4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one	go back to main search page
Accession:	CHEBI:32692	browse the term
Definition:	A nitrosamine that has formula C10H13N3O2.
Synonyms:	exact_synonym:	4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one
	related_synonym:	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; Formula=C10H13N3O2; InChI=1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3; InChIKey=FLAQQSHRLBFIEZ-UHFFFAOYSA-N; NNK; NNK (carcinogen); SMILES=CN(CCCC(=O)c1cccnc1)N=O
	xref:	Beilstein:3548355; CAS:64091-91-4; KEGG:C16453
	xref_mesh:	MESH:C016583

show annotations for term's descendants Sort by:
Rat (309) Mouse (304) Human (312) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (304)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ABCB1B mRNA

PMID:14600272 PMID:23052194

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

ATP-binding cassette, sub-family member 2

affects abundance

ABCC2 protein affects the abundance of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone metabolite

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

aconitase 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ACO1 mRNA

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of ACSL1 mRNA

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

1-acylglycerol-3-phosphate O-acyltransferase 1

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of AGPAT1 mRNA

NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423

G

allograft inflammatory factor 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of AIF1 mRNA

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

aldo-keto reductase family 1, member C21

increases metabolic processing

AKR1C2 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

aldo-keto reductase family 1, member C6

increases metabolic processing

AKR1C4 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876

G

thymoma viral proto-oncogene 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:12511591 PMID:34784199

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aldehyde dehydrogenase family 1, subfamily A1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ALDH1A1 mRNA

PMID:14600272 PMID:22484513 PMID:23052194

NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829

G

aldehyde dehydrogenase family 7, member A1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ALDH7A1 mRNA

NCBI chr18:56,657,794...56,706,112
Ensembl chr18:56,642,759...56,706,023

G

annexin A2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ANXA2 mRNA

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

apurinic/apyrimidinic endonuclease 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of APEX1 mRNA

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

aph1 homolog B, gamma secretase subunit

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of APH1B mRNA

NCBI chr 9:66,682,484...66,704,671
Ensembl chr 9:66,682,484...66,702,772

G

AT-rich interaction domain 4B

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of ARID4B mRNA

NCBI chr13:14,238,334...14,374,188
Ensembl chr13:14,237,817...14,374,188

G

argininosuccinate lyase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ASL mRNA

NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088

G

activating transcription factor 1

increases phosphorylation
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein
Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]

NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125

G

activating transcription factor 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

ataxia telangiectasia mutated

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

ATP synthase membrane subunit c locus 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of ATP5MC1 mRNA

NCBI chr11:95,963,619...95,966,520
Ensembl chr11:95,959,678...95,966,496

G

ATPase, H+ transporting, lysosomal V1 subunit D

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ATP6V1D mRNA

PMID:14600272 PMID:22484513 PMID:23052194

NCBI chr12:78,889,756...78,908,810
Ensembl chr12:78,887,499...78,908,412

G

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of B4GALT1 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of B4GALT1 mRNA]

NCBI chr 4:40,804,602...40,855,711
Ensembl chr 4:40,804,602...40,854,005

G

BCL2-associated agonist of cell death

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BAD protein
SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BAD protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BAD protein]

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BarH like homeobox 1

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BARHL1 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BARHL1 mRNA]

NCBI chr 2:28,797,692...28,807,996
Ensembl chr 2:28,797,691...28,806,680

G

BCL2-associated X protein

multiple interactions
increases expression
decreases expression

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BAX mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BAX protein

PMID:14600272 PMID:15890375 PMID:21882252 PMID:22484513 PMID:23052194 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions
increases expression

Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BCL2 mRNA]; SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BCL2 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BCL2 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BCL2 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BCL2 protein

PMID:16582591 PMID:16835749 PMID:18508827 PMID:21776270

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

betaine-homocysteine methyltransferase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BHMT mRNA

NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469

G

baculoviral IAP repeat-containing 3

increases expression
multiple interactions
increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein
SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein]; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein]
NNK increases expression of BIRC3 protein in nonsmall cell lung cancer cells

CTD
RGD

PMID:18508827 PMID:18508827

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

baculoviral IAP repeat-containing 5

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BIRC5 mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone affects the localization of and results in increased expression of BIRC5 protein

PMID:21167638 PMID:21776270

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

bolA family member 3

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BOLA3 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BOLA3 mRNA]

NCBI chr 6:83,326,129...83,337,118
Ensembl chr 6:83,326,129...83,337,118

G

breast cancer 1, early onset

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BRCA1 mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of BRCA1 mRNA

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

BTG anti-proliferation factor 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BTG2 mRNA

PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

BTG anti-proliferation factor 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BTG3 mRNA

PMID:22484513 PMID:23052194

NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080

G

caspase 8

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CASP8 mRNA

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

carbonyl reductase 1

multiple interactions
increases metabolic processing

Ethacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Quercetin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Vitamin K 3 inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393

G

C-C motif chemokine ligand 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CCL2 protein

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cyclin B1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CCNB1 mRNA

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D1

multiple interactions
increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK4 protein binds to CCND1 protein]; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK6 protein binds to CCND1 protein]; Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Benzamides analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 protein

PMID:14600272 PMID:15890375 PMID:18805435 PMID:22484513 PMID:28321046 More...

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin E1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCNE1 protein

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

cyclin G1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCNG1 mRNA

PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194

NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138

G

chaperonin containing TCP1 subunit 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCT3 mRNA

NCBI chr 3:88,204,442...88,229,073
Ensembl chr 3:88,204,423...88,229,074

G

cell division cycle 20

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cadherin 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDH2 protein

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cyclin dependent kinase 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDK1 mRNA

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 16

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDK16 mRNA

NCBI chr X:20,554,210...20,566,119
Ensembl chr X:20,554,193...20,566,119

G

cyclin dependent kinase 4

multiple interactions
increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK4 protein binds to CCND1 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDK4 mRNA

PMID:15890375 PMID:18805435

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase 6

multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK6 protein binds to CCND1 protein]

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions
decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1A protein]; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein; SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDKN1A protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDKN1A protein]; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1A mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDKN1A mRNA

PMID:14600272 PMID:15890375 PMID:18508827 PMID:18805435 PMID:20421341 More...

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1B protein]

PMID:18805435 PMID:30236600

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 2A

multiple interactions

[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A mRNA; [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A protein

NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890

G

carboxylesterase 2C

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CES2C mRNA

NCBI chr 8:105,573,700...105,581,115
Ensembl chr 8:105,573,700...105,581,115

G

carboxylesterase 2H

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CES2 mRNA

PMID:14600272 PMID:22484513

NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810

G

cell growth regulator with EF hand domain 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CGREF1 mRNA

PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194

NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935

G

cell growth regulator with ring finger domain 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CGRRF1 mRNA

NCBI chr14:47,069,591...47,091,655
Ensembl chr14:47,069,582...47,091,650

G

chromodomain helicase DNA binding protein 1-like

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHD1L mRNA

NCBI chr 3:97,468,056...97,517,538
Ensembl chr 3:97,468,058...97,517,519

G

cholinergic receptor, nicotinic, alpha polypeptide 7

increases expression
affects binding
increases activity

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHRNA7 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone binds to CHRNA7 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of CHRNA7 protein

PMID:16835749 PMID:17459420 PMID:19027725

NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317

G

cholinergic receptor, nicotinic, alpha polypeptide 9

multiple interactions

[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein

NCBI chr 5:66,092,317...66,134,823
Ensembl chr 5:66,092,264...66,134,669

G

contactin 1

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]; Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]

NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848

G

collagen, type VI, alpha 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of COL6A1 protein

NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002

G

COMM domain containing 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of COMMD1 mRNA

NCBI chr11:22,849,728...22,934,539
Ensembl chr11:22,846,136...22,932,382

G

cytochrome c oxidase assembly protein 17, copper chaperone

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of COX17 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of COX17 mRNA]

NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659

G

complement C3b/C4b receptor 1 like

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CR1L mRNA

NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein
Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

crystallin, alpha B

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CRYAB mRNA

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

cystatin B

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CSTB mRNA

NCBI chr10:78,261,504...78,263,456
Ensembl chr10:78,261,503...78,263,456

G

catenin beta 1

multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CTNNB1 protein; Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CTNNB1 protein]; wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin D

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSD mRNA

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

cathepsin S

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSS mRNA

NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714

G

C-X-C motif chemokine ligand 10

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CXCL10 mRNA

PMID:14600272 PMID:15890375

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 15

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CXCL8 protein

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome b5 type A (microsomal)

multiple interactions

CYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996

G

cytochrome b5 reductase 3

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CYB5R3 mRNA

NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CYP1A1 mRNA; CYP1A1 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; Grape Seed Proanthocyanidins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CYP1A1 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CYP1A1 mRNA]

PMID:11774366 PMID:20146248 PMID:23052194

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases activity

CYP1A2 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYP1A2 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:11774366 PMID:15728263

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

CYP1B1 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; Grape Seed Proanthocyanidins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CYP1B1 mRNA]

PMID:11774366 PMID:20146248

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily a, polypeptide 5

increases hydroxylation
affects metabolic processing
multiple interactions
increases metabolic processing
increases activity

CYP2A6 results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYP2A6 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; CYP2A6 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; CYP2A6 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYP2A6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; CYP2A6 results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:11259349 PMID:11684323 PMID:11774366 PMID:11805739 PMID:12115524 More...

NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases activity
affects metabolic processing
multiple interactions

CYP2B6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
CYP2B6 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
[CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:10799646 PMID:12920169 PMID:32672941

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily c, polypeptide 38

multiple interactions

CYP2C19 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 2, subfamily d, polypeptide 22

increases metabolic processing

CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects metabolic processing
increases activity
increases metabolic processing

CYP2E1 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of CYP2E1 protein
CYP2E1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:9774145 PMID:12115524 PMID:12920169

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

death associated protein kinase 1

increases methylation

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased methylation of DAPK1 promoter

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

decorin

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DCN mRNA

NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005

G

dimethylarginine dimethylaminohydrolase 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DDAH1 mRNA

NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032

G

DExD box helicase 21

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DDX21 mRNA

NCBI chr10:62,416,026...62,438,077
Ensembl chr10:62,416,030...62,438,060

G

dehydrogenase/reductase 3

increases metabolic processing

DHRS3 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683

G

dyskeratosis congenita 1, dyskerin

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKC1 mRNA

NCBI chr X:74,139,460...74,153,382
Ensembl chr X:74,139,460...74,153,383

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]; Benzamides analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]; diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]; wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

deleted in malignant brain tumors 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DMBT1 mRNA

NCBI chr 7:130,633,787...130,723,357
Ensembl chr 7:130,633,776...130,723,357

G

dihydropyrimidine dehydrogenase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DPYD mRNA

NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573

G

dual specificity phosphatase 6

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DUSP6 mRNA

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

deoxyuridine triphosphatase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DUT mRNA

NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528

G

eukaryotic translation elongation factor 1 gamma

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EEF1G mRNA

NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843

G

eukaryotic translation elongation factor 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EEF2 mRNA

NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332

G

epidermal growth factor receptor

increases phosphorylation
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein
Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EIF4EBP1 mRNA
[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein

PMID:12511591 PMID:15890375

NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702

G

epoxide hydrolase 1, microsomal

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EPHX1 mRNA

PMID:14600272 PMID:15890375 PMID:22484513

NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469

G

family with sequence similarity 162, member A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of FAM162A mRNA

NCBI chr16:35,864,214...35,891,931
Ensembl chr16:35,864,131...35,891,964

G

fatty acid synthase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of FASN protein

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

flap structure specific endonuclease 1

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FEN1 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FEN1 protein
NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FEN1 protein]

NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533

G

FK506 binding protein 4

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of FKBP4 mRNA

NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640

G

fibronectin 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FN1 mRNA

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FBJ osteosarcoma oncogene

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FOS mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

forkhead box P1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of FOXP1 mRNA alternative form

NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682

G

ferritin heavy polypeptide 1

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of FTH1 mRNA

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

FXYD domain-containing ion transport regulator 3

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of FXYD3 mRNA

NCBI chr 7:30,769,960...30,776,122
Ensembl chr 7:30,767,597...30,776,129

G

growth arrest and DNA-damage-inducible 45 alpha

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GADD45A mRNA

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

growth arrest specific 6

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GAS6 mRNA

PMID:14600272 PMID:15890375

NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490

G

GATA binding protein 3

multiple interactions
increases activity
increases expression

Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]; Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GATA3 mRNA

PMID:16582591 PMID:16835749

NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845

G

glutamate-cysteine ligase, catalytic subunit

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GCLC mRNA

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

growth differentiation factor 15

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GDF15 mRNA

PMID:14600272 PMID:15890375 PMID:23052194

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

glutaminase 2 (liver, mitochondrial)

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GLS2 mRNA

NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873

G

predicted gene, 40318

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA]

NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039

G

glycine N-methyltransferase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GNMT mRNA

NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094

G

glutamate receptor, ionotropic, AMPA3 (alpha 3)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GRIA3 mRNA

NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478

G

GrpE-like 1, mitochondrial

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GRPEL1 mRNA

NCBI chr 5:36,622,529...36,631,421
Ensembl chr 5:36,622,342...36,631,424

G

glycogen synthase kinase 3 alpha

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein

NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276

G

glycogen synthase kinase 3 beta

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione synthetase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSS mRNA

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

glutathione S-transferase, alpha 1 (Ya)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSTA5 mRNA

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase, alpha 2 (Yc2)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSTA2 mRNA

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase, alpha 4

decreases expression
increases activity
increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GSTA4 mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GSTA4 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSTA4 mRNA

NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631

G

GTP binding protein 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GTPBP1 mRNA

NCBI chr15:79,574,202...79,605,680
Ensembl chr15:79,575,046...79,605,680

G

histocompatibility 2, class II antigen A, beta 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RT1-BB mRNA

NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393

G

H2A.X variant histone

multiple interactions
increases phosphorylation
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein; Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein]; CYP2A13 protein promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form]; Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form

PMID:15890375 PMID:21882252 PMID:26231820 PMID:34784199 PMID:35435490

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

H2A.Z variant histone 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of H2AZ1 mRNA

NCBI chr 3:137,570,248...137,572,683
Ensembl chr 3:137,570,248...137,572,683

G

H3.4 histone, cluster member

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H3-4 mRNA

NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364

G

hemoglobin alpha, adult chain 2

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HBA2 mRNA

NCBI chr11:32,246,492...32,247,310
Ensembl chr11:32,246,489...32,247,298

G

hypocretin (orexin) receptor 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HCRTR2 mRNA

NCBI chr 9:76,133,162...76,230,905
Ensembl chr 9:76,133,162...76,231,138

G

histidine decarboxylase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HDC mRNA

NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219

G

hes family bHLH transcription factor 1

multiple interactions
increases expression

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HES1 mRNA]

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

high mobility group box 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of HMGB2 mRNA

NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033

G

heme oxygenase 1

multiple interactions
increases expression

SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 mRNA

PMID:15890375 PMID:18508827

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions
increases mutagenesis

[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene; Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of HPRT1 gene

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions
increases reduction

drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Ethinyl Estradiol inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Progesterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Testosterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA; Grape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

heat shock factor 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSF1 mRNA

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 9

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPA9 mRNA

NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410

G

heat shock protein 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPB1 mRNA

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock protein 1 (chaperonin 10)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPE1 mRNA

NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466

G

heat shock 105kDa/110kDa protein 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPH1 mRNA

NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841

G

insulin degrading enzyme

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IDE mRNA

NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010

G

insulin-like growth factor binding protein 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IGFBP1 mRNA

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

insulin-like growth factor binding protein 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IGFBP2 mRNA

PMID:22484513 PMID:23052194

NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633

G

insulin-like growth factor binding protein 3

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of IGFBP3 mRNA

NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923

G

interleukin 6

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of IL6 protein

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

indolethylamine N-methyltransferase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of INMT mRNA

NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028

G

integrator complex subunit 4

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of INTS4 mRNA

NCBI chr 7:97,130,158...97,190,605
Ensembl chr 7:97,130,163...97,190,602

G

interferon regulatory factor 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IRF1 mRNA

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

G

jun proto-oncogene

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of JUN mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of JUN mRNA

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

Kirsten rat sarcoma viral oncogene homolog

increases mutagenesis
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of KRAS gene
[Lipopolysaccharides co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of KRAS gene

PMID:18271921 PMID:21868532

NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965

G

keratin 15

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of KRT15 mRNA

NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754

G

laminin, alpha 5

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of LAMA5 mRNA

NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652

G

lectin, galactose binding, soluble 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of LGALS3 mRNA

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

leukotriene B4 receptor 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of LTB4R mRNA

NCBI chr14:56,002,154...56,005,951
Ensembl chr14:56,003,419...56,005,951

G

mitogen-activated protein kinase kinase 1

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein]

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

mitogen-activated protein kinase kinase 2

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K2 protein]

NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions
increases activity

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of MAPK1 protein; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of MAPK1 protein

PMID:15603589 PMID:16671086 PMID:17459420 PMID:18508827 PMID:21882252 More...

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases activity
multiple interactions
increases phosphorylation

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of MAPK3 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of MAPK3 protein; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK3 protein; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]

PMID:15603589 PMID:16671086 PMID:17459420 PMID:18508827 PMID:21882252 More...

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

methionine adenosyltransferase 1A

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MAT1A mRNA

NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369

G

melanoma cell adhesion molecule

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MCAM mRNA

NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024

G

minichromosome maintenance complex component 6

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MCM6 mRNA

NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401

G

transformed mouse 3T3 cell double minute 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA

PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

O-6-methylguanine-DNA methyltransferase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MGMT mRNA

PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

microRNA 155

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MIR155 mRNA

NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092

G

microRNA 21a

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MSH2 protein]

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

MIS18 kinetochore protein A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MIS18A mRNA

NCBI chr16:90,516,200...90,524,259
Ensembl chr16:90,516,200...90,524,292

G

antigen identified by monoclonal antibody Ki 67

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MKI67 protein

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

mutL homolog 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MLH1 mRNA

NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859

G

matrix metallopeptidase 9

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MMP9 mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of MMP9 mRNA

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

mitochondrial ribosomal protein L41

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of MRPL41 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of MRPL41 mRNA]

NCBI chr 2:24,862,482...24,865,110
Ensembl chr 2:24,864,129...24,865,110

G

mutS homolog 2

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MSH2 mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of and affects the localization of MSH2 protein; MIR21 mRNA affects the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MSH2 protein]

NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141

G

metallothionein 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MT1A mRNA

PMID:14600272 PMID:15890375

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MT2 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MT2A mRNA

PMID:14600272 PMID:15890375

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

metastasis-associated gene family, member 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MTA2 mRNA

NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667

G

myelocytomatosis oncogene

increases activity
increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of MYC protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MYC mRNA

PMID:15890375 PMID:17459420

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

Nanog homeobox

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NANOG protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein

NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592

G

nucleosome assembly protein 1-like 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NAP1L1 mRNA

NCBI chr10:111,308,754...111,334,011
Ensembl chr10:111,309,084...111,334,011

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

increases activity
increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of NFKB1 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NFKB1 mRNA
Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NFKB1 mRNA]; Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NFKB1 mRNA]; SN50 peptide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of NFKB1 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of NFKB1 protein]

PMID:16582591 PMID:16835749 PMID:18508827

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases phosphorylation

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of NFKBIA protein

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

non-homologous end joining factor 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NHEJ1 mRNA

NCBI chr 1:75,006,505...75,101,870
Ensembl chr 1:75,006,298...75,101,844

G

NIPBL cohesin loading factor

increases expression
increases response to substance
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NIPBL mRNA alternative form
NIPBL mRNA alternative form results in increased susceptibility to 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of FEN1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PCNA protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XRCC1 protein]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form]

NCBI chr15:8,319,308...8,494,799
Ensembl chr15:8,320,101...8,473,947

G

NPC intracellular cholesterol transporter 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NPC1 mRNA

NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457

G

nucleophosmin 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NPM1 mRNA

NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206

G

NAD(P)H dehydrogenase, quinone 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NQO1 mRNA

PMID:14600272 PMID:15890375

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

neuronal cell adhesion molecule

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRCAM mRNA

NCBI chr12:44,375,568...44,651,977
Ensembl chr12:44,375,668...44,648,747

G

neuregulin 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNA

PMID:14600272 PMID:15890375 PMID:23052194

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

nucleotide binding protein-like

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of NUBPL mRNA

NCBI chr12:52,144,529...52,357,753
Ensembl chr12:52,144,520...52,359,527

G

nuclear protein transcription regulator 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of NUPR1 mRNA

PMID:15890375 PMID:23052194

NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033

G

ornithine aminotransferase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of OAT mRNA

PMID:14600272 PMID:22484513

NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127

G

occludin

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of OCLN protein

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

ornithine decarboxylase, structural 1

increases activity
increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of ODC1 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ODC1 mRNA
tocopheryloxybutyric acid inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of ODC1 protein]; tocopheryloxybutyric acid inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ODC1 mRNA]

PMID:11301052 PMID:15890375

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

poly (ADP-ribose) polymerase family, member 1

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein
NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

proliferating cell nuclear antigen

multiple interactions
increases expression
decreases expression

Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PCNA mRNA]; NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PCNA protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PCNA mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PCNA protein

PMID:15890375 PMID:16582591 PMID:16835749 PMID:35435490

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

proprotein convertase subtilisin/kexin type 2

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PCSK2 mRNA

NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205

G

programmed cell death 4

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PDCD4 mRNA

NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291

G

period circadian clock 1

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA]

NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786

G

phosphogluconate dehydrogenase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PGD mRNA

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

3-phosphoglycerate dehydrogenase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PHGDH mRNA

NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306

G

pleckstrin homology like domain, family A, member 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PHLDA3 mRNA

PMID:22484513 PMID:23052194

NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874

G

phospholipase A2, group IIA (platelets, synovial fluid)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLA2G2A mRNA

NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497

G

phospholipase A2, group IVA (cytosolic, calcium-dependent)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLA2G4A mRNA

NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041

G

plasminogen activator, urokinase

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PLAU mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PLAU mRNA

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

polo like kinase 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLK2 mRNA

NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378

G

phospholamban

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLN mRNA

NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083

G

cytochrome p450 oxidoreductase

affects response to substance

POR affects the susceptibility to 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

peroxiredoxin 6

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PRDX6 protein

NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789

G

proteasome subunit alpha 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA1 mRNA

NCBI chr 7:113,863,785...113,875,351
Ensembl chr 7:113,863,841...113,875,353

G

proteasome subunit alpha 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA2 mRNA

NCBI chr13:14,787,827...14,800,258
Ensembl chr13:14,787,825...14,848,821

G

proteasome subunit alpha 4

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA4 mRNA

NCBI chr 9:54,858,074...54,865,316
Ensembl chr 9:54,858,074...54,865,314

G

proteasome subunit alpha 5

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PSMA5 mRNA

NCBI chr 3:108,164,242...108,187,268
Ensembl chr 3:108,164,242...108,187,290

G

proteasome subunit alpha 7

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMA7 mRNA

NCBI chr 2:179,678,160...179,684,257
Ensembl chr 2:179,678,167...179,684,226

G

proteasome (prosome, macropain) subunit, beta type 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMB1 mRNA

NCBI chr17:15,695,983...15,718,538
Ensembl chr17:15,695,283...15,720,013

G

proteasome (prosome, macropain) subunit, beta type 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMB3 mRNA

NCBI chr11:97,594,260...97,604,326
Ensembl chr11:97,594,225...97,604,326

G

proteasome (prosome, macropain) subunit, beta type 4

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMB4 mRNA

NCBI chr 3:94,791,635...94,794,269
Ensembl chr 3:94,791,404...94,794,272

G

proteasome (prosome, macropain) subunit, beta type 5

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMB5 mRNA

NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479

G

protease (prosome, macropain) 26S subunit, ATPase 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC1 mRNA

NCBI chr12:100,076,461...100,089,623
Ensembl chr12:100,076,413...100,089,664

G

proteasome (prosome, macropain) 26S subunit, ATPase 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC2 mRNA

NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785

G

proteasome (prosome, macropain) 26S subunit, ATPase, 4

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC4 mRNA

NCBI chr 7:27,741,127...27,749,517
Ensembl chr 7:27,741,132...27,749,526

G

protease (prosome, macropain) 26S subunit, ATPase 5

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC5 mRNA

NCBI chr11:106,147,011...106,153,938
Ensembl chr11:106,146,980...106,153,946

G

proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMD1 mRNA

NCBI chr 1:85,992,341...86,067,017
Ensembl chr 1:85,992,109...86,066,873

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases activity

[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased abundance of Dinoprostone]; Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]; Propranolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]; SB 203580 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]; U 0126 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]

PMID:15762874 PMID:18805435

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

PTK2 protein tyrosine kinase 2

multiple interactions

[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of PTK2 protein

NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129

G

protein tyrosine phosphatase 4a1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PTP4A1 mRNA

NCBI chr 1:30,979,384...30,988,838
Ensembl chr 1:30,979,383...30,988,390
Ensembl chr 1:30,979,383...30,988,390

G

pituitary tumor-transforming gene 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PTTG1 mRNA

NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078

G

R3H domain containing 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of R3HDM2 mRNA

NCBI chr10:127,216,201...127,335,253
Ensembl chr10:127,216,196...127,335,253

G

RAD23 homolog B, nucleotide excision repair protein

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RAD23B mRNA

NCBI chr 4:55,350,042...55,392,237
Ensembl chr 4:55,350,043...55,392,237

G

v-raf-leukemia viral oncogene 1

increases activity

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of RAF1 protein

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

retinoic acid receptor, beta

increases methylation

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased methylation of RARB promoter

NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924

G

RB transcriptional corepressor 1

multiple interactions
increases phosphorylation
decreases expression

4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of RB1 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RB1 mRNA

PMID:15890375 PMID:18805435

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of RELA protein

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

regulatory factor X, 1 (influences HLA class II expression)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RFX1 mRNA

NCBI chr 8:84,789,787...84,823,630
Ensembl chr 8:84,793,463...84,823,621

G

repulsive guidance molecule family member B

multiple interactions

[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of RGMB mRNA

NCBI chr17:16,024,923...16,051,508
Ensembl chr17:16,023,450...16,051,301

G

Rhesus blood group-associated C glycoprotein

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RHCG mRNA

NCBI chr 7:79,243,111...79,267,405
Ensembl chr 7:79,243,111...79,267,405

G

Ras homolog enriched in brain

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RHEB mRNA

NCBI chr 5:25,007,821...25,047,359
Ensembl chr 5:25,007,821...25,047,622

G

ras homolog family member B

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RHOB mRNA

PMID:14600272 PMID:22484513

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

ribosomal protein L10

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL10 mRNA

NCBI chr X:73,314,463...73,316,741
Ensembl chr X:73,314,418...73,316,741

G

ribosomal protein L10A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL10A mRNA

NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007

G

ribosomal protein L13

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL13 mRNA

NCBI chr 8:123,829,089...123,831,983
Ensembl chr 8:123,829,089...123,831,983

G

ribosomal protein L15

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL15 mRNA

NCBI chr14:4,198,710...4,201,873
Ensembl chr14:4,198,305...4,201,873

G

ribosomal protein L17

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL17 mRNA

NCBI chr18:75,132,049...75,136,455
Ensembl chr18:75,131,629...75,136,452

G

ribosomal protein L23

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL23 mRNA

NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263

G

ribosomal protein L6

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL6 mRNA

NCBI chr 5:121,342,564...121,347,304
Ensembl chr 5:121,342,544...121,347,304

G

ribosomal protein L7A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL7A mRNA

NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330

G

ribosomal protein L8

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL8 mRNA

NCBI chr15:76,788,271...76,790,518
Ensembl chr15:76,788,278...76,790,514

G

ribosomal protein S15A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS15A mRNA

NCBI chr 7:117,703,597...117,715,370
Ensembl chr 7:117,703,595...117,715,411

G

ribosomal protein S19

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS19 mRNA

PMID:14600272 PMID:15890375

NCBI chr 7:24,584,013...24,589,236
Ensembl chr 7:24,583,796...24,589,231

G

ribosomal protein S24

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS24 mRNA

NCBI chr14:24,540,786...24,545,925
Ensembl chr14:24,537,193...24,547,027

G

ribosomal protein S27-like

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS27L mRNA

NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798

G

ribosomal protein S3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS3 mRNA

NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945

G

ribosomal protein S4, X-linked

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS4X mRNA

NCBI chr X:101,228,548...101,232,929
Ensembl chr X:101,228,547...101,233,000

G

ribosomal protein S6 kinase, polypeptide 1

multiple interactions
increases phosphorylation

[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of RPS6KB1 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of RPS6KB1 protein

NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631

G

ribosomal protein S7

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS7 mRNA

NCBI chr12:28,680,846...28,685,952
Ensembl chr12:28,680,853...28,685,952

G

ribosomal protein SA

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPSA mRNA

NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435

G

S100 calcium binding protein A4

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of S100A4 mRNA
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of S100A4 mRNA

NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352

G

serine dehydratase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SDS mRNA

NCBI chr 5:120,614,612...120,621,997
Ensembl chr 5:120,614,591...120,621,997

G

selenoprotein O

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SELENOO mRNA

NCBI chr15:88,973,241...88,984,542
Ensembl chr15:88,973,287...88,984,543

G

selenoprotein W

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SELENOW mRNA

NCBI chr 7:15,651,133...15,656,296
Ensembl chr 7:15,651,133...15,656,327

G

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SERPINA7 mRNA

NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985

G

solute carrier family 19 (thiamine transporter), member 2

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A2 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A2 protein
[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A2 protein] which results in decreased uptake of Thiamine

NCBI chr 1:164,076,615...164,092,954
Ensembl chr 1:164,076,615...164,092,954

G

solute carrier family 19, member 3

multiple interactions
decreases expression

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein] which results in decreased uptake of Thiamine
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein

NCBI chr 1:82,990,242...83,016,541
Ensembl chr 1:82,990,244...83,016,169

G

solute carrier family 9 (sodium/hydrogen exchanger), member 9

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC9A9 mRNA

NCBI chr 9:94,551,945...95,112,505
Ensembl chr 9:94,551,962...95,112,498

G

SMG1 nonsense mediated mRNA decay associated PI3K related kinase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SMG1 mRNA

NCBI chr 7:117,730,531...117,843,026
Ensembl chr 7:117,730,531...117,842,893

G

SPARC related modular calcium binding 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SMOC1 mRNA

NCBI chr12:81,073,582...81,233,188
Ensembl chr12:81,073,582...81,233,188

G

snail family zinc finger 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SNAI2 protein

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

sterol O-acyltransferase 2

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SOAT2 mRNA

NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904

G

small proline-rich protein 1B

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of SPRR1B mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of SPRR1B mRNA]

NCBI chr 3:92,344,115...92,346,124
Ensembl chr 3:92,344,116...92,346,096

G

spectrin alpha, non-erythrocytic 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SPTAN1 mRNA

NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463

G

signal transducer and activator of transcription 1

increases activity
increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA
Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]; Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA]; Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]

PMID:16582591 PMID:16835749

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

stathmin 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STMN1 mRNA

NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154

G

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TAP1 mRNA

NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199

G

threonyl-tRNA synthetase 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TARS1 mRNA

NCBI chr15:11,383,749...11,399,744
Ensembl chr15:11,382,387...11,399,751

G

tyrosine aminotransferase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TAT mRNA

NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435

G

transforming growth factor beta regulated gene 4

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TBRG4 mRNA

NCBI chr11:6,565,598...6,576,089
Ensembl chr11:6,565,598...6,576,067

G

translocase of inner mitochondrial membrane 10B

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TIMM10B mRNA

NCBI chr 7:105,289,652...105,304,955
Ensembl chr 7:105,289,263...105,292,844
Ensembl chr 7:105,289,263...105,292,844

G

tissue inhibitor of metalloproteinase 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TIMP1 mRNA

PMID:14600272 PMID:15890375

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

thymosin beta 10

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TMSB10 mRNA

NCBI chr 6:72,934,330...72,935,731
Ensembl chr 6:72,934,330...72,935,731

G

tumor necrosis factor, alpha-induced protein 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TNFAIP3 mRNA

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor necrosis factor receptor superfamily, member 8

multiple interactions

[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA]

NCBI chr 4:144,993,702...145,041,734
Ensembl chr 4:144,993,707...145,041,734

G

topoisomerase (DNA) II alpha

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TOP2A mRNA

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

tumor protein D52

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TPD52 mRNA

NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783

G

transformation related protein 53

multiple interactions
affects localization
decreases expression
increases phosphorylation
increases ADP-ribosylation
increases expression

4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TP53 protein]; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone inhibits the reaction [sodium arsenite affects the localization of TP53 protein]; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone inhibits the reaction [sodium arsenite results in increased activity of TP53 protein]
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone affects the localization of TP53 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of TP53 protein
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased ADP-ribosylation of TP53 protein
[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of TRP53 mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TP53 protein

PMID:18805435 PMID:19931552 PMID:20421341 PMID:21167638 PMID:21776270 More...

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 binding protein 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TP53BP1 protein

NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888

G

TSC22 domain family, member 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TSC22D1 mRNA
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TSC22 mRNA

PMID:15890375 PMID:19038236

NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205

G

tubulin, alpha 1C

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TUBA1C mRNA

NCBI chr15:98,927,772...98,935,986
Ensembl chr15:98,927,772...98,935,991

G

tubulin, beta 5 class I

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TUBB5 mRNA

NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198

G

twist basic helix-loop-helix transcription factor 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TWIST1 mRNA

NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828

G

thymidylate synthase

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TYMS mRNA

PMID:14600272 PMID:15890375 PMID:23052194

NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615

G

ubiquitin A-52 residue ribosomal protein fusion product 1

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of UBA52 mRNA

NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451

G

ubiquitin-conjugating enzyme E2R 2

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of UBE2R2 mRNA

NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A5

increases glucuronidation

UGT1A4 gene polymorphism results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; UGT1A4 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:14871856 PMID:31307193

NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases glucuronidation

UGT2B17 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389

G

UDP glucuronosyltransferase 2 family, polypeptide B34

increases glucuronidation
decreases glucuronidation

UGT2B7 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
UGT2B7 gene polymorphism results in decreased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

PMID:14871856 PMID:31307193

NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796

G

vascular endothelial growth factor A

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of VEGFA mRNA

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vimentin

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of VIM mRNA

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

xanthine dehydrogenase

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XDH mRNA

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

G

X-linked inhibitor of apoptosis

increases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of XIAP protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

exportin 1

decreases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XPO1 protein

NCBI chr11:23,205,768...23,248,250
Ensembl chr11:23,206,055...23,248,249

G

X-ray repair complementing defective repair in Chinese hamster cells 1

decreases expression
multiple interactions

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XRCC1 mRNA; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XRCC1 protein
NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of XRCC1 protein]

NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865

G

zinc finger matrin type 3

increases expression

4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ZMAT3 mRNA

PMID:14600272 PMID:15890375

NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22307
chemical entity	22306
group	22154
inorganic group	21105
nitroso group	5219
nitroso compound	5219
nitrosamine	3808
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one	304
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol	0
Path 2
Term	Annotations
CHEBI ontology	22307
subatomic particle	22302
composite particle	22302
hadron	22302
baryon	22302
nucleon	22302
atomic nucleus	22302
atom	22302
main group element atom	22182
p-block element atom	22182
carbon group element atom	21984
carbon atom	21924
organic molecular entity	21924
organic molecule	21750
organic cyclic compound	21366
organic heterocyclic compound	20382
organic heteromonocyclic compound	18770
pyridines	11808
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one	304
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol	0

paths to the root