Kynu (kynureninase) - Rat Genome Database

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Gene: Kynu (kynureninase) Ictidomys tridecemlineatus
Analyze
Symbol: Kynu
Name: kynureninase
RGD ID: 12732549
Description: ENCODES a protein that exhibits kynureninase activity (ortholog); pyridoxal phosphate binding (ortholog); INVOLVED IN aging (ortholog); tryptophan catabolic process to acetyl-CoA (ortholog); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 1 (ortholog); Catel Manzke syndrome (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303107,812,529 - 107,984,835 (+)NCBI
SpeTri2.0NW_00493646933,632,885 - 33,805,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
mitochondrion  (IEA)
nucleoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Kynu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303107,812,529 - 107,984,835 (+)NCBI
SpeTri2.0NW_00493646933,632,885 - 33,805,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KYNU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,877,664 - 143,055,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2142,877,657 - 143,055,833 (+)EnsemblGRCh38hg38GRCh38
GRCh372143,635,233 - 143,813,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,351,665 - 143,516,355 (+)NCBINCBI36hg18NCBI36
Build 342143,468,950 - 143,633,606NCBI
Celera2137,347,656 - 137,512,293 (+)NCBI
Cytogenetic Map2q22.2NCBI
HuRef2135,626,307 - 135,791,074 (+)NCBIHuRef
CHM1_12143,640,202 - 143,804,900 (+)NCBICHM1_1
T2T-CHM13v2.02143,325,958 - 143,504,091 (+)NCBI
Kynu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39243,445,270 - 43,573,060 (+)NCBIGRCm39mm39
GRCm39 Ensembl243,445,341 - 43,572,734 (+)Ensembl
GRCm38243,555,258 - 43,683,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl243,555,329 - 43,682,715 (+)EnsemblGRCm38mm10GRCm38
MGSCv37243,410,849 - 43,538,235 (+)NCBIGRCm37mm9NCBIm37
MGSCv36243,377,338 - 43,504,724 (+)NCBImm8
Celera245,275,609 - 45,403,071 (+)NCBICelera
Cytogenetic Map2BNCBI
Kynu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2327,778,646 - 27,929,470 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)Ensembl
Rnor_6.0328,416,926 - 28,566,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl328,416,954 - 28,566,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0333,622,141 - 33,770,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4324,046,242 - 24,195,898 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1323,942,613 - 24,092,267 (+)NCBI
Celera326,096,675 - 26,244,576 (+)NCBICelera
Cytogenetic Map3q12NCBI
Kynu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554409,420,009 - 9,536,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554409,420,141 - 9,536,767 (+)NCBIChiLan1.0ChiLan1.0
KYNU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B146,976,053 - 147,131,298 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B146,975,995 - 147,132,634 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B16,792,401 - 16,947,766 (-)NCBIMhudiblu_PPA_v0panPan3
KYNU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11945,022,450 - 45,150,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1945,022,072 - 45,149,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1945,274,902 - 45,404,061 (+)NCBI
ROS_Cfam_1.01946,479,473 - 46,607,767 (+)NCBI
ROS_Cfam_1.0 Ensembl1946,479,626 - 46,607,752 (+)Ensembl
UMICH_Zoey_3.11945,139,690 - 45,268,624 (+)NCBI
UNSW_CanFamBas_1.01945,269,758 - 45,399,409 (+)NCBI
UU_Cfam_GSD_1.01946,664,690 - 46,794,435 (+)NCBI
KYNU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,850,544 - 8,982,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,847,335 - 8,982,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2159,760,379 - 9,821,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KYNU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11028,230,129 - 28,394,103 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1028,230,508 - 28,394,076 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040171,182,800 - 171,346,370 (-)NCBIVero_WHO_p1.0
Kynu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473242,627,715 - 42,753,165 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473242,627,789 - 42,751,037 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013358843   ⟹   XP_013214297
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303107,812,529 - 107,984,835 (+)NCBI
SpeTri2.0NW_00493646933,632,885 - 33,805,158 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040294268   ⟹   XP_040150202
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303107,875,427 - 107,984,835 (+)NCBI
Protein Sequences
Protein RefSeqs XP_013214297 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3274420 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013214297   ⟸   XM_013358843
- Peptide Label: isoform X2
- UniProtKB: I3MDA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040150202   ⟸   XM_040294268
- Peptide Label: isoform X1
Protein Domains
Aminotran_5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009286 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008342 ENTREZGENE
  ENSSTOP00000008342.2 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009296.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_V_dom UniProtKB/TrEMBL
  Kynureninase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
NCBI Gene Kynu ENTREZGENE
PANTHER PTHR14084 UniProtKB/TrEMBL
Pfam Aminotran_5 UniProtKB/TrEMBL
PIRSF KYNU UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
TIGRFAMs kynureninase UniProtKB/TrEMBL
UniProt I3MDA8 ENTREZGENE, UniProtKB/TrEMBL