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Gene: Gls2 (glutaminase 2 (liver, mitochondrial)) Mus musculus
Symbol: Gls2
Name: glutaminase 2 (liver, mitochondrial)
RGD ID: 735898
Description: Predicted to have glutaminase activity. Predicted to be involved in glutamine family amino acid metabolic process; reactive oxygen species metabolic process; and regulation of apoptotic process. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; limb; nervous system; skeleton; and urinary system. Orthologous to human GLS2 (glutaminase 2); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330074B06Rik; AI195532; GA; GLS; glutaminase liver isoform, mitochondrial; KIAA4146; L; L-glutaminase; L-glutamine amidohydrolase; Lga; liver mitochondrial glutaminase
Homo sapiens (human) : GLS2 (glutaminase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gls2 (glutaminase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gls2 (glutaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GLS2 (glutaminase 2)
Canis lupus familiaris (dog) : GLS2 (glutaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gls2 (glutaminase 2)
Sus scrofa (pig) : GLS2 (glutaminase 2)
Chlorocebus sabaeus (African green monkey) : GLS2 (glutaminase 2)
Heterocephalus glaber (naked mole-rat) : Gls2 (glutaminase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl10128,194,457 - 128,210,004 (+)EnsemblGRCm38mm10GRCm38
GRCm3810128,194,635 - 128,210,004 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710127,631,691 - 127,647,060 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,597,639 - 127,612,883 (+)NCBImm8
Celera10130,589,515 - 130,604,841 (+)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gls2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735898
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.