CLEC2A (C-type lectin domain family 2 member A) - Rat Genome Database

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Gene: CLEC2A (C-type lectin domain family 2 member A) Homo sapiens
Analyze
Symbol: CLEC2A
Name: C-type lectin domain family 2 member A
RGD ID: 1348681
HGNC Page HGNC:24191
Description: Enables protein homodimerization activity. Predicted to be involved in natural killer cell mediated cytotoxicity. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; regulation of actin filament polymerization; and regulation of interleukin-2 production. Located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-type lectin domain family 2, member A; INPE5792; KACL; keratinocyte-associated C-type lectin; PILAR; proliferation-induced lymphocyte-associated receptor; UNQ5792
RGD Orthologs
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,877,742 - 9,932,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,898,673 - 9,932,370 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,051,275 - 10,084,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,942,539 - 9,976,213 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,942,538 - 9,976,213NCBI
Celera1215,227,207 - 15,246,360 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,808,730 - 9,827,882 (-)NCBIHuRef
CHM1_11210,034,842 - 10,053,995 (-)NCBICHM1_1
T2T-CHM13v2.0129,767,385 - 9,818,588 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12975309   PMID:18046548   PMID:18550855   PMID:18976975   PMID:19630798   PMID:20194751   PMID:21873635   PMID:25150298   PMID:25510854   PMID:26416420   PMID:27960039   PMID:31901221  
PMID:32061658   PMID:32296183  


Genomics

Comparative Map Data
CLEC2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,877,742 - 9,932,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,898,673 - 9,932,370 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,051,275 - 10,084,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,942,539 - 9,976,213 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,942,538 - 9,976,213NCBI
Celera1215,227,207 - 15,246,360 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,808,730 - 9,827,882 (-)NCBIHuRef
CHM1_11210,034,842 - 10,053,995 (-)NCBICHM1_1
T2T-CHM13v2.0129,767,385 - 9,818,588 (-)NCBIT2T-CHM13v2.0
Clec2i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,864,550 - 128,875,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,864,551 - 128,875,130 (+)EnsemblGRCm39 Ensembl
GRCm386128,887,587 - 128,898,168 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,887,588 - 128,898,167 (+)EnsemblGRCm38mm10GRCm38
MGSCv376128,837,632 - 128,846,870 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,853,233 - 128,862,471 (+)NCBIMGSCv36mm8
Celera6130,597,441 - 130,606,678 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.1NCBI
CLEC2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,400,814 - 15,426,096 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,399,252 - 15,422,248 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,959,826 - 9,981,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,195,632 - 10,229,273 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,195,862 - 10,229,273 (-)Ensemblpanpan1.1panPan2
LOC101956536
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,452,283 - 97,455,414 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936902583,850 - 586,981 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,790,411 - 9,813,839 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,790,671 - 9,813,543 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660891,864,876 - 1,887,797 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CLEC2A
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
NM_001130711.1(CLEC2A):c.56-2947A>G single nucleotide variant Lung cancer [RCV000110525] Chr12:9929290 [GRCh38]
Chr12:10081889 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
chr12:10074776-18800953 complex variant complex Breast ductal adenocarcinoma [RCV000207105] Chr12:10074776..18800953 [GRCh37]
Chr12:12p13.31-12.3		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.31-13.2(chr12:10015048-10124253)x1 copy number loss See cases [RCV000448782] Chr12:10015048..10124253 [GRCh37]
Chr12:12p13.31-13.2		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1		 likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2		 pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.31-13.2(chr12:9904449-10253713)x3 copy number gain not provided [RCV000737769] Chr12:9904449..10253713 [GRCh37]
Chr12:12p13.31-13.2		 benign
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21		 pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.31-13.2(chr12:10030182-10123036)x1 copy number loss not provided [RCV000846121] Chr12:10030182..10123036 [GRCh37]
Chr12:12p13.31-13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.31-13.2(chr12:10049346-10322120)x3 copy number gain not provided [RCV002473879] Chr12:10049346..10322120 [GRCh37]
Chr12:12p13.31-13.2		 uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NC_000012.12:g.9876748_9972593del deletion not provided [RCV001837403] Chr12:9876748..9972593 [GRCh38]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
NM_001130711.2(CLEC2A):c.131T>C (p.Ile44Thr) single nucleotide variant Inborn genetic diseases [RCV002905767] Chr12:9926268 [GRCh38]
Chr12:10078867 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.222C>G (p.His74Gln) single nucleotide variant Inborn genetic diseases [RCV002752972] Chr12:9893024 [GRCh38]
Chr12:10045623 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.236C>T (p.Pro79Leu) single nucleotide variant Inborn genetic diseases [RCV002752973] Chr12:9893038 [GRCh38]
Chr12:10045637 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.119G>A (p.Cys40Tyr) single nucleotide variant Inborn genetic diseases [RCV002864405] Chr12:9884982 [GRCh38]
Chr12:10037581 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.599C>T (p.Thr200Met) single nucleotide variant Inborn genetic diseases [RCV002689933] Chr12:9895808 [GRCh38]
Chr12:10048407 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.526A>T (p.Thr176Ser) single nucleotide variant Inborn genetic diseases [RCV002973967] Chr12:9895735 [GRCh38]
Chr12:10048334 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.466A>C (p.Ser156Arg) single nucleotide variant Inborn genetic diseases [RCV002951799] Chr12:9913625 [GRCh38]
Chr12:10066224 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.310C>T (p.Arg104Cys) single nucleotide variant Inborn genetic diseases [RCV002925866] Chr12:9893112 [GRCh38]
Chr12:10045711 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.259G>A (p.Gly87Arg) single nucleotide variant Inborn genetic diseases [RCV002768289] Chr12:9893061 [GRCh38]
Chr12:10045660 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.402T>G (p.Phe134Leu) single nucleotide variant Inborn genetic diseases [RCV002875486] Chr12:9893464 [GRCh38]
Chr12:10046063 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.242C>G (p.Ala81Gly) single nucleotide variant Inborn genetic diseases [RCV002929284] Chr12:9922130 [GRCh38]
Chr12:10074729 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.191A>C (p.Gln64Pro) single nucleotide variant Inborn genetic diseases [RCV002788823] Chr12:9888754 [GRCh38]
Chr12:10041353 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.325G>A (p.Ala109Thr) single nucleotide variant Inborn genetic diseases [RCV002709171] Chr12:9916785 [GRCh38]
Chr12:10069384 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.348T>G (p.Ile116Met) single nucleotide variant Inborn genetic diseases [RCV002804377] Chr12:9893150 [GRCh38]
Chr12:10045749 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.268T>C (p.Tyr90His) single nucleotide variant Inborn genetic diseases [RCV002675396] Chr12:9893070 [GRCh38]
Chr12:10045669 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.173G>A (p.Cys58Tyr) single nucleotide variant Inborn genetic diseases [RCV002878470] Chr12:9922199 [GRCh38]
Chr12:10074798 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4 copy number gain Pallister-Killian syndrome [RCV003154827] Chr12:176047..34179852 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_001190765.1(KLRF2):c.314A>T (p.Asp105Val) single nucleotide variant Inborn genetic diseases [RCV003189067] Chr12:9893116 [GRCh38]
Chr12:10045715 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.303C>A (p.Asp101Glu) single nucleotide variant Inborn genetic diseases [RCV003203504] Chr12:9922069 [GRCh38]
Chr12:10074668 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001190765.1(KLRF2):c.26C>T (p.Thr9Met) single nucleotide variant Inborn genetic diseases [RCV003178825] Chr12:9881621 [GRCh38]
Chr12:10034220 [GRCh37]
Chr12:12p13.31		 likely benign
NM_001190765.1(KLRF2):c.115G>C (p.Gly39Arg) single nucleotide variant Inborn genetic diseases [RCV003386546] Chr12:9884978 [GRCh38]
Chr12:10037577 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.249A>C (p.Lys83Asn) single nucleotide variant Inborn genetic diseases [RCV003355293] Chr12:9922123 [GRCh38]
Chr12:10074722 [GRCh37]
Chr12:12p13.31		 uncertain significance
NM_001130711.2(CLEC2A):c.411G>A (p.Trp137Ter) single nucleotide variant not provided [RCV003396209] Chr12:9913680 [GRCh38]
Chr12:10066279 [GRCh37]
Chr12:12p13.31		 likely benign
Single allele duplication not provided [RCV003448692] Chr12:188053..34856694 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3 copy number gain not specified [RCV003986979] Chr12:173786..34835641 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:228
Interacting mature miRNAs:235
Transcripts:ENST00000339766, ENST00000455827
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1 6 1113 1 4 635
Low 5 9 2 24 232 3 129 3 115 7 2 4 70 1
Below cutoff 318 798 212 85 442 50 877 413 1518 42 518 316 39 1 259 652 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_207375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007063074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007063075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007063076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF127467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU095393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU095394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000339766   ⟹   ENSP00000339732
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,898,673 - 9,932,347 (-)Ensembl
RefSeq Acc Id: ENST00000455827   ⟹   ENSP00000396163
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,913,227 - 9,932,370 (-)Ensembl
RefSeq Acc Id: NM_001130711   ⟹   NP_001124183
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,913,227 - 9,932,370 (-)NCBI
GRCh371210,051,272 - 10,084,980 (-)NCBI
Celera1215,227,207 - 15,246,360 (-)RGD
HuRef129,808,730 - 9,827,882 (-)RGD
CHM1_11210,034,842 - 10,053,995 (-)NCBI
T2T-CHM13v2.0129,799,446 - 9,818,588 (-)NCBI
Sequence:
RefSeq Acc Id: NM_207375   ⟹   NP_997258
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,898,676 - 9,932,370 (-)NCBI
CHM1_11210,020,286 - 10,053,995 (-)NCBI
T2T-CHM13v2.0129,784,894 - 9,818,588 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011520654   ⟹   XP_011518956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,898,676 - 9,932,370 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011520657   ⟹   XP_011518959
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,877,742 - 9,932,370 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047428829   ⟹   XP_047284785
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,913,227 - 9,932,370 (-)NCBI
RefSeq Acc Id: XM_047428830   ⟹   XP_047284786
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,898,676 - 9,932,370 (-)NCBI
RefSeq Acc Id: XM_054372023   ⟹   XP_054227998
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,799,446 - 9,818,588 (-)NCBI
RefSeq Acc Id: XM_054372024   ⟹   XP_054227999
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,767,385 - 9,818,588 (-)NCBI
RefSeq Acc Id: XM_054372025   ⟹   XP_054228000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,784,894 - 9,818,588 (-)NCBI
RefSeq Acc Id: XR_007063074
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,877,742 - 9,932,370 (-)NCBI
RefSeq Acc Id: XR_007063075
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,877,742 - 9,932,370 (-)NCBI
RefSeq Acc Id: XR_007063076
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,877,742 - 9,932,370 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001124183   ⟸   NM_001130711
- Peptide Label: isoform 1
- UniProtKB: A9QKS2 (UniProtKB/Swiss-Prot),   A5Y4G5 (UniProtKB/Swiss-Prot),   A9QKS3 (UniProtKB/Swiss-Prot),   Q6UVW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_997258   ⟸   NM_207375
- Peptide Label: isoform 2
- UniProtKB: Q6UVW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011518959   ⟸   XM_011520657
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011518956   ⟸   XM_011520654
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000396163   ⟸   ENST00000455827
RefSeq Acc Id: ENSP00000339732   ⟸   ENST00000339766
RefSeq Acc Id: XP_047284786   ⟸   XM_047428830
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047284785   ⟸   XM_047428829
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054227999   ⟸   XM_054372024
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054228000   ⟸   XM_054372025
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054227998   ⟸   XM_054372023
- Peptide Label: isoform X2
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UVW9-F1-model_v2 AlphaFold Q6UVW9 1-174 view protein structure

Promoters
RGD ID:7223137
Promoter ID:EPDNEW_H17314
Type:multiple initiation site
Name:CLEC2A_1
Description:C-type lectin domain family 2 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,932,368 - 9,932,428EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24191 AgrOrtholog
COSMIC CLEC2A COSMIC
Ensembl Genes ENSG00000188393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000339766 ENTREZGENE
  ENST00000339766.8 UniProtKB/Swiss-Prot
  ENST00000455827 ENTREZGENE
  ENST00000455827.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000188393 GTEx
HGNC ID HGNC:24191 ENTREZGENE
Human Proteome Map CLEC2A Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  NKR-like_CTLD UniProtKB/Swiss-Prot
KEGG Report hsa:387836 UniProtKB/Swiss-Prot
NCBI Gene 387836 ENTREZGENE
OMIM 612087 OMIM
PANTHER C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER A UniProtKB/Swiss-Prot
  C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PharmGKB PA142672099 PharmGKB
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt A5Y4G5 ENTREZGENE
  A9QKS2 ENTREZGENE
  A9QKS3 ENTREZGENE
  CLC2A_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A5Y4G5 UniProtKB/Swiss-Prot
  A9QKS2 UniProtKB/Swiss-Prot
  A9QKS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 CLEC2A  C-type lectin domain family 2 member A  CLEC2A  C-type lectin domain family 2, member A  Symbol and/or name change 5135510 APPROVED