Nipbl (NIPBL cohesin loading factor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nipbl (NIPBL cohesin loading factor) Mus musculus
Analyze
Symbol: Nipbl
Name: NIPBL cohesin loading factor
RGD ID: 1550472
MGI Page MGI
Description: Enables mediator complex binding activity and promoter-specific chromatin binding activity. Involved in cohesin loading; positive regulation of neuron migration; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; fat cell differentiation; and positive regulation of ossification. Located in chromatin and nucleus. Part of integrator complex. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and nose. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921518A06Rik; 4933421G18Rik; C79399; delangin homolog; Idn3; Nipped-B homolog; Nipped-B homolog (Drosophila); nipped-B-like protein; SCC2 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,319,308 - 8,494,799 (-)NCBIGRCm39mm39
GRCm39 Ensembl158,320,101 - 8,473,947 (-)Ensembl
GRCm38158,289,824 - 8,465,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,290,617 - 8,444,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37158,241,225 - 8,394,463 (-)NCBIGRCm37mm9NCBIm37
MGSCv36158,238,440 - 8,391,678 (-)NCBImm8
Celera158,136,258 - 8,289,610 (-)NCBICelera
Cytogenetic Map15A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (IBA,ISO)
cellular protein localization  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to X-ray  (ISO)
cognition  (ISO)
cohesin loading  (IMP,ISO)
developmental growth  (ISO)
digestive tract development  (IBA)
ear morphogenesis  (ISO)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic digestive tract morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic viscerocranium morphogenesis  (IBA,IMP)
establishment of mitotic sister chromatid cohesion  (IBA)
establishment of protein localization to chromatin  (IBA)
external genitalia morphogenesis  (ISO)
eye morphogenesis  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (IMP)
forelimb morphogenesis  (ISO)
gall bladder development  (ISO)
heart development  (IMP)
heart morphogenesis  (IBA,ISO)
maintenance of mitotic sister chromatid cohesion  (ISO)
mitotic sister chromatid cohesion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of histone deacetylation  (ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of neuron migration  (IMP)
positive regulation of ossification  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
regulation of developmental growth  (ISO)
regulation of embryonic development  (ISO)
regulation of gene expression  (IEA)
regulation of hair cycle  (ISO)
regulation of transcription by RNA polymerase II  (IMP)
replication-born double-strand break repair via sister chromatid exchange  (IBA)
sensory perception of sound  (ISO)
stem cell population maintenance  (IMP)
uterus morphogenesis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IAGP)
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal behavioral response to anesthetic  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal myocardium compact layer morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal pharyngeal arch mesenchyme morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal upper lip morphology  (IAGP)
abnormal ventricle myocardium morphology  (IAGP)
absent corpus callosum  (IAGP)
atrial septal defect  (IAGP)
atrium hypoplasia  (IAGP)
brachydactyly  (IAGP)
circling  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased corpus callosum size  (IAGP)
decreased cranial neural crest cell proliferation  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased length of long bones  (IAGP)
decreased white adipose tissue amount  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed intramembranous bone ossification  (IAGP)
eclabion  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
eye inflammation  (IAGP)
eyelids open at birth  (IAGP)
face hypoplasia  (IAGP)
limb grasping  (IAGP)
lowered ear position  (IAGP)
mandible hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
microcephaly  (IAGP)
midface hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
short humerus  (IAGP)
short mandible  (IAGP)
short radius  (IAGP)
shortened head  (IAGP)
small ethmoid bone  (IAGP)
small mandible  (IAGP)
upturned snout  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15033168   PMID:15146185  
PMID:15146186   PMID:15328020   PMID:15489334   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17967808   PMID:18799693   PMID:19763162   PMID:20360068   PMID:20720539  
PMID:21677750   PMID:21873635   PMID:23920377   PMID:24287868   PMID:24457600   PMID:24700590   PMID:25255084   PMID:26206533   PMID:26496610   PMID:26725122   PMID:27606604   PMID:28041881  
PMID:28671696   PMID:28855971   PMID:29094699   PMID:29379197   PMID:32325033   PMID:32800293   PMID:32907847   PMID:33323119  


Genomics

Comparative Map Data
Nipbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,319,308 - 8,494,799 (-)NCBIGRCm39mm39
GRCm39 Ensembl158,320,101 - 8,473,947 (-)Ensembl
GRCm38158,289,824 - 8,465,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,290,617 - 8,444,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37158,241,225 - 8,394,463 (-)NCBIGRCm37mm9NCBIm37
MGSCv36158,238,440 - 8,391,678 (-)NCBImm8
Celera158,136,258 - 8,289,610 (-)NCBICelera
Cytogenetic Map15A1NCBI
NIPBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl536,876,769 - 37,066,413 (+)EnsemblGRCh38hg38GRCh38
GRCh38536,876,769 - 37,066,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37536,876,871 - 37,066,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,912,742 - 37,101,678 (+)NCBINCBI36hg18NCBI36
Celera536,763,790 - 36,952,889 (+)NCBI
Cytogenetic Map5p13.2NCBI
HuRef536,829,492 - 37,018,602 (+)NCBIHuRef
CHM1_1536,879,597 - 37,068,738 (+)NCBICHM1_1
Nipbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2257,399,443 - 57,586,770 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl257,399,445 - 57,565,899 (-)Ensembl
Rnor_6.0257,508,830 - 57,676,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,509,428 - 57,600,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0278,992,721 - 79,160,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4257,908,828 - 58,099,422 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1257,837,538 - 58,006,254 (-)NCBI
Celera253,014,297 - 53,179,686 (-)NCBICelera
Cytogenetic Map2q16NCBI
Nipbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542621,666,857 - 21,841,515 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542621,666,958 - 21,841,515 (+)NCBIChiLan1.0ChiLan1.0
NIPBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1578,585,649 - 78,772,665 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl578,585,649 - 78,698,184 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0573,306,527 - 73,491,367 (-)NCBIMhudiblu_PPA_v0panPan3
NIPBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1471,583,118 - 71,780,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl471,583,732 - 71,780,852 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha471,193,245 - 71,390,556 (-)NCBI
ROS_Cfam_1.0472,093,046 - 72,290,807 (-)NCBI
UMICH_Zoey_3.1471,840,270 - 72,037,537 (-)NCBI
UNSW_CanFamBas_1.0471,962,190 - 72,159,916 (-)NCBI
UU_Cfam_GSD_1.0472,493,866 - 72,691,524 (-)NCBI
Nipbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213226,330,734 - 226,501,147 (+)NCBI
SpeTri2.0NW_0049365184,870,686 - 5,041,099 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NIPBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1622,152,501 - 22,363,847 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11622,152,455 - 22,364,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21623,393,877 - 23,512,467 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NIPBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,748,112 - 35,940,075 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl435,829,386 - 35,941,271 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607126,085,896 - 26,277,759 (+)NCBIVero_WHO_p1.0
Nipbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475917,899,152 - 18,078,213 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126661  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,360,377 - 8,360,625UniSTSGRCm38
MGSCv37158,310,377 - 8,310,625UniSTSGRCm37
Celera158,205,366 - 8,205,614UniSTS
Cytogenetic Map15A2UniSTS
Whitehead/MRC_RH1569.56UniSTS
D2Rat385  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,403,256 - 8,403,490UniSTSGRCm38
MGSCv37158,353,256 - 8,353,490UniSTSGRCm37
Celera158,248,365 - 8,248,599UniSTS
Cytogenetic Map15A2UniSTS
MARC_21845-21846:1025102921:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,365,884 - 8,366,694UniSTSGRCm38
MGSCv37158,315,884 - 8,316,694UniSTSGRCm37
Celera158,210,873 - 8,211,683UniSTS
Cytogenetic Map15A2UniSTS
RH76750  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38158,290,803 - 8,290,902UniSTSGRCm38
MGSCv37158,240,803 - 8,240,902UniSTSGRCm37
Celera158,135,836 - 8,135,935UniSTS
Cytogenetic Map15A2UniSTS
Omy1296INRA  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381567,991,896 - 67,993,152UniSTSGRCm38
MGSCv371567,823,458 - 67,824,714UniSTSGRCm37
Celera1569,508,152 - 69,509,408UniSTS
Cytogenetic Map15A2UniSTS
Nipbl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15A2UniSTS
cM Map153.82UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120460347Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120460347Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120460347Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120460347Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120460347Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120460347Mouse
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120460347Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273109Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101304Mouse
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218650Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15321068524388090Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346456637464566Mouse
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562040839620528Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15610000038000000Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15610000050900000Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15680000045100000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
27095922Pglq11_mpelvic girdle length QTL 11, 10 week (mouse)15810000038900000Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15810000047800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:96
Interacting mature miRNAs:96
Transcripts:ENSMUST00000052965
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_027707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02129952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ627033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ640138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV246194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000052965   ⟹   ENSMUSP00000059385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl158,320,101 - 8,473,947 (-)Ensembl
GRCm38.p6 Ensembl158,290,617 - 8,444,463 (-)Ensembl
RefSeq Acc Id: NM_027707   ⟹   NP_081983
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,308 - 8,473,947 (-)NCBI
GRCm38158,289,824 - 8,444,463 (-)NCBI
MGSCv37158,241,225 - 8,394,463 (-)RGD
Celera158,134,857 - 8,289,610 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_201232   ⟹   NP_957684
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,308 - 8,473,947 (-)NCBI
GRCm38158,289,824 - 8,444,463 (-)NCBI
MGSCv37158,241,225 - 8,394,463 (-)RGD
Celera158,134,857 - 8,289,610 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519994   ⟹   XP_006520057
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,790 - 8,494,799 (-)NCBI
GRCm38158,290,306 - 8,465,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006519995   ⟹   XP_006520058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,790 - 8,494,794 (-)NCBI
GRCm38158,290,306 - 8,465,310 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006519996   ⟹   XP_006520059
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,790 - 8,474,148 (-)NCBI
GRCm38158,290,306 - 8,444,621 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004938871
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39158,319,790 - 8,474,148 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_081983   ⟸   NM_027707
- Peptide Label: isoform a
- UniProtKB: Q6KCD5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_957684   ⟸   NM_201232
- Peptide Label: isoform b
- UniProtKB: Q6KCD5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520058   ⟸   XM_006519995
- Peptide Label: isoform X1
- UniProtKB: Q6KCD5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520057   ⟸   XM_006519994
- Peptide Label: isoform X1
- UniProtKB: Q6KCD5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520059   ⟸   XM_006519996
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000059385   ⟸   ENSMUST00000052965
Protein Domains
Nipped-B_C

Promoters
RGD ID:6826280
Promoter ID:MM_KWN:17992
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC007VEP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36158,242,856 - 8,243,707 (-)MPROMDB
RGD ID:6826277
Promoter ID:MM_KWN:17996
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung
Transcripts:NM_027707,   NM_201232,   XM_983841_GM8105
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36158,393,971 - 8,394,527 (-)MPROMDB
RGD ID:8683368
Promoter ID:EPDNEW_M19714
Type:initiation region
Name:Nipbl_1
Description:Mus musculus NIPBL cohesin loading factor , transcript varianta, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19715  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38158,444,470 - 8,444,530EPDNEW
RGD ID:8683370
Promoter ID:EPDNEW_M19715
Type:initiation region
Name:Nipbl_2
Description:Mus musculus NIPBL cohesin loading factor , transcript varianta, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19714  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38158,444,644 - 8,444,704EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913976 AgrOrtholog
Ensembl Genes ENSMUSG00000022141 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000059385 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052965 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cohesin_HEAT UniProtKB/Swiss-Prot
  Nipped-B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCC2/Nipped-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71175 UniProtKB/Swiss-Prot
MGD MGI:1913976 ENTREZGENE
NCBI Gene 71175 ENTREZGENE
PANTHER PTHR21704 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cohesin_HEAT UniProtKB/Swiss-Prot
  Nipped-B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nipbl PhenoGen
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NIPBL_MOUSE UniProtKB/Swiss-Prot
  Q05CI1_MOUSE UniProtKB/TrEMBL
  Q3TPM9_MOUSE UniProtKB/TrEMBL
  Q497G5_MOUSE UniProtKB/TrEMBL
  Q6KCD5 ENTREZGENE
UniProt Secondary Q6KC78 UniProtKB/Swiss-Prot
  Q7TNS4 UniProtKB/Swiss-Prot
  Q8BKV4 UniProtKB/Swiss-Prot
  Q8CES9 UniProtKB/Swiss-Prot
  Q9CUC6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Nipbl  NIPBL cohesin loading factor    Nipped-B homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED