Akr1c21 (aldo-keto reductase family 1, member C21) - Rat Genome Database

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Gene: Akr1c21 (aldo-keto reductase family 1, member C21) Mus musculus
Analyze
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
RGD ID: 1323510
MGI Page MGI
Description: Enables NADP binding activity; lithocholic acid binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C4 (aldo-keto reductase family 1 member C4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; 9430025F20Rik; AI315367; aldo-keto reductase family 1 member C21; DD1; DD3; dihydrodiol dehydrogenase type 1; dihydrodiol dehydrogenase type 3; MGC102401
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,624,074 - 4,636,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,624,074 - 4,636,540 (+)EnsemblGRCm39 Ensembl
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBIMGSCv36mm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-aminophenol  (ISO)
2-hexenal  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxybenzoic acid  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrobenzyl bromide  (ISO)
5-alpha-THDOC  (ISO)
5-fluorouracil  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
ampicillin  (ISO)
androstane-3,17-diol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzyl cinnamate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clodronic acid  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
dienogest  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
estazolam  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol dimethacrylate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
fenamic acid  (ISO)
fenofibrate  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gedunin  (ISO)
geranial  (ISO)
glipizide  (ISO)
glyburide  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyoxal  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexestrol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidurea  (ISO)
indometacin  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
malathion  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methyl non-2-ynoate  (ISO)
methylmercury chloride  (ISO)
n-propyl gallate  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nitrazepam  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octyl gallate  (ISO)
oxcarbazepine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
para-Cresidine  (ISO)
paracetamol  (ISO)
Paraoxon-methyl  (ISO)
parathion-methyl  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
Phenyl glycidyl ether  (ISO)
phenylacetaldehyde  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
progesterone  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
salicylic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12562828   PMID:14681479   PMID:15577209   PMID:16018803   PMID:16141072   PMID:16141073   PMID:16511129   PMID:17034817  
PMID:17442338   PMID:19237748   PMID:20124700   PMID:21677750   PMID:21873635   PMID:34590152  


Genomics

Comparative Map Data
Akr1c21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,624,074 - 4,636,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,624,074 - 4,636,540 (+)EnsemblGRCm39 Ensembl
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBIMGSCv36mm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.56NCBI
AKR1C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,987,775 - 5,018,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,987,775 - 5,018,031 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,029,967 - 5,060,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
T2T-CHM13v2.0104,988,109 - 5,018,344 (-)NCBIT2T-CHM13v2.0
Akr1c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Celera1765,292,033 - 65,339,839 (-)NCBICelera
Cytogenetic Map17q12.2NCBI

Variants

.
Variants in Akr1c21
421 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:157
Interacting mature miRNAs:159
Transcripts:ENSMUST00000021628, ENSMUST00000137279
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse

Markers in Region
AI315367  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
Whitehead/MRC_RH1374.98UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000021628   ⟹   ENSMUSP00000021628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,624,074 - 4,636,540 (+)Ensembl
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,627,156 - 4,633,861 (+)Ensembl
GRCm38.p6 Ensembl134,577,157 - 4,583,862 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223285   ⟹   ENSMUSP00000152465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,624,074 - 4,636,540 (+)Ensembl
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)Ensembl
RefSeq Acc Id: NM_029901   ⟹   NP_084177
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39134,624,074 - 4,636,542 (+)NCBI
GRCm38134,574,075 - 4,586,543 (+)ENTREZGENE
MGSCv37134,573,321 - 4,585,789 (+)RGD
Celera134,543,969 - 4,562,535 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_084177   ⟸   NM_029901
- UniProtKB: Q6P8V0 (UniProtKB/Swiss-Prot),   Q9CX32 (UniProtKB/Swiss-Prot),   Q91WR5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000152465   ⟸   ENSMUST00000223285
RefSeq Acc Id: ENSMUSP00000021628   ⟸   ENSMUST00000021628
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91WR5-F1-model_v2 AlphaFold Q91WR5 1-323 view protein structure

Promoters
RGD ID:6823690
Promoter ID:MM_KWN:13157
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000074985,   NM_029901
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36134,573,201 - 4,573,701 (+)MPROMDB
RGD ID:8679532
Promoter ID:EPDNEW_M17797
Type:multiple initiation site
Name:Akr1c21_1
Description:Mus musculus aldo-keto reductase family 1, member C21 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38134,574,080 - 4,574,140EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924587 AgrOrtholog
Ensembl Genes ENSMUSG00000021207 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021628 ENTREZGENE
  ENSMUST00000021628.4 UniProtKB/Swiss-Prot
  ENSMUST00000223285.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/Swiss-Prot
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:77337 UniProtKB/Swiss-Prot
MGD MGI:1924587 ENTREZGENE
NCBI Gene 77337 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akr1c21 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VLH1_MOUSE UniProtKB/TrEMBL
  AK1CL_MOUSE UniProtKB/Swiss-Prot
  Q6P8V0 ENTREZGENE
  Q91WR5 ENTREZGENE
  Q9CX32 ENTREZGENE
UniProt Secondary Q6P8V0 UniProtKB/Swiss-Prot
  Q9CX32 UniProtKB/Swiss-Prot