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Gene: TYMP (thymidine phosphorylase) Homo sapiens
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Symbol: TYMP
Name: thymidine phosphorylase
Description: Exhibits protein homodimerization activity and thymidine phosphorylase activity. Involved in several processes, including regulation of gastric motility; regulation of myelination; and regulation of transmission of nerve impulse. Predicted to localize to cytosol. Implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Biomarker of several diseases, including carcinoma (multiple); common bile duct neoplasm; ductal carcinoma in situ; female reproductive organ cancer (multiple); and germ cell cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ECGF; ECGF1; gliostatin; hPD-ECGF; MEDPS1; MNGIE; MNGIE; MTDPS1; myoneurogastrointestinal encephalopathy syndrome; PDECGF; tdRPase; TP
Orthologs:
Mus musculus (house mouse) : Tymp (thymidine phosphorylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tymp (thymidine phosphorylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tymp (thymidine phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMP (thymidine phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tymp (thymidine phosphorylase)
Chlorocebus sabaeus (African green monkey) : TYMP (thymidine phosphorylase)
Heterocephalus glaber (naked mole-rat) : Tymp (thymidine phosphorylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2250,525,752 - 50,530,032 (-)EnsemblGRCh38hg38GRCh38
GRCh382250,525,752 - 50,530,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372250,964,181 - 50,968,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,311,047 - 49,315,321 (-)NCBINCBI36hg18NCBI36
Build 342249,254,324 - 49,258,599NCBI
Celera2234,840,208 - 34,844,541 (-)NCBI
Cytogenetic Map22q13.33ENTREZGENE
HuRef2233,855,199 - 33,859,532 (-)NCBIHuRef
CHM1_12250,922,918 - 50,927,220 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TYMP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313979
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.