Kynu (kynureninase) - Rat Genome Database

Name: Kynu
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Kynu (kynureninase) Ictidomys tridecemlineatus

Analyze

Symbol:

Kynu

Name:

kynureninase

RGD ID:

12732549

Description:

ENCODES a protein that exhibits kynureninase activity (ortholog); pyridoxal phosphate binding (ortholog); INVOLVED IN tryptophan catabolic process to acetyl-CoA (ortholog); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 1 (ortholog); Catel Manzke syndrome (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KYNU (kynureninase)	NCBI	Ortholog
Mus musculus (house mouse):	Kynu (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Kynu (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kynu (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KYNU (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KYNU (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KYNU (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KYNU (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kynu (kynureninase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	107,812,529 - 107,984,835 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	33,632,892 - 33,734,433 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	33,632,885 - 33,805,158 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 1 (ISO)

Catel Manzke syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hydroxykynureninuria (ISO)

hypertension (ISO)

Inflammation (ISO)

Mowat-Wilson syndrome (ISO)

neurodegenerative disease (ISO)

Vertebral, Cardiac, Renal, and Limb Defects Syndrome 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' NAD biosynthetic process from tryptophan (IEA)

anthranilate metabolic process (IEA)

L-kynurenine catabolic process (IEA)

NAD biosynthetic process (IEA)

pyridine nucleotide biosynthetic process (IEA)

quinolinate biosynthetic process (IEA)

response to type II interferon (IEA)

response to vitamin B6 (IEA)

tryptophan catabolic process (IEA)

tryptophan catabolic process to acetyl-CoA (ISO)

tryptophan catabolic process to kynurenine (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

Molecular Function

3-hydroxykynureninase activity (IEA)

hydrolase activity (IEA)

kynureninase activity (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

pyridoxal phosphate binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

kynurenine metabolic pathway (ISO)

tryptophan metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Kynu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	107,812,529 - 107,984,835 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	33,632,892 - 33,734,433 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	33,632,885 - 33,805,158 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KYNU
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	142,877,664 - 143,055,833 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	142,877,657 - 143,055,833 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	143,635,233 - 143,813,402 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	143,351,665 - 143,516,355 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	143,468,950 - 143,633,606	NCBI
Celera	2	137,347,656 - 137,512,293 (+)	NCBI		Celera
Cytogenetic Map	2	q22.2	NCBI
HuRef	2	135,626,307 - 135,791,074 (+)	NCBI		HuRef
CHM1_1	2	143,640,202 - 143,804,900 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	143,325,958 - 143,504,091 (+)	NCBI		T2T-CHM13v2.0

Kynu
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	43,445,270 - 43,572,734 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	43,445,341 - 43,572,734 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	43,555,258 - 43,683,048 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	43,555,329 - 43,682,715 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	43,410,849 - 43,538,235 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	43,377,338 - 43,504,724 (+)	NCBI		MGSCv36	mm8
Celera	2	45,275,609 - 45,403,071 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	25.64	NCBI

Kynu
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	48,188,286 - 48,338,996 (+)	NCBI		GRCr8
mRatBN7.2	3	27,778,646 - 27,929,470 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	27,778,772 - 27,929,488 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	31,169,534 - 31,320,227 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	39,754,563 - 39,905,257 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	37,572,172 - 37,723,939 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	28,416,926 - 28,566,939 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	28,416,954 - 28,566,928 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	33,622,141 - 33,770,793 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	24,046,242 - 24,195,898 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	23,942,613 - 24,092,267 (+)	NCBI
Celera	3	26,096,675 - 26,244,576 (+)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

Kynu
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	9,420,009 - 9,536,761 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	9,420,141 - 9,536,767 (+)	NCBI	ChiLan1.0	ChiLan1.0

KYNU
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	31,861,346 - 32,151,868 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	31,876,156 - 32,166,772 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	16,792,401 - 16,947,766 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	146,976,053 - 147,131,298 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	146,975,995 - 147,132,634 (+)	Ensembl	panpan1.1		panPan2

KYNU
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	45,022,450 - 45,150,977 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	45,022,072 - 45,149,339 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	45,274,902 - 45,404,061 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	46,479,473 - 46,607,767 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	46,479,626 - 46,607,752 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	45,139,690 - 45,268,624 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	45,269,758 - 45,399,409 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	46,664,690 - 46,794,435 (+)	NCBI		UU_Cfam_GSD_1.0

KYNU
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	8,850,544 - 8,982,891 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	8,847,335 - 8,982,951 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	9,760,379 - 9,821,853 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KYNU
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	28,230,129 - 28,394,103 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	28,230,508 - 28,394,076 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	171,182,800 - 171,346,370 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kynu
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	42,627,715 - 42,753,165 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	42,627,789 - 42,751,037 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013358843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009296 ⟹ ENSSTOP00000008342

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936469	33,632,892 - 33,734,433 (-)	Ensembl

RefSeq Acc Id:

XM_013358843 ⟹ XP_013214297

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	107,812,529 - 107,984,835 (+)	NCBI
SpeTri2.0	NW_004936469	33,632,885 - 33,805,158 (-)	NCBI

Sequence:

show sequence

GGTTGAACTGGTTCCCAGATCACTTCTCACATATGGCCCCTTGCCTGGCTTGCTGCTTCTCCTG
TCTCTTGGACCTAGAACAGCTGTGATGGAGCCTTCACCTCTTGAGCTGCCATCTGACACGGTGC
AACGCATCGCAGCTGAGCTCAGATGTCACCCAACAGATGAACAGGTGGCTCTACGCCTAGATGA
GGAAGATACACTGAAGCATTTCAGGGAGTGTTTTTATATTCCCAAAATGCAGGATCTGCCTCCA
ATTGATTTATCTTTAGTGAATAAGGAAGAAAATTCCATTTATTTCTTGGGGAATTCTCTTGGCC
TTCAACCAAAATTGGTTAAAACATTTCTTGAAGAAGAACTTGATAAATGGGCTAAAATGGGAGC
CTATGGGCATGATGTAGGAAAACGCCCTTGGATTGTAGGAGATGAGATCATTGTAGGCCTTATG
AAGGACATTGTAGGAGCTAAGGAGAAAGAAATAGCCCTAATGAATGCTTTGACCGTTAATTTAC
ATCTCCTACTTTTATCATTTTTCAAGCCTACACCAAAACGGCATAAAATTCTTCTAGAAGCCAA
AGCCTTCCCTTCTGATCATTATGCTATAGAGTCACAGCTTCAACTTCACGGACTTAATGTTGAA
AGAAGTATGCGGATGATAAAGCCACGAGAGGGAGAAGAAATATTAAGGATGGAGGATATTCTTG
AAGTAATTGAGAAGGAAGGAGACTCTATTGCAGTGATCCTGTTCAGCGGGCTGCATTTTTACAC
TGGACAGCTCTTCGATATGCCTGCCATTACAAAAGCTGGACAAGCAAAGGGTTGTTTTGTTGGC
TTTGATCTGGCACATGCAGTTGGAAACGTTGAACTCCACTTACATGACTGGGGAGTCGATTTTG
CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGTCTTGCTGGTGCCTTTGTCCA
TGAAAAGCATGACCACACAATAAAACCTACGTTAGTGGGATGGTTTGGCCATGAACTCAGCACC
AGATTTAAAATGGATAACAAGCTACAGTTAATCCCTGGGGTCAGTGGATTCCGTATTTCCAATC
CTCCCATTTTGTTGGTCTGTTCATTGCATGCTAGTTTGGAGATCTTTAGGCAAGCGACTATAAA
AGCACTGAGGAAAAAATCCATTTTGCTAACTGGTTATCTGGAATACATGATCAAGCTTTACTTT
AACAAAGACATAGGAGGAACCAAGAAACCAATTGTGAATATAATTACTCCATCCAATATAGAGG
ATCGGGGCTGCCAATTGACACTAACGTTTTCTATTCCCAAGAAAAATGTTTTTGAAGAACTAGA
AAAAAGAGGAGTTGTTTGTGACAAGCGAGAACCAAATGGGATTCGAGTGGCTCCAGTTCCTCTC
TACAATTCTTTTCATGATGTTTATAAATTTATCAATTTGCTTTCTTCTGTAATTGATTCTGTGG
AAACAAAAAAGTAGCGATGTTCTTATTATTAACTTACACAAATTTACTGAAAGATGCCTTATTT
TACTACTATTCAATTTTTAATTTTTAAAAATA

hide sequence

RefSeq Acc Id:

XM_040294268 ⟹ XP_040150202

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	107,875,427 - 107,984,835 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013214297	(Get FASTA)	NCBI Sequence Viewer
	XP_040150202	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008342.2
GenBank Protein	KAG3274420	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013214297 ⟸ XM_013358843
- Peptide Label:	isoform X2
- UniProtKB:	I3MDA8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPSPLELPSDTVQRIAAELRCHPTDEQVALRLDEEDTLKHFRECFYIPKMQDLPPIDLSLVNK EENSIYFLGNSLGLQPKLVKTFLEEELDKWAKMGAYGHDVGKRPWIVGDEIIVGLMKDIVGAKE KEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQLQLHGLNVERSMRMIKP REGEEILRMEDILEVIEKEGDSIAVILFSGLHFYTGQLFDMPAITKAGQAKGCFVGFDLAHAVG NVELHLHDWGVDFACWCSYKYLNAGAGGLAGAFVHEKHDHTIKPTLVGWFGHELSTRFKMDNKL QLIPGVSGFRISNPPILLVCSLHASLEIFRQATIKALRKKSILLTGYLEYMIKLYFNKDIGGTK KPIVNIITPSNIEDRGCQLTLTFSIPKKNVFEELEKRGVVCDKREPNGIRVAPVPLYNSFHDVY KFINLLSSVIDSVETKK hide sequence

RefSeq Acc Id:	XP_040150202 ⟸ XM_040294268
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSSTOP00000008342 ⟸ ENSSTOT00000009296

Protein Domains

Aminotransferase class V

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009286	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009296.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/TrEMBL
InterPro	Aminotrans_V_dom	UniProtKB/TrEMBL
	Kynureninase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_small	UniProtKB/TrEMBL
NCBI Gene	Kynu	ENTREZGENE
PANTHER	KYNURENINASE	UniProtKB/TrEMBL
	PTHR14084	UniProtKB/TrEMBL
Pfam	Aminotran_5	UniProtKB/TrEMBL
PIRSF	KYNU	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53383	UniProtKB/TrEMBL
UniProt	I3MDA8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB