KYNU (kynureninase) - Rat Genome Database

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Gene: KYNU (kynureninase) Homo sapiens
Analyze
Symbol: KYNU
Name: kynureninase
RGD ID: 734173
HGNC Page HGNC
Description: Exhibits 3-hydroxykynureninase activity; kynureninase activity; and protein homodimerization activity. Involved in several processes, including carboxylic acid metabolic process; pyridine-containing compound biosynthetic process; and response to interferon-gamma. Localizes to cytosol; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: kynureninase (L-kynurenine hydrolase); KYNUU; l-kynurenine hydrolase; VCRL2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: KYNUP1   KYNUP2   KYNUP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2142,877,657 - 143,055,833 (+)EnsemblGRCh38hg38GRCh38
GRCh382142,877,664 - 143,055,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,635,233 - 143,813,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,351,665 - 143,516,355 (+)NCBINCBI36hg18NCBI36
Build 342143,468,950 - 143,633,606NCBI
Celera2137,347,656 - 137,512,293 (+)NCBI
Cytogenetic Map2q22.2NCBI
HuRef2135,626,307 - 135,791,074 (+)NCBIHuRef
CHM1_12143,640,202 - 143,804,900 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (EXP)
cisplatin  (EXP)
clomiphene  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (EXP)
diarsenic trioxide  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (EXP)
diquat  (EXP)
dorsomorphin  (EXP)
endosulfan  (ISO)
estrone  (EXP)
etoposide  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gamma-linolenic acid  (EXP)
genistein  (EXP)
glafenine  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
GW 4064  (ISO)
hexestrol  (EXP)
hydrogen peroxide  (EXP)
kynurenine  (EXP)
lamivudine  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
mestranol  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methomyl  (ISO)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nimesulide  (ISO)
nitroglycerin  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zidovudine  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IDA,ISO,TAS)
mitochondrion  (IDA)
nucleoplasm  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1939450   PMID:6468727   PMID:8125298   PMID:8706755   PMID:9291104   PMID:11985583   PMID:12477932   PMID:14704851   PMID:16080802   PMID:16712791   PMID:17207965   PMID:17334708  
PMID:18029348   PMID:20379614   PMID:20877624   PMID:21873635   PMID:22012986   PMID:22658674   PMID:22863883   PMID:22939629   PMID:23503679   PMID:24667918   PMID:25343990   PMID:26344197  
PMID:26496610   PMID:26725996   PMID:28792876   PMID:30575818   PMID:31332944   PMID:31478661   PMID:32296183   PMID:32416067  


Genomics

Comparative Map Data
KYNU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2142,877,657 - 143,055,833 (+)EnsemblGRCh38hg38GRCh38
GRCh382142,877,664 - 143,055,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,635,233 - 143,813,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,351,665 - 143,516,355 (+)NCBINCBI36hg18NCBI36
Build 342143,468,950 - 143,633,606NCBI
Celera2137,347,656 - 137,512,293 (+)NCBI
Cytogenetic Map2q22.2NCBI
HuRef2135,626,307 - 135,791,074 (+)NCBIHuRef
CHM1_12143,640,202 - 143,804,900 (+)NCBICHM1_1
Kynu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39243,445,270 - 43,573,060 (+)NCBIGRCm39mm39
GRCm39 Ensembl243,445,341 - 43,572,727 (+)Ensembl
GRCm38243,555,258 - 43,683,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl243,555,329 - 43,682,715 (+)EnsemblGRCm38mm10GRCm38
MGSCv37243,410,849 - 43,538,235 (+)NCBIGRCm37mm9NCBIm37
MGSCv36243,377,338 - 43,504,724 (+)NCBImm8
Celera245,275,609 - 45,403,071 (+)NCBICelera
Cytogenetic Map2BNCBI
Kynu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2327,778,646 - 27,929,470 (+)NCBI
Rnor_6.0 Ensembl328,416,954 - 28,566,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0328,416,926 - 28,566,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0333,622,141 - 33,770,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4324,046,242 - 24,195,898 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1323,942,613 - 24,092,267 (+)NCBI
Celera326,096,675 - 26,244,576 (+)NCBICelera
Cytogenetic Map3q12NCBI
Kynu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554409,420,009 - 9,536,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554409,420,141 - 9,536,767 (+)NCBIChiLan1.0ChiLan1.0
KYNU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B146,976,053 - 147,131,298 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B146,975,995 - 147,132,634 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B16,792,401 - 16,947,766 (-)NCBIMhudiblu_PPA_v0panPan3
KYNU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11945,022,450 - 45,150,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1945,022,072 - 45,149,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1945,274,902 - 45,404,061 (+)NCBI
ROS_Cfam_1.01946,479,473 - 46,607,767 (+)NCBI
UMICH_Zoey_3.11945,139,690 - 45,268,624 (+)NCBI
UNSW_CanFamBas_1.01945,269,758 - 45,399,409 (+)NCBI
UU_Cfam_GSD_1.01946,664,690 - 46,794,435 (+)NCBI
Kynu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303107,812,529 - 107,984,835 (+)NCBI
SpeTri2.0NW_00493646933,632,885 - 33,805,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KYNU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,850,665 - 8,982,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,847,335 - 8,982,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2159,760,379 - 9,821,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KYNU
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11028,230,129 - 28,394,103 (+)NCBI
ChlSab1.1 Ensembl1028,230,508 - 28,394,076 (+)Ensembl
Kynu
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473242,627,789 - 42,751,037 (+)NCBI

Position Markers
WI-11702  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372143,799,721 - 143,799,850UniSTSGRCh37
Build 362143,516,191 - 143,516,320RGDNCBI36
Celera2137,512,129 - 137,512,258RGD
Cytogenetic Map2q22.2UniSTS
HuRef2135,790,910 - 135,791,039UniSTS
GeneMap99-GB4 RH Map2487.5UniSTS
Whitehead-RH Map2777.2UniSTS
NCBI RH Map21043.4UniSTS
SHGC-132405  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372143,717,189 - 143,717,461UniSTSGRCh37
Build 362143,433,659 - 143,433,931RGDNCBI36
Celera2137,429,588 - 137,429,861RGD
Cytogenetic Map2q22.2UniSTS
HuRef2135,708,276 - 135,708,549UniSTS
TNG Radiation Hybrid Map277206.0UniSTS
A004C41  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372143,799,654 - 143,799,807UniSTSGRCh37
Build 362143,516,124 - 143,516,277RGDNCBI36
Celera2137,512,062 - 137,512,215RGD
Cytogenetic Map2q22.2UniSTS
HuRef2135,790,843 - 135,790,996UniSTS
GeneMap99-GB4 RH Map2494.64UniSTS
SHGC-33569  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372143,698,005 - 143,698,129UniSTSGRCh37
Build 362143,414,475 - 143,414,599RGDNCBI36
Celera2137,410,403 - 137,410,527RGD
Cytogenetic Map2q22.2UniSTS
HuRef2135,689,088 - 135,689,212UniSTS
GeneMap99-GB4 RH Map2495.46UniSTS
Whitehead-RH Map2773.8UniSTS
GeneMap99-G3 RH Map26706.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:416
Count of miRNA genes:318
Interacting mature miRNAs:341
Transcripts:ENST00000264170, ENST00000375773, ENST00000409512, ENST00000410015, ENST00000424385, ENST00000460143
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 19 2 177 174 460 177 23 5 8 88 87 101 3 1
Low 398 1138 991 326 1292 282 818 107 420 245 683 1183 55 1 706 313 3 1
Below cutoff 2019 1843 557 123 196 6 3495 2059 3269 84 685 325 117 498 2456 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001032998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_923058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC013437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC013444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL548658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW290980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW296221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB151988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264170   ⟹   ENSP00000264170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,877,664 - 143,055,833 (+)Ensembl
RefSeq Acc Id: ENST00000375773   ⟹   ENSP00000364928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,877,657 - 142,990,052 (+)Ensembl
RefSeq Acc Id: ENST00000409512   ⟹   ENSP00000386731
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,877,664 - 143,042,172 (+)Ensembl
RefSeq Acc Id: ENST00000410015   ⟹   ENSP00000387296
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,877,666 - 142,947,421 (+)Ensembl
RefSeq Acc Id: ENST00000424385   ⟹   ENSP00000401190
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,877,684 - 142,954,871 (+)Ensembl
RefSeq Acc Id: ENST00000460143
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,918,679 - 142,958,075 (+)Ensembl
RefSeq Acc Id: ENST00000612147   ⟹   ENSP00000481930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,918,679 - 142,967,494 (+)Ensembl
RefSeq Acc Id: ENST00000613664   ⟹   ENSP00000482009
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,927,659 - 142,971,393 (+)Ensembl
RefSeq Acc Id: ENST00000621320   ⟹   ENSP00000484801
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2142,885,395 - 142,964,752 (+)Ensembl
RefSeq Acc Id: NM_001032998   ⟹   NP_001028170
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 142,990,065 (+)NCBI
GRCh372143,506,497 - 143,799,885 (+)NCBI
Build 362143,351,665 - 143,463,576 (+)NCBI Archive
HuRef2135,626,307 - 135,791,074 (+)ENTREZGENE
CHM1_12143,640,202 - 143,752,144 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001199241   ⟹   NP_001186170
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 143,055,833 (+)NCBI
GRCh372143,506,497 - 143,799,885 (+)NCBI
HuRef2135,626,307 - 135,791,074 (+)ENTREZGENE
CHM1_12143,640,202 - 143,804,900 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003937   ⟹   NP_003928
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 143,055,833 (+)NCBI
GRCh372143,506,497 - 143,799,885 (+)NCBI
Build 362143,351,665 - 143,516,355 (+)NCBI Archive
HuRef2135,626,307 - 135,791,074 (+)ENTREZGENE
CHM1_12143,640,202 - 143,804,900 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512102   ⟹   XP_011510404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,931,397 - 143,042,311 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005217   ⟹   XP_016860706
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 143,000,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024453208   ⟹   XP_024308976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,881,940 - 143,042,311 (+)NCBI
Sequence:
RefSeq Acc Id: XR_923058
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 143,042,311 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001186170   ⟸   NM_001199241
- Peptide Label: isoform a
- UniProtKB: Q16719 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003928   ⟸   NM_003937
- Peptide Label: isoform a
- UniProtKB: Q16719 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001028170   ⟸   NM_001032998
- Peptide Label: isoform b
- UniProtKB: Q16719 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011510404   ⟸   XM_011512102
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016860706   ⟸   XM_017005217
- Peptide Label: isoform X3
- UniProtKB: Q16719 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024308976   ⟸   XM_024453208
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000387296   ⟸   ENST00000410015
RefSeq Acc Id: ENSP00000401190   ⟸   ENST00000424385
RefSeq Acc Id: ENSP00000484801   ⟸   ENST00000621320
RefSeq Acc Id: ENSP00000364928   ⟸   ENST00000375773
RefSeq Acc Id: ENSP00000481930   ⟸   ENST00000612147
RefSeq Acc Id: ENSP00000482009   ⟸   ENST00000613664
RefSeq Acc Id: ENSP00000386731   ⟸   ENST00000409512
RefSeq Acc Id: ENSP00000264170   ⟸   ENST00000264170
Protein Domains
Aminotran_5

Promoters
RGD ID:6861672
Promoter ID:EPDNEW_H4001
Type:initiation region
Name:KYNU_1
Description:kynureninase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382142,877,664 - 142,877,724EPDNEW
RGD ID:6797204
Promoter ID:HG_KWN:35255
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000392874,   ENST00000410015,   NM_001032998,   OTTHUMT00000254772,   OTTHUMT00000332173,   UC010FNM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362143,351,021 - 143,351,722 (+)MPROMDB
RGD ID:6852434
Promoter ID:EP74026
Type:initiation region
Name:HS_KYNU
Description:Kynureninase (L-kynurenine hydrolase).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 362143,351,703 - 143,351,763EPD
RGD ID:6797724
Promoter ID:HG_KWN:35256
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000332174
Position:
Human AssemblyChrPosition (strand)Source
Build 362143,392,081 - 143,392,932 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003937.2(KYNU):c.373+4412G>T single nucleotide variant Lung cancer [RCV000091497] Chr2:142932153 [GRCh38]
Chr2:143689722 [GRCh37]
Chr2:2q22.2
uncertain significance
GRCh38/hg38 2q22.1-22.3(chr2:140186521-146528244)x1 copy number loss See cases [RCV000051018] Chr2:140186521..146528244 [GRCh38]
Chr2:140944090..147285812 [GRCh37]
Chr2:140660560..147002282 [NCBI36]
Chr2:2q22.1-22.3
pathogenic
GRCh38/hg38 2q22.2-22.3(chr2:141666537-147845662)x1 copy number loss See cases [RCV000054086] Chr2:141666537..147845662 [GRCh38]
Chr2:142424106..148603231 [GRCh37]
Chr2:142140576..148319701 [NCBI36]
Chr2:2q22.2-22.3
pathogenic
NM_003937.2(KYNU):c.169+1G>A single nucleotide variant Malignant melanoma [RCV000060344] Chr2:142885537 [GRCh38]
Chr2:143643106 [GRCh37]
Chr2:143359576 [NCBI36]
Chr2:2q22.2
not provided
NM_003937.3(KYNU):c.592A>G (p.Thr198Ala) single nucleotide variant Hydroxykynureninuria [RCV000148021] Chr2:142960633 [GRCh38]
Chr2:143718202 [GRCh37]
Chr2:2q22.2
pathogenic|likely pathogenic|not provided
NM_003937.3(KYNU):c.563G>A (p.Arg188Gln) single nucleotide variant not provided [RCV000148022] Chr2:142957696 [GRCh38]
Chr2:143715265 [GRCh37]
Chr2:2q22.2
uncertain significance|not provided
GRCh38/hg38 2q22.1-22.3(chr2:136937358-146681810)x1 copy number loss See cases [RCV000137506] Chr2:136937358..146681810 [GRCh38]
Chr2:137694928..147439378 [GRCh37]
Chr2:137411398..147155848 [NCBI36]
Chr2:2q22.1-22.3
pathogenic
GRCh38/hg38 2q22.1-22.2(chr2:140659197-142948096)x3 copy number gain See cases [RCV000137664] Chr2:140659197..142948096 [GRCh38]
Chr2:141416766..143705665 [GRCh37]
Chr2:141133236..143422135 [NCBI36]
Chr2:2q22.1-22.2
uncertain significance
GRCh38/hg38 2q22.2(chr2:142197989-143208649)x3 copy number gain See cases [RCV000143645] Chr2:142197989..143208649 [GRCh38]
Chr2:142955558..143966218 [GRCh37]
Chr2:142672028..143682688 [NCBI36]
Chr2:2q22.2
likely benign|uncertain significance
GRCh37/hg19 2q22.1-22.3(chr2:138578298-144874187)x1 copy number loss See cases [RCV000449099] Chr2:138578298..144874187 [GRCh37]
Chr2:2q22.1-22.3
likely pathogenic
Single allele duplication MBD5 associated neurodevelopmental disorder [RCV000454618] Chr2:140621941..149324662 [GRCh37]
Chr2:2q22.1-23.1
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_003937.3(KYNU):c.468T>A (p.Tyr156Ter) single nucleotide variant Congenital NAD deficiency disorder [RCV000496184]|Vertebral, cardiac, renal, and limb defects syndrome 2 [RCV000505808]|not provided [RCV000522905] Chr2:142956235 [GRCh38]
Chr2:143713804 [GRCh37]
Chr2:2q22.2
pathogenic|likely pathogenic
NM_003937.3(KYNU):c.1045_1051del (p.Phe349fs) deletion Congenital NAD deficiency disorder [RCV000496114]|Vertebral, cardiac, renal, and limb defects syndrome 2 [RCV000505812]|not provided [RCV000520521] Chr2:143040430..143040436 [GRCh38]
Chr2:143797999..143798005 [GRCh37]
Chr2:2q22.2
pathogenic
NM_003937.3(KYNU):c.170-1G>T single nucleotide variant Congenital NAD deficiency disorder [RCV000496147]|Vertebral, cardiac, renal, and limb defects syndrome 2 [RCV000505804] Chr2:142918608 [GRCh38]
Chr2:143676177 [GRCh37]
Chr2:2q22.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_003937.3(KYNU):c.759T>C (p.His253=) single nucleotide variant not provided [RCV000894540] Chr2:142985113 [GRCh38]
Chr2:143742682 [GRCh37]
Chr2:2q22.2
benign
NM_003937.3(KYNU):c.303T>C (p.Gly101=) single nucleotide variant not provided [RCV000894981] Chr2:142927671 [GRCh38]
Chr2:143685240 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.585G>A (p.Gly195=) single nucleotide variant not provided [RCV000883675] Chr2:142960626 [GRCh38]
Chr2:143718195 [GRCh37]
Chr2:2q22.2
benign
NM_003937.3(KYNU):c.732T>C (p.Gly244=) single nucleotide variant not provided [RCV000915143] Chr2:142985086 [GRCh38]
Chr2:143742655 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.291-7A>G single nucleotide variant not provided [RCV000904248] Chr2:142927652 [GRCh38]
Chr2:143685221 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.74C>T (p.Thr25Met) single nucleotide variant not provided [RCV000972582] Chr2:142885441 [GRCh38]
Chr2:143643010 [GRCh37]
Chr2:2q22.2
benign
NM_003937.3(KYNU):c.123C>T (p.His41=) single nucleotide variant not provided [RCV000966826] Chr2:142885490 [GRCh38]
Chr2:143643059 [GRCh37]
Chr2:2q22.2
benign
NM_003937.3(KYNU):c.729+9G>A single nucleotide variant not provided [RCV000883088] Chr2:142960779 [GRCh38]
Chr2:143718348 [GRCh37]
Chr2:2q22.2
benign
NM_003937.3(KYNU):c.828+9G>A single nucleotide variant not provided [RCV000974004] Chr2:142985191 [GRCh38]
Chr2:143742760 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.195T>C (p.Asp65=) single nucleotide variant not provided [RCV000936487] Chr2:142918634 [GRCh38]
Chr2:143676203 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.828+8C>T single nucleotide variant not provided [RCV000943103] Chr2:142985190 [GRCh38]
Chr2:143742759 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.60C>T (p.Leu20=) single nucleotide variant not provided [RCV000982675] Chr2:142885427 [GRCh38]
Chr2:143642996 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.1260A>G (p.Lys420=) single nucleotide variant not provided [RCV000982501] Chr2:143040646 [GRCh38]
Chr2:143798215 [GRCh37]
Chr2:2q22.2
likely benign
GRCh37/hg19 2q22.2-22.3(chr2:143192287-144325954)x3 copy number gain not provided [RCV000849947] Chr2:143192287..144325954 [GRCh37]
Chr2:2q22.2-22.3
uncertain significance
GRCh37/hg19 2q22.2(chr2:143290896-143804910)x3 copy number gain not provided [RCV000847135] Chr2:143290896..143804910 [GRCh37]
Chr2:2q22.2
uncertain significance
NM_003937.3(KYNU):c.121C>T (p.His41Tyr) single nucleotide variant not provided [RCV000901517] Chr2:142885488 [GRCh38]
Chr2:143643057 [GRCh37]
Chr2:2q22.2
likely benign
NM_003937.3(KYNU):c.1047T>C (p.Phe349=) single nucleotide variant not provided [RCV000889456] Chr2:143040433 [GRCh38]
Chr2:143798002 [GRCh37]
Chr2:2q22.2
benign
GRCh37/hg19 2q22.2(chr2:142738538-143643346)x3 copy number gain not provided [RCV001005325] Chr2:142738538..143643346 [GRCh37]
Chr2:2q22.2
uncertain significance
Single allele deletion Mowat-Wilson syndrome [RCV001250753] Chr2:137639637..146827604 [GRCh37]
Chr2:2q22.1-22.3
pathogenic
NC_000002.12:g.142877008_142961693del deletion Catel Manzke syndrome [RCV001256672] Chr2:142877008..142961693 [GRCh38]
Chr2:143634577..143719262 [GRCh37]
Chr2:2q22.2
pathogenic
NM_003937.3(KYNU):c.1282C>T (p.Arg428Trp) single nucleotide variant Catel Manzke syndrome [RCV001256673] Chr2:143042056 [GRCh38]
Chr2:143799625 [GRCh37]
Chr2:2q22.2
pathogenic
NM_003937.3(KYNU):c.989G>A (p.Arg330Gln) single nucleotide variant Catel Manzke syndrome [RCV001256674] Chr2:143033269 [GRCh38]
Chr2:143790838 [GRCh37]
Chr2:2q22.2
pathogenic
NM_003937.3(KYNU):c.326G>C (p.Trp109Ser) single nucleotide variant Catel Manzke syndrome [RCV001256675] Chr2:142927694 [GRCh38]
Chr2:143685263 [GRCh37]
Chr2:2q22.2
pathogenic
GRCh37/hg19 2q21.3-23.3(chr2:136473383-152727396) copy number gain Global developmental delay [RCV001352659] Chr2:136473383..152727396 [GRCh37]
Chr2:2q21.3-23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6469 AgrOrtholog
COSMIC KYNU COSMIC
Ensembl Genes ENSG00000115919 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264170 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000364928 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386731 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387296 UniProtKB/TrEMBL
  ENSP00000401190 UniProtKB/TrEMBL
  ENSP00000481930 UniProtKB/TrEMBL
  ENSP00000482009 UniProtKB/TrEMBL
  ENSP00000484801 UniProtKB/TrEMBL
Ensembl Transcript ENST00000264170 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000375773 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409512 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000410015 UniProtKB/TrEMBL
  ENST00000424385 UniProtKB/TrEMBL
  ENST00000612147 UniProtKB/TrEMBL
  ENST00000613664 UniProtKB/TrEMBL
  ENST00000621320 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000115919 GTEx
HGNC ID HGNC:6469 ENTREZGENE
Human Proteome Map KYNU Human Proteome Map
InterPro Aminotrans_V_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kynureninase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8942 UniProtKB/Swiss-Prot
NCBI Gene 8942 ENTREZGENE
OMIM 236800 OMIM
  605197 OMIM
  617661 OMIM
PANTHER PTHR14084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30258 PharmGKB
PIRSF KYNU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs kynureninase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WYM2_HUMAN UniProtKB/TrEMBL
  A0A087WYQ7_HUMAN UniProtKB/TrEMBL
  A0A087X297_HUMAN UniProtKB/TrEMBL
  A8K4D5_HUMAN UniProtKB/TrEMBL
  A8K7T0_HUMAN UniProtKB/TrEMBL
  B8ZZA3_HUMAN UniProtKB/TrEMBL
  F8WEP1_HUMAN UniProtKB/TrEMBL
  KYNU_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53SX6_HUMAN UniProtKB/TrEMBL
  Q53SY0_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2RCZ5 UniProtKB/Swiss-Prot
  D3DP79 UniProtKB/Swiss-Prot
  Q6I9T2 UniProtKB/Swiss-Prot
  Q9BVW3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-17 KYNU  kynureninase  KYNU  kynureninase  Symbol and/or name change 5135510 APPROVED
2011-07-27 KYNU  kynureninase  KYNU  kynureninase (L-kynurenine hydrolase)  Symbol and/or name change 5135510 APPROVED