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Gene: USP18 (ubiquitin specific peptidase 18) Homo sapiens
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Symbol: USP18
Name: ubiquitin specific peptidase 18
Description: Predicted to have ISG15-specific protease activity; cysteine-type endopeptidase activity; and thiol-dependent ubiquitin-specific protease activity. Involved in regulation of inflammatory response. Localizes to cytosol and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; ISG43; PTORCH2; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; ubl thioesterase 18; ubl thiolesterase 18; UBP43
Orthologs:
Mus musculus (house mouse) : Usp18 (ubiquitin specific peptidase 18)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp18 (ubiquitin specific peptidase 18)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp18 (ubiquitin specific peptidase 18)
Canis lupus familiaris (dog) : USP18 (ubiquitin specific peptidase 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp18 (ubiquitin specific peptidase 18)
Sus scrofa (pig) : USP18 (ubiquitin specific peptidase 18)
Chlorocebus sabaeus (African green monkey) : USP18 (ubiquitin specific peptidase 18)
Heterocephalus glaber (naked mole-rat) : Usp18 (ubiquitin specific peptidase 18)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2218,150,170 - 18,177,397 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,149,855 - 18,177,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,632,758 - 18,660,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,012,758 - 17,040,164 (+)NCBINCBI36hg18NCBI36
Build 342217,007,311 - 17,034,714NCBI
Celera222,251,821 - 2,269,866 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef222,445,183 - 2,472,579 (+)NCBIHuRef
CHM1_12218,632,478 - 18,659,884 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on USP18
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353279
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.