AQP9 (aquaporin 9) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AQP9 (aquaporin 9) Homo sapiens
Analyze
Symbol: AQP9
Name: aquaporin 9
RGD ID: 735505
HGNC Page HGNC
Description: Enables channel activity and nucleobase transmembrane transporter activity. Involved in several processes, including cellular response to cAMP; glycerol transport; and nucleobase transport. Located in intracellular membrane-bounded organelle. Is integral component of plasma membrane. Implicated in kidney disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-9; aquaglyceroporin-9; aquaporin-9; HsT17287; small solute channel 1; SSC1; T17287
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1558,138,169 - 58,185,911 (+)EnsemblGRCh38hg38GRCh38
GRCh381558,138,169 - 58,185,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371558,430,368 - 58,478,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,217,700 - 56,265,402 (+)NCBINCBI36hg18NCBI36
Build 341556,217,770 - 56,265,401NCBI
Celera1535,319,964 - 35,368,212 (+)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1535,253,376 - 35,301,102 (+)NCBIHuRef
CHM1_11558,548,384 - 58,596,089 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetamide  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
androstane-3,17-diol  (ISO)
antimony(0)  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
cholesterol  (EXP)
choline  (ISO)
cobalt atom  (EXP)
cyclosporin A  (EXP)
D-glucitol  (ISO)
D-mannitol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diprotium oxide  (EXP,ISO)
endosulfan  (EXP)
fenofibrate  (EXP)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (ISO)
glycerol  (ISO)
heptachlor  (ISO)
indirubin-3'-monoxime  (ISO)
isoflavones  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lonidamine  (ISO)
LY294002  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mirex  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP)
nigericin  (EXP)
nitrofen  (ISO)
O-methyleugenol  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phloretin  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP,ISO)
selenic acid  (EXP)
selenous acid  (EXP)
serpentine asbestos  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
styrene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiourea  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
Tungsten carbide  (EXP)
undecane  (ISO)
urea  (EXP,ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
water  (EXP,ISO)
zidovudine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Colon cancer  (IAGP)
References

Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9405233   PMID:9514918   PMID:9733774   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10510269   PMID:10564231  
PMID:11001937   PMID:11034202   PMID:11076974   PMID:11466204   PMID:11573934   PMID:11597198   PMID:12084581   PMID:12477932   PMID:12681500   PMID:14701836   PMID:15336539   PMID:15489334  
PMID:15592307   PMID:15948717   PMID:16480766   PMID:16596446   PMID:17081983   PMID:17178220   PMID:17346701   PMID:17525633   PMID:17545093   PMID:17636236   PMID:18197497   PMID:18202181  
PMID:18401671   PMID:18501347   PMID:18511455   PMID:18652774   PMID:18718702   PMID:18762715   PMID:19100828   PMID:19481256   PMID:19615702   PMID:19629726   PMID:19772916   PMID:19802720  
PMID:19916714   PMID:19953087   PMID:20220109   PMID:20378617   PMID:20379614   PMID:20424473   PMID:20587318   PMID:20732771   PMID:20960106   PMID:21251984   PMID:21873454   PMID:21873635  
PMID:21945491   PMID:22262958   PMID:22319637   PMID:22425521   PMID:22916037   PMID:23238960   PMID:23383108   PMID:23448163   PMID:23563754   PMID:23573219   PMID:23612070   PMID:23866971  
PMID:24086629   PMID:24418844   PMID:24463099   PMID:24643204   PMID:25105540   PMID:25416956   PMID:25604497   PMID:26313002   PMID:26344197   PMID:26837049   PMID:27022216   PMID:27082037  
PMID:27121567   PMID:27187384   PMID:27216981   PMID:27329843   PMID:28360107   PMID:28640255   PMID:28798983   PMID:28942694   PMID:29040430   PMID:29351212   PMID:29678898   PMID:29901079  
PMID:30320400   PMID:30420639   PMID:31070762   PMID:31703694   PMID:32229502   PMID:32296183   PMID:32513696   PMID:32891005   PMID:33462668   PMID:33579525   PMID:33961781   PMID:34268141  


Genomics

Comparative Map Data
AQP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1558,138,169 - 58,185,911 (+)EnsemblGRCh38hg38GRCh38
GRCh381558,138,169 - 58,185,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371558,430,368 - 58,478,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,217,700 - 56,265,402 (+)NCBINCBI36hg18NCBI36
Build 341556,217,770 - 56,265,401NCBI
Celera1535,319,964 - 35,368,212 (+)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1535,253,376 - 35,301,102 (+)NCBIHuRef
CHM1_11558,548,384 - 58,596,089 (+)NCBICHM1_1
Aqp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,017,941 - 71,075,170 (-)NCBIGRCm39mm39
GRCm39 Ensembl971,017,941 - 71,075,964 (-)Ensembl
GRCm38971,110,659 - 71,167,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,110,659 - 71,168,682 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,958,468 - 71,011,096 (-)NCBIGRCm37mm9NCBIm37
MGSCv36970,909,221 - 70,961,849 (-)NCBImm8
Celera968,318,271 - 68,366,608 (-)NCBICelera
Cytogenetic Map9DNCBI
Aqp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,797,231 - 71,837,485 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl871,797,234 - 71,837,395 (-)Ensembl
Rnor_6.0877,559,621 - 77,599,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,559,624 - 77,599,781 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,483,006 - 75,523,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,611,485 - 75,651,646 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,630,541 - 75,670,700 (-)NCBI
Celera869,899,442 - 69,939,523 (+)NCBICelera
Cytogenetic Map8q24NCBI
Aqp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,253,571 - 16,302,657 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545016,253,706 - 16,346,602 (-)NCBIChiLan1.0ChiLan1.0
AQP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,418,767 - 55,466,541 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,418,767 - 55,466,541 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01537,107,061 - 37,154,887 (+)NCBIMhudiblu_PPA_v0panPan3
AQP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,223,413 - 23,271,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,225,331 - 23,269,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,195,554 - 23,244,048 (+)NCBI
ROS_Cfam_1.03023,381,591 - 23,430,109 (+)NCBI
UMICH_Zoey_3.13023,314,125 - 23,361,613 (+)NCBI
UNSW_CanFamBas_1.03023,398,650 - 23,446,048 (+)NCBI
UU_Cfam_GSD_1.03023,540,476 - 23,589,012 (+)NCBI
Aqp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,473,023 - 101,514,878 (+)NCBI
SpeTri2.0NW_00493647119,321,366 - 19,361,227 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,765,680 - 113,848,685 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,798,380 - 113,848,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,897,935 - 125,959,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,326,108 - 25,374,743 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,326,087 - 25,373,336 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048115,941,107 - 115,988,513 (+)NCBIVero_WHO_p1.0
Aqp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478113,650,612 - 13,691,175 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D15S198  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,471,604 - 58,471,809UniSTSGRCh37
Build 361556,258,896 - 56,259,101RGDNCBI36
Celera1535,361,703 - 35,361,912RGD
Cytogenetic Map15qUniSTS
HuRef1535,294,591 - 35,294,800UniSTS
Marshfield Genetic Map1551.21RGD
Marshfield Genetic Map1551.21UniSTS
Genethon Genetic Map1550.8UniSTS
deCODE Assembly Map1556.46UniSTS
GeneMap99-GB4 RH Map15209.78UniSTS
Whitehead-RH Map15189.5UniSTS
Whitehead-YAC Contig Map15 UniSTS
RH98507  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,477,871 - 58,478,058UniSTSGRCh37
Build 361556,265,163 - 56,265,350RGDNCBI36
Celera1535,367,973 - 35,368,160RGD
Cytogenetic Map15qUniSTS
HuRef1535,300,863 - 35,301,050UniSTS
GeneMap99-GB4 RH Map15206.95UniSTS
SHGC-2193  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,471,660 - 58,471,767UniSTSGRCh37
Build 361556,258,952 - 56,259,059RGDNCBI36
Celera1535,361,759 - 35,361,870RGD
Cytogenetic Map15qUniSTS
HuRef1535,294,647 - 35,294,758UniSTS
RH119218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,464,769 - 58,465,085UniSTSGRCh37
Build 361556,252,061 - 56,252,377RGDNCBI36
Celera1535,354,873 - 35,355,189RGD
Cytogenetic Map15qUniSTS
HuRef1535,287,762 - 35,288,078UniSTS
TNG Radiation Hybrid Map1520251.0UniSTS
SHGC-150628  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,471,543 - 58,471,822UniSTSGRCh37
Build 361556,258,835 - 56,259,114RGDNCBI36
Celera1535,361,642 - 35,361,925RGD
Cytogenetic Map15qUniSTS
HuRef1535,294,530 - 35,294,813UniSTS
TNG Radiation Hybrid Map1520254.0UniSTS
ATC-P10583  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,463,980 - 58,464,145UniSTSGRCh37
Build 361556,251,272 - 56,251,437RGDNCBI36
Celera1535,354,084 - 35,354,249RGD
Cytogenetic Map15qUniSTS
HuRef1535,286,973 - 35,287,138UniSTS
Whitehead-YAC Contig Map15 UniSTS
PMC61180P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,430,489 - 58,430,835UniSTSGRCh37
Build 361556,217,781 - 56,218,127RGDNCBI36
Celera1535,320,045 - 35,320,391RGD
Cytogenetic Map15qUniSTS
HuRef1535,253,457 - 35,253,803UniSTS
AQP9_51  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,477,376 - 58,478,127UniSTSGRCh37
Build 361556,264,668 - 56,265,419RGDNCBI36
Celera1535,367,478 - 35,368,229RGD
HuRef1535,300,368 - 35,301,119UniSTS
D15S1283  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,475,665 - 58,475,814UniSTSGRCh37
Build 361556,262,957 - 56,263,106RGDNCBI36
Celera1535,365,768 - 35,365,917RGD
Cytogenetic Map15qUniSTS
HuRef1535,298,656 - 35,298,805UniSTS
RH1645  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371558,475,665 - 58,475,883UniSTSGRCh37
Build 361556,262,957 - 56,263,175RGDNCBI36
Celera1535,365,768 - 35,365,986RGD
Cytogenetic Map15qUniSTS
HuRef1535,298,656 - 35,298,874UniSTS
GeneMap99-GB4 RH Map15213.81UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2218
Count of miRNA genes:602
Interacting mature miRNAs:670
Transcripts:ENST00000219919, ENST00000536493, ENST00000558772, ENST00000559443
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 241 6 6 241 6
Medium 49 624 402 403 892 402 1326 14 17 29 81 609 2 431 685 1
Low 1039 1366 832 109 473 16 1534 930 1821 221 875 618 93 744 908 1
Below cutoff 1200 715 446 80 164 15 1220 1186 1726 135 397 180 66 29 1161 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC066616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE042553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB528930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC296768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC410284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC250945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC311134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000219919   ⟹   ENSP00000219919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1558,138,381 - 58,185,911 (+)Ensembl
RefSeq Acc Id: ENST00000536493   ⟹   ENSP00000441390
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1558,138,381 - 58,185,911 (+)Ensembl
RefSeq Acc Id: ENST00000558772   ⟹   ENSP00000452673
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1558,138,169 - 58,184,579 (+)Ensembl
RefSeq Acc Id: ENST00000559443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1558,138,263 - 58,146,895 (+)Ensembl
RefSeq Acc Id: NM_001320635   ⟹   NP_001307564
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,381 - 58,185,911 (+)NCBI
CHM1_11558,548,371 - 58,596,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320636   ⟹   NP_001307565
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,169 - 58,185,911 (+)NCBI
CHM1_11558,548,344 - 58,596,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020980   ⟹   NP_066190
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,381 - 58,185,911 (+)NCBI
GRCh371558,430,374 - 58,478,110 (+)NCBI
Build 361556,217,700 - 56,265,402 (+)NCBI Archive
HuRef1535,253,376 - 35,301,102 (+)ENTREZGENE
CHM1_11558,548,371 - 58,596,086 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_066190   ⟸   NM_020980
- Peptide Label: isoform 1
- UniProtKB: O43315 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307565   ⟸   NM_001320636
- Peptide Label: isoform 3
- UniProtKB: H0YK62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307564   ⟸   NM_001320635
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSP00000452673   ⟸   ENST00000558772
RefSeq Acc Id: ENSP00000219919   ⟸   ENST00000219919
RefSeq Acc Id: ENSP00000441390   ⟸   ENST00000536493

Promoters
RGD ID:7229651
Promoter ID:EPDNEW_H20571
Type:initiation region
Name:AQP9_1
Description:aquaporin 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20572  EPDNEW_H20573  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,196 - 58,138,256EPDNEW
RGD ID:7229653
Promoter ID:EPDNEW_H20572
Type:initiation region
Name:AQP9_2
Description:aquaporin 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20571  EPDNEW_H20573  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,381 - 58,138,441EPDNEW
RGD ID:7229655
Promoter ID:EPDNEW_H20573
Type:initiation region
Name:AQP9_3
Description:aquaporin 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20571  EPDNEW_H20572  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381558,138,487 - 58,138,547EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.3-22.2(chr15:57456076-61907285)x1 copy number loss See cases [RCV000050884] Chr15:57456076..61907285 [GRCh38]
Chr15:57748274..62199484 [GRCh37]
Chr15:55535566..59986776 [NCBI36]
Chr15:15q21.3-22.2
pathogenic
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1 copy number loss See cases [RCV000051621] Chr15:50864913..59646577 [GRCh38]
Chr15:51157110..59938776 [GRCh37]
Chr15:48944402..57726068 [NCBI36]
Chr15:15q21.2-22.2
pathogenic
GRCh38/hg38 15q21.3-22.2(chr15:57567950-63019415)x1 copy number loss See cases [RCV000051622] Chr15:57567950..63019415 [GRCh38]
Chr15:57860148..63311614 [GRCh37]
Chr15:55647440..61098667 [NCBI36]
Chr15:15q21.3-22.2
pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:54713558-62769295)x1 copy number loss See cases [RCV000446622] Chr15:54713558..62769295 [GRCh37]
Chr15:15q21.3-22.2
pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q21.3(chr15:57518653-58974175)x3 copy number gain See cases [RCV000511567] Chr15:57518653..58974175 [GRCh37]
Chr15:15q21.3
likely pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58088503-62221756)x1 copy number loss See cases [RCV000510898] Chr15:58088503..62221756 [GRCh37]
Chr15:15q21.3-22.2
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58441151-60270526)x3 copy number gain not provided [RCV000683699] Chr15:58441151..60270526 [GRCh37]
Chr15:15q21.3-22.2
uncertain significance
GRCh37/hg19 15q21.3(chr15:57608623-59029582)x3 copy number gain not provided [RCV000683698] Chr15:57608623..59029582 [GRCh37]
Chr15:15q21.3
uncertain significance
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3 copy number gain not provided [RCV000845891] Chr15:48000433..60747551 [GRCh37]
Chr15:15q21.1-22.2
pathogenic
GRCh37/hg19 15q21.3(chr15:57414627-58960510)x3 copy number gain not provided [RCV001259696] Chr15:57414627..58960510 [GRCh37]
Chr15:15q21.3
uncertain significance
GRCh37/hg19 15q21.3(chr15:58461372-58897874)x3 copy number gain not provided [RCV001259698] Chr15:58461372..58897874 [GRCh37]
Chr15:15q21.3
uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:643 AgrOrtholog
COSMIC AQP9 COSMIC
Ensembl Genes ENSG00000103569 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000219919 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000441390 UniProtKB/Swiss-Prot
  ENSP00000452673 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000219919 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000536493 UniProtKB/Swiss-Prot
  ENST00000558772 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000103569 GTEx
HGNC ID HGNC:643 ENTREZGENE
Human Proteome Map AQP9 Human Proteome Map
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:366 UniProtKB/Swiss-Prot
NCBI Gene 366 ENTREZGENE
OMIM 602914 OMIM
PANTHER PTHR43829:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24927 PharmGKB
PRINTS AQUAPORIN9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AQP9_HUMAN UniProtKB/Swiss-Prot
  H0YK62 ENTREZGENE, UniProtKB/TrEMBL
  O43315 ENTREZGENE
  Q6FGT0_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q9NP32 UniProtKB/Swiss-Prot