Dpyd (dihydropyrimidine dehydrogenase) - Rat Genome Database

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Gene: Dpyd (dihydropyrimidine dehydrogenase) Mus musculus
Analyze
Symbol: Dpyd
Name: dihydropyrimidine dehydrogenase
RGD ID: 1550111
MGI Page MGI
Description: Enables dihydropyrimidine dehydrogenase (NADP+) activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Acts upstream of or within pyrimidine nucleobase catabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI315208; DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP+]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DP; DPD; E330028L06Rik; MGC37940
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)EnsemblGRCm39 Ensembl
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBIMGSCv36mm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
1-benzylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
camptothecin  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
Gimeracil  (ISO)
glafenine  (ISO)
glycidol  (ISO)
Heliotrine  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
L-ethionine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
menadione  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
Tegafur  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
wogonin  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer. Ajiki T, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1391-6.
2. Combination of low-dose docetaxel and standard-dose S-1 for the treatment of advanced gastric cancer: efficacy, toxicity, and potential predictive factor. Cui Y, etal., Cancer Chemother Pharmacol. 2013 Jan;71(1):145-52. doi: 10.1007/s00280-012-1991-y. Epub 2012 Oct 12.
3. Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the development of fluoropyrimidine-related toxicity in patients with high-grade toxicity and patients with excellent tolerance of fluoropyrimidine-based chemotherapy. Kleibl Z, etal., Neoplasma. 2009;56(4):303-16.
4. Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats. Kobuchi S, etal., Eur J Drug Metab Pharmacokinet. 2013 Sep;38(3):171-81. doi: 10.1007/s13318-012-0114-9. Epub 2012 Nov 30.
5. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Kuramochi H, etal., Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9. Epub 2008 Feb 29.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer. Nakahara O, etal., Int J Clin Oncol. 2010 Feb;15(1):39-45.
8. [Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats]. Ogata Y, etal., Gan To Kagaku Ryoho. 2001 May;28(5):655-60.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Identification of new SNPs associated with severe toxicity to capecitabine. Pellicer M, etal., Pharmacol Res. 2017 Jun;120:133-137. doi: 10.1016/j.phrs.2017.03.021. Epub 2017 Mar 27.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2). Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.
18. Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats. Tateishi T, etal., Drug Metab Dispos. 1999 Jun;27(6):651-4.
19. 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase. Tatsumi K, etal., J Biochem. 1993 Dec;114(6):912-8.
20. Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients. Teh LK, etal., Ther Drug Monit. 2013 Oct;35(5):624-30. doi: 10.1097/FTD.0b013e318290acd2.
21. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. van Kuilenburg AB, etal., Clin Cancer Res. 2000 Dec;6(12):4705-12.
22. Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation. Van Kuilenburg AB, etal., Int J Cancer. 2002 Sep 20;101(3):253-8.
23. DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia. Zhao XQ, etal., Tumour Biol. 2016 Feb 4.
Additional References at PubMed
PMID:5472365   PMID:8083224   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12527935   PMID:12651209   PMID:14681479   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22008794   PMID:26212757   PMID:27626380   PMID:33798452   PMID:34653361  


Genomics

Comparative Map Data
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)EnsemblGRCm39 Ensembl
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBIMGSCv36mm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
T2T-CHM13v2.0196,925,834 - 97,768,903 (-)NCBIT2T-CHM13v2.0
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22206,609,043 - 207,474,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2206,609,122 - 207,474,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2214,264,321 - 215,128,440 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02212,171,713 - 213,035,662 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02206,997,314 - 207,861,463 (+)NCBIRnor_WKY
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q41NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha654,459,524 - 55,250,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0652,128,811 - 52,919,237 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl652,128,798 - 52,936,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1651,820,117 - 52,610,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0651,800,205 - 52,590,810 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0652,232,854 - 53,023,930 (+)NCBIUU_Cfam_GSD_1.0
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058106,508,890 - 107,287,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365371,660,477 - 2,439,273 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,414 - 120,712,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603555,476 - 898,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir27ammu-miR-27a-3pOncomiRDBexternal_infoNANA22306127
Mir134mmu-miR-134-5pOncomiRDBexternal_infoNANA22306127
Mir582mmu-miR-582-5pOncomiRDBexternal_infoNANA22306127
Mir27bmmu-miR-27b-3pOncomiRDBexternal_infoNANA22306127

Predicted Target Of
Summary Value
Count of predictions:532
Count of miRNA genes:370
Interacting mature miRNAs:438
Transcripts:ENSMUST00000039177, ENSMUST00000126254, ENSMUST00000129148, ENSMUST00000149101, ENSMUST00000150950
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse

Markers in Region
39.MMHAP58FRE12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383119,285,084 - 119,285,283UniSTSGRCm38
MGSCv373118,988,002 - 118,988,201UniSTSGRCm37
Celera3125,693,456 - 125,693,655UniSTS
Cytogenetic Map3G1UniSTS
Whitehead_YAC3 UniSTS
mHAa23g10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383119,194,782 - 119,194,945UniSTSGRCm38
MGSCv373118,897,700 - 118,897,863UniSTSGRCm37
Celera3125,602,861 - 125,603,024UniSTS
Cytogenetic Map3G1UniSTS
Whitehead_YAC3 UniSTS
mHAa23e6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383118,560,737 - 118,560,887UniSTSGRCm38
MGSCv373118,263,655 - 118,263,805UniSTSGRCm37
Celera3124,968,969 - 124,969,119UniSTS
Cytogenetic Map3G1UniSTS
Whitehead_YAC3 UniSTS
D3Mit344  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383119,152,705 - 119,152,952UniSTSGRCm38
MGSCv373118,855,623 - 118,855,870UniSTSGRCm37
Celera3125,560,510 - 125,560,757UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead Genetic340.4UniSTS
D3Mit79  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383118,620,862 - 118,621,011UniSTSGRCm38
MGSCv373118,323,780 - 118,323,929UniSTSGRCm37
Celera3125,029,505 - 125,029,656UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead Genetic340.4UniSTS
Whitehead_YAC3 UniSTS
AI315208  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383119,432,448 - 119,432,566UniSTSGRCm38
MGSCv373119,135,366 - 119,135,484UniSTSGRCm37
Celera3125,843,363 - 125,843,481UniSTS
Cytogenetic Map3G1UniSTS
Whitehead/MRC_RH31393.37UniSTS
UniSTS:494239  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38657,322,648 - 57,323,730UniSTSGRCm38
GRCm383119,275,859 - 119,277,207UniSTSGRCm38
MGSCv373118,978,777 - 118,980,125UniSTSGRCm37
MGSCv37657,272,642 - 57,273,724UniSTSGRCm37
Celera3125,684,218 - 125,685,565UniSTS
Cytogenetic Map6B3UniSTS
Cytogenetic Map3G1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_170778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02023836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC894423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000039177   ⟹   ENSMUSP00000039429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)Ensembl
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126254
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,355,779 - 118,592,768 (+)Ensembl
GRCm38.p6 Ensembl3118,562,130 - 118,799,119 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129148
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,604,871 - 118,693,480 (+)Ensembl
GRCm38.p6 Ensembl3118,811,222 - 118,899,831 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149101   ⟹   ENSMUSP00000143022
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,355,829 - 118,468,422 (+)Ensembl
GRCm38.p6 Ensembl3118,562,180 - 118,674,773 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150950
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,355,826 - 118,576,928 (+)Ensembl
GRCm38.p6 Ensembl3118,562,177 - 118,783,279 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3118,355,835 - 118,356,801 (+)Ensembl
GRCm38.p6 Ensembl3118,562,186 - 118,563,152 (+)Ensembl
RefSeq Acc Id: NM_170778   ⟹   NP_740748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393118,355,829 - 119,226,573 (+)NCBI
GRCm383118,562,180 - 119,432,924 (+)NCBI
MGSCv373118,265,096 - 119,135,836 (+)RGD
Celera3124,970,410 - 125,843,833 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240318   ⟹   XP_011238620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393118,355,758 - 118,812,933 (+)NCBI
GRCm383118,562,109 - 119,019,284 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_740748   ⟸   NM_170778
- UniProtKB: Q8CHR6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011238620   ⟸   XM_011240318
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000143022   ⟸   ENSMUST00000149101
RefSeq Acc Id: ENSMUSP00000039429   ⟸   ENSMUST00000039177
Protein Domains
4Fe-4S ferredoxin-type   Fer4_20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHR6-F1-model_v2 AlphaFold Q8CHR6 1-1025 view protein structure

Promoters
RGD ID:6833664
Promoter ID:MM_KWN:35922
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver
Transcripts:OTTMUST00000064012,   OTTMUST00000064013,   OTTMUST00000064014,   OTTMUST00000064015
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363118,264,896 - 118,265,396 (+)MPROMDB
RGD ID:6882210
Promoter ID:EPDNEW_M4556
Type:multiple initiation site
Name:Dpyd_1
Description:Mus musculus dihydropyrimidine dehydrogenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383118,562,180 - 118,562,240EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2139667 AgrOrtholog
Ensembl Genes ENSMUSG00000033308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000039429 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000143022.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039177 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000149101.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPD_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPYD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:99586 UniProtKB/Swiss-Prot
MGD MGI:2139667 ENTREZGENE
NCBI Gene 99586 ENTREZGENE
PANTHER PTHR43073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHO_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DPYD RGD
PhenoGen Dpyd PhenoGen
PROSITE 4FE4S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pyrD_sub1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JF48_MOUSE UniProtKB/TrEMBL
  DPYD_MOUSE UniProtKB/Swiss-Prot
  Q3UEP3_MOUSE UniProtKB/TrEMBL
  Q80XT4_MOUSE UniProtKB/TrEMBL
  Q811I9_MOUSE UniProtKB/TrEMBL
  Q8BW32_MOUSE UniProtKB/TrEMBL
  Q8CHR6 ENTREZGENE
  Q8K150_MOUSE UniProtKB/TrEMBL