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Gene: Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1) Mus musculus
Symbol: Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Description: Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; brain development; and regulation of response to DNA damage stimulus. Localizes to the ERCC4-ERCC1 complex and nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; hematologic cancer (multiple); hepatobiliary system cancer (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human XRCC1 (X-ray repair cross complementing 1); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH (+)-dexrazoxane; (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA repair protein XRCC1; MGC102556; X-ray repair cross-complementing protein 1; Xrcc-1
Homo sapiens (human) : XRCC1 (X-ray repair cross complementing 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrcc1 (X-ray repair cross complementing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc1 (X-ray repair cross complementing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC1 (X-ray repair cross complementing 1)
Canis lupus familiaris (dog) : XRCC1 (X-ray repair cross complementing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc1 (X-ray repair cross complementing 1)
Sus scrofa (pig) : XRCC1 (X-ray repair cross complementing 1)
Chlorocebus sabaeus (African green monkey) : XRCC1 (X-ray repair cross complementing 1)
Heterocephalus glaber (naked mole-rat) : Xrcc1 (X-ray repair cross complementing 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl724,546,289 - 24,573,440 (+)Ensembl
GRCm38724,546,699 - 24,573,438 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37725,332,169 - 25,358,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv36724,255,049 - 24,282,192 (+)NCBImm8
Celera719,161,255 - 19,187,540 (+)NCBICelera
Cytogenetic Map7 A3NCBI
cM Map711.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Xrcc1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732969
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.