Bhmt (betaine-homocysteine methyltransferase) - Rat Genome Database

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Gene: Bhmt (betaine-homocysteine methyltransferase) Mus musculus
Analyze
Symbol: Bhmt
Name: betaine-homocysteine methyltransferase
RGD ID: 1550381
MGI Page MGI
Description: Enables betaine-homocysteine S-methyltransferase activity. Acts upstream of or within methionine biosynthetic process. Predicted to be located in extracellular exosome and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in several structures, including brain ventricle and choroid plexus; early conceptus; gonad; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in cerebral infarction and pulmonary embolism. Orthologous to human BHMT (betaine--homocysteine S-methyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: betaine--homocysteine S-methyltransferase 1; MGC117976; MGC46866
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bhmt-ps1   Bhmt1b  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,753,399 - 93,774,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,753,183 - 93,774,469 (-)EnsemblGRCm39 Ensembl
GRCm381393,616,891 - 93,637,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,616,675 - 93,637,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371394,386,846 - 94,407,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,717,644 - 94,738,511 (-)NCBIMGSCv36mm8
Celera1397,222,393 - 97,243,812 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (EXP)
(1->4)-beta-D-glucan  (EXP)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
1,2-dichloroethane  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
andrographolide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
diquat  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenthion  (EXP)
fentin chloride  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
glafenine  (ISO)
glucose  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
imidacloprid  (ISO)
imipramine  (ISO)
iodide salt  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
yohimbine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
2. Searching QTL by gene expression: analysis of diabesity. Brown AC, etal., BMC Genet 2005 Mar 10;6(1):12.
3. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
4. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, etal., Genomics 2004 Nov;84(5):876-89.
7. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Lever M and Slow S, Clin Biochem. 2010 Jun;43(9):732-44. doi: 10.1016/j.clinbiochem.2010.03.009. Epub 2010 Mar 25.
8. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. BHMT polymorphism and susceptibility to PTE in Chinese patients. Zhang WH, etal., Eur Rev Med Pharmacol Sci. 2023 May;27(9):4098-4102. doi: 10.26355/eurrev_202305_32317.
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10854776   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11087663   PMID:11158293   PMID:12477932   PMID:12819125   PMID:14681479   PMID:15131763  
PMID:15217352   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17705221   PMID:19158324   PMID:21267068   PMID:21677750   PMID:21873635   PMID:21878621   PMID:22362777   PMID:22847001  
PMID:23014492   PMID:24194600   PMID:25381154   PMID:26166573   PMID:26481005   PMID:27626380   PMID:28179424   PMID:28190767   PMID:28715642   PMID:29204947   PMID:30753104   PMID:30768359  
PMID:31040226   PMID:31208716   PMID:34262907   PMID:34702858   PMID:37203331   PMID:38078651   PMID:38355793   PMID:38804232  


Genomics

Comparative Map Data
Bhmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,753,399 - 93,774,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,753,183 - 93,774,469 (-)EnsemblGRCm39 Ensembl
GRCm381393,616,891 - 93,637,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,616,675 - 93,637,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371394,386,846 - 94,407,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,717,644 - 94,738,511 (-)NCBIMGSCv36mm8
Celera1397,222,393 - 97,243,812 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.87NCBI
BHMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38579,111,809 - 79,132,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl579,111,809 - 79,132,288 (+)EnsemblGRCh38hg38GRCh38
GRCh37578,407,632 - 78,428,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,443,360 - 78,463,869 (+)NCBINCBI36Build 36hg18NCBI36
Build 34578,443,438 - 78,463,863NCBI
Celera574,300,507 - 74,323,326 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,613,559 - 73,636,443 (+)NCBIHuRef
CHM1_1577,840,080 - 77,860,596 (+)NCBICHM1_1
T2T-CHM13v2.0579,592,579 - 79,615,902 (+)NCBIT2T-CHM13v2.0
Bhmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,594,852 - 26,614,429 (-)NCBIGRCr8
mRatBN7.2224,859,871 - 24,879,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,859,873 - 24,879,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,887,170 - 31,906,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0229,987,440 - 30,007,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,813,713 - 24,832,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,236,573 - 23,256,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,236,575 - 23,256,158 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,417,998 - 42,437,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4223,923,651 - 23,943,320 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1223,844,021 - 23,863,689 (-)NCBI
Celera220,935,059 - 20,954,426 (-)NCBICelera
Cytogenetic Map2q12NCBI
Bhmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542521,991,665 - 22,009,855 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542521,992,219 - 22,009,389 (-)NCBIChiLan1.0ChiLan1.0
BHMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,174,948 - 36,195,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,328,575 - 34,351,766 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,181,183 - 36,201,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,670,854 - 36,691,942 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,670,854 - 36,728,993 (-)Ensemblpanpan1.1panPan2
BHMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,732,381 - 27,752,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,734,108 - 27,752,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha328,973,220 - 28,991,599 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,652,772 - 27,671,416 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,651,360 - 27,671,308 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,591,867 - 27,610,507 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,570,180 - 27,588,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,851,113 - 27,869,743 (-)NCBIUU_Cfam_GSD_1.0
LOC101972215
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,901,611 - 183,920,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,938,092 - 6,957,363 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,938,100 - 6,956,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,910,603 - 87,935,252 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1287,911,093 - 87,935,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,406,703 - 89,431,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BHMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,331,551 - 73,352,259 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,332,259 - 73,352,434 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,178,695 - 22,198,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,617,948 - 3,642,860 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248693,618,895 - 3,639,621 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhmt
860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:180
Interacting mature miRNAs:199
Transcripts:ENSMUST00000099309, ENSMUST00000124193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse

Markers in Region
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC158524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI114914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG078929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY773713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB948151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000099309   ⟹   ENSMUSP00000096912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1393,753,183 - 93,774,469 (-)Ensembl
GRCm38.p6 Ensembl1393,616,675 - 93,637,961 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1393,758,389 - 93,774,074 (-)Ensembl
GRCm38.p6 Ensembl1393,621,881 - 93,637,566 (-)Ensembl
RefSeq Acc Id: NM_016668   ⟹   NP_057877
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391393,753,399 - 93,774,266 (-)NCBI
GRCm381393,616,891 - 93,637,758 (-)ENTREZGENE
MGSCv371394,386,846 - 94,407,713 (-)RGD
Celera1397,222,393 - 97,243,812 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_057877   ⟸   NM_016668
- UniProtKB: Q3UL72 (UniProtKB/Swiss-Prot),   Q3UEM1 (UniProtKB/Swiss-Prot),   Q561N0 (UniProtKB/Swiss-Prot),   O35490 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000096912   ⟸   ENSMUST00000099309
Protein Domains
Hcy-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35490-F1-model_v2 AlphaFold O35490 1-407 view protein structure

Promoters
RGD ID:8681008
Promoter ID:EPDNEW_M18535
Type:initiation region
Name:Bhmt_2
Description:Mus musculus betaine-homocysteine methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18536  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381393,637,566 - 93,637,626EPDNEW
RGD ID:8681010
Promoter ID:EPDNEW_M18536
Type:initiation region
Name:Bhmt_1
Description:Mus musculus betaine-homocysteine methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18535  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381393,637,780 - 93,637,840EPDNEW
RGD ID:6823733
Promoter ID:MM_KWN:14921
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000059960,   OTTMUST00000059961
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361394,407,181 - 94,407,681 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339972 AgrOrtholog
Ensembl Genes ENSMUSG00000069324 UniProtKB/Swiss-Prot
  ENSMUSG00000074768 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000091776.7 UniProtKB/Swiss-Prot
  ENSMUST00000099309 ENTREZGENE
  ENSMUST00000099309.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.330 UniProtKB/Swiss-Prot
InterPro Betaine-hCys_S-MeTrfase_BHMT UniProtKB/Swiss-Prot
  BHMT UniProtKB/Swiss-Prot
  HCY_dom UniProtKB/Swiss-Prot
  HCY_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:12116 UniProtKB/Swiss-Prot
MGD MGI:1339972 ENTREZGENE
NCBI Gene 12116 ENTREZGENE
PANTHER BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
  BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam S-methyl_trans UniProtKB/Swiss-Prot
PhenoGen Bhmt PhenoGen
PIRSF Betaine_HMT UniProtKB/Swiss-Prot
PROSITE HCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF82282 UniProtKB/Swiss-Prot
UniProt BHMT1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEM1 ENTREZGENE
  Q3UL72 ENTREZGENE
  Q561N0 ENTREZGENE
UniProt Secondary Q3UEM1 UniProtKB/Swiss-Prot
  Q3UL72 UniProtKB/Swiss-Prot
  Q561N0 UniProtKB/Swiss-Prot