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Gene: Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1) Mus musculus
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Symbol: Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Description: Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; brain development; and regulation of response to DNA damage stimulus. Localizes to the ERCC4-ERCC1 complex and nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; hematologic cancer (multiple); hepatobiliary system cancer (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human XRCC1 (X-ray repair cross complementing 1); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH (+)-dexrazoxane; (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA repair protein XRCC1; MGC102556; X-ray repair cross-complementing protein 1; Xrcc-1
Orthologs:
Homo sapiens (human) : XRCC1 (X-ray repair cross complementing 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrcc1 (X-ray repair cross complementing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc1 (X-ray repair cross complementing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC1 (X-ray repair cross complementing 1)
Canis lupus familiaris (dog) : XRCC1 (X-ray repair cross complementing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc1 (X-ray repair cross complementing 1)
Sus scrofa (pig) : XRCC1 (X-ray repair cross complementing 1)
Chlorocebus sabaeus (African green monkey) : XRCC1 (X-ray repair cross complementing 1)
Heterocephalus glaber (naked mole-rat) : Xrcc1 (X-ray repair cross complementing 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl724,546,289 - 24,573,440 (+)Ensembl
GRCm38724,546,699 - 24,573,438 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37725,332,169 - 25,358,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv36724,255,049 - 24,282,192 (+)NCBImm8
Celera719,161,255 - 19,187,540 (+)NCBICelera
Cytogenetic Map7 A3NCBI
cM Map711.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Xrcc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732969
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.