RGD Reference Report - Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. - Rat Genome Database

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Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide.

Authors: Okayama, A  Ogawa, Y  Goto, S  Yamatodani, A  Wada, H  Okuno, E  Takikawa, O  Kido, R 
Citation: Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
RGD ID: 2290313
Pubmed: (View Article at PubMed) PMID:3400092

Eight-week-old female Wistar rats were exposed to carbon disulfide for 6 hr a day, 5 days a week, for 12 weeks in inhalation chambers. Then the activities of the main enzymes of tryptophan metabolism (i.e., L-tryptophan 2,3-dioxygenase, indoleamine 2,3-dioxygenase, kynurenine 3-hydroxylase, kynureninase, and kynurenine aminotransferases) in their tissues were determined. The results showed that exposure to carbon disulfide caused a significant increase in the activities of kynureninase and kynurenine-2-oxoglutarate aminotransferase in the kidneys, but only a slight increase in their activities in the liver. The activities of L-tryptophan 2,3-dioxygenase and kynurenine 3-hydroxylase also tended to increase, but the increases were not statistically significant. These results suggests that the kynurenine pathway of tryptophan metabolism in the kidneys of rats exposed to carbon disulfide is activated and that the increased activities of kynurenine-2-oxoglutarate aminotransferase in the kidneys may cause the increased excretion of tryptophan metabolites after tryptophan loading as shown in an earlier study (A. Okayama, L. Fun, A. Yamatodani, Y. Ogawa, H. Wada, and S. Goto, 1987, Arch. Toxicol. 60, 460-463.

Gene Ontology Annotations    

Biological Process

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Aadat  (aminoadipate aminotransferase)
Ido1  (indoleamine 2,3-dioxygenase 1)
Kmo  (kynurenine 3-monooxygenase)
Kynu  (kynureninase)
Tdo2  (tryptophan 2,3-dioxygenase)

Genes (Mus musculus)
Aadat  (aminoadipate aminotransferase)
Ido1  (indoleamine 2,3-dioxygenase 1)
Kmo  (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase))
Kynu  (kynureninase)
Tdo2  (tryptophan 2,3-dioxygenase)

Genes (Homo sapiens)
AADAT  (aminoadipate aminotransferase)
IDO1  (indoleamine 2,3-dioxygenase 1)
KMO  (kynurenine 3-monooxygenase)
KYNU  (kynureninase)
TDO2  (tryptophan 2,3-dioxygenase)

Additional Information