Psmb4 (proteasome (prosome, macropain) subunit, beta type 4) - Rat Genome Database

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Gene: Psmb4 (proteasome (prosome, macropain) subunit, beta type 4) Mus musculus
Analyze
Symbol: Psmb4
Name: proteasome (prosome, macropain) subunit, beta type 4
RGD ID: 62169
MGI Page MGI
Description: Exhibits lipopolysaccharide binding activity. Involved in negative regulation of inflammatory response to antigenic stimulus. Localizes to proteasome core complex. Is expressed in cerebral cortex and embryo. Orthologous to human PSMB4 (proteasome 20S subunit beta 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: low molecular mass protein 3; macropain beta chain; multicatalytic endopeptidase complex beta chain; Pro; Pros-27; proteasome beta chain; proteasome chain 3; proteasome subunit beta type-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19058  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,791,635 - 94,794,269 (-)NCBIGRCm39mm39
GRCm39 Ensembl394,791,404 - 94,794,272 (-)Ensembl
GRCm38394,884,324 - 94,886,958 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,884,093 - 94,886,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv37394,688,246 - 94,690,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36394,969,728 - 94,972,336 (-)NCBImm8
Celera396,315,024 - 96,317,658 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
buspirone  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
cefaloridine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
elemental selenium  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
leflunomide  (ISO)
lithocholic acid  (ISO)
methapyrilene  (ISO)
miconazole  (EXP)
microcystin RR  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel subsulfide  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
PhIP  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
poly(propylene imine) macromolecule  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
stattic  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9197541   PMID:10349636   PMID:10852819   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12874245   PMID:12904583   PMID:14610273  
PMID:14706451   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16857966   PMID:17139257   PMID:19521500   PMID:20498273   PMID:21267068   PMID:21565611   PMID:21677750  
PMID:21873635   PMID:26496610   PMID:32325033  


Genomics

Comparative Map Data
Psmb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,791,635 - 94,794,269 (-)NCBIGRCm39mm39
GRCm39 Ensembl394,791,404 - 94,794,272 (-)Ensembl
GRCm38394,884,324 - 94,886,958 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,884,093 - 94,886,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv37394,688,246 - 94,690,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36394,969,728 - 94,972,336 (-)NCBImm8
Celera396,315,024 - 96,317,658 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
PSMB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1151,399,560 - 151,401,937 (+)EnsemblGRCh38hg38GRCh38
GRCh381151,399,573 - 151,401,937 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371151,372,049 - 151,374,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,638,665 - 149,641,036 (+)NCBINCBI36hg18NCBI36
Build 341148,185,113 - 148,187,485NCBI
Celera1124,487,307 - 124,489,678 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,750,051 - 122,752,422 (+)NCBIHuRef
CHM1_11152,767,631 - 152,770,002 (+)NCBICHM1_1
Psmb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22182,442,757 - 182,445,532 (-)NCBI
Rnor_6.0 Ensembl2196,043,618 - 196,046,311 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02196,043,546 - 196,046,320 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02215,536,945 - 215,539,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42189,778,476 - 189,781,169 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12189,732,542 - 189,735,229 (-)NCBI
Celera2174,986,061 - 174,988,835 (-)NCBICelera
Cytogenetic Map2q34NCBI
Psmb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955589976,321 - 978,617 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955589976,216 - 978,566 (-)NCBIChiLan1.0ChiLan1.0
PSMB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11130,404,234 - 130,406,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,404,234 - 130,406,638 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01126,758,604 - 126,760,989 (+)NCBIMhudiblu_PPA_v0panPan3
PSMB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,461,208 - 60,463,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,461,240 - 60,463,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,904,234 - 59,906,625 (+)NCBI
ROS_Cfam_1.01761,477,234 - 61,479,628 (+)NCBI
UMICH_Zoey_3.11760,305,058 - 60,307,449 (+)NCBI
UNSW_CanFamBas_1.01760,391,008 - 60,393,402 (+)NCBI
UU_Cfam_GSD_1.01761,119,636 - 61,122,029 (+)NCBI
Psmb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,580,235 - 22,582,975 (+)NCBI
SpeTri2.0NW_0049365801,610,635 - 1,613,357 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,835,546 - 97,837,921 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1497,835,544 - 97,837,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,036,322 - 107,038,687 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,291,727 - 12,294,120 (-)NCBI
ChlSab1.1 Ensembl2012,291,070 - 12,294,311 (-)Ensembl
Psmb4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477219,124,327 - 19,126,731 (+)NCBI

Position Markers
stSG627163  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38394,885,716 - 94,886,857UniSTSGRCm38
MGSCv37394,689,638 - 94,690,779UniSTSGRCm37
Celera396,316,416 - 96,317,557UniSTS
Cytogenetic Map3F2UniSTS
cM Map343.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390603910100556821Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:521
Count of miRNA genes:304
Interacting mature miRNAs:330
Transcripts:ENSMUST00000005923, ENSMUST00000133412, ENSMUST00000134133, ENSMUST00000136143
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000005923   ⟹   ENSMUSP00000005923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl394,884,093 - 94,886,961 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133412
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl394,884,898 - 94,886,862 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134133
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl394,884,322 - 94,884,843 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl394,884,917 - 94,886,745 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl394,885,307 - 94,885,955 (-)Ensembl
RefSeq Acc Id: NM_008945   ⟹   NP_032971
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,791,635 - 94,794,269 (-)NCBI
GRCm38394,884,324 - 94,886,958 (-)ENTREZGENE
MGSCv37394,688,246 - 94,690,880 (-)RGD
Celera396,315,024 - 96,317,658 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032971   ⟸   NM_008945
- UniProtKB: P99026 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000005923   ⟸   ENSMUST00000005923

Promoters
RGD ID:6834318
Promoter ID:MM_KWN:35230
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   MEF_B6
Transcripts:OTTMUST00000047085
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,688,526 - 94,689,392 (-)MPROMDB
RGD ID:6834319
Promoter ID:MM_KWN:35231
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000047083,   OTTMUST00000047084,   OTTMUST00000055693
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,690,671 - 94,691,171 (-)MPROMDB
RGD ID:6881516
Promoter ID:EPDNEW_M4209
Type:initiation region
Name:Psmb4_1
Description:Mus musculus proteasome (prosome, macropain) subunit, beta type4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38394,886,927 - 94,886,987EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098257 AgrOrtholog
Ensembl Genes ENSMUSG00000005779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000005923 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005923 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Proteasome_beta4 UniProtKB/Swiss-Prot
  Proteasome_bsu_CS UniProtKB/Swiss-Prot
  Proteasome_sua/b UniProtKB/Swiss-Prot
  Proteasome_suB-type UniProtKB/Swiss-Prot
KEGG Report mmu:19172 UniProtKB/Swiss-Prot
MGD MGI:1098257 ENTREZGENE
NCBI Gene 19172 ENTREZGENE
PANTHER PTHR11599:SF5 UniProtKB/Swiss-Prot
Pfam Proteasome UniProtKB/Swiss-Prot
PhenoGen Psmb4 PhenoGen
PIRSF Psome_endopept_beta UniProtKB/Swiss-Prot
PROSITE PROTEASOME_BETA_1 UniProtKB/Swiss-Prot
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
UniProt P99026 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3THC0 UniProtKB/Swiss-Prot
  Q3THI3 UniProtKB/Swiss-Prot
  Q3U0S0 UniProtKB/Swiss-Prot
  Q3UVQ4 UniProtKB/Swiss-Prot
  Q62008 UniProtKB/Swiss-Prot
  Q8BK27 UniProtKB/Swiss-Prot
  Q91VV7 UniProtKB/Swiss-Prot