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Gene: SIRT3 (sirtuin 3) Homo sapiens
Symbol: SIRT3
Name: sirtuin 3
RGD ID: 1318106
Description: Exhibits sequence-specific DNA binding activity and zinc ion binding activity. Involved in aerobic respiration; peptidyl-lysine deacetylation; and positive regulation of oxidoreductase activity. Localizes to mitochondrial matrix and protein-containing complex. Biomarker of Alzheimer's disease and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; regulatory protein SIR2 homolog 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIR2L3; sirtuin; sirtuin type 3
Mus musculus (house mouse) : Sirt3 (sirtuin 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sirt3 (sirtuin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt3 (sirtuin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT3 (sirtuin 3)
Canis lupus familiaris (dog) : SIRT3 (sirtuin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt3 (sirtuin 3)
Sus scrofa (pig) : SIRT3 (sirtuin 3)
Chlorocebus sabaeus (African green monkey) : SIRT3 (sirtuin 3)
Heterocephalus glaber (naked mole-rat) : Sirt3 (sirtuin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11215,030 - 236,931 (-)EnsemblGRCh38hg38GRCh38
GRCh3811215,030 - 236,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711215,030 - 236,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611205,030 - 226,362 (-)NCBINCBI36hg18NCBI36
Build 3411206,138 - 226,416NCBI
Celera11322,773 - 343,832 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef1135,047 - 56,030 (-)NCBIHuRef
CHM1_111213,704 - 234,799 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIRT3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318106
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.