Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1) - Rat Genome Database

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Gene: Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1) Mus musculus
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Symbol: Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
RGD ID: 732969
MGI Page MGI
Description: Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; negative regulation of protein ADP-ribosylation; and regulation of response to DNA damage stimulus. Acts upstream of or within DNA repair and hippocampus development. Located in chromosome, telomeric region. Part of ERCC4-ERCC1 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); respiratory system cancer (multiple); and urinary system cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA repair protein XRCC1; MGC102556; X-ray repair cross-complementing protein 1; Xrcc-; Xrcc-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,246,124 - 24,272,863 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,245,714 - 24,272,865 (+)EnsemblGRCm39 Ensembl
GRCm38724,546,699 - 24,573,438 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,546,289 - 24,573,440 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,332,169 - 25,358,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,255,049 - 24,282,192 (+)NCBIMGSCv36mm8
Celera719,161,255 - 19,187,540 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map711.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
5 Alpha Fluorouracil Toxicity  (ISO)
acute lymphoblastic leukemia  (ISO)
asphyxia neonatorum  (ISO)
autosomal recessive spinocerebellar ataxia 26  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Birth Weight  (ISO)
Breast Neoplasms  (ISO)
cataract  (IEP)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (IMP)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
contact dermatitis  (ISO)
Erythema  (ISO)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
gallbladder cancer  (ISO)
gastric cardia adenocarcinoma  (ISO)
gastric cardia carcinoma  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
impotence  (ISO)
in situ carcinoma  (ISO)
invasive ductal carcinoma  (ISO)
laryngeal carcinoma  (ISO)
leiomyoma  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Mesothelioma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
Mouth Neoplasms  (ISO)
myelodysplastic syndrome  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Occupational Diseases  (ISO)
oral mucosa leukoplakia  (ISO)
pancreatic cancer  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Salivary Gland Neoplasms  (ISO)
schizophrenia  (ISO)
seminoma  (ISO)
senile cataract  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
stomatitis  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-quinic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
ATP  (EXP)
belinostat  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
floxuridine  (ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
gefitinib  (ISO)
genistein  (EXP)
ginsenoside Rg1  (ISO)
glutathione  (EXP)
hydrogen peroxide  (ISO)
idarubicin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead chromate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levetiracetam  (ISO)
lipopolysaccharide  (ISO)
lupeol  (ISO)
LY294002  (ISO)
malonaldehyde  (EXP)
mancozeb  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
mithramycin  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nicotine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PhIP  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
platinum  (ISO)
platinum(0)  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sodium arsenite  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
theaflavin  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
ubiquinones  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain interneuron morphology  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal DNA repair  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermatogonia morphology  (IAGP)
absent mesoderm  (IAGP)
asthenozoospermia  (IAGP)
ataxia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased catalase activity  (IAGP)
decreased embryo size  (IAGP)
decreased testis weight  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
failure to gastrulate  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased testis apoptosis  (IAGP)
loss of GABAergic neurons  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
seizures  (IAGP)
small cerebellum  (IAGP)
small testis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Genetic polymorphisms and metastatic breast cancer survival. Allen-Brady K Future Oncol. 2007 Apr;3(2):155-8.
2. The X-ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis. Almeida Pereira Leite ST, etal., Ann Hepatol. 2013 Sep-Oct;12(5):733-9.
3. DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population. Arizono K, etal., Jpn J Clin Oncol. 2008 Mar;38(3):186-91. doi: 10.1093/jjco/hym176. Epub 2008 Feb 12.
4. The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. Artac M, etal., J Cancer Res Clin Oncol. 2010 Jun;136(6):803-9. doi: 10.1007/s00432-009-0720-3. Epub 2009 Nov 12.
5. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Batar B, etal., Leuk Res. 2009 Jun;33(6):759-63. doi: 10.1016/j.leukres.2008.11.005. Epub 2008 Dec 19.
6. The X-ray Repair Cross-Complementing Group 1 Arg399Gln Genetic Polymorphism and Risk of Hepatocellular Carcinoma in an Iranian Population. Bazgir A, etal., Middle East J Dig Dis. 2018 Jan;10(1):40-44. doi: 10.15171/mejdd.2017.89. Epub 2018 Jan 10.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Association study of single nucleotide polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in Chinese Han population. Bi J, etal., Biomed Res Int. 2013;2013:138785. doi: 10.1155/2013/138785. Epub 2013 Jul 30.
9. Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. Bose S, etal., Gene. 2013 May 1;519(2):231-7. doi: 10.1016/j.gene.2013.02.025. Epub 2013 Feb 27.
10. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Bu D, etal., Breast Cancer Res Treat. 2006 Oct;99(3):257-65. Epub 2006 Apr 5.
11. Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. Burri RJ, etal., Radiat Res. 2008 Jul;170(1):49-59.
12. Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. Cao Y, etal., BMC Cancer. 2006 Jun 26;6:167. doi: 10.1186/1471-2407-6-167.
13. Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer. Chen S, etal., Genet Mol Res. 2016 Sep 9;15(3). pii: gmr8342. doi: 10.4238/gmr.15038342.
14. Haplotype analysis of the XRCC1 gene and laryngeal cancer. Chen W, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):525-9. doi: 10.1089/gtmb.2013.0434. Epub 2014 Jun 23.
15. Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients. Chen X, etal., Cell Oncol (Dordr). 2018 Oct;41(5):527-539. doi: 10.1007/s13402-018-0390-8. Epub 2018 Aug 7.
16. Association between the c.910A>G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population. Chen XQ, etal., Braz J Med Biol Res. 2013 Dec;46(12):1028-1032. doi: 10.1590/1414-431X20133396. Epub 2013 Dec 2.
17. mRNA levels of the hypoxia inducible factor (HIF-1) and DNA repair genes in perinatal asphyxia of the rat. Chiappe-Gutierrez M, etal., Life Sci. 1998;63(13):1157-67.
18. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. De Ruyck K, etal., Mutat Res. 2007 Jul 28;631(2):101-10. doi: 10.1016/j.mrgentox.2007.03.010. Epub 2007 Apr 21.
19. Association between the C.1161G>A and C.1779C>G genetic variants of XRCC1 gene and hepatocellular carcinoma risk in Chinese population. Deng X, etal., Int J Biol Sci. 2013;9(3):289-94. doi: 10.7150/ijbs.5928. Epub 2013 Mar 7.
20. The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung. Divine KK, etal., Mutat Res. 2001 Jan 5;461(4):273-8. doi: 10.1016/s0921-8777(00)00059-8.
21. Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non-small cell lung cancer in East Chinese Han population. Du Y, etal., Clin Respir J. 2016 May;10(3):311-7. doi: 10.1111/crj.12218. Epub 2014 Nov 3.
22. The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer. Dufloth RM, etal., Genet Mol Res. 2008 Jul 1;7(3):574-82.
23. DNA repair polymorphisms and treatment outcomes of patients with malignant mesothelioma treated with gemcitabine-platinum combination chemotherapy. Erčulj N, etal., J Thorac Oncol. 2012 Oct;7(10):1609-17. doi: 10.1097/JTO.0b013e3182653d31.
24. DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors. Felix FA, etal., Arch Oral Biol. 2021 Jan;121:104987. doi: 10.1016/j.archoralbio.2020.104987. Epub 2020 Nov 11.
25. XRCC1 Gene Polymorphisms and miR-21 Expression in Patients with Colorectal Carcinoma. Fouad H, etal., Eurasian J Med. 2017 Jun;49(2):132-136. doi: 10.5152/eurasianjmed.2017.17021.
26. DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia. Ganster C, etal., Genes Chromosomes Cancer. 2009 Sep;48(9):760-7. doi: 10.1002/gcc.20680.
27. Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population. Gu M, etal., Virol J. 2018 Mar 20;15(1):47. doi: 10.1186/s12985-018-0962-2.
28. XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients. Guan Q, etal., Oncol Lett. 2017 Sep;14(3):2783-2788. doi: 10.3892/ol.2017.6522. Epub 2017 Jul 5.
29. Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo. Halim NH, etal., Asian Pac J Cancer Prev. 2016;17(4):1925-31. doi: 10.7314/apjcp.2016.17.4.1925.
30. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Hao B, etal., Oncogene. 2006 Jun 15;25(25):3613-20. doi: 10.1038/sj.onc.1209355. Epub 2006 May 1.
31. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. Hirata H, etal., Biochem Biophys Res Commun. 2006 Apr 21;342(4):1058-62. Epub 2006 Feb 17.
32. [Correlation of the sensitivity of NP chemotherapy in non-small lung cancer with DNA repair gene XRCC1 polymorphism]. Hong CY, etal., Ai Zheng. 2009 Dec;28(12):1291-7. doi: 10.5732/cjc.009.10139.
33. Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. Hong YC, etal., Int J Cancer. 2005 Sep 1;116(3):428-32. doi: 10.1002/ijc.21019.
34. SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. Hsu LI, etal., Toxicol Appl Pharmacol. 2008 Apr 15;228(2):144-55. Epub 2007 Dec 14.
35. Association between XRCC1 and ERCC1 single-nucleotide polymorphisms and the efficacy of concurrent radiochemotherapy in patients with esophageal squamous cell carcinoma. Huang X, etal., Oncol Lett. 2017 Feb;13(2):704-714. doi: 10.3892/ol.2016.5496. Epub 2016 Dec 14.
36. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Hung RJ, etal., Am J Epidemiol. 2005 Nov 15;162(10):925-42. Epub 2005 Oct 12.
37. DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma. Jeon YT, etal., Hum Reprod. 2005 Jun;20(6):1586-9. Epub 2005 Mar 10.
38. Genetic polymorphisms of XRCC1 gene and susceptibility to hepatocellular carcinoma in Chinese population. Jiang T, etal., Med Oncol. 2014 Apr;31(4):887. doi: 10.1007/s12032-014-0887-6. Epub 2014 Feb 26.
39. Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population. Jin JJ, etal., Genet Mol Res. 2016 Jun 10;15(2). pii: gmr4661. doi: 10.4238/gmr.15024661.
40. Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome. Joshi D, etal., Ann Hematol. 2016 Jan;95(1):79-85.
41. Assoication of XRCC1 gene polymorphisms with risk of non-small cell lung cancer. Kang S, etal., Int J Clin Exp Pathol. 2015 Apr 1;8(4):4171-6. eCollection 2015.
42. DNA repair genes polymorphisms and risk of colorectal cancer in Saudi patients. Karam RA, etal., Arab J Gastroenterol. 2016 Sep;17(3):117-120. doi: 10.1016/j.ajg.2016.08.005. Epub 2016 Sep 27.
43. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
44. XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine polymorphisms are associated with response to platinum-based neoadjuvant chemotherapy in cervical cancer. Kim K, etal., Gynecol Oncol. 2008 Dec;111(3):509-15. Epub 2008 Oct 12.
45. Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. Kiran M, etal., Mol Cell Biochem. 2009 Jul;327(1-2):7-13. doi: 10.1007/s11010-009-0035-3. Epub 2009 Feb 5.
46. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
47. A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. Lao T, etal., Mutagenesis. 2008 Nov;23(6):523-32. Epub 2008 Sep 2.
48. Genetic polymorphisms of XRCC1 and risk of the esophageal cancer. Lee JM, etal., Int J Cancer. 2001 Jul 20;95(4):240-6. doi: 10.1002/1097-0215(20010720)95:4<240::aid-ijc1041>3.0.co;2-1.
49. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
50. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. Li D, etal., J Clin Oncol. 2006 Apr 10;24(11):1720-8. Epub 2006 Mar 6.
51. XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients. Li H, etal., Radiat Oncol. 2013 Feb 1;8:31. doi: 10.1186/1748-717X-8-31.
52. Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair. Li N, etal., DNA Repair (Amst). 2007 Sep 1;6(9):1297-306. Epub 2007 Apr 6.
53. Association of DNA base-excision repair XRCC1, OGG1 and APE1 gene polymorphisms with nasopharyngeal carcinoma susceptibility in a Chinese population. Li Q, etal., Asian Pac J Cancer Prev. 2013;14(9):5145-51. doi: 10.7314/apjcp.2013.14.9.5145.
54. Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Li QW, etal., Asian Pac J Cancer Prev. 2012;13(1):191-4. doi: 10.7314/apjcp.2012.13.1.191.
55. [The influence of XRCC1 gene polymorphism on the prognosis and safety of stage Ⅲ patients with colorectal cancer who received oxaliplatin based adjuvant chemotherapy]. Li RX, etal., Zhonghua Yi Xue Za Zhi. 2021 Mar 23;101(11):759-765. doi: 10.3760/cma.j.cn112137-20200708-02061.
56. Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population. Li XF, etal., Genet Mol Res. 2014 Jan 10;13(1):160-6. doi: 10.4238/2014.January.10.7.
57. Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Liu B, etal., Eur J Hum Genet. 2007 Oct;15(10):1049-53. doi: 10.1038/sj.ejhg.5201884. Epub 2007 Jun 27.
58. Role of XRCC1 and ERCC5 polymorphisms on clinical outcomes in advanced non-small cell lung cancer. Liu D, etal., Genet Mol Res. 2014 Apr 17;13(2):3100-7. doi: 10.4238/2014.April.17.6.
59. Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer. Liu JY, etal., Genet Mol Res. 2015 Aug 28;14(3):10331-7. doi: 10.4238/2015.August.28.19.
60. Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis. Liu WB, etal., Biochem Biophys Res Commun. 2011 May 20;408(4):595-601. doi: 10.1016/j.bbrc.2011.04.067. Epub 2011 Apr 21.
61. Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population. Liu Y, etal., Hepatogastroenterology. 2012 Jun;59(116):977-80. doi: 10.5754/hge12187.
62. Association analysis between the c.1804C>A genetic polymorphism of XRCC1 gene and risk of hepatocellular carcinoma in Chinese population. Liu Y, etal., Med Oncol. 2014 Mar;31(3):854. doi: 10.1007/s12032-014-0854-2. Epub 2014 Feb 14.
63. Genetic polymorphisms of ERCC1‑118, XRCC1‑399 and GSTP1‑105 are associated with the clinical outcome of gastric cancer patients receiving oxaliplatin‑based adjuvant chemotherapy. Liu YP, etal., Mol Med Rep. 2013 Jun;7(6):1904-11. doi: 10.3892/mmr.2013.1435. Epub 2013 Apr 22.
64. Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese. Luo YF, etal., Curr Eye Res. 2011 Jul;36(7):632-6. doi: 10.3109/02713683.2011.571358. Epub 2011 May 20.
65. Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer. Lv H, etal., Pathol Oncol Res. 2012 Oct;18(4):1009-14. doi: 10.1007/s12253-012-9536-6. Epub 2012 May 2.
66. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Majumder M, etal., Int J Cancer. 2007 May 15;120(10):2148-56.
67. Domain specific interaction in the XRCC1-DNA polymerase beta complex. Marintchev A, etal., Nucleic Acids Res 2000 May 15;28(10):2049-59.
68. Polymorphisms of base-excision repair genes and the hepatocarcinogenesis. Mattar MM, etal., Gene. 2018 Oct 30;675:62-68. doi: 10.1016/j.gene.2018.06.056. Epub 2018 Jun 20.
69. XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility. McNeill DR, etal., Nucleic Acids Res. 2011 Oct;39(18):7992-8004. doi: 10.1093/nar/gkr280. Epub 2011 Jul 6.
70. MGDs mouse GO annotations MGD data from the GO Consortium
71. MGD IEA MGD IEA
72. Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. Miao X, etal., Gastroenterology. 2006 Aug;131(2):420-7. doi: 10.1053/j.gastro.2006.05.050.
73. XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population. Naguib M, etal., Asian Pac J Cancer Prev. 2020 Apr 1;21(4):1031-1037. doi: 10.31557/APJCP.2020.21.4.1031.
74. Polymorphism of the DNA Repair Gene XRCC1 (Arg194Trp) and its role in Colorectal Cancer in Kashmiri Population: a Case Control Study. Nissar S, etal., Asian Pac J Cancer Prev. 2015;16(15):6385-90.
75. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
76. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
77. XRCC1 gene polymorphism, diet and risk of colorectal cancer in Thailand. Poomphakwaen K, etal., Asian Pac J Cancer Prev. 2014;15(17):7479-86. doi: 10.7314/apjcp.2014.15.17.7479.
78. Association study of single nucleotide polymorphisms in XRCC1 gene with the risk of gastric cancer in Chinese population. Qiao W, etal., Int J Biol Sci. 2013 Aug 9;9(7):753-8. doi: 10.7150/ijbs.6783. eCollection 2013.
79. Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures. Quach N, etal., Brain Res. 2005 May 3;1042(2):236-40.
80. Mouse MP Annotation Import Pipeline RGD automated import pipeline
81. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
82. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
83. DNA repair gene XRCC1 polymorphisms and bladder cancer risk. Sak SC, etal., BMC Genet. 2007 Apr 10;8:13.
84. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Salimizand H, etal., Tumour Biol. 2016 Jan;37(1):791-8. doi: 10.1007/s13277-015-3874-4. Epub 2015 Aug 7.
85. XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Italian population. Santonocito C, etal., Int J Biol Markers. 2017 May 4;32(2):e190-e194. doi: 10.5301/jbm.5000241.
86. BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin. Shim HJ, etal., Cancer Sci. 2010 May;101(5):1247-54. doi: 10.1111/j.1349-7006.2010.01514.x. Epub 2010 Mar 12.
87. Polymorphisms of XRCC1 and XRCC2 DNA Repair genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India. Singh SA and Ghosh SK, Asian Pac J Cancer Prev. 2016;17(6):2811-9.
88. Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. Sreeja L, etal., J Cancer Res Clin Oncol. 2008 Jun;134(6):645-52. doi: 10.1007/s00432-007-0328-4. Epub 2007 Oct 19.
89. Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population. Srivastava A, etal., Ann Surg Oncol. 2009 Jun;16(6):1695-703. Epub 2009 Mar 6.
90. Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene? Suh KW, etal., Ann Surg Oncol. 2006 Nov;13(11):1379-85. doi: 10.1245/s10434-006-9112-y. Epub 2006 Sep 29.
91. Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients. Sun X, etal., Lung Cancer. 2009 Aug;65(2):230-6. doi: 10.1016/j.lungcan.2008.11.014. Epub 2009 Jan 20.
92. Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) Polymorphisms in Familial and Sporadic Breast Cancer Predisposition and Survival: An Indian Report. Syamala VS, etal., Pathol Oncol Res. 2008 Dec 4.
93. Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients. Tahara T, etal., Anticancer Res. 2011 Feb;31(2):705-10.
94. No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study. Thyagarajan B, etal., Cancer Detect Prev. 2006;30(4):313-21. Epub 2006 Sep 11.
95. ERCC1/BRCA1 expression and gene polymorphisms as prognostic and predictive factors in advanced NSCLC treated with or without cisplatin. Tiseo M, etal., Br J Cancer. 2013 Apr 30;108(8):1695-703. doi: 10.1038/bjc.2013.127. Epub 2013 Apr 2.
96. Association of XRCC1 gene polymorphisms with the susceptibility and chromosomal aberration of testicular germ cell tumors. Tsuchiya N, etal., Int J Oncol. 2006 May;28(5):1217-23.
97. Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Tumer TB, etal., Arch Toxicol. 2012 Mar;86(3):431-9. doi: 10.1007/s00204-011-0760-8. Epub 2011 Oct 9.
98. XRCC-1 Gene Polymorphism (Arg399Gln) and Susceptibility to Development of Lung Cancer in Cohort of North Indian Population: A Pilot Study. Uppal V, etal., J Clin Diagn Res. 2014 Nov;8(11):CC17-20. doi: 10.7860/JCDR/2014/10061.5132. Epub 2014 Nov 20.
99. Polymorphism of DNA repair gene xrcc1 and lung cancer risk. Wang H and Liu Z, Cell Biochem Biophys. 2014 Dec;70(3):1881-6. doi: 10.1007/s12013-014-0146-7.
100. The impacts of genetic polymorphisms in genes of base excision repair pathway on the efficacy and acute toxicities of (chemo)radiotherapy in patients with nasopharyngeal carcinoma. Wang J, etal., Oncotarget. 2017 Aug 10;8(45):78633-78641. doi: 10.18632/oncotarget.20203. eCollection 2017 Oct 3.
101. Association of the XRCC1 c.1178G>A genetic polymorphism with lung cancer risk in Chinese. Wang L, etal., Asian Pac J Cancer Prev. 2014;15(9):4095-9.
102. Roles of XRCC1/XPD/ERCC1 Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization. Wang XC, etal., Genet Test Mol Biomarkers. 2016 Apr;20(4):176-84. doi: 10.1089/gtmb.2015.0267. Epub 2016 Feb 26.
103. [Single nucleotide polymorphisms in XRCC1 and clinical response to platin-based chemotherapy in advanced non-small cell lung cancer]. Wang ZH, etal., Ai Zheng. 2004 Aug;23(8):865-8.
104. Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. Wolf N, etal., Mol Vis. 2008 Feb 5;14:274-85.
105. Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population. Wu WQ, etal., Genet Mol Res. 2016 Oct 5;15(4). pii: gmr8525. doi: 10.4238/gmr.15048525.
106. Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population. Xia WF, etal., Genet Mol Res. 2014 Feb 28;13(1):1314-22. doi: 10.4238/2014.February.28.3.
107. [Effect of the XRCC1 and XRCC3 genetic polymorphisms on the efficacy of platinum-based chemotherapy in patients with advanced non-small cell lung cancer]. Xu C, etal., Zhongguo Fei Ai Za Zhi. 2011 Dec;14(12):912-7. doi: 10.3779/j.issn.1009-3419.2011.12.03.
108. Zhonghua nan ke xue = National journal of andrology Xu Z, etal., Zhonghua Nan Ke Xue. 2007 Apr;13(4):327-31.
109. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. Yang Y, etal., J Neurochem. 2010 Jan;112(1):134-49. Epub 2009 Oct 15.
110. Genetic polymorphisms of the DNA repair gene and risk of nasopharyngeal carcinoma. Yang ZH, etal., DNA Cell Biol. 2007 Jul;26(7):491-6. doi: 10.1089/dna.2006.0537.
111. Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Yin J, etal., Cancer Genet Cytogenet. 2009 Jan 1;188(1):26-31. doi: 10.1016/j.cancergencyto.2008.08.013.
112. Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. Yin Z, etal., BMC Cancer. 2009 Dec 15;9:439. doi: 10.1186/1471-2407-9-439.
113. Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma. Yu MW, etal., J Natl Cancer Inst. 2003 Oct 1;95(19):1485-8. doi: 10.1093/jnci/djg051.
114. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Yuan T, etal., Cancer Epidemiol. 2011 Apr;35(2):170-4. doi: 10.1016/j.canep.2010.08.008. Epub 2010 Sep 21.
115. Implication of polymorphisms in DNA repair genes in prognosis of hepatocellular carcinoma. Yue AM, etal., Asian Pac J Cancer Prev. 2013;14(1):355-8. doi: 10.7314/apjcp.2013.14.1.355.
116. Association of polymorphisms in X-ray repair cross complementing 1 gene and risk of esophageal squamous cell carcinoma in a Chinese population. Yun YX, etal., Biomed Res Int. 2015;2015:509215. doi: 10.1155/2015/509215. Epub 2015 Feb 1.
117. Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy. Zhang L, etal., Genet Mol Res. 2014 Jan 14;13(1):228-36. doi: 10.4238/2014.January.14.2.
118. Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans. Zhang L, etal., Hepatology. 2012 Apr;55(4):1008-18. doi: 10.1002/hep.25513.
119. Polymorphisms of ERCC1 and XRCC1 predict the overall survival of advanced gastric cancer patients receiving oxaliplatin-based chemotherapy. Zhang L, etal., Int J Clin Exp Med. 2015 Oct 15;8(10):18375-82. eCollection 2015.
120. Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Zhang X, etal., Cancer Res. 2005 Feb 1;65(3):722-6.
121. The association between four SNPs of X-ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma. Zhang Y, etal., Oncol Lett. 2016 May;11(5):3508-3514. doi: 10.3892/ol.2016.4384. Epub 2016 Mar 29.
122. Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Zhao Y, etal., Asian Pac J Cancer Prev. 2012;13(2):665-9. doi: 10.7314/apjcp.2012.13.2.665.
Additional References at PubMed
PMID:1486805   PMID:1638085   PMID:1981054   PMID:2558854   PMID:3736579   PMID:7789989   PMID:7892645   PMID:7959765   PMID:8617494   PMID:8812484   PMID:8862781   PMID:9078548  
PMID:9363683   PMID:10191063   PMID:10349636   PMID:10512203   PMID:10677679   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11893245   PMID:12477932   PMID:12520002  
PMID:14610273   PMID:14642568   PMID:14690602   PMID:14729942   PMID:15489334   PMID:15498778   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:17101782   PMID:17257586  
PMID:17616806   PMID:18348985   PMID:18682529   PMID:18799693   PMID:19103743   PMID:19208635   PMID:19633665   PMID:20362541   PMID:20362542   PMID:20595612   PMID:20975950   PMID:21390131  
PMID:21390132   PMID:21652643   PMID:21677750   PMID:21873635   PMID:21967769   PMID:22308491   PMID:22392994   PMID:22522401   PMID:23042675   PMID:23355608   PMID:23603834   PMID:23871146  
PMID:24409475   PMID:24457600   PMID:24793032   PMID:25971543   PMID:26206133   PMID:26290337   PMID:26304019   PMID:27916276   PMID:28002403   PMID:28179111   PMID:28436431   PMID:29100039  
PMID:29477978   PMID:30274781   PMID:30538199   PMID:30595499   PMID:30998386   PMID:31043584   PMID:32098917   PMID:32123907   PMID:32325033   PMID:33087478  


Genomics

Comparative Map Data
Xrcc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,246,124 - 24,272,863 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,245,714 - 24,272,865 (+)EnsemblGRCm39 Ensembl
GRCm38724,546,699 - 24,573,438 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,546,289 - 24,573,440 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,332,169 - 25,358,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,255,049 - 24,282,192 (+)NCBIMGSCv36mm8
Celera719,161,255 - 19,187,540 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map711.42NCBI
XRCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,543,311 - 43,575,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1943,543,311 - 43,580,473 (-)EnsemblGRCh38hg38GRCh38
GRCh371944,047,463 - 44,079,679 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,739,304 - 48,771,555 (-)NCBINCBI36Build 36hg18NCBI36
Build 341948,739,303 - 48,771,555NCBI
Celera1940,850,091 - 40,882,209 (-)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,478,136 - 40,510,489 (-)NCBIHuRef
CHM1_11944,049,115 - 44,081,452 (-)NCBICHM1_1
T2T-CHM13v2.01946,364,840 - 46,397,157 (-)NCBIT2T-CHM13v2.0
Xrcc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,140,495 - 80,168,705 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,141,207 - 80,168,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,534,876 - 85,562,653 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0194,084,721 - 94,112,152 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0187,290,702 - 87,318,402 (+)NCBIRnor_WKY
Rnor_6.0181,412,635 - 81,441,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,413,353 - 81,441,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,673,571 - 82,701,082 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,834,167 - 79,860,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,912,277 - 79,938,411 (+)NCBI
Celera174,594,313 - 74,621,523 (+)NCBICelera
Cytogenetic Map1q21NCBI
Xrcc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,293,416 - 1,315,839 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,293,416 - 1,315,839 (-)NCBIChiLan1.0ChiLan1.0
XRCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11949,093,928 - 49,125,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,094,014 - 49,125,520 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01940,485,052 - 40,522,188 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
XRCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,548,719 - 111,571,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,548,719 - 111,571,816 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,028,445 - 111,051,541 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,158,850 - 112,181,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,158,850 - 112,181,954 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,746,938 - 111,770,215 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,380,774 - 111,403,889 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,265,054 - 112,288,168 (+)NCBIUU_Cfam_GSD_1.0
Xrcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,407,084 - 16,436,413 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706751,108 - 783,777 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936706752,571 - 783,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,403,689 - 50,425,729 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,403,691 - 50,425,730 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,158,742 - 46,180,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XRCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,062,149 - 37,095,138 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl637,060,439 - 37,095,094 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607316,603,474 - 16,637,686 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xrcc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,087,611 - 1,113,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,087,611 - 1,113,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSMUST00000063249
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse

Markers in Region
Xrcc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38724,573,079 - 24,573,325UniSTSGRCm38
MGSCv37725,358,098 - 25,358,344UniSTSGRCm37
Celera719,187,181 - 19,187,427UniSTS
Cytogenetic Map7A3-B2UniSTS
cM Map75.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001785520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_881685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU020161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000063249   ⟹   ENSMUSP00000070995
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,246,575 - 24,272,863 (+)Ensembl
GRCm38.p6 Ensembl724,547,150 - 24,573,438 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205453
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,271,651 - 24,272,859 (+)Ensembl
GRCm38.p6 Ensembl724,572,226 - 24,573,434 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205561
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,246,623 - 24,260,108 (+)Ensembl
GRCm38.p6 Ensembl724,547,198 - 24,560,683 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205564
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,264,994 - 24,266,965 (+)Ensembl
GRCm38.p6 Ensembl724,565,569 - 24,567,540 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205573   ⟹   ENSMUSP00000146105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,245,714 - 24,272,860 (+)Ensembl
GRCm38.p6 Ensembl724,546,289 - 24,573,435 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205575
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,271,139 - 24,272,859 (+)Ensembl
GRCm38.p6 Ensembl724,571,714 - 24,573,434 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,269,127 - 24,270,135 (+)Ensembl
GRCm38.p6 Ensembl724,569,702 - 24,570,710 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,246,758 - 24,266,364 (+)Ensembl
GRCm38.p6 Ensembl724,547,333 - 24,566,939 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206153
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,269,955 - 24,272,865 (+)Ensembl
GRCm38.p6 Ensembl724,570,530 - 24,573,440 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,269,282 - 24,270,351 (+)Ensembl
GRCm38.p6 Ensembl724,569,857 - 24,570,926 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,266,787 - 24,270,117 (+)Ensembl
GRCm38.p6 Ensembl724,567,362 - 24,570,692 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,246,710 - 24,247,967 (+)Ensembl
GRCm38.p6 Ensembl724,547,285 - 24,548,542 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206889
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,246,626 - 24,251,684 (+)Ensembl
GRCm38.p6 Ensembl724,547,201 - 24,552,259 (+)Ensembl
RefSeq Acc Id: NM_001360168   ⟹   NP_001347097
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,124 - 24,272,863 (+)NCBI
GRCm38724,546,699 - 24,573,438 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001360169   ⟹   NP_001347098
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,250,912 - 24,272,863 (+)NCBI
GRCm38724,551,487 - 24,573,438 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001360170   ⟹   NP_001347099
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,124 - 24,260,108 (+)NCBI
GRCm38724,546,699 - 24,560,683 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009532   ⟹   NP_033558
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,124 - 24,272,863 (+)NCBI
GRCm38724,546,699 - 24,573,438 (+)NCBI
MGSCv37725,332,169 - 25,358,457 (+)RGD
Celera719,161,255 - 19,187,540 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001785520
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,129 - 24,272,861 (+)NCBI
GRCm38724,546,704 - 24,573,436 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004934060
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,129 - 24,272,861 (+)NCBI
Sequence:
RefSeq Acc Id: XR_881685
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,246,129 - 24,272,861 (+)NCBI
GRCm38724,546,704 - 24,573,436 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033558   ⟸   NM_009532
- Peptide Label: isoform 1
- UniProtKB: Q7TNQ5 (UniProtKB/Swiss-Prot),   Q60596 (UniProtKB/Swiss-Prot),   Q3TGI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347097   ⟸   NM_001360168
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001347099   ⟸   NM_001360170
- Peptide Label: isoform 4
- UniProtKB: Q8BQS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001347098   ⟸   NM_001360169
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000146105   ⟸   ENSMUST00000205573
RefSeq Acc Id: ENSMUSP00000070995   ⟸   ENSMUST00000063249
Protein Domains
BRCT   XRCC1_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60596-F1-model_v2 AlphaFold Q60596 1-631 view protein structure

Promoters
RGD ID:6892194
Promoter ID:EPDNEW_M9548
Type:single initiation site
Name:Xrcc1_2
Description:Mus musculus X-ray repair complementing defective repair in Chinesehamster cells 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9549  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38724,546,341 - 24,546,401EPDNEW
RGD ID:6892196
Promoter ID:EPDNEW_M9549
Type:initiation region
Name:Xrcc1_1
Description:Mus musculus X-ray repair complementing defective repair in Chinesehamster cells 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9548  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38724,547,201 - 24,547,261EPDNEW
RGD ID:6842348
Promoter ID:MM_KWN:49376
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009532,   UC009FPY.1,   UC009FPZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,331,839 - 25,332,339 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99137 AgrOrtholog
Ensembl Genes ENSMUSG00000051768 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000070995 UniProtKB/Swiss-Prot
  ENSMUSP00000146105 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063249 UniProtKB/Swiss-Prot
  ENSMUST00000205573 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.10190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRCT_XRCC1_rpt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xrcc1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22594 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99137 ENTREZGENE
NCBI Gene 22594 ENTREZGENE
Pfam BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRCT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB XRCC1 RGD
PhenoGen Xrcc1 PhenoGen
PROSITE BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TGI0 ENTREZGENE, UniProtKB/TrEMBL
  Q3TN28_MOUSE UniProtKB/TrEMBL
  Q3U2B4_MOUSE UniProtKB/TrEMBL
  Q60596 ENTREZGENE
  Q7TNQ5 ENTREZGENE
  Q8BQS1 ENTREZGENE, UniProtKB/TrEMBL
  XRCC1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3THC5 UniProtKB/Swiss-Prot
  Q5U435 UniProtKB/Swiss-Prot
  Q7TNQ5 UniProtKB/Swiss-Prot