Selenow (selenoprotein W) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Selenow (selenoprotein W) Mus musculus
Analyze
Symbol: Selenow
Name: selenoprotein W
RGD ID: 11284
MGI Page MGI
Description: Predicted to enable oxidoreductase activity. Acts upstream of or within erythrocyte differentiation; response to lipopolysaccharide; and response to stress. Predicted to be located in cytoplasm and plasma membrane. Is expressed in brain and ganglia. Orthologous to human SELENOW (selenoprotein W).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: selenoprotein W, muscle 1; selW; Sep; Sepw1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39715,651,133 - 15,656,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl715,651,133 - 15,656,327 (-)EnsemblGRCm39 Ensembl
GRCm38715,917,208 - 15,922,371 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl715,917,208 - 15,922,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv37716,502,557 - 16,507,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,075,730 - 15,080,848 (-)NCBIMGSCv36mm8
Celera713,115,873 - 13,121,036 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicyclanil  (EXP)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
ethanol  (EXP)
fenthion  (EXP)
flavonoids  (ISO)
glutathione  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
lead(0)  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
pyrogallol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
topotecan  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (TAS)
cytosol  (IBA)
plasma membrane  (TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Chae TH, etal., Mamm Genome 2002 May;13(5):239-44.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9256076   PMID:9315310   PMID:10333732   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11215511   PMID:12062442   PMID:12477932   PMID:14610273   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16876868   PMID:17503775   PMID:19466610   PMID:19935881   PMID:20367607   PMID:20956524   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22982242   PMID:23302927   PMID:24726955   PMID:27645994   PMID:29615406   PMID:30973865   PMID:31299423   PMID:31509445   PMID:33859201   PMID:34321999   PMID:34615966   PMID:36336122  
PMID:36516721   PMID:38355793   PMID:38683225   PMID:39020075  


Genomics

Comparative Map Data
Selenow
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39715,651,133 - 15,656,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl715,651,133 - 15,656,327 (-)EnsemblGRCm39 Ensembl
GRCm38715,917,208 - 15,922,371 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl715,917,208 - 15,922,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv37716,502,557 - 16,507,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,075,730 - 15,080,848 (-)NCBIMGSCv36mm8
Celera713,115,873 - 13,121,036 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.62NCBI
SELENOW
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,778,703 - 47,784,682 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,778,677 - 47,784,686 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,281,960 - 48,287,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,973,654 - 52,979,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 341952,973,653 - 52,979,751NCBI
Celera1945,087,540 - 45,093,641 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1944,708,351 - 44,714,452 (+)NCBIHuRef
CHM1_11948,284,165 - 48,290,265 (+)NCBICHM1_1
T2T-CHM13v2.01950,609,522 - 50,615,500 (+)NCBIT2T-CHM13v2.0
Selenow
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8185,727,631 - 85,732,703 (-)NCBIGRCr8
mRatBN7.2176,599,441 - 76,604,514 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,599,464 - 76,604,500 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl176,598,779 - 76,604,724 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,974,548 - 81,979,557 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,538,613 - 90,543,622 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,729,686 - 83,734,695 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0177,530,692 - 77,535,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,803,475 - 77,808,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,533,148 - 77,535,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,799,172 - 78,804,245 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,249,869 - 76,254,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,327,980 - 76,333,020 (-)NCBI
Celera171,089,734 - 71,094,810 (-)NCBICelera
Cytogenetic Map1q21NCBI
Selenow
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555741,522,304 - 1,526,862 (+)NCBIChiLan1.0ChiLan1.0
LOC106634549
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21195,738,266 - 195,739,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11194,857,104 - 194,858,696 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0130,374,648 - 30,375,515 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1131,397,890 - 31,412,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,425,939 - 53,428,515 (+)Ensemblpanpan1.1panPan2
SELENOW
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,285,443 - 108,289,551 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,285,443 - 108,289,568 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,768,244 - 107,772,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,811,307 - 108,815,497 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11108,479,650 - 108,483,762 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,124,201 - 108,128,312 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,991,920 - 108,996,033 (-)NCBIUU_Cfam_GSD_1.0
Selenow
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,740,658 - 19,751,877 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366641,358,753 - 1,361,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELENOW
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,470,787 - 53,474,652 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,470,563 - 53,474,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,000,933 - 49,004,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELENOW
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120101,740,545 - 101,741,532 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603314,919,248 - 14,919,909 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Selenow
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,129,073 - 6,132,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:196
Interacting mature miRNAs:202
Transcripts:ENSMUST00000044355
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000044355   ⟹   ENSMUSP00000038943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,651,133 - 15,656,327 (-)Ensembl
GRCm38.p6 Ensembl715,917,208 - 15,922,402 (-)Ensembl
RefSeq Acc Id: NM_009156   ⟹   NP_033182
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39715,651,133 - 15,656,296 (-)NCBI
GRCm38715,917,208 - 15,922,371 (-)ENTREZGENE
MGSCv37716,502,557 - 16,507,720 (-)RGD
Celera713,115,873 - 13,121,036 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033182   ⟸   NM_009156
- UniProtKB: P49904 (UniProtKB/Swiss-Prot),   O35965 (UniProtKB/Swiss-Prot),   Q9JIC2 (UniProtKB/Swiss-Prot),   P63300 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000038943   ⟸   ENSMUST00000044355

Promoters
RGD ID:6891892
Promoter ID:EPDNEW_M9397
Type:initiation region
Name:Selenow_1
Description:Mus musculus selenoprotein W , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38715,922,346 - 15,922,406EPDNEW
RGD ID:6848206
Promoter ID:MM_ACW:43574
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:SEPW1.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,502,706 - 16,503,206 (-)MPROMDB
RGD ID:6849241
Promoter ID:MM_XEF:6400
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B6
Transcripts:NM_213977
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,505,206 - 16,506,157 (-)MPROMDB
RGD ID:6842000
Promoter ID:MM_KWN:48868
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000049826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,507,584 - 16,508,084 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100878 AgrOrtholog
Ensembl Genes ENSMUSG00000041571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044355 ENTREZGENE
  ENSMUST00000044355.11 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Selenoprotein_Rdx-typ UniProtKB/Swiss-Prot
  SelW_related UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:20364 UniProtKB/Swiss-Prot
MGD MGI:1100878 ENTREZGENE
NCBI Gene 20364 ENTREZGENE
PANTHER SELENOPROTEIN W UniProtKB/Swiss-Prot
  SELENOPROTEIN W UniProtKB/Swiss-Prot
Pfam Rdx UniProtKB/Swiss-Prot
PhenoGen Selenow PhenoGen
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt O35965 ENTREZGENE
  P49904 ENTREZGENE
  P63300 ENTREZGENE
  Q9JIC2 ENTREZGENE
  SELW_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O35965 UniProtKB/Swiss-Prot
  P49904 UniProtKB/Swiss-Prot
  Q9JIC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-25 Selenow  selenoprotein W  Sepw1  selenoprotein W, muscle 1  Symbol and/or name change 5135510 APPROVED