RGD:68433	6480464	Dihydrotestosterone results in increased expression of AQP9 mRNA; Dihydrotestosterone results in increased expression of AQP9 more ...	CTD	PMID:17026757
AQP9	Human	17beta-hydroxy-5alpha-androstan-3-one	multiple interactions	EXP		6480464	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in decreased expression of AQP9 mRNA]	CTD	PMID:20378617
AQP9	Human	17beta-hydroxy-5alpha-androstan-3-one	decreases expression	EXP		6480464	Dihydrotestosterone results in decreased expression of AQP9 mRNA; Dihydrotestosterone results in decreased expression of AQP9 more ...	CTD	PMID:20378617
AQP9	Human	2,2',4,4'-Tetrabromodiphenyl ether	affects expression	ISO	RGD:68648	6480464	2,2',4,4'-tetrabromodiphenyl ether affects the expression of AQP9 mRNA	CTD	PMID:30294300
AQP9	Human	2,3,4,7,8-Pentachlorodibenzofuran	decreases expression	ISO	RGD:68433	6480464	2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of AQP9 mRNA	CTD	PMID:21724226
AQP9	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:68648	6480464	Tetrachlorodibenzodioxin results in increased expression of AQP9 mRNA	CTD	PMID:18796159
AQP9	Human	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AQP9 mRNA	CTD	PMID:26159488
AQP9	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of AQP9 mRNA	CTD	PMID:20106945\|PMID:26159488
AQP9	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:68433	6480464	Tetrachlorodibenzodioxin results in decreased expression of AQP9 mRNA	CTD	PMID:19490992\|PMID:21215274\|PMID:21724226
AQP9	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:68648	6480464	Tetrachlorodibenzodioxin affects the expression of AQP9 mRNA	CTD	PMID:21570461
AQP9	Human	2,3,7,8-Tetrachlorodibenzofuran	decreases expression	ISO	RGD:68433	6480464	2,3,7,8-tetrachlorodibenzofuran results in decreased expression of AQP9 mRNA	CTD	PMID:21724226
AQP9	Human	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	RGD:68648	6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of AQP9 mRNA	CTD	PMID:38648751
AQP9	Human	2-hydroxypropanoic acid	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Lactic Acid	CTD	PMID:9733774
AQP9	Human	2-hydroxypropanoic acid	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Lactic Acid	CTD	PMID:28798983
AQP9	Human	2-hydroxypropanoic acid	multiple interactions	EXP		6480464	arsenite inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Carbonyl Cyanide more ...	CTD	PMID:28798983
AQP9	Human	2-hydroxypropanoic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of AQP9 mRNA	CTD	PMID:30851411
AQP9	Human	3-hydroxybutyric acid	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of 3-Hydroxybutyric Acid	CTD	PMID:9733774
AQP9	Human	4,4'-diaminodiphenylmethane	decreases expression	ISO	RGD:68648	6480464	4,4'-diaminodiphenylmethane results in decreased expression of AQP9 mRNA	CTD	PMID:18648102
AQP9	Human	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:68648	6480464	bisphenol S results in decreased expression of AQP9 mRNA	CTD	PMID:39298647
AQP9	Human	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:68648	6480464	Fenretinide results in increased expression of AQP9 mRNA	CTD	PMID:28973697
AQP9	Human	5-azacytidine	multiple interactions	EXP		6480464	[Azacitidine results in increased expression of AQP9 mRNA] which results in increased uptake of arsenic more ...	CTD	PMID:25953102
AQP9	Human	5-azacytidine	increases expression	EXP		6480464	Azacitidine results in increased expression of AQP9 mRNA	CTD	PMID:25953102
AQP9	Human	5-fluorouracil	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Fluorouracil	CTD	PMID:9733774
AQP9	Human	6-propyl-2-thiouracil	decreases expression	ISO	RGD:68433	6480464	Propylthiouracil results in decreased expression of AQP9 mRNA	CTD	PMID:25825206
AQP9	Human	7,9-dihydro-1H-purine-2,6,8(3H)-trione	multiple interactions	EXP		6480464	AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]	CTD	PMID:21051542
AQP9	Human	acetamide	decreases expression	ISO	RGD:68433	6480464	acetamide results in decreased expression of AQP9 mRNA	CTD	PMID:31881176
AQP9	Human	adenine	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Adenine	CTD	PMID:9733774
AQP9	Human	aflatoxin B1	affects expression	EXP		6480464	Aflatoxin B1 affects the expression of AQP9 protein	CTD	PMID:20106945
AQP9	Human	aflatoxin B1	decreases expression	EXP		6480464	Aflatoxin B1 results in decreased expression of AQP9 mRNA	CTD	PMID:27153756
AQP9	Human	aflatoxin B1	decreases expression	ISO	RGD:68648	6480464	Aflatoxin B1 results in decreased expression of AQP9 mRNA	CTD	PMID:19770486
AQP9	Human	all-trans-retinoic acid	multiple interactions	EXP		6480464	[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of AQP9 mRNA; [Tretinoin results in more ...	CTD	PMID:16968895\|PMID:19225113\|PMID:30093655
AQP9	Human	all-trans-retinoic acid	increases expression	EXP		6480464	Tretinoin results in increased expression of AQP9; Tretinoin results in increased expression of AQP9 mRNA; more ...	CTD	PMID:16968895\|PMID:22940758\|PMID:30093655\|PMID:33167477
AQP9	Human	ammonium chloride	affects expression	ISO	RGD:68433	6480464	Ammonium Chloride affects the expression of AQP9 mRNA	CTD	PMID:16483693
AQP9	Human	amphetamine	increases expression	ISO	RGD:68433	6480464	Amphetamine results in increased expression of AQP9 mRNA	CTD	PMID:30779732
AQP9	Human	androstane-3,17-diol	increases expression	ISO	RGD:68433	6480464	Androstane-3,17-diol results in increased expression of AQP9 mRNA; Androstane-3,17-diol results in increased expression of AQP9 more ...	CTD	PMID:17026757
AQP9	Human	antimony(0)	multiple interactions	EXP		6480464	AQP9 protein results in increased uptake of and results in increased susceptibility to Antimony	CTD	PMID:15336539
AQP9	Human	antirheumatic drug	decreases expression	EXP		6480464	Antirheumatic Agents results in decreased expression of AQP9 mRNA	CTD	PMID:24449571
AQP9	Human	arsane	multiple interactions	EXP		6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of AQP9 more ...	CTD	PMID:32525701\|PMID:36504884
AQP9	Human	arsane	increases expression	EXP		6480464	Arsenic results in increased expression of AQP9 mRNA	CTD	PMID:23866971\|PMID:28615018
AQP9	Human	arsenic acid	multiple interactions	EXP		6480464	[sodium arsenate results in increased abundance of arsenic acid] which results in increased expression of more ...	CTD	PMID:38630284
AQP9	Human	arsenic acid	increases transport	EXP		6480464	AQP9 protein results in increased transport of arsenic acid	CTD	PMID:38630284
AQP9	Human	arsenic atom	multiple interactions	EXP		6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of AQP9 more ...	CTD	PMID:32525701\|PMID:36504884
AQP9	Human	arsenic atom	increases expression	EXP		6480464	Arsenic results in increased expression of AQP9 mRNA	CTD	PMID:23866971\|PMID:28615018
AQP9	Human	arsenite(3-)	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of arsenite	CTD	PMID:11972053
AQP9	Human	arsenite(3-)	increases response to substance	EXP		6480464	AQP9 protein results in increased susceptibility to arsenite	CTD	PMID:29566083
AQP9	Human	arsenite(3-)	multiple interactions	EXP		6480464	[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AQP9 more ...	CTD	PMID:28798983\|PMID:38630284
AQP9	Human	arsenite(3-)	increases uptake	ISO	RGD:68648	6480464	AQP9 protein results in increased uptake of arsenite	CTD	PMID:19341753
AQP9	Human	arsenite(3-)	multiple interactions	ISO	RGD:68648	6480464	Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]	CTD	PMID:19341753
AQP9	Human	arsenite(3-)	increases response to substance	ISO	RGD:68648	6480464	AQP9 protein results in increased susceptibility to arsenite	CTD	PMID:19341753
AQP9	Human	arsenous acid	increases response to substance	EXP		6480464	AQP9 protein results in increased susceptibility to Arsenic Trioxide	CTD	PMID:16968895
AQP9	Human	arsenous acid	increases import	EXP		6480464	AQP9 protein results in increased import of Arsenic Trioxide	CTD	PMID:16968895
AQP9	Human	arsenous acid	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Arsenic Trioxide	CTD	PMID:19100828\|PMID:35590355
AQP9	Human	arsenous acid	affects expression	EXP		6480464	Arsenic Trioxide affects the expression of AQP9 protein	CTD	PMID:19100828
AQP9	Human	arsenous acid	increases expression	EXP		6480464	Arsenic Trioxide results in increased expression of AQP9 protein	CTD	PMID:21945491
AQP9	Human	arsenous acid	multiple interactions	EXP		6480464	[Azacitidine results in increased expression of AQP9 mRNA] which results in increased uptake of Arsenic more ...	CTD	PMID:15336539\|PMID:16968895\|PMID:19225113\|PMID:23563754\|PMID:25953102\|PMID:30093655\|PMID:35590355
AQP9	Human	astragaloside IV	increases expression	ISO	RGD:68648	6480464	astragaloside A results in increased expression of AQP9 mRNA; astragaloside A results in increased expression more ...	CTD	PMID:37918281
AQP9	Human	atrazine	affects methylation	ISO	RGD:68433	6480464	Atrazine affects the methylation of AQP9 gene	CTD	PMID:28931070
AQP9	Human	Azoxymethane	multiple interactions	ISO	RGD:68648	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AQP9 more ...	CTD	PMID:29950665
AQP9	Human	benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of AQP9 mRNA	CTD	PMID:20064835\|PMID:32234424
AQP9	Human	benzo[a]pyrene	increases methylation	EXP		6480464	Benzo(a)pyrene results in increased methylation of AQP9 promoter	CTD	PMID:27901495
AQP9	Human	benzo[a]pyrene	affects methylation	EXP		6480464	Benzo(a)pyrene affects the methylation of AQP9 5' UTR	CTD	PMID:27901495
AQP9	Human	benzo[a]pyrene	decreases expression	ISO	RGD:68648	6480464	Benzo(a)pyrene results in decreased expression of AQP9 mRNA	CTD	PMID:19770486
AQP9	Human	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:68648	6480464	Diethylhexyl Phthalate results in increased expression of AQP9 mRNA	CTD	PMID:34319233
AQP9	Human	bisphenol A	decreases expression	ISO	RGD:68433	6480464	bisphenol A results in decreased expression of AQP9 mRNA	CTD	PMID:25181051
AQP9	Human	bisphenol A	affects expression	ISO	RGD:68433	6480464	bisphenol A affects the expression of AQP9 mRNA	CTD	PMID:30903817
AQP9	Human	buta-1,3-diene	decreases expression	ISO	RGD:68648	6480464	1,3-butadiene results in decreased expression of AQP9 mRNA	CTD	PMID:29038090
AQP9	Human	calcitriol	decreases expression	EXP		6480464	Calcitriol results in decreased expression of AQP9 mRNA	CTD	PMID:36504884
AQP9	Human	calcitriol	multiple interactions	EXP		6480464	Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in more ...	CTD	PMID:36504884
AQP9	Human	cannabidiol	increases expression	ISO	RGD:68648	6480464	Cannabidiol results in increased expression of AQP9 mRNA	CTD	PMID:21542829\|PMID:30742662
AQP9	Human	cannabidiol	multiple interactions	ISO	RGD:68648	6480464	[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in increased expression of AQP9 mRNA	CTD	PMID:30742662
AQP9	Human	carbon nanotube	increases expression	EXP		6480464	Nanotubes, Carbon results in increased expression of AQP9 mRNA	CTD	PMID:29348435
AQP9	Human	carbonyl cyanide p-trifluoromethoxyphenylhydrazone	multiple interactions	EXP		6480464	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; more ...	CTD	PMID:28798983
AQP9	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to AQP9 gene]	CTD	PMID:28238834
AQP9	Human	cholesterol	increases expression	EXP		6480464	Cholesterol results in increased expression of AQP9 mRNA	CTD	PMID:26296894
AQP9	Human	choline	multiple interactions	ISO	RGD:68648	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ...	CTD	PMID:20938992
AQP9	Human	cobalt atom	multiple interactions	EXP		6480464	[tungsten carbide co-treated with Cobalt] results in decreased expression of AQP9 mRNA	CTD	PMID:18078969
AQP9	Human	copper(II) chloride	increases expression	EXP		6480464	cupric chloride results in increased expression of AQP9 mRNA	CTD	PMID:38568856
AQP9	Human	curcumin	increases expression	EXP		6480464	Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 more ...	CTD	PMID:34675983
AQP9	Human	cycloastragenol	increases expression	ISO	RGD:68648	6480464	cycloastragenol results in increased expression of AQP9 mRNA; cycloastragenol results in increased expression of AQP9 more ...	CTD	PMID:37918281
AQP9	Human	cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of AQP9 mRNA	CTD	PMID:20106945
AQP9	Human	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of AQP9 mRNA	CTD	PMID:27989131
AQP9	Human	D-glucitol	multiple interactions	ISO	RGD:68648	6480464	Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]	CTD	PMID:19341753
AQP9	Human	D-glucitol	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Sorbitol	CTD	PMID:9733774
AQP9	Human	D-mannitol	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Mannitol	CTD	PMID:9733774
AQP9	Human	dextran sulfate	multiple interactions	ISO	RGD:68648	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AQP9 more ...	CTD	PMID:29950665
AQP9	Human	diarsenic trioxide	increases response to substance	EXP		6480464	AQP9 protein results in increased susceptibility to Arsenic Trioxide	CTD	PMID:16968895
AQP9	Human	diarsenic trioxide	increases expression	EXP		6480464	Arsenic Trioxide results in increased expression of AQP9 protein	CTD	PMID:21945491
AQP9	Human	diarsenic trioxide	increases import	EXP		6480464	AQP9 protein results in increased import of Arsenic Trioxide	CTD	PMID:16968895
AQP9	Human	diarsenic trioxide	multiple interactions	EXP		6480464	[Azacitidine results in increased expression of AQP9 mRNA] which results in increased uptake of Arsenic more ...	CTD	PMID:15336539\|PMID:16968895\|PMID:19225113\|PMID:23563754\|PMID:25953102\|PMID:30093655\|PMID:35590355
AQP9	Human	diarsenic trioxide	affects expression	EXP		6480464	Arsenic Trioxide affects the expression of AQP9 protein	CTD	PMID:19100828
AQP9	Human	diarsenic trioxide	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Arsenic Trioxide	CTD	PMID:19100828\|PMID:35590355
AQP9	Human	Dibutyl phosphate	affects expression	EXP		6480464	di-n-butylphosphoric acid affects the expression of AQP9 mRNA	CTD	PMID:37042841
AQP9	Human	dibutyl phthalate	increases expression	ISO	RGD:68433	6480464	Dibutyl Phthalate results in increased expression of AQP9 mRNA	CTD	PMID:21266533
AQP9	Human	diclofenac	decreases expression	ISO	RGD:68648	6480464	Diclofenac results in decreased expression of AQP9 mRNA	CTD	PMID:35537566
AQP9	Human	dieldrin	decreases expression	ISO	RGD:68433	6480464	Dieldrin results in decreased expression of AQP9 mRNA	CTD	PMID:23153324
AQP9	Human	dimethylarsinic acid	increases expression	EXP		6480464	Cacodylic Acid results in increased expression of AQP9 mRNA	CTD	PMID:38630284
AQP9	Human	dioxygen	multiple interactions	ISO	RGD:68433	6480464	[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression more ...	CTD	PMID:33729688
AQP9	Human	diprotium oxide	multiple interactions	ISO	RGD:68433	6480464	CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the more ...	CTD	PMID:10205677\|PMID:12606488\|PMID:21259319\|PMID:22114114\|PMID:9733774
AQP9	Human	diprotium oxide	increases transport	ISO	RGD:68433	6480464	AQP9 protein results in increased transport of Water	CTD	PMID:10205677\|PMID:21259319\|PMID:22114114\|PMID:9733774
AQP9	Human	diprotium oxide	multiple interactions	EXP		6480464	Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:9514918
AQP9	Human	diprotium oxide	increases transport	EXP		6480464	AQP9 protein results in increased transport of Water	CTD	PMID:9514918
AQP9	Human	diprotium oxide	affects transport	ISO	RGD:68433	6480464	AQP9 protein affects the transport of Water	CTD	PMID:12606488
AQP9	Human	endosulfan	multiple interactions	EXP		6480464	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AQP9 mRNA	CTD	PMID:26159488
AQP9	Human	fenofibrate	decreases expression	EXP		6480464	Fenofibrate results in decreased expression of AQP9 mRNA	CTD	PMID:25572481
AQP9	Human	fenthion	decreases expression	ISO	RGD:68648	6480464	Fenthion results in decreased expression of AQP9 mRNA	CTD	PMID:34813904
AQP9	Human	fipronil	decreases expression	ISO	RGD:68433	6480464	fipronil results in decreased expression of AQP9 mRNA	CTD	PMID:23962444\|PMID:34044035
AQP9	Human	folic acid	multiple interactions	ISO	RGD:68648	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ...	CTD	PMID:20938992
AQP9	Human	formaldehyde	increases expression	EXP		6480464	Formaldehyde results in increased expression of AQP9 mRNA	CTD	PMID:23649840
AQP9	Human	genistein	decreases expression	ISO	RGD:68433	6480464	Genistein results in decreased expression of AQP9 mRNA	CTD	PMID:20381596
AQP9	Human	glycerol	increases abundance	ISO	RGD:68648	6480464	AQP9 gene mutant form results in increased abundance of Glycerol	CTD	PMID:17360690
AQP9	Human	glycerol	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Glycerol	CTD	PMID:22114114\|PMID:9733774
AQP9	Human	glycerol	increases transport	ISO	RGD:68433	6480464	AQP9 protein results in increased transport of Glycerol	CTD	PMID:10205677
AQP9	Human	glycerol	multiple interactions	ISO	RGD:68433	6480464	[Estradiol results in decreased expression of AQP9 mRNA] which results in decreased uptake of Glycerol	CTD	PMID:22114114
AQP9	Human	glycerol	multiple interactions	ISO	RGD:68648	6480464	AQP9 protein affects the uptake of and affects the metabolism of Glycerol	CTD	PMID:17360690
AQP9	Human	heptachlor	decreases expression	ISO	RGD:68433	6480464	Heptachlor results in decreased expression of AQP9 mRNA	CTD	PMID:23153324
AQP9	Human	homovanillic acid	multiple interactions	ISO	RGD:68648	6480464	AQP9 gene mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Homovanillic Acid]	CTD	PMID:29566083
AQP9	Human	indirubin	multiple interactions	ISO	RGD:68648	6480464	[[tetraarsenic tetrasulfide co-treated with indirubin] results in increased expression of AQP9 protein] which results in more ...	CTD	PMID:18344322
AQP9	Human	indirubin-3'-monoxime	multiple interactions	ISO	RGD:68648	6480464	indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin-3'-monoxime promotes more ...	CTD	PMID:18344322
AQP9	Human	isoflavones	multiple interactions	ISO	RGD:68433	6480464	Isoflavones inhibits the reaction [Estradiol results in increased expression of AQP9 mRNA]	CTD	PMID:20381596
AQP9	Human	L-methionine	multiple interactions	ISO	RGD:68648	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ...	CTD	PMID:20938992
AQP9	Human	lamivudine	multiple interactions	ISO	RGD:68648	6480464	[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA	CTD	PMID:18313992
AQP9	Human	lipopolysaccharide	multiple interactions	EXP		6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of AQP9 mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
AQP9	Human	lipopolysaccharide	increases expression	EXP		6480464	Lipopolysaccharides results in increased expression of AQP9 mRNA	CTD	PMID:35811015
AQP9	Human	lonidamine	multiple interactions	ISO	RGD:68433	6480464	lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of more ...	CTD	PMID:12606488
AQP9	Human	LY294002	multiple interactions	EXP		6480464	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in decreased expression of AQP9 mRNA]	CTD	PMID:20378617
AQP9	Human	malathion	increases expression	EXP		6480464	Malathion results in increased expression of AQP9 mRNA	CTD	PMID:37047231
AQP9	Human	mercury atom	multiple interactions	ISO	RGD:68433	6480464	Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:21259319
AQP9	Human	mercury dichloride	multiple interactions	EXP		6480464	Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:9514918
AQP9	Human	mercury dichloride	decreases activity	ISO	RGD:68433	6480464	Mercuric Chloride results in decreased activity of AQP9 protein	CTD	PMID:9733774
AQP9	Human	mercury dichloride	multiple interactions	ISO	RGD:68433	6480464	Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:10205677\|PMID:22114114\|PMID:9733774
AQP9	Human	mercury dichloride	decreases activity	EXP		6480464	Mercuric Chloride results in decreased activity of AQP9 protein	CTD	PMID:9514918
AQP9	Human	mercury(0)	multiple interactions	ISO	RGD:68433	6480464	Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:21259319
AQP9	Human	mirex	decreases expression	ISO	RGD:68433	6480464	Mirex results in decreased expression of AQP9 mRNA	CTD	PMID:23153324
AQP9	Human	N-methyl-4-phenylpyridinium	decreases expression	ISO	RGD:68433	6480464	1-Methyl-4-phenylpyridinium results in decreased expression of AQP9 mRNA	CTD	PMID:28801915
AQP9	Human	N-methyl-4-phenylpyridinium	decreases response to substance	ISO	RGD:68648	6480464	AQP9 gene mutant form results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	CTD	PMID:29566083
AQP9	Human	N-methyl-4-phenylpyridinium	increases transport	ISO	RGD:68433	6480464	AQP9 protein results in increased transport of 1-Methyl-4-phenylpyridinium	CTD	PMID:29566083
AQP9	Human	N-methyl-4-phenylpyridinium	increases response to substance	EXP		6480464	AQP9 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium	CTD	PMID:29566083
AQP9	Human	N-methyl-4-phenylpyridinium	multiple interactions	ISO	RGD:68648	6480464	AQP9 gene mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Homovanillic Acid]	CTD	PMID:29566083
AQP9	Human	N-nitrosodiethylamine	decreases expression	ISO	RGD:68433	6480464	Diethylnitrosamine results in decreased expression of AQP9 mRNA	CTD	PMID:19638242
AQP9	Human	nickel sulfate	decreases expression	EXP		6480464	nickel sulfate results in decreased expression of AQP9 mRNA	CTD	PMID:18651567
AQP9	Human	nigericin	multiple interactions	EXP		6480464	Nigericin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Nigericin inhibits more ...	CTD	PMID:28798983
AQP9	Human	nitrofen	increases expression	ISO	RGD:68433	6480464	nitrofen results in increased expression of AQP9 mRNA	CTD	PMID:33484710
AQP9	Human	O-methyleugenol	decreases expression	EXP		6480464	methyleugenol results in decreased expression of AQP9 mRNA	CTD	PMID:32234424
AQP9	Human	okadaic acid	decreases expression	EXP		6480464	Okadaic Acid results in decreased expression of AQP9 mRNA	CTD	PMID:38832940
AQP9	Human	orphenadrine	affects expression	ISO	RGD:68433	6480464	Orphenadrine affects the expression of AQP9 mRNA	CTD	PMID:23665939
AQP9	Human	oxaliplatin	multiple interactions	ISO	RGD:68433	6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of AQP9 mRNA	CTD	PMID:25729387
AQP9	Human	oxaliplatin	increases expression	ISO	RGD:68433	6480464	oxaliplatin results in increased expression of AQP9 mRNA	CTD	PMID:25729387
AQP9	Human	ozone	decreases expression	ISO	RGD:68433	6480464	Ozone results in decreased expression of AQP9 mRNA	CTD	PMID:26667333
AQP9	Human	ozone	multiple interactions	EXP		6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of AQP9 mRNA	CTD	PMID:35430440
AQP9	Human	ozone	multiple interactions	ISO	RGD:68648	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
AQP9	Human	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of AQP9 mRNA	CTD	PMID:21420995\|PMID:29067470
AQP9	Human	perfluorononanoic acid	decreases expression	EXP		6480464	perfluoro-n-nonanoic acid results in decreased expression of AQP9 mRNA	CTD	PMID:32588087
AQP9	Human	perfluorooctane-1-sulfonic acid	affects expression	ISO	RGD:68648	6480464	perfluorooctane sulfonic acid affects the expression of AQP9 mRNA	CTD	PMID:19429403
AQP9	Human	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:68648	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AQP9 mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
AQP9	Human	perfluorooctane-1-sulfonic acid	decreases expression	EXP		6480464	perfluorooctane sulfonic acid results in decreased expression of AQP9 mRNA	CTD	PMID:32588087
AQP9	Human	perfluorooctane-1-sulfonic acid	decreases expression	ISO	RGD:68433	6480464	perfluorooctane sulfonic acid results in decreased expression of AQP9 mRNA	CTD	PMID:18692542
AQP9	Human	perfluorooctanoic acid	affects expression	ISO	RGD:68648	6480464	perfluorooctanoic acid affects the expression of AQP9 mRNA	CTD	PMID:19429403
AQP9	Human	perfluorooctanoic acid	decreases expression	EXP		6480464	perfluorooctanoic acid results in decreased expression of AQP9 mRNA	CTD	PMID:32588087
AQP9	Human	perfluorooctanoic acid	decreases expression	ISO	RGD:68433	6480464	perfluorooctanoic acid results in decreased expression of AQP9 mRNA	CTD	PMID:19162173
AQP9	Human	phenformin	increases expression	ISO	RGD:68433	6480464	Phenformin results in increased expression of AQP9 mRNA	CTD	PMID:31324951
AQP9	Human	phloretin	multiple interactions	ISO	RGD:68433	6480464	Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the more ...	CTD	PMID:12606488\|PMID:9733774
AQP9	Human	phloretin	multiple interactions	EXP		6480464	Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits more ...	CTD	PMID:28798983
AQP9	Human	phloretin	decreases activity	ISO	RGD:68433	6480464	Phloretin results in decreased activity of AQP9 protein	CTD	PMID:21259319\|PMID:9733774
AQP9	Human	piperonyl butoxide	decreases expression	ISO	RGD:68433	6480464	Piperonyl Butoxide results in decreased expression of AQP9 mRNA	CTD	PMID:22484513
AQP9	Human	pirinixic acid	decreases expression	ISO	RGD:68648	6480464	pirinixic acid results in decreased expression of AQP9 mRNA	CTD	PMID:18445702
AQP9	Human	pirinixic acid	decreases expression	ISO	RGD:68433	6480464	pirinixic acid results in decreased expression of AQP9 mRNA	CTD	PMID:19162173\|PMID:22484513
AQP9	Human	potassium dichromate	decreases expression	ISO	RGD:68648	6480464	Potassium Dichromate results in decreased expression of AQP9 mRNA	CTD	PMID:23608068
AQP9	Human	pregnenolone 16alpha-carbonitrile	decreases expression	ISO	RGD:68433	6480464	Pregnenolone Carbonitrile results in decreased expression of AQP9 mRNA	CTD	PMID:19162173
AQP9	Human	quercetin	decreases expression	ISO	RGD:68433	6480464	Quercetin results in decreased expression of AQP9 mRNA; Quercetin results in decreased expression of AQP9 more ...	CTD	PMID:28431985
AQP9	Human	rac-lactic acid	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Lactic Acid	CTD	PMID:9733774
AQP9	Human	rac-lactic acid	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Lactic Acid	CTD	PMID:28798983
AQP9	Human	rac-lactic acid	multiple interactions	EXP		6480464	arsenite inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Carbonyl Cyanide more ...	CTD	PMID:28798983
AQP9	Human	rac-lactic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of AQP9 mRNA	CTD	PMID:30851411
AQP9	Human	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	EXP		6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of AQP9 mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
AQP9	Human	selenic acid	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Selenic Acid analog	CTD	PMID:28798983
AQP9	Human	selenic acid	multiple interactions	EXP		6480464	arsenite inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin more ...	CTD	PMID:28798983
AQP9	Human	selenous acid	multiple interactions	EXP		6480464	arsenite inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]; Carbonyl Cyanide more ...	CTD	PMID:28798983
AQP9	Human	selenous acid	increases uptake	EXP		6480464	AQP9 protein results in increased uptake of Selenious Acid	CTD	PMID:28798983
AQP9	Human	serpentine asbestos	increases expression	EXP		6480464	Asbestos, Serpentine results in increased expression of AQP9 mRNA	CTD	PMID:24160326
AQP9	Human	sodium arsenate	multiple interactions	EXP		6480464	[sodium arsenate results in increased abundance of arsenic acid] which results in increased expression of more ...	CTD	PMID:32525701\|PMID:38630284
AQP9	Human	sodium arsenite	increases response to substance	ISO	RGD:68648	6480464	AQP9 gene mutant form results in increased susceptibility to sodium arsenite	CTD	PMID:19805235
AQP9	Human	sodium arsenite	multiple interactions	EXP		6480464	[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of AQP9 more ...	CTD	PMID:36504884\|PMID:38630284
AQP9	Human	sodium arsenite	increases expression	EXP		6480464	sodium arsenite results in increased expression of AQP9 mRNA	CTD	PMID:38568856
AQP9	Human	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of AQP9 mRNA	CTD	PMID:29301061
AQP9	Human	sodium arsenite	decreases expression	ISO	RGD:68648	6480464	sodium arsenite results in decreased expression of AQP9 mRNA	CTD	PMID:29108910
AQP9	Human	sodium arsenite	affects transport	ISO	RGD:68648	6480464	AQP9 protein affects the transport of sodium arsenite	CTD	PMID:19805235
AQP9	Human	sodium arsenite	increases expression	ISO	RGD:68648	6480464	sodium arsenite results in increased expression of AQP9 mRNA; sodium arsenite results in increased expression more ...	CTD	PMID:19733843
AQP9	Human	streptozocin	increases expression	ISO	RGD:68433	6480464	Streptozocin results in increased expression of AQP9 protein	CTD	PMID:22114114
AQP9	Human	styrene	increases expression	ISO	RGD:68433	6480464	Styrene results in increased expression of AQP9 mRNA	CTD	PMID:17654243
AQP9	Human	tamoxifen	multiple interactions	ISO	RGD:68648	6480464	Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 mRNA]; more ...	CTD	PMID:23213263
AQP9	Human	tamoxifen	decreases expression	ISO	RGD:68648	6480464	Tamoxifen results in decreased expression of AQP9 mRNA	CTD	PMID:23213263
AQP9	Human	Tanshinone I	multiple interactions	ISO	RGD:68648	6480464	[[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] more ...	CTD	PMID:18344322
AQP9	Human	Tesaglitazar	decreases expression	ISO	RGD:68433	6480464	tesaglitazar results in decreased expression of AQP9 mRNA	CTD	PMID:21515302
AQP9	Human	testosterone	decreases expression	ISO	RGD:68648	6480464	Testosterone results in decreased expression of AQP9 mRNA	CTD	PMID:21669218
AQP9	Human	tetrachloromethane	increases expression	ISO	RGD:68433	6480464	Carbon Tetrachloride results in increased expression of AQP9 mRNA	CTD	PMID:16644059
AQP9	Human	tetrachloromethane	decreases expression	ISO	RGD:68433	6480464	Carbon Tetrachloride results in decreased expression of AQP9 mRNA	CTD	PMID:31150632
AQP9	Human	tetrachloromethane	multiple interactions	ISO	RGD:68433	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AQP9 mRNA]	CTD	PMID:31150632
AQP9	Human	thiourea	increases uptake	ISO	RGD:68433	6480464	AQP9 protein results in increased uptake of Thiourea	CTD	PMID:9733774
AQP9	Human	titanium dioxide	decreases expression	ISO	RGD:68648	6480464	titanium dioxide results in decreased expression of AQP9 mRNA	CTD	PMID:29264374
AQP9	Human	titanium dioxide	multiple interactions	ISO	RGD:68648	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AQP9 more ...	CTD	PMID:29950665
AQP9	Human	topotecan	multiple interactions	ISO	RGD:68433	6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of AQP9 mRNA	CTD	PMID:25729387
AQP9	Human	triphenyl phosphate	affects expression	ISO	RGD:68433	6480464	triphenyl phosphate affects the expression of AQP9 mRNA	CTD	PMID:30589522
AQP9	Human	triphenyl phosphate	affects expression	EXP		6480464	triphenyl phosphate affects the expression of AQP9 mRNA	CTD	PMID:37042841
AQP9	Human	triptonide	increases expression	ISO	RGD:68648	6480464	triptonide results in increased expression of AQP9 mRNA	CTD	PMID:33045310
AQP9	Human	troglitazone	increases expression	ISO	RGD:68433	6480464	troglitazone results in increased expression of AQP9 mRNA	CTD	PMID:21515302
AQP9	Human	troglitazone	decreases expression	EXP		6480464	troglitazone results in decreased expression of AQP9 mRNA	CTD	PMID:25572481
AQP9	Human	trovafloxacin	decreases expression	ISO	RGD:68648	6480464	trovafloxacin results in decreased expression of AQP9 mRNA	CTD	PMID:35537566
AQP9	Human	Tungsten carbide	multiple interactions	EXP		6480464	[tungsten carbide co-treated with Cobalt] results in decreased expression of AQP9 mRNA	CTD	PMID:18078969
AQP9	Human	undecane	decreases expression	ISO	RGD:68433	6480464	undecane results in decreased expression of AQP9 protein	CTD	PMID:17337753
AQP9	Human	urea	increases transport	ISO	RGD:68433	6480464	AQP9 protein results in increased transport of Urea	CTD	PMID:10205677\|PMID:29566083
AQP9	Human	urea	increases transport	EXP		6480464	AQP9 protein results in increased transport of Urea	CTD	PMID:9514918
AQP9	Human	valdecoxib	decreases expression	ISO	RGD:68433	6480464	valdecoxib results in decreased expression of AQP9 mRNA	CTD	PMID:24136188
AQP9	Human	valproic acid	affects expression	ISO	RGD:68648	6480464	Valproic Acid affects the expression of AQP9 mRNA	CTD	PMID:17963808
AQP9	Human	vinclozolin	affects expression	ISO	RGD:68433	6480464	vinclozolin affects the expression of AQP9 mRNA	CTD	PMID:19015723
AQP9	Human	vincristine	increases expression	EXP		6480464	Vincristine results in increased expression of AQP9 mRNA	CTD	PMID:23649840
AQP9	Human	vitamin D	increases expression	EXP		6480464	Vitamin D results in increased expression of AQP9 protein	CTD	PMID:15336539
AQP9	Human	water	multiple interactions	ISO	RGD:68433	6480464	CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the more ...	CTD	PMID:10205677\|PMID:12606488\|PMID:21259319\|PMID:22114114\|PMID:9733774
AQP9	Human	water	increases transport	EXP		6480464	AQP9 protein results in increased transport of Water	CTD	PMID:9514918
AQP9	Human	water	multiple interactions	EXP		6480464	Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]	CTD	PMID:9514918
AQP9	Human	water	increases transport	ISO	RGD:68433	6480464	AQP9 protein results in increased transport of Water	CTD	PMID:10205677\|PMID:21259319\|PMID:22114114\|PMID:9733774
AQP9	Human	water	affects transport	ISO	RGD:68433	6480464	AQP9 protein affects the transport of Water	CTD	PMID:12606488
AQP9	Human	zidovudine	multiple interactions	EXP		6480464	[Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA	CTD	PMID:20370541
AQP9	Human	zidovudine	multiple interactions	ISO	RGD:68648	6480464	[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA	CTD	PMID:18313992
AQP9	Human	zinc dichloride	decreases expression	ISO	RGD:68648	6480464	zinc chloride results in decreased expression of AQP9 mRNA	CTD	PMID:37797845

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	amine transport	involved_in	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	canalicular bile acid transport		ISO	RGD:68433	9068941		RGD	PMID:11932260\|REF_RGD_ID:625402
AQP9	Human	cellular response to cAMP	involved_in	IEP		150520179	PMID:17636236	UniProt	PMID:17636236
AQP9	Human	detoxification of arsenic-containing substance	involved_in	ISS	UniProtKB:Q9JJJ3	150520179		UniProt	GO_REF:0000024
AQP9	Human	detoxification of arsenic-containing substance	involved_in	IEA	UniProtKB:Q9JJJ3\|ensembl:ENSMUSP00000074063	150520179		Ensembl	GO_REF:0000107
AQP9	Human	glycerol transmembrane transport	involved_in	TAS		150520179		Reactome	Reactome:R-HSA-432030
AQP9	Human	glycerol transmembrane transport	involved_in	IBA	MGI:1314647\|MGI:1333777\|PANTHER:PTN000440994\|RGD:2145\|RGD:68428\|SGD:S000003966\|UniProtKB:O14520\|UniProtKB:O43315\|UniProtKB:P0AER0\|UniProtKB:Q585Q8\|UniProtKB:Q92482\|UniProtKB:Q96PS8\|WB:WBGene00000169\|WB:WBGene00000171\|WB:WBGene00000175\|ZFIN:ZDB-GENE-050809-119	150520179		GO_Central	GO_REF:0000033
AQP9	Human	glycerol transmembrane transport	involved_in	IDA		150520179	PMID:30420639	UniProt	PMID:30420639
AQP9	Human	hydrogen peroxide transmembrane transport	involved_in	IEA	GO:0140070	150520179		GOC	GO_REF:0000108
AQP9	Human	polyol transmembrane transport	involved_in	ISO	RGD:68433	9068941	PMID:9733774	UniProt	PMID:9733774\|REF_RGD_ID:68217
AQP9	Human	purine nucleobase transmembrane transport	involved_in	IEA	GO:0005345	150520179		GOC	GO_REF:0000108
AQP9	Human	purine nucleobase transport	involved_in	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	pyrimidine nucleobase transport	involved_in	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	pyrimidine-containing compound transmembrane transport	involved_in	IEA	GO:0005350	150520179		GOC	GO_REF:0000108
AQP9	Human	response to pain		ISO	RGD:68433	9068941		RGD	PMID:31746418\|REF_RGD_ID:152995474
AQP9	Human	transmembrane transport	involved_in	IEA	InterPro:IPR000425	150520179		InterPro	GO_REF:0000002
AQP9	Human	urea transmembrane transport	involved_in	IMP		150520179	PMID:9514918	UniProt	PMID:9514918
AQP9	Human	water transport		ISO	RGD:68433	9068941		RGD	PMID:11932260\|REF_RGD_ID:625402
AQP9	Human	water transport	involved_in	IBA	MGI:1314647\|MGI:1333777\|PANTHER:PTN000440995\|RGD:2145\|RGD:68428\|RGD:68433\|UniProtKB:O14520\|UniProtKB:O43315\|UniProtKB:Q8II36\|UniProtKB:Q92482\|UniProtKB:Q96PS8\|WB:WBGene00000170\|WB:WBGene00000171\|WB:WBGene00000175	150520179		GO_Central	GO_REF:0000033
AQP9	Human	water transport	involved_in	IEA	GO:0015250	150520179		GOC	GO_REF:0000108
AQP9	Human	water transport	involved_in	IDA		150520179	PMID:30420639	UniProt	PMID:30420639

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	basolateral plasma membrane		ISO	RGD:68433	9068941		RGD	PMID:11932260\|REF_RGD_ID:625402
AQP9	Human	basolateral plasma membrane	located_in	IEA	UniProtKB:Q9JJJ3\|ensembl:ENSMUSP00000074063	150520179		Ensembl	GO_REF:0000107
AQP9	Human	basolateral plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0026	150520179		UniProt	GO_REF:0000044
AQP9	Human	basolateral plasma membrane	located_in	ISS	UniProtKB:Q9JJJ3	150520179		UniProt	GO_REF:0000024
AQP9	Human	basolateral plasma membrane	is_active_in	IBA	MGI:1333777\|MGI:1891066\|PANTHER:PTN001057757\|RGD:68428\|RGD:68433\|WB:WBGene00000169	150520179		GO_Central	GO_REF:0000033
AQP9	Human	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	150520179		UniProt	GO_REF:0000044
AQP9	Human	membrane	located_in	IEA	InterPro:IPR000425	150520179		InterPro	GO_REF:0000002
AQP9	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
AQP9	Human	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044
AQP9	Human	plasma membrane	is_active_in	IBA	MGI:1314647\|MGI:1333777\|MGI:1891066\|PANTHER:PTN000440994\|RGD:2145\|RGD:68428\|RGD:68433\|SGD:S000003966\|UniProtKB:O14520\|UniProtKB:O43315\|UniProtKB:P0AER0\|UniProtKB:Q585Q8\|UniProtKB:Q92482\|UniProtKB:Q96PS8\|WB:WBGene00000169	150520179		GO_Central	GO_REF:0000033
AQP9	Human	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043
AQP9	Human	plasma membrane	located_in	TAS		150520179		Reactome	Reactome:R-HSA-432049\|Reactome:R-HSA-507868\|Reactome:R-HSA-507869\|Reactome:R-HSA-507870\|Reactome:R-HSA-507871\|Reactome:R-HSA-507873\|Reactome:R-HSA-507875
AQP9	Human	plasma membrane	located_in	IEA	ARBA:ARBA00027801	150520179		UniProt	GO_REF:0000117
AQP9	Human	plasma membrane	is_active_in	IDA		150520179	PMID:9514918	UniProt	PMID:9514918

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	channel activity	enables	IDA		150520179	PMID:10564231, PMID:35054513	UniProt	PMID:10564231\|PMID:35054513
AQP9	Human	channel activity	enables	IEA	UniProtKB:Q9JJJ3\|ensembl:ENSMUSP00000074063	150520179		Ensembl	GO_REF:0000107
AQP9	Human	channel activity	enables	IEA	InterPro:IPR000425	150520179		InterPro	GO_REF:0000002
AQP9	Human	glycerol channel activity	enables	IBA	PANTHER:PTN000440994\|RGD:2145\|RGD:68428\|RGD:68433\|SGD:S000001840\|SGD:S000003966\|UniProtKB:O14520\|UniProtKB:P0AER0\|UniProtKB:Q585Q8\|UniProtKB:Q92482\|UniProtKB:Q96PS8	150520179		GO_Central	GO_REF:0000033
AQP9	Human	glycerol channel activity	enables	IDA		150520179	PMID:10564231, PMID:30420639, PMID:35054513	UniProt	PMID:10564231\|PMID:30420639\|PMID:35054513
AQP9	Human	glycerol channel activity	enables	EXP		150520179	PMID:10564231, PMID:18762715	Reactome	PMID:10564231\|PMID:18762715
AQP9	Human	glycerol channel activity	NOT\|enables	IDA		150520179	PMID:9514918	UniProt	PMID:9514918
AQP9	Human	hydrogen peroxide channel activity	enables	IMP		150520179	PMID:26837049	UniProt	PMID:26837049
AQP9	Human	hydrogen peroxide channel activity	enables	IEA	UniProtKB:Q9JJJ3\|ensembl:ENSMUSP00000074063	150520179		Ensembl	GO_REF:0000107
AQP9	Human	polyol transmembrane transporter activity	enables	ISO	RGD:68433	9068941	PMID:9733774	UniProt	PMID:9733774\|REF_RGD_ID:68217
AQP9	Human	protein binding		ISO	RGD:2332	9068941		RGD	PMID:25270793\|REF_RGD_ID:11567217
AQP9	Human	protein binding	enables	IPI	UniProtKB:O75084\|UniProtKB:O95470\|UniProtKB:P01350\|UniProtKB:P02787\|UniProtKB:P05090\|UniProtKB:P09466\|UniProtKB:P24593\|UniProtKB:P30301\|UniProtKB:Q08AM2\|UniProtKB:Q14802-3\|UniProtKB:Q4LDR2\|UniProtKB:Q7Z7G2\|UniProtKB:Q8N6F1-2\|UniProtKB:Q8TAF8\|UniProtKB:Q9BV81\|UniProtKB:Q9BVC6\|UniProtKB:Q9BVK6\|UniProtKB:Q9NRX5\|UniProtKB:Q9NVC3\|UniProtKB:Q9NVV5-2\|UniProtKB:Q9P0B6\|UniProtKB:Q9UM44	150520179	PMID:32296183	IntAct	PMID:32296183
AQP9	Human	protein binding	enables	IPI	UniProtKB:Q969F0	150520179	PMID:25416956	IntAct	PMID:25416956
AQP9	Human	purine nucleobase transmembrane transporter activity	enables	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	pyrimidine nucleobase transmembrane transporter activity	enables	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	urea channel activity	enables	IDA		150520179	PMID:10564231, PMID:9514918	UniProt	PMID:10564231\|PMID:9514918
AQP9	Human	urea channel activity	enables	IEA	UniProtKB:Q9JJJ3\|ensembl:ENSMUSP00000074063	150520179		Ensembl	GO_REF:0000107
AQP9	Human	urea transmembrane transporter activity	enables	ISS	UniProtKB:P56627	150520179		UniProt	GO_REF:0000024
AQP9	Human	water channel activity		ISO	RGD:68433	9068941		RGD	PMID:11932260\|REF_RGD_ID:625402
AQP9	Human	water channel activity	enables	IBA	PANTHER:PTN000440995\|RGD:2145\|RGD:68428\|RGD:68433\|UniProtKB:O14520\|UniProtKB:O43315\|UniProtKB:Q585Q8\|UniProtKB:Q92482\|UniProtKB:Q96PS8\|WB:WBGene00000170\|WB:WBGene00000171\|WB:WBGene00000175	150520179		GO_Central	GO_REF:0000033
AQP9	Human	water channel activity	enables	IEA	ARBA:ARBA00034972	150520179		UniProt	GO_REF:0000117
AQP9	Human	water channel activity	enables	IDA		150520179	PMID:30420639, PMID:9514918	UniProt	PMID:30420639\|PMID:9514918

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	water transport pathway		TAS		2312795		RGD

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
AQP9	Human	bile acid transport pathway		IEA		6907045		KEGG	hsa:04976

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (EXP)

acute promyelocytic leukemia (EXP)

Arsenic Poisoning (EXP)

autism spectrum disorder (EXP)

Bloom syndrome (IAGP)

colorectal cancer (IAGP)

juvenile rheumatoid arthritis (EXP)

leukemia (EXP)

MPTP Poisoning (EXP)

Neuralgia (ISO)

Optic Nerve Injuries (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(-)-demecolcine (EXP)

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,4,7,8-Pentachlorodibenzofuran (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (EXP,ISO)

3-hydroxybutyric acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (ISO)

7,9-dihydro-1H-purine-2,6,8(3H)-trione (EXP)

acetamide (ISO)

adenine (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP)

ammonium chloride (ISO)

amphetamine (ISO)

androstane-3,17-diol (ISO)

antimony(0) (EXP)

antirheumatic drug (EXP)

arsane (EXP)

arsenic acid (EXP)

arsenic atom (EXP)

arsenite(3-) (EXP,ISO)

arsenous acid (EXP)

astragaloside IV (ISO)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

buta-1,3-diene (ISO)

calcitriol (EXP)

cannabidiol (ISO)

carbon nanotube (EXP)

carbonyl cyanide p-trifluoromethoxyphenylhydrazone (EXP)

CGP 52608 (EXP)

cholesterol (EXP)

choline (ISO)

cobalt atom (EXP)

copper(II) chloride (EXP)

curcumin (EXP)

cycloastragenol (ISO)

cyclosporin A (EXP)

D-glucitol (ISO)

D-mannitol (ISO)

dextran sulfate (ISO)

diarsenic trioxide (EXP)

Dibutyl phosphate (EXP)

dibutyl phthalate (ISO)

diclofenac (ISO)

dieldrin (ISO)

dimethylarsinic acid (EXP)

dioxygen (ISO)

diprotium oxide (EXP,ISO)

endosulfan (EXP)

fenofibrate (EXP)

fenthion (ISO)

fipronil (ISO)

folic acid (ISO)

formaldehyde (EXP)

genistein (ISO)

glycerol (ISO)

heptachlor (ISO)

homovanillic acid (ISO)

indirubin (ISO)

indirubin-3'-monoxime (ISO)

isoflavones (ISO)

L-methionine (ISO)

lamivudine (ISO)

lipopolysaccharide (EXP)

lonidamine (ISO)

LY294002 (EXP)

malathion (EXP)

mercury atom (ISO)

mercury dichloride (EXP,ISO)

mercury(0) (ISO)

mirex (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (ISO)

nickel sulfate (EXP)

nigericin (EXP)

nitrofen (ISO)

O-methyleugenol (EXP)

okadaic acid (EXP)

orphenadrine (ISO)

oxaliplatin (ISO)

ozone (EXP,ISO)

paracetamol (EXP)

perfluorononanoic acid (EXP)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenformin (ISO)

phloretin (EXP,ISO)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

rac-lactic acid (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

selenic acid (EXP)

selenous acid (EXP)

serpentine asbestos (EXP)

sodium arsenate (EXP)

sodium arsenite (EXP,ISO)

streptozocin (ISO)

styrene (ISO)

tamoxifen (ISO)

Tanshinone I (ISO)

Tesaglitazar (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thiourea (ISO)

titanium dioxide (ISO)

topotecan (ISO)

triphenyl phosphate (EXP,ISO)

triptonide (ISO)

troglitazone (EXP,ISO)

trovafloxacin (ISO)

Tungsten carbide (EXP)

undecane (ISO)

urea (EXP,ISO)

valdecoxib (ISO)

valproic acid (ISO)

vinclozolin (ISO)

vincristine (EXP)

vitamin D (EXP)

water (EXP,ISO)

zidovudine (EXP,ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amine transport (ISS)

canalicular bile acid transport (ISO)

cellular response to cAMP (IEP)

detoxification of arsenic-containing substance (IEA,ISS)

glycerol transmembrane transport (IBA,IDA,TAS)

hydrogen peroxide transmembrane transport (IEA)

polyol transmembrane transport (ISO)

purine nucleobase transmembrane transport (IEA)

purine nucleobase transport (ISS)

pyrimidine nucleobase transport (ISS)

pyrimidine-containing compound transmembrane transport (IEA)

response to pain (ISO)

transmembrane transport (IEA)

urea transmembrane transport (IMP)

water transport (IBA,IDA,IEA,ISO)

Cellular Component

basolateral plasma membrane (IBA,IEA,ISO,ISS)

membrane (IEA)

plasma membrane (IBA,IDA,IEA,TAS)

Molecular Function

channel activity (IDA,IEA)

glycerol channel activity (EXP,IBA,IDA)

hydrogen peroxide channel activity (IEA,IMP)

polyol transmembrane transporter activity (ISO)

protein binding (IPI,ISO)

purine nucleobase transmembrane transporter activity (ISS)

pyrimidine nucleobase transmembrane transporter activity (ISS)

urea channel activity (IDA,IEA)

urea transmembrane transporter activity (ISS)

water channel activity (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

water transport pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Changes in ocular aquaporin expression following optic nerve crush.	Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40.
2.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
3.	Aquaporins in the kidney.	Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	At low doses ethanol maintains blood-brain barrier (BBB) integrity after hypoxia and reoxygenation: a brain slice study.	Peng C, etal., Neurol Res. 2013 Oct;35(8):790-7. doi: 10.1179/1743132813Y.0000000198. Epub 2013 Apr 12.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models.	Wu J, etal., Mol Med Rep. 2020 Jan;21(1):291-303. doi: 10.3892/mmr.2019.10829. Epub 2019 Nov 20.

Additional References at PubMed

PMID:1373524	PMID:1510932	PMID:7530250	PMID:9369468	PMID:9405233	PMID:9514918	PMID:9733774	PMID:9806845	PMID:9829975	PMID:10318966	PMID:10510269	PMID:10564231
PMID:11001937	PMID:11034202	PMID:11076974	PMID:11466204	PMID:11573934	PMID:11597198	PMID:12084581	PMID:12477932	PMID:12681500	PMID:14701836	PMID:15336539	PMID:15489334
PMID:15592307	PMID:15948717	PMID:16480766	PMID:16596446	PMID:17081983	PMID:17178220	PMID:17346701	PMID:17525633	PMID:17545093	PMID:17636236	PMID:18197497	PMID:18202181
PMID:18401671	PMID:18501347	PMID:18511455	PMID:18652774	PMID:18718702	PMID:18762715	PMID:19100828	PMID:19481256	PMID:19615702	PMID:19629726	PMID:19772916	PMID:19802720
PMID:19916714	PMID:19953087	PMID:20220109	PMID:20378617	PMID:20379614	PMID:20424473	PMID:20587318	PMID:20732771	PMID:20960106	PMID:21251984	PMID:21873454	PMID:21873635
PMID:21945491	PMID:22262958	PMID:22319637	PMID:22425521	PMID:22916037	PMID:23238960	PMID:23383108	PMID:23448163	PMID:23563754	PMID:23573219	PMID:23612070	PMID:23866971
PMID:24086629	PMID:24418844	PMID:24463099	PMID:24643204	PMID:25105540	PMID:25416956	PMID:25604497	PMID:26313002	PMID:26344197	PMID:26837049	PMID:27022216	PMID:27082037
PMID:27121567	PMID:27187384	PMID:27216981	PMID:27329843	PMID:28360107	PMID:28640255	PMID:28798983	PMID:28942694	PMID:29040430	PMID:29351212	PMID:29678898	PMID:29901079
PMID:30320400	PMID:30420639	PMID:31070762	PMID:31703694	PMID:32229502	PMID:32296183	PMID:32513696	PMID:32891005	PMID:33462668	PMID:33579525	PMID:33759071	PMID:33961781
PMID:34268141	PMID:34470136	PMID:34786702	PMID:34927322	PMID:35054513	PMID:35076928	PMID:35477402	PMID:35508193	PMID:37360194	PMID:38279209

Genomics

Comparative Map Data

AQP9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	58,138,169 - 58,185,911 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	58,138,169 - 58,185,911 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	58,430,368 - 58,478,110 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	56,217,700 - 56,265,402 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	56,217,770 - 56,265,401	NCBI
Celera	15	35,319,964 - 35,368,212 (+)	NCBI		Celera
Cytogenetic Map	15	q21.3	NCBI
HuRef	15	35,253,376 - 35,301,102 (+)	NCBI		HuRef
CHM1_1	15	58,548,384 - 58,596,089 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	55,940,466 - 55,988,212 (+)	NCBI		T2T-CHM13v2.0

Aqp9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	71,017,941 - 71,075,170 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	71,017,941 - 71,075,964 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	71,110,659 - 71,167,849 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	71,110,659 - 71,168,682 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	70,958,468 - 71,011,096 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	70,909,221 - 70,961,849 (-)	NCBI		MGSCv36	mm8
Celera	9	68,318,271 - 68,366,608 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	39.85	NCBI

Aqp9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	80,678,027 - 80,718,273 (-)	NCBI		GRCr8
mRatBN7.2	8	71,797,231 - 71,837,485 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	71,797,234 - 71,837,395 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	77,331,526 - 77,371,805 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	75,604,495 - 75,644,778 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	73,441,536 - 73,481,821 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	77,559,621 - 77,599,781 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	77,559,624 - 77,599,781 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	75,483,006 - 75,523,423 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	75,611,485 - 75,651,646 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	75,630,541 - 75,670,700 (-)	NCBI
Celera	8	69,899,442 - 69,939,523 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Aqp9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	16,253,571 - 16,302,657 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	16,253,706 - 16,346,602 (-)	NCBI	ChiLan1.0	ChiLan1.0

AQP9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	47,401,033 - 47,449,700 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	51,583,319 - 51,631,999 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	37,107,061 - 37,154,887 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	55,418,767 - 55,466,541 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	55,418,767 - 55,466,541 (+)	Ensembl	panpan1.1		panPan2

AQP9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	23,223,413 - 23,271,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	23,225,331 - 23,269,076 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	23,195,554 - 23,244,048 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	23,381,591 - 23,430,109 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	23,383,410 - 23,429,056 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	23,314,125 - 23,361,613 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	23,398,650 - 23,446,048 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	23,540,476 - 23,589,012 (+)	NCBI		UU_Cfam_GSD_1.0

Aqp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	101,473,023 - 101,514,878 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	19,321,426 - 19,362,146 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	19,321,366 - 19,361,227 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	113,794,040 - 113,848,683 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	113,798,380 - 113,848,452 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	125,897,935 - 125,959,201 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	25,326,108 - 25,374,743 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	25,326,087 - 25,373,336 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	115,941,107 - 115,988,513 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	13,648,065 - 13,691,260 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	13,650,612 - 13,691,175 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in AQP9
33 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 15q21.3-22.2(chr15:57456076-61907285)x1	copy number loss	See cases [RCV000050884]	Chr15:57456076..61907285 [GRCh38] Chr15:57748274..62199484 [GRCh37] Chr15:55535566..59986776 [NCBI36] Chr15:15q21.3-22.2	pathogenic
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1	copy number loss	See cases [RCV000051621]	Chr15:50864913..59646577 [GRCh38] Chr15:51157110..59938776 [GRCh37] Chr15:48944402..57726068 [NCBI36] Chr15:15q21.2-22.2	pathogenic
GRCh38/hg38 15q21.3-22.2(chr15:57567950-63019415)x1	copy number loss	See cases [RCV000051622]	Chr15:57567950..63019415 [GRCh38] Chr15:57860148..63311614 [GRCh37] Chr15:55647440..61098667 [NCBI36] Chr15:15q21.3-22.2	pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:54713558-62769295)x1	copy number loss	See cases [RCV000446622]	Chr15:54713558..62769295 [GRCh37] Chr15:15q21.3-22.2	pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4	copy number gain	See cases [RCV000447123]	Chr15:41745084..102354798 [GRCh37] Chr15:15q15.1-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4	copy number gain	See cases [RCV000447765]	Chr15:20733395..102511616 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3	copy number gain	See cases [RCV000510717]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)	copy number gain	See cases [RCV000512019]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q21.3(chr15:57518653-58974175)x3	copy number gain	See cases [RCV000511567]	Chr15:57518653..58974175 [GRCh37] Chr15:15q21.3	likely pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58088503-62221756)x1	copy number loss	See cases [RCV000510898]	Chr15:58088503..62221756 [GRCh37] Chr15:15q21.3-22.2	pathogenic
NM_020980.5(AQP9):c.829T>C (p.Phe277Leu)	single nucleotide variant	not specified [RCV004305866]	Chr15:58184076 [GRCh38] Chr15:58476275 [GRCh37] Chr15:15q21.3	uncertain significance
Single allele	duplication	not provided [RCV000677926]	Chr15:31115047..102354857 [GRCh37] Chr15:15q13.2-26.3	pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58441151-60270526)x3	copy number gain	not provided [RCV000683699]	Chr15:58441151..60270526 [GRCh37] Chr15:15q21.3-22.2	uncertain significance
GRCh37/hg19 15q21.3(chr15:57608623-59029582)x3	copy number gain	not provided [RCV000683698]	Chr15:57608623..59029582 [GRCh37] Chr15:15q21.3	uncertain significance
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3	copy number gain	not provided [RCV000751155]	Chr15:20016811..102493540 [GRCh37] Chr15:15q11.1-26.3	pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3	copy number gain	not provided [RCV000751156]	Chr15:20071673..102461162 [GRCh37] Chr15:15q11.1-26.3	pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3	copy number gain	not provided [RCV000845891]	Chr15:48000433..60747551 [GRCh37] Chr15:15q21.1-22.2	pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48589845-63543438)x3	copy number gain	not provided [RCV002472512]	Chr15:48589845..63543438 [GRCh37] Chr15:15q21.1-22.2	pathogenic
GRCh37/hg19 15q21.3(chr15:57414627-58960510)x3	copy number gain	not provided [RCV001259696]	Chr15:57414627..58960510 [GRCh37] Chr15:15q21.3	uncertain significance
GRCh37/hg19 15q21.3(chr15:58461372-58897874)x3	copy number gain	not provided [RCV001259698]	Chr15:58461372..58897874 [GRCh37] Chr15:15q21.3	uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup	duplication	Bloom syndrome [RCV001343104]\|Familial colorectal cancer [RCV001325176]	Chr15:32964879..91358519 [GRCh37] Chr15:15q13.3-26.1	uncertain significance
NM_020980.5(AQP9):c.158G>A (p.Arg53His)	single nucleotide variant	not specified [RCV004194477]	Chr15:58166719 [GRCh38] Chr15:58458918 [GRCh37] Chr15:15q21.3	likely benign
NM_020980.5(AQP9):c.415G>A (p.Val139Met)	single nucleotide variant	not specified [RCV004147995]	Chr15:58174956 [GRCh38] Chr15:58467155 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.457G>A (p.Ala153Thr)	single nucleotide variant	not specified [RCV004138876]	Chr15:58174998 [GRCh38] Chr15:58467197 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.764C>T (p.Ala255Val)	single nucleotide variant	not specified [RCV004155514]	Chr15:58184011 [GRCh38] Chr15:58476210 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.455C>G (p.Pro152Arg)	single nucleotide variant	not specified [RCV004085433]	Chr15:58174996 [GRCh38] Chr15:58467195 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.604G>A (p.Val202Ile)	single nucleotide variant	not specified [RCV004210925]	Chr15:58179236 [GRCh38] Chr15:58471435 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.77C>A (p.Thr26Asn)	single nucleotide variant	not specified [RCV004224691]	Chr15:58138642 [GRCh38] Chr15:58430841 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.229G>T (p.Gly77Cys)	single nucleotide variant	not specified [RCV004112365]	Chr15:58166790 [GRCh38] Chr15:58458989 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.476C>T (p.Ala159Val)	single nucleotide variant	not specified [RCV004225315]	Chr15:58175017 [GRCh38] Chr15:58467216 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.587T>C (p.Ile196Thr)	single nucleotide variant	not specified [RCV004276545]	Chr15:58179219 [GRCh38] Chr15:58471418 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.587T>G (p.Ile196Ser)	single nucleotide variant	not specified [RCV004336131]	Chr15:58179219 [GRCh38] Chr15:58471418 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.626T>G (p.Leu209Arg)	single nucleotide variant	not specified [RCV004365313]	Chr15:58179258 [GRCh38] Chr15:58471457 [GRCh37] Chr15:15q21.3	uncertain significance
GRCh37/hg19 15q21.3-22.2(chr15:54020810-62086530)x1	copy number loss	not provided [RCV003483234]	Chr15:54020810..62086530 [GRCh37] Chr15:15q21.3-22.2	pathogenic
NM_020980.5(AQP9):c.357C>T (p.Thr119=)	single nucleotide variant	not provided [RCV003394877]	Chr15:58173186 [GRCh38] Chr15:58465385 [GRCh37] Chr15:15q21.3	likely benign
NM_020980.5(AQP9):c.214A>G (p.Ile72Val)	single nucleotide variant	not specified [RCV004420058]	Chr15:58166775 [GRCh38] Chr15:58458974 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.358G>A (p.Val120Ile)	single nucleotide variant	not specified [RCV004420060]	Chr15:58173187 [GRCh38] Chr15:58465386 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.871C>T (p.Leu291Phe)	single nucleotide variant	not specified [RCV004420062]	Chr15:58184118 [GRCh38] Chr15:58476317 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.296G>T (p.Trp99Leu)	single nucleotide variant	not specified [RCV004420059]	Chr15:58173125 [GRCh38] Chr15:58465324 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.555G>T (p.Leu185Phe)	single nucleotide variant	not specified [RCV004420061]	Chr15:58179187 [GRCh38] Chr15:58471386 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.770T>C (p.Ile257Thr)	single nucleotide variant	not specified [RCV004664843]	Chr15:58184017 [GRCh38] Chr15:58476216 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.461C>T (p.Pro154Leu)	single nucleotide variant	not specified [RCV004664826]	Chr15:58175002 [GRCh38] Chr15:58467201 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.377A>G (p.Asp126Gly)	single nucleotide variant	not specified [RCV004656133]	Chr15:58174918 [GRCh38] Chr15:58467117 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.149G>T (p.Ser50Ile)	single nucleotide variant	not specified [RCV004664833]	Chr15:58166710 [GRCh38] Chr15:58458909 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.275G>A (p.Cys92Tyr)	single nucleotide variant	not specified [RCV004839778]	Chr15:58173104 [GRCh38] Chr15:58465303 [GRCh37] Chr15:15q21.3	uncertain significance
GRCh37/hg19 15q21.3-22.31(chr15:57544843-64324372)x1	copy number loss	not provided [RCV004819382]	Chr15:57544843..64324372 [GRCh37] Chr15:15q21.3-22.31	pathogenic
GRCh37/hg19 15q21.3(chr15:54281939-58773686)x1	copy number loss	not provided [RCV004819381]	Chr15:54281939..58773686 [GRCh37] Chr15:15q21.3	pathogenic
NM_020980.5(AQP9):c.856C>A (p.Pro286Thr)	single nucleotide variant	not specified [RCV004839781]	Chr15:58184103 [GRCh38] Chr15:58476302 [GRCh37] Chr15:15q21.3	uncertain significance
NM_020980.5(AQP9):c.232G>A (p.Val78Ile)	single nucleotide variant	not specified [RCV004839779]	Chr15:58166793 [GRCh38] Chr15:58458992 [GRCh37] Chr15:15q21.3	uncertain significance
GRCh37/hg19 15q21.3-22.2(chr15:58414853-63240164)x1	copy number loss	not provided [RCV004819873]	Chr15:58414853..63240164 [GRCh37] Chr15:15q21.3-22.2	uncertain significance
NM_020980.5(AQP9):c.181A>G (p.Asn61Asp)	single nucleotide variant	not specified [RCV004839780]	Chr15:58166742 [GRCh38] Chr15:58458941 [GRCh37] Chr15:15q21.3	uncertain significance

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	2218
Count of miRNA genes:	602
Interacting mature miRNAs:	670
Transcripts:	ENST00000219919, ENST00000536493, ENST00000558772, ENST00000559443
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597441068	GWAS1537142_H	glycine measurement QTL GWAS1537142 (human)		2e-15	glycine measurement	blood amino acid measurement (CMO:0003730)	15	58138564	58138565	Human
597528316	GWAS1624390_H	level of Phosphatidylethanolamine (16:0_20:4) in blood serum QTL GWAS1624390 (human)		5e-16	level of Phosphatidylethanolamine (16:0_20:4) in blood serum		15	58149167	58149168	Human
597145830	GWAS1241904_H	low density lipoprotein cholesterol measurement QTL GWAS1241904 (human)		1e-10	low density lipoprotein cholesterol measurement	blood low density lipoprotein cholesterol level (CMO:0000053)	15	58156088	58156089	Human
597137379	GWAS1233453_H	dimethylglycine measurement QTL GWAS1233453 (human)		5e-12	dimethylglycine measurement		15	58144971	58144972	Human
2299958	PRSTS330_H	Prostate tumor susceptibility QTL 330 (human)	1.02	0.0151	Prostate tumor susceptibility		15	34790230	60790230	Human
597524011	GWAS1620085_H	glycine measurement QTL GWAS1620085 (human)		7e-12	glycine measurement	blood amino acid measurement (CMO:0003730)	15	58142189	58142190	Human
597528331	GWAS1624405_H	level of Phosphatidylethanolamine (18:0_18:2) in blood serum QTL GWAS1624405 (human)		1e-13	level of Phosphatidylethanolamine (18:0_18:2) in blood serum		15	58149167	58149168	Human
597527994	GWAS1624068_H	level of Phosphatidylethanolamine (16:0_18:2) in blood serum QTL GWAS1624068 (human)		4e-09	level of Phosphatidylethanolamine (16:0_18:2) in blood serum		15	58149167	58149168	Human
597148239	GWAS1244313_H	high density lipoprotein cholesterol measurement QTL GWAS1244313 (human)		1e-09	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	15	58156088	58156089	Human
597205876	GWAS1301950_H	glycine measurement QTL GWAS1301950 (human)		3e-09	glycine measurement	blood amino acid measurement (CMO:0003730)	15	58174896	58174897	Human
1559354	LDLPS4_H	Low density lipoprotein particle size QTL 4 (human)	2.2	0.019	LDL particle size		15	34790230	60790230	Human
406996525	GWAS645501_H	coronary artery calcification QTL GWAS645501 (human)		3e-27	coronary artery calcification		15	58179780	58179781	Human

Markers in Region

D15S198

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,471,604 - 58,471,809	UniSTS	GRCh37
Build 36	15	56,258,896 - 56,259,101	RGD	NCBI36
Celera	15	35,361,703 - 35,361,912	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,294,591 - 35,294,800	UniSTS
Marshfield Genetic Map	15	51.21	UniSTS
Marshfield Genetic Map	15	51.21	RGD
Genethon Genetic Map	15	50.8	UniSTS
deCODE Assembly Map	15	56.46	UniSTS
GeneMap99-GB4 RH Map	15	209.78	UniSTS
Whitehead-RH Map	15	189.5	UniSTS
Whitehead-YAC Contig Map	15		UniSTS

RH98507

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,477,871 - 58,478,058	UniSTS	GRCh37
Build 36	15	56,265,163 - 56,265,350	RGD	NCBI36
Celera	15	35,367,973 - 35,368,160	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,300,863 - 35,301,050	UniSTS
GeneMap99-GB4 RH Map	15	206.95	UniSTS

SHGC-2193

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,471,660 - 58,471,767	UniSTS	GRCh37
Build 36	15	56,258,952 - 56,259,059	RGD	NCBI36
Celera	15	35,361,759 - 35,361,870	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,294,647 - 35,294,758	UniSTS

RH119218

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,464,769 - 58,465,085	UniSTS	GRCh37
Build 36	15	56,252,061 - 56,252,377	RGD	NCBI36
Celera	15	35,354,873 - 35,355,189	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,287,762 - 35,288,078	UniSTS
TNG Radiation Hybrid Map	15	20251.0	UniSTS

SHGC-150628

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,471,543 - 58,471,822	UniSTS	GRCh37
Build 36	15	56,258,835 - 56,259,114	RGD	NCBI36
Celera	15	35,361,642 - 35,361,925	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,294,530 - 35,294,813	UniSTS
TNG Radiation Hybrid Map	15	20254.0	UniSTS

ATC-P10583

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,463,980 - 58,464,145	UniSTS	GRCh37
Build 36	15	56,251,272 - 56,251,437	RGD	NCBI36
Celera	15	35,354,084 - 35,354,249	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,286,973 - 35,287,138	UniSTS
Whitehead-YAC Contig Map	15		UniSTS

PMC61180P1

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,430,489 - 58,430,835	UniSTS	GRCh37
Build 36	15	56,217,781 - 56,218,127	RGD	NCBI36
Celera	15	35,320,045 - 35,320,391	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,253,457 - 35,253,803	UniSTS

AQP9_51

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,477,376 - 58,478,127	UniSTS	GRCh37
Build 36	15	56,264,668 - 56,265,419	RGD	NCBI36
Celera	15	35,367,478 - 35,368,229	RGD
HuRef	15	35,300,368 - 35,301,119	UniSTS

D15S1283

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,475,665 - 58,475,814	UniSTS	GRCh37
Build 36	15	56,262,957 - 56,263,106	RGD	NCBI36
Celera	15	35,365,768 - 35,365,917	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,298,656 - 35,298,805	UniSTS

RH1645

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	58,475,665 - 58,475,883	UniSTS	GRCh37
Build 36	15	56,262,957 - 56,263,175	RGD	NCBI36
Celera	15	35,365,768 - 35,365,986	RGD
Cytogenetic Map	15	q	UniSTS
HuRef	15	35,298,656 - 35,298,874	UniSTS
GeneMap99-GB4 RH Map	15	213.81	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
1204	2288	2754	2197	4581	1686	2114	3	598	1770	439	2027	6923	6239	9	3564	810	1636	1408	161

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_011975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001320635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001320636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_020980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB008775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC025431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC066616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF016495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF102870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK313214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC026258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE042553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB528930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR542027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DC296768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DC410284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC250945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC311134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000219919 ⟹ ENSP00000219919

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	58,138,381 - 58,185,911 (+)	Ensembl

Ensembl Acc Id:

ENST00000536493 ⟹ ENSP00000441390

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	58,138,381 - 58,185,911 (+)	Ensembl

Ensembl Acc Id:

ENST00000558772 ⟹ ENSP00000452673

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	58,138,169 - 58,184,579 (+)	Ensembl

Ensembl Acc Id:

ENST00000559443

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	58,138,263 - 58,146,895 (+)	Ensembl

RefSeq Acc Id:

NM_001320635 ⟹ NP_001307564

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,381 - 58,185,911 (+)	NCBI
CHM1_1	15	58,548,371 - 58,596,089 (+)	NCBI
T2T-CHM13v2.0	15	55,940,678 - 55,988,212 (+)	NCBI

Sequence:

show sequence

CCACCAGAAGACGATTAAGCCACAGCCTCTAATTGGAACGGCATTTGTACAGTCAGAGACTCTT
ACCAGACATCTCCAGGAATCTGTGAGCCATTGTCAAAACGTCCATTTTCATCTGGCTGTGAAAG
TGAGGACCACAACAGGTAGGTATTGGTAGAAACAGGAGTCCTCAGAGAAGCCCCAAGATGCAGC
CTGAGGGAGCAGAAAAGGGAAAAAGCTTCAAGCAGAGACTGGTCTTGAAGAGCAGCTTAGCGAA
AGAAACCCTCTCTGAGTTCTTGGGCACGTTCATCTTGATTGTCCTTGGATGTGGCTGTGTTGCC
CAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATCAATGTTGGATTTTCAATGG
CAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGTGGTCACATCAACCCAGCTGTGTC
TTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTCAAATTGCCATTTTATGTGGGAGCCCAG
TTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTCTTTGGCATTTACTATGATGGACTTATGTCCT
TTGCTGGTGGAAAACTGCTGATCGTGGGAGAAAATGCAACAGCACACATTTTTGCAACATACCC
AGCTCCGTATCTATCTCTGGCGAACGCATTTGCAGATCAAAGCTGGAAACAACTTCTGGTGGAT
TCCTGTAGTGGGCCCTTTGGTTGGTGCTGTCATTGGAGGCCTCATCTATGTTCTTGTCATTGAA
ATCCACCATCCAGAGCCTGACTCAGTCTTTAAGACAGAACAATCTGAGGACAAACCAGAGAAAT
ATGAACTCAGTGTCATCATGTAGTGGCATGCTCAGCTCTGGATTTGCAGTCAGTTTGGGATTCT
CTTCAGAAAGATGGCATCTAAGTGTCTGTGTTCTTGTAAGCCTGAGGTGGAATCCACCCAGTTT
TGTCTGCTAGCCATATGGGACATCTAATTGGAAAAGCATCTGCATAAAAGTTTGGAAACAATGA
CCACTTCTCTACCATTGTCCCCCACCCCCACCCCCCAGAATAACGCTGACTGTCCCCTGAAACA
GCCTTCTCTCCTGCCCTGTTTATTTCATCCTCGATGGGAATTCTTGCTAGGTAAGCACTAATAA
CTCGGCATCTTGACGATAGTCCCATTTGGGTGGTTTCAGCTGCACTATCTGTATGAAATGGTGT
CACCAAAACCCTTTTCTTCAGTATCGACAAAGATTACATTCTGAGTACCAACCAAACCCTAAAT
TGAAAGACAAAACTATGGTTTCAGTCAACATATTCATGAATTAGGGAGCTAATGGGTTAAGCTT
CCAGTTCCCGCTATGCTACTGGATTTGTATAAATACTGATATTCTCCAAACCTAGTGGTGTAGG
GAGCAAGAGAATGCAGCTGGAAGGCACAAGGGGAGGACATTGTGGCATTCAGAAACTGCAGGAG
ACAAGATGAATTTGAGAAGCCAAATGGAATTTTTAATGGAAACCATTTATCAGATTAATCTCTT
GCTCTCCTGCATTTTAGAGGACACCAATTAATTTCCTGGTCTTTAGTATATAATAACCTAAAAT
ACCATTGTAACCTCAGTCATGAAAAATACATCACTCTGTCTTTTTAGCTCAAATGTATTTTCCT
AATTGCCCACTTGAGAACAGACATTTGACAAGTTATATCAACGACTGTGCTTGTCCATTATTTT
ACACATGCCCTAGAAGCCAAAACTGAAAGCCACTGGATCCTGGTCTAGCTGAATCTTCAGAGTG
GGAGGTCTCCAAAAAGATATTACCTTATTGGGCTTAACAATTCACAAGGCACTTTCACACCCAT
TATCTAATTTAATCCTCATAATGACTATGTGAGGCAAATGCCACATTGCCCATTTTTCAGATAA
AGAAACAAAATCTTAGGGAAGATAAGTTGAGTTGTCCAAGAGCACACTGAAAGTTGAATGTTAT
CTAATGCATTCCTCTACCTTTCAGAAGATCAGTAGCTGGCTGACAATCTTTGCCAAATCTTCCT
TGCTAGCCAGAAGTGGAATTGGCAGCTTCTAGAATATGTACACCTCTGGACAAAATGTTCCTCA
ATCTTAAGATACAAAGACCCTCATTGTCTGGGTCTATTCCCACACTTACTGAGTACAGATGAAG
GAAAGTGGTAGCAATTTAATCATAACTTTCATTTGCTGAAAAACATTATGAGAAGGCCTCCCTT
CCTAAGCCACCTCTGGTCTTGCTAAGTCTTGATCTTGCTTCCTGCCAGCACCAAACATTACATT
CAGGGGATTTCCTCTGGCTCAGTCTTTTCCCCTTGAAGTTCTCTAATAGATGTTACTTTTGACA
AAAGATCGCCTATGAGTTACAAGCACCAGGGGATGCTCTACATCAAGGGATGCACCTTCAGTCA
AACTGTCAAAAAGCCCAGAATTCCCAAAGGCATTAGGTTTCCCAACTGCTTTGTGCTGATATCA
GAACAGCAGAAATTAAATGTGAAATGTTTCTGATGACTTATGTTCTACAATCTATGGACATACG
GGATTTTTTTTTCTTGCTTTGAAGCTACCTGGATATTTCCTATTTGAAATAAAATTGTTCGGTC
ATTGTTG

hide sequence

RefSeq Acc Id:

NM_001320636 ⟹ NP_001307565

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,169 - 58,185,911 (+)	NCBI
CHM1_1	15	58,548,344 - 58,596,089 (+)	NCBI
T2T-CHM13v2.0	15	55,940,466 - 55,988,212 (+)	NCBI

Sequence:

show sequence

AAAATCTTTTCTGGACCAGGGCCCGTCACTGTGATTTGGCAACACAACTGGCACATCTCTTTTC
TCATCTCTTGAAAAAAACCAACAGAGAAAAAAGTACCTTGAGAATAAAGGTCCTTGGATGTGGC
TGTGTTGCCCAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATCAATGTTGGAT
TTTCAATGGCAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGTGGTCACATCAACCC
AGCTGTGTCTTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTCAAATTGCCATTTTATGTG
GGAGCCCAGTTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTCTTTGGCATTTACTATGATGGAC
TTATGTCCTTTGCTGGTGGAAAACTGCTGATCGTGGGAGAAAATGCAACAGCACACATTTTTGC
AACATACCCAGCTCCGTATCTATCTCTGGCGAACGCATTTGCAGATCAAGTGGTGGCCACCATG
ATACTCCTCATAATCGTCTTTGCCATCTTTGACTCCAGAAACTTGGGAGCCCCCAGAGGCCTAG
AGCCCATTGCCATCGGCCTCCTGATTATTGTCATTGCTTCCTCCCTGGGACTGAACAGTGGCTG
TGCCATGAACCCAGCTCGAGACCTGAGTCCCAGACTTTTCACTGCCTTGGCAGGCTGGGGGTTT
GAAGTCTTCAGAGCTGGAAACAACTTCTGGTGGATTCCTGTAGTGGGCCCTTTGGTTGGTGCTG
TCATTGGAGGCCTCATCTATGTTCTTGTCATTGAAATCCACCATCCAGAGCCTGACTCAGTCTT
TAAGACAGAACAATCTGAGGACAAACCAGAGAAATATGAACTCAGTGTCATCATGTAGTGGCAT
GCTCAGCTCTGGATTTGCAGTCAGTTTGGGATTCTCTTCAGAAAGATGGCATCTAAGTGTCTGT
GTTCTTGTAAGCCTGAGGTGGAATCCACCCAGTTTTGTCTGCTAGCCATATGGGACATCTAATT
GGAAAAGCATCTGCATAAAAGTTTGGAAACAATGACCACTTCTCTACCATTGTCCCCCACCCCC
ACCCCCCAGAATAACGCTGACTGTCCCCTGAAACAGCCTTCTCTCCTGCCCTGTTTATTTCATC
CTCGATGGGAATTCTTGCTAGGTAAGCACTAATAACTCGGCATCTTGACGATAGTCCCATTTGG
GTGGTTTCAGCTGCACTATCTGTATGAAATGGTGTCACCAAAACCCTTTTCTTCAGTATCGACA
AAGATTACATTCTGAGTACCAACCAAACCCTAAATTGAAAGACAAAACTATGGTTTCAGTCAAC
ATATTCATGAATTAGGGAGCTAATGGGTTAAGCTTCCAGTTCCCGCTATGCTACTGGATTTGTA
TAAATACTGATATTCTCCAAACCTAGTGGTGTAGGGAGCAAGAGAATGCAGCTGGAAGGCACAA
GGGGAGGACATTGTGGCATTCAGAAACTGCAGGAGACAAGATGAATTTGAGAAGCCAAATGGAA
TTTTTAATGGAAACCATTTATCAGATTAATCTCTTGCTCTCCTGCATTTTAGAGGACACCAATT
AATTTCCTGGTCTTTAGTATATAATAACCTAAAATACCATTGTAACCTCAGTCATGAAAAATAC
ATCACTCTGTCTTTTTAGCTCAAATGTATTTTCCTAATTGCCCACTTGAGAACAGACATTTGAC
AAGTTATATCAACGACTGTGCTTGTCCATTATTTTACACATGCCCTAGAAGCCAAAACTGAAAG
CCACTGGATCCTGGTCTAGCTGAATCTTCAGAGTGGGAGGTCTCCAAAAAGATATTACCTTATT
GGGCTTAACAATTCACAAGGCACTTTCACACCCATTATCTAATTTAATCCTCATAATGACTATG
TGAGGCAAATGCCACATTGCCCATTTTTCAGATAAAGAAACAAAATCTTAGGGAAGATAAGTTG
AGTTGTCCAAGAGCACACTGAAAGTTGAATGTTATCTAATGCATTCCTCTACCTTTCAGAAGAT
CAGTAGCTGGCTGACAATCTTTGCCAAATCTTCCTTGCTAGCCAGAAGTGGAATTGGCAGCTTC
TAGAATATGTACACCTCTGGACAAAATGTTCCTCAATCTTAAGATACAAAGACCCTCATTGTCT
GGGTCTATTCCCACACTTACTGAGTACAGATGAAGGAAAGTGGTAGCAATTTAATCATAACTTT
CATTTGCTGAAAAACATTATGAGAAGGCCTCCCTTCCTAAGCCACCTCTGGTCTTGCTAAGTCT
TGATCTTGCTTCCTGCCAGCACCAAACATTACATTCAGGGGATTTCCTCTGGCTCAGTCTTTTC
CCCTTGAAGTTCTCTAATAGATGTTACTTTTGACAAAAGATCGCCTATGAGTTACAAGCACCAG
GGGATGCTCTACATCAAGGGATGCACCTTCAGTCAAACTGTCAAAAAGCCCAGAATTCCCAAAG
GCATTAGGTTTCCCAACTGCTTTGTGCTGATATCAGAACAGCAGAAATTAAATGTGAAATGTTT
CTGATGACTTATGTTCTACAATCTATGGACATACGGGATTTTTTTTTCTTGCTTTGAAGCTACC
TGGATATTTCCTATTTGAAATAAAATTGTTCGGTCATTGTTG

hide sequence

RefSeq Acc Id:

NM_020980 ⟹ NP_066190

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,381 - 58,185,911 (+)	NCBI
GRCh37	15	58,430,374 - 58,478,110 (+)	NCBI
Build 36	15	56,217,700 - 56,265,402 (+)	NCBI Archive
HuRef	15	35,253,376 - 35,301,102 (+)	ENTREZGENE
CHM1_1	15	58,548,371 - 58,596,086 (+)	NCBI
T2T-CHM13v2.0	15	55,940,678 - 55,988,212 (+)	NCBI

Sequence:

show sequence

CCACCAGAAGACGATTAAGCCACAGCCTCTAATTGGAACGGCATTTGTACAGTCAGAGACTCTT
ACCAGACATCTCCAGGAATCTGTGAGCCATTGTCAAAACGTCCATTTTCATCTGGCTGTGAAAG
TGAGGACCACAACAGGTAGGTATTGGTAGAAACAGGAGTCCTCAGAGAAGCCCCAAGATGCAGC
CTGAGGGAGCAGAAAAGGGAAAAAGCTTCAAGCAGAGACTGGTCTTGAAGAGCAGCTTAGCGAA
AGAAACCCTCTCTGAGTTCTTGGGCACGTTCATCTTGATTGTCCTTGGATGTGGCTGTGTTGCC
CAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATCAATGTTGGATTTTCAATGG
CAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGTGGTCACATCAACCCAGCTGTGTC
TTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTCAAATTGCCATTTTATGTGGGAGCCCAG
TTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTCTTTGGCATTTACTATGATGGACTTATGTCCT
TTGCTGGTGGAAAACTGCTGATCGTGGGAGAAAATGCAACAGCACACATTTTTGCAACATACCC
AGCTCCGTATCTATCTCTGGCGAACGCATTTGCAGATCAAGTGGTGGCCACCATGATACTCCTC
ATAATCGTCTTTGCCATCTTTGACTCCAGAAACTTGGGAGCCCCCAGAGGCCTAGAGCCCATTG
CCATCGGCCTCCTGATTATTGTCATTGCTTCCTCCCTGGGACTGAACAGTGGCTGTGCCATGAA
CCCAGCTCGAGACCTGAGTCCCAGACTTTTCACTGCCTTGGCAGGCTGGGGGTTTGAAGTCTTC
AGAGCTGGAAACAACTTCTGGTGGATTCCTGTAGTGGGCCCTTTGGTTGGTGCTGTCATTGGAG
GCCTCATCTATGTTCTTGTCATTGAAATCCACCATCCAGAGCCTGACTCAGTCTTTAAGACAGA
ACAATCTGAGGACAAACCAGAGAAATATGAACTCAGTGTCATCATGTAGTGGCATGCTCAGCTC
TGGATTTGCAGTCAGTTTGGGATTCTCTTCAGAAAGATGGCATCTAAGTGTCTGTGTTCTTGTA
AGCCTGAGGTGGAATCCACCCAGTTTTGTCTGCTAGCCATATGGGACATCTAATTGGAAAAGCA
TCTGCATAAAAGTTTGGAAACAATGACCACTTCTCTACCATTGTCCCCCACCCCCACCCCCCAG
AATAACGCTGACTGTCCCCTGAAACAGCCTTCTCTCCTGCCCTGTTTATTTCATCCTCGATGGG
AATTCTTGCTAGGTAAGCACTAATAACTCGGCATCTTGACGATAGTCCCATTTGGGTGGTTTCA
GCTGCACTATCTGTATGAAATGGTGTCACCAAAACCCTTTTCTTCAGTATCGACAAAGATTACA
TTCTGAGTACCAACCAAACCCTAAATTGAAAGACAAAACTATGGTTTCAGTCAACATATTCATG
AATTAGGGAGCTAATGGGTTAAGCTTCCAGTTCCCGCTATGCTACTGGATTTGTATAAATACTG
ATATTCTCCAAACCTAGTGGTGTAGGGAGCAAGAGAATGCAGCTGGAAGGCACAAGGGGAGGAC
ATTGTGGCATTCAGAAACTGCAGGAGACAAGATGAATTTGAGAAGCCAAATGGAATTTTTAATG
GAAACCATTTATCAGATTAATCTCTTGCTCTCCTGCATTTTAGAGGACACCAATTAATTTCCTG
GTCTTTAGTATATAATAACCTAAAATACCATTGTAACCTCAGTCATGAAAAATACATCACTCTG
TCTTTTTAGCTCAAATGTATTTTCCTAATTGCCCACTTGAGAACAGACATTTGACAAGTTATAT
CAACGACTGTGCTTGTCCATTATTTTACACATGCCCTAGAAGCCAAAACTGAAAGCCACTGGAT
CCTGGTCTAGCTGAATCTTCAGAGTGGGAGGTCTCCAAAAAGATATTACCTTATTGGGCTTAAC
AATTCACAAGGCACTTTCACACCCATTATCTAATTTAATCCTCATAATGACTATGTGAGGCAAA
TGCCACATTGCCCATTTTTCAGATAAAGAAACAAAATCTTAGGGAAGATAAGTTGAGTTGTCCA
AGAGCACACTGAAAGTTGAATGTTATCTAATGCATTCCTCTACCTTTCAGAAGATCAGTAGCTG
GCTGACAATCTTTGCCAAATCTTCCTTGCTAGCCAGAAGTGGAATTGGCAGCTTCTAGAATATG
TACACCTCTGGACAAAATGTTCCTCAATCTTAAGATACAAAGACCCTCATTGTCTGGGTCTATT
CCCACACTTACTGAGTACAGATGAAGGAAAGTGGTAGCAATTTAATCATAACTTTCATTTGCTG
AAAAACATTATGAGAAGGCCTCCCTTCCTAAGCCACCTCTGGTCTTGCTAAGTCTTGATCTTGC
TTCCTGCCAGCACCAAACATTACATTCAGGGGATTTCCTCTGGCTCAGTCTTTTCCCCTTGAAG
TTCTCTAATAGATGTTACTTTTGACAAAAGATCGCCTATGAGTTACAAGCACCAGGGGATGCTC
TACATCAAGGGATGCACCTTCAGTCAAACTGTCAAAAAGCCCAGAATTCCCAAAGGCATTAGGT
TTCCCAACTGCTTTGTGCTGATATCAGAACAGCAGAAATTAAATGTGAAATGTTTCTGATGACT
TATGTTCTACAATCTATGGACATACGGGATTTTTTTTTCTTGCTTTGAAGCTACCTGGATATTT
CCTATTTGAAATAAAATTGTTCGGTCATTGTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001307564	(Get FASTA)	NCBI Sequence Viewer
	NP_001307565	(Get FASTA)	NCBI Sequence Viewer
	NP_066190	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF16677	(Get FASTA)	NCBI Sequence Viewer
	AAF27983	(Get FASTA)	NCBI Sequence Viewer
	AAH26258	(Get FASTA)	NCBI Sequence Viewer
	BAA24864	(Get FASTA)	NCBI Sequence Viewer
	BAG36029	(Get FASTA)	NCBI Sequence Viewer
	BAG61864	(Get FASTA)	NCBI Sequence Viewer
	CAG46824	(Get FASTA)	NCBI Sequence Viewer
	CBJ05770	(Get FASTA)	NCBI Sequence Viewer
	CBJ21222	(Get FASTA)	NCBI Sequence Viewer
	EAW77532	(Get FASTA)	NCBI Sequence Viewer
	EAW77533	(Get FASTA)	NCBI Sequence Viewer
	EAW77534	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000219919
	ENSP00000219919.4
	ENSP00000452673
GenBank Protein	O43315	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_066190 ⟸ NM_020980
- Peptide Label:	isoform 1
- UniProtKB:	Q9NP32 (UniProtKB/Swiss-Prot), O43315 (UniProtKB/Swiss-Prot), Q6FGT0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGF SMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGL MSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLE PIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAV IGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM hide sequence

RefSeq Acc Id:	NP_001307565 ⟸ NM_001320636
- Peptide Label:	isoform 3
- UniProtKB:	H0YK62 (UniProtKB/TrEMBL), B4DT52 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLM SFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEP IAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVI GGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM hide sequence

RefSeq Acc Id:	NP_001307564 ⟸ NM_001320635
- Peptide Label:	isoform 2
- Sequence:	show sequence MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGF SMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGL MSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQSWKQLLVDSCSGPFGWCCHWRPHLCSC H hide sequence

Ensembl Acc Id:

ENSP00000452673 ⟸ ENST00000558772

Ensembl Acc Id:

ENSP00000219919 ⟸ ENST00000219919

Ensembl Acc Id:

ENSP00000441390 ⟸ ENST00000536493

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O43315-F1-model_v2	AlphaFold	O43315	1-295	view protein structure

Promoters

RGD ID:

7229651

Promoter ID:

EPDNEW_H20571

Type:

initiation region

Name:

AQP9_1

Description:

aquaporin 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H20572 EPDNEW_H20573

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,196 - 58,138,256	EPDNEW

RGD ID:

7229653

Promoter ID:

EPDNEW_H20572

Type:

initiation region

Name:

AQP9_2

Description:

aquaporin 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H20571 EPDNEW_H20573

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,381 - 58,138,441	EPDNEW

RGD ID:

7229655

Promoter ID:

EPDNEW_H20573

Type:

initiation region

Name:

AQP9_3

Description:

aquaporin 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H20571 EPDNEW_H20572

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	58,138,487 - 58,138,547	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:643	AgrOrtholog
COSMIC	AQP9	COSMIC
Ensembl Genes	ENSG00000103569	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000219919	ENTREZGENE
	ENST00000219919.9	UniProtKB/Swiss-Prot
	ENST00000558772	ENTREZGENE
Gene3D-CATH	1.20.1080.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000103569	GTEx
HGNC ID	HGNC:643	ENTREZGENE
Human Proteome Map	AQP9	Human Proteome Map
InterPro	Aquaporin-like	UniProtKB/Swiss-Prot
	Aquaporin_9	UniProtKB/Swiss-Prot
	MIP	UniProtKB/Swiss-Prot
	MIP/Aquaporin	UniProtKB/Swiss-Prot
	MIP_CS	UniProtKB/Swiss-Prot
KEGG Report	hsa:366	UniProtKB/Swiss-Prot
NCBI Gene	366	ENTREZGENE
OMIM	602914	OMIM
PANTHER	AQUAPORIN OR AQUAGLYCEROPORIN RELATED	UniProtKB/Swiss-Prot
	PTHR43829:SF6	UniProtKB/Swiss-Prot
Pfam	MIP	UniProtKB/Swiss-Prot
PharmGKB	PA24927	PharmGKB
PRINTS	AQUAPORIN9	UniProtKB/Swiss-Prot
	MINTRINSICP	UniProtKB/Swiss-Prot
PROSITE	MIP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF81338	UniProtKB/Swiss-Prot
UniProt	AQP9_HUMAN	UniProtKB/Swiss-Prot
	B4DT52	ENTREZGENE, UniProtKB/TrEMBL
	H0YK62	ENTREZGENE, UniProtKB/TrEMBL
	O43315	ENTREZGENE
	Q6FGT0	ENTREZGENE, UniProtKB/TrEMBL
	Q9NP32	ENTREZGENE
UniProt Secondary	Q9NP32	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)