17beta-estradiol decreases expression ISO H3-4 (Homo sapiens) 6480464 Estradiol results in decreased expression of H3-4 mRNA CTD PMID:31614463 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO H3-4 (Homo sapiens) 6480464 [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein CTD PMID:17468514 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO H3-4 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of H3-4 mRNA CTD PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine increases acetylation ISO H3-4 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased acetylation of H3-4 protein CTD PMID:15964790 2-amino-2-deoxy-D-galactopyranose increases expression ISO H3f4 (Rattus norvegicus) 6480464 Galactosamine results in increased expression of H3F4 mRNA CTD PMID:11779202 4,4'-sulfonyldiphenol decreases methylation EXP 6480464 bisphenol S results in decreased methylation of H3F4 exon CTD PMID:33297965 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO H3-4 (Homo sapiens) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H3-4 mRNA CTD PMID:19038236 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 Decitabine promotes the reaction [H3F4 protein modified form binds to RHOX5 promoter] CTD PMID:19679824 5-aza-2'-deoxycytidine multiple interactions ISO H3-4 (Homo sapiens) 6480464 [[Decitabine co-treated with trichostatin A] affects the acetylation of H3-4 protein] which affects the expression of CDH1 mRNA more ... CTD PMID:15657354 more ... 5-aza-2'-deoxycytidine increases acetylation EXP 6480464 Decitabine results in increased acetylation of H3F4 protein CTD PMID:19109157 and PMID:19679824 5-aza-2'-deoxycytidine decreases methylation ISO H3-4 (Homo sapiens) 6480464 Decitabine results in decreased methylation of H3-4 and Decitabine results in decreased methylation of H3-4 protein CTD PMID:18291368 more ... 5-aza-2'-deoxycytidine affects methylation ISO H3-4 (Homo sapiens) 6480464 [Decitabine affects the methylation of H3-4 protein] which affects the methylation of CDKN2A gene and Decitabine affects the methylation of H3-4 protein CTD PMID:15959780 and PMID:18410530 5-azacytidine multiple interactions ISO H3-4 (Homo sapiens) 6480464 Azacitidine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 9-cis-retinoic acid multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene] and Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein] CTD PMID:15964820 aflatoxin B1 increases methylation ISO H3-4 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of H3-4 gene CTD PMID:27153756 aldehydo-D-glucose multiple interactions ISO H3f4 (Rattus norvegicus) 6480464 Glucose promotes the reaction [H3F4 protein modified form binds to PKLR promoter] CTD PMID:16644726 all-trans-retinoic acid increases acetylation ISO H3-4 (Homo sapiens) 6480464 Tretinoin results in increased acetylation of H3-4 protein CTD PMID:16613989 all-trans-retinoic acid decreases acetylation EXP 6480464 Tretinoin results in decreased acetylation of H3F4 protein CTD PMID:16415856 all-trans-retinoic acid increases methylation EXP 6480464 Tretinoin results in increased methylation of H3F4 gene CTD PMID:16415856 all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin promotes the reaction [[H3F4 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter] and Tretinoin promotes the reaction [[H3F4 protein modified form binds to CBX1 protein] which binds to ZFP42 promoter] CTD PMID:16415856 all-trans-retinoic acid increases acetylation EXP 6480464 Tretinoin results in increased acetylation of H3F4 protein CTD PMID:16845368 all-trans-retinoic acid multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the methylation of H3-4 protein and [Decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [H3-4 protein modified form binds to RARB promoter] CTD PMID:15959780 all-trans-retinol multiple interactions EXP 6480464 Vitamin A affects the reaction [H3F4 protein modified form binds to PCK1 promoter] CTD PMID:16317119 all-trans-retinol increases acetylation EXP 6480464 Vitamin A results in increased acetylation of H3F4 protein CTD PMID:16317119 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO H3-4 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [5-(2 more ... CTD PMID:16179969 arsane multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Arsenic co-treated with Nickel] results in increased acetylation of H3-4 protein and [Arsenic co-treated with Nickel] results in increased methylation of H3-4 protein CTD PMID:21385672 arsane increases methylation ISO H3-4 (Homo sapiens) 6480464 Arsenic results in increased methylation of H3-4 protein CTD PMID:21385672 arsenic atom multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Arsenic co-treated with Nickel] results in increased acetylation of H3-4 protein and [Arsenic co-treated with Nickel] results in increased methylation of H3-4 protein CTD PMID:21385672 arsenic atom increases methylation ISO H3-4 (Homo sapiens) 6480464 Arsenic results in increased methylation of H3-4 protein CTD PMID:21385672 arsenite(3-) multiple interactions EXP 6480464 arsenite results in increased phosphorylation of and results in increased acetylation of H3F4 protein CTD PMID:11689710 arsenous acid increases acetylation EXP 6480464 Arsenic Trioxide results in increased acetylation of H3F4 protein CTD PMID:19679824 arsenous acid multiple interactions ISO H3-4 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of and results in increased acetylation of H3-4 protein CTD PMID:12388546 benzo[a]pyrene multiple interactions ISO H3-4 (Homo sapiens) 6480464 [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein CTD PMID:17468514 benzo[a]pyrene decreases expression ISO H3-4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of H3-4 protein CTD PMID:33044785 benzo[a]pyrene multiple interactions EXP 6480464 Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [H3F4 protein modified form binds to CYP1A1 promoter]] CTD PMID:17682057 berberine decreases expression ISO H3-4 (Homo sapiens) 6480464 Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 biguanides affects methylation ISO H3-4 (Homo sapiens) 6480464 Biguanides analog affects the methylation of H3-4 protein CTD PMID:17463086 biphenyl-4-amine decreases methylation ISO H3-4 (Homo sapiens) 6480464 4-biphenylamine results in decreased methylation of H3-4 protein CTD PMID:17468514 biphenyl-4-amine multiple interactions ISO H3-4 (Homo sapiens) 6480464 [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein CTD PMID:17468514 bisphenol A increases expression ISO H3f4 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of H3F4 mRNA CTD PMID:25181051 butyric acid increases acetylation ISO H3-4 (Homo sapiens) 6480464 Butyric Acid results in increased acetylation of H3-4 protein CTD PMID:14576182 CGP 52608 multiple interactions ISO H3-4 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to H3-4 gene] CTD PMID:28238834 chromium atom multiple interactions EXP 6480464 Chromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [H3F4 protein modified form binds to CYP1A1 promoter]] CTD PMID:17682057 copper atom multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA CTD PMID:24690739 crocidolite asbestos increases expression EXP 6480464 Asbestos and Crocidolite results in increased expression of H3F4 mRNA CTD PMID:18192500 curcumin increases acetylation ISO H3f4 (Rattus norvegicus) 6480464 Curcumin results in increased acetylation of H3F4 protein CTD PMID:18204486 curcumin increases phosphorylation ISO H3f4 (Rattus norvegicus) 6480464 Curcumin results in increased phosphorylation of H3F4 protein CTD PMID:18204486 D-glucose multiple interactions ISO H3f4 (Rattus norvegicus) 6480464 Glucose promotes the reaction [H3F4 protein modified form binds to PKLR promoter] CTD PMID:16644726 diarsenic trioxide multiple interactions ISO H3-4 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of and results in increased acetylation of H3-4 protein CTD PMID:12388546 diarsenic trioxide increases acetylation EXP 6480464 Arsenic Trioxide results in increased acetylation of H3F4 protein CTD PMID:19679824 dimethyl sulfoxide multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene] and Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein] CTD PMID:15964820 dimethyl sulfoxide decreases methylation ISO H3-4 (Homo sapiens) 6480464 Dimethyl Sulfoxide results in decreased methylation of H3-4 protein CTD PMID:15964820 disodium selenite multiple interactions ISO H3-4 (Homo sapiens) 6480464 Sodium Selenite affects the reaction [H3-4 protein modified form binds to GSTP1 promoter] CTD PMID:18676679 disodium selenite decreases methylation ISO H3-4 (Homo sapiens) 6480464 Sodium Selenite results in decreased methylation of H3-4 CTD PMID:18676679 disodium selenite increases acetylation ISO H3-4 (Homo sapiens) 6480464 Sodium Selenite results in increased acetylation of H3-4 CTD PMID:18676679 disulfiram multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA CTD PMID:24690739 entinostat multiple interactions ISO H3-4 (Homo sapiens) 6480464 [fludarabine co-treated with entinostat] results in increased acetylation of H3-4 protein CTD PMID:15059916 entinostat increases acetylation ISO H3-4 (Homo sapiens) 6480464 entinostat results in increased acetylation of H3-4 protein CTD PMID:34665271 entinostat increases acetylation EXP 6480464 entinostat results in increased acetylation of H3F4 protein CTD PMID:19679824 entinostat multiple interactions EXP 6480464 entinostat promotes the reaction [H3F4 protein modified form binds to RHOX5 promoter] CTD PMID:19679824 furan decreases acetylation ISO H3f4 (Rattus norvegicus) 6480464 furan results in decreased acetylation of H3F4 protein CTD PMID:25539665 furan decreases methylation ISO H3f4 (Rattus norvegicus) 6480464 furan results in decreased methylation of H3F4 protein CTD PMID:25539665 genistein increases expression ISO H3-4 (Homo sapiens) 6480464 Genistein results in increased expression of H3-4 protein modified form CTD PMID:19221000 glucose multiple interactions ISO H3f4 (Rattus norvegicus) 6480464 Glucose promotes the reaction [H3F4 protein modified form binds to PKLR promoter] CTD PMID:16644726 homocysteine multiple interactions ISO H3-4 (Homo sapiens) 6480464 Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 hydrogen peroxide decreases acetylation EXP 6480464 Hydrogen Peroxide results in decreased acetylation of H3F4 protein CTD PMID:18560803 hydrogen peroxide multiple interactions EXP 6480464 GPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of H3F4 protein] CTD PMID:18560803 iron atom increases methylation ISO H3-4 (Homo sapiens) 6480464 Iron results in increased methylation of H3-4 protein CTD PMID:21385672 iron atom multiple interactions ISO H3-4 (Homo sapiens) 6480464 [[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein CTD PMID:16603237 iron(0) increases methylation ISO H3-4 (Homo sapiens) 6480464 Iron results in increased methylation of H3-4 protein CTD PMID:21385672 iron(0) multiple interactions ISO H3-4 (Homo sapiens) 6480464 [[Iron co-treated with Ketoglutaric Acids] results in increased activity of KDM3A protein] which results in decreased methylation of H3-4 protein CTD PMID:16603237 lipopolysaccharide increases expression ISO H3f4 (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased expression of H3F4 mRNA CTD PMID:11779202 LY294002 multiple interactions EXP 6480464 [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased acetylation of H3F4 protein CTD PMID:16256798 methoxyacetic acid increases acetylation ISO H3f4 (Rattus norvegicus) 6480464 methoxyacetic acid results in increased acetylation of H3F4 protein CTD PMID:18199887 mocetinostat increases acetylation ISO H3-4 (Homo sapiens) 6480464 mocetinostat results in increased acetylation of H3-4 protein CTD PMID:19215824 N-methyl-4-phenylpyridinium increases expression ISO H3-4 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of H3-4 protein CTD PMID:24675778 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of H3F4 mRNA CTD PMID:15766596 nickel atom multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Arsenic co-treated with Nickel] results in increased acetylation of H3-4 protein and [Arsenic co-treated with Nickel] results in increased methylation of H3-4 protein CTD PMID:21385672 nickel atom increases methylation ISO H3-4 (Homo sapiens) 6480464 Nickel results in increased methylation of H3-4 protein CTD PMID:16648469 and PMID:21385672 nickel dichloride increases methylation ISO H3-4 (Homo sapiens) 6480464 nickel chloride results in increased methylation of H3-4 protein CTD PMID:16522665 and PMID:19371620 nickel dichloride decreases acetylation ISO H3-4 (Homo sapiens) 6480464 nickel chloride results in decreased acetylation of H3-4 protein CTD PMID:16522665 nickel sulfate increases methylation ISO H3-4 (Homo sapiens) 6480464 nickel sulfate results in increased methylation of H3-4 protein CTD PMID:19371620 nickel sulfate increases methylation ISO H3f4 (Rattus norvegicus) 6480464 nickel sulfate results in increased methylation of H3F4 protein CTD PMID:19371620 panobinostat increases acetylation ISO H3-4 (Homo sapiens) 6480464 Panobinostat results in increased acetylation of H3-4 protein CTD PMID:19215824 PhIP multiple interactions ISO H3-4 (Homo sapiens) 6480464 [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein CTD PMID:17468514 PhIP decreases methylation ISO H3-4 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased methylation of H3-4 protein CTD PMID:17468514 potassium chromate increases methylation ISO H3-4 (Homo sapiens) 6480464 potassium chromate(VI) results in increased methylation of H3-4 protein CTD PMID:19371620 quercetin multiple interactions ISO H3-4 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in decreased acetylation of H3-4 protein] CTD PMID:18377872 quercetin decreases acetylation ISO H3-4 (Homo sapiens) 6480464 Quercetin results in decreased acetylation of H3-4 protein CTD PMID:18377872 quizartinib multiple interactions ISO H3-4 (Homo sapiens) 6480464 quizartinib promotes the reaction [romidepsin results in increased acetylation of H3-4 protein] CTD PMID:34665271 romidepsin increases acetylation ISO H3-4 (Homo sapiens) 6480464 romidepsin results in increased acetylation of H3-4 protein CTD PMID:16006969 and PMID:34665271 romidepsin multiple interactions ISO H3-4 (Homo sapiens) 6480464 quizartinib promotes the reaction [romidepsin results in increased acetylation of H3-4 protein] CTD PMID:34665271 silicon dioxide increases expression ISO H3-4 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of H3-4 mRNA CTD PMID:25895662 sodium arsenite multiple interactions ISO H3-4 (Homo sapiens) 6480464 [sodium arsenite affects the acetylation of H3-4 protein] which affects the methylation of ALDH7A1 promoter more ... CTD PMID:12547826 and PMID:18448484 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of H3F4 mRNA CTD PMID:37682722 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of H3F4 protein CTD PMID:15327774 sodium arsenite increases methylation ISO H3-4 (Homo sapiens) 6480464 sodium arsenite results in increased methylation of H3-4 protein CTD PMID:19371620 sodium arsenite decreases methylation ISO H3-4 (Homo sapiens) 6480464 sodium arsenite results in decreased methylation of H3-4 protein CTD PMID:19371620 sunitinib increases expression ISO H3-4 (Homo sapiens) 6480464 Sunitinib results in increased expression of H3-4 mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO H3-4 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of H3-4 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO H3-4 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased methylation of H3-4 gene CTD PMID:27509014 trichostatin A multiple interactions ISO H3-4 (Homo sapiens) 6480464 [[3-deazaneplanocin co-treated with trichostatin A] affects the acetylation of and affects the methylation of H3-4 protein] which affects the expression of DACT3 more ... CTD PMID:15959780 more ... trichostatin A increases acetylation EXP 6480464 trichostatin A results in increased acetylation of H3F4 protein CTD PMID:11689710 trichostatin A decreases methylation ISO H3-4 (Homo sapiens) 6480464 trichostatin A results in decreased methylation of H3-4 protein CTD PMID:18291368 trichostatin A increases acetylation ISO H3-4 (Homo sapiens) 6480464 trichostatin A results in increased acetylation of H3-4 and trichostatin A results in increased acetylation of H3-4 protein CTD PMID:15959780 more ... triptonide increases expression EXP 6480464 triptonide results in increased expression of H3F4 mRNA CTD PMID:33045310 valproic acid increases methylation ISO H3-4 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of H3-4 gene CTD PMID:29154799 valproic acid increases acylation EXP 6480464 Valproic Acid results in increased acylation of H3F4 protein CTD PMID:15737665 valproic acid multiple interactions ISO H3-4 (Homo sapiens) 6480464 [Decitabine co-treated with Valproic Acid] results in decreased methylation of H3-4 protein and [Valproic Acid co-treated with Decitabine] results in increased acetylation of H3-4 protein CTD PMID:19030781 valproic acid increases acetylation ISO H3-4 (Homo sapiens) 6480464 Valproic Acid results in increased acetylation of H3-4 protein CTD PMID:14576182 more ... vorinostat increases acetylation ISO H3-4 (Homo sapiens) 6480464 Vorinostat results in increased acetylation of H3-4 protein CTD PMID:17431121