Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TBRG4 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of TBRG4 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of TBRG4 mRNA] | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of TBRG4 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBRG4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of TBRG4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of TBRG4 mRNA | CTD | PMID:26496021 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:19095052 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBRG4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TBRG4 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TBRG4 mRNA | CTD | PMID:21296121 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TBRG4 mRNA | CTD | PMID:19465110 and PMID:19770486 | 2,4-dinitrotoluene | affects expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of TBRG4 mRNA | CTD | PMID:21346803 | 4,4'-sulfonyldiphenol | affects expression | ISO | TBRG4 (Homo sapiens) | 6480464 | bisphenol S affects the expression of TBRG4 protein | CTD | PMID:31945527 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TBRG4 mRNA | CTD | PMID:19038236 | 4-amino-2,6-dinitrotoluene | affects expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of TBRG4 mRNA | CTD | PMID:21346803 | 5-fluorouracil | increases expression | EXP | | 6480464 | Fluorouracil results in increased expression of TBRG4 mRNA | CTD | PMID:19272435 | 6-propyl-2-thiouracil | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of TBRG4 mRNA | CTD | PMID:30047161 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of TBRG4 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TBRG4 mRNA | CTD | PMID:23724009 | aristolochic acid A | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of TBRG4 mRNA | CTD | PMID:33212167 | Aroclor 1254 | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of TBRG4 mRNA | CTD | PMID:16934159 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TBRG4 mRNA | CTD | PMID:19770486 | bisphenol A | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of TBRG4 mRNA and bisphenol A results in decreased expression of TBRG4 protein | CTD | PMID:25047013 more ... | bisphenol A | multiple interactions | ISO | TBRG4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TBRG4 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TBRG4 mRNA | CTD | PMID:33221593 | bisphenol A | increases methylation | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of TBRG4 gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TBRG4 mRNA | CTD | PMID:30816183 | bisphenol A | affects expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of TBRG4 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of TBRG4 mRNA | CTD | PMID:26496021 | cadmium dichloride | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of TBRG4 mRNA | CTD | PMID:21297351 and PMID:33453195 | caffeine | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Caffeine results in decreased expression of TBRG4 mRNA | CTD | PMID:20864626 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon results in increased expression of TBRG4 mRNA | CTD | PMID:31978390 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of TBRG4 mRNA | CTD | PMID:17585979 | clofibric acid | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBRG4 mRNA | CTD | PMID:17602206 | dioxygen | multiple interactions | EXP | | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TBRG4 mRNA | CTD | PMID:30529165 | fipronil | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of TBRG4 mRNA | CTD | PMID:23962444 | flutamide | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of TBRG4 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of TBRG4 mRNA] | CTD | PMID:22206623 | FR900359 | increases phosphorylation | ISO | TBRG4 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of TBRG4 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | TBRG4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TBRG4 gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of TBRG4 mRNA | CTD | PMID:22061828 | hypochlorous acid | decreases expression | EXP | | 6480464 | Hypochlorous Acid results in decreased expression of TBRG4 mRNA | CTD | PMID:19376150 | ivermectin | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of TBRG4 protein | CTD | PMID:32959892 | methimazole | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of TBRG4 mRNA | CTD | PMID:30047161 | methoxyacetic acid | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | methoxyacetic acid results in decreased expression of TBRG4 mRNA | CTD | PMID:20864626 | methyl methanesulfonate | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of TBRG4 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | methylmercuric chloride results in decreased expression of TBRG4 mRNA | CTD | PMID:20864626 | Monobutylphthalate | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | monobutyl phthalate results in decreased expression of TBRG4 mRNA | CTD | PMID:20864626 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of TBRG4 protein | CTD | PMID:26558463 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Methylnitronitrosoguanidine results in increased expression of TBRG4 mRNA | CTD | PMID:12634122 | N-nitrosodiethylamine | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBRG4 mRNA | CTD | PMID:17602206 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TBRG4 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TBRG4 mRNA | CTD | PMID:21420995 | paraquat | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Paraquat results in increased expression of TBRG4 mRNA | CTD | PMID:32680482 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of TBRG4 mRNA | CTD | PMID:18301758 and PMID:23811191 | potassium dichromate | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Potassium Dichromate results in decreased expression of TBRG4 protein | CTD | PMID:23718831 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of TBRG4 mRNA | CTD | PMID:28903501 | propiconazole | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | propiconazole results in increased expression of TBRG4 mRNA | CTD | PMID:30047161 | SB 431542 | multiple interactions | ISO | TBRG4 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of TBRG4 protein | CTD | PMID:37664457 | sodium arsenite | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TBRG4 mRNA | CTD | PMID:34032870 | sodium dichromate | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | sodium bichromate results in increased expression of TBRG4 mRNA | CTD | PMID:25993096 | sulfadimethoxine | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of TBRG4 mRNA | CTD | PMID:30047161 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of TBRG4 mRNA | CTD | PMID:17555576 | tetrachloromethane | increases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of TBRG4 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TBRG4 mRNA] | CTD | PMID:31150632 | thimerosal | decreases expression | EXP | | 6480464 | Thimerosal results in decreased expression of TBRG4 mRNA | CTD | PMID:24675092 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of TBRG4 mRNA | CTD | PMID:29264374 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of TBRG4 mRNA | CTD | PMID:19042947 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of TBRG4 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TBRG4 mRNA | CTD | PMID:21427059 | valproic acid | increases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TBRG4 protein | CTD | PMID:29501571 | valproic acid | decreases expression | ISO | TBRG4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TBRG4 mRNA | CTD | PMID:28001369 and PMID:29501571 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of TBRG4 mRNA | CTD | PMID:17292431 and PMID:17963808 | valproic acid | increases methylation | ISO | TBRG4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of TBRG4 gene | CTD | PMID:29154799 | vinclozolin | decreases expression | ISO | Tbrg4 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of TBRG4 mRNA | CTD | PMID:23034163 | |