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G |
Cartpt |
CART prepropeptide |
multiple interactions |
EXP |
alpha-MSH binds to and results in increased activity of CARTPT protein |
CTD |
PMID:15659233 |
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NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
alpha-MSH results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; Resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29486182 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]; Resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29486182 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mitf |
melanocyte inducing transcription factor |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [alpha-MSH results in increased expression of MITF protein]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]; Resveratrol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] |
CTD |
PMID:29486182 |
|
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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G |
Retn |
resistin |
increases expression |
ISO |
alpha-MSH analog results in increased expression of RETN mRNA |
CTD |
PMID:15522996 |
|
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Tyr |
tyrosinase |
multiple interactions increases activity increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [alpha-MSH results in increased expression of TYR protein]; alisol B inhibits the reaction [alpha-MSH results in increased activity of TYR protein]; glabridin inhibits the reaction [alpha-MSH results in increased activity of TYR protein]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]; Resveratrol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] |
CTD |
PMID:28051915 PMID:29486182 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Tyrp1 |
tyrosinase-related protein 1 |
increases expression multiple interactions |
ISO |
alpha-MSH results in increased expression of TYRP1 protein Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] |
CTD |
PMID:29486182 |
|
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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G |
Ace2 |
angiotensin converting enzyme 2 |
affects abundance |
ISO |
[ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of angiotensin I (1-7); [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin I |
CTD |
PMID:27649628 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ace2 |
angiotensin converting enzyme 2 |
affects abundance |
ISO |
[ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II |
CTD |
PMID:27649628 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II |
CTD |
PMID:27649628 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression |
EXP |
Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein |
CTD |
PMID:12969123 |
|
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] |
CTD |
PMID:38230784 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression |
ISO |
angiotensin II increases expression of mRNA in mouse heart |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
ISO |
angiotensin II increases expression of mRNA in mouse heart |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA] |
CTD |
PMID:38230784 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA] |
CTD |
PMID:33746155 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression |
ISO |
Angiotensin II results in increased expression of COL3A1 mRNA |
CTD |
PMID:33746155 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
Angiotensin II results in increased expression of EDNRB protein |
CTD |
PMID:15007106 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Esrra |
estrogen related receptor, alpha |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of ESRRA protein celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]] |
CTD |
PMID:37269933 |
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NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein] |
CTD |
PMID:38230784 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Id1 |
inhibitor of DNA binding 1 |
increases expression |
ISO |
angiotensin II increases expression of mRNA in mouse heart |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of IL1B mRNA naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA] |
CTD |
PMID:38230784 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein] |
CTD |
PMID:38230784 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak2 |
Janus kinase 2 |
increases phosphorylation |
ISO |
Angiotensin II increases phosphorylation of JAK2 protein in liver |
RGD |
PMID:22613986 |
RGD:127285667 |
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Klf4 |
KLF transcription factor 4 |
increases expression |
ISO |
angiotensin II increases expression of KLF4 mRNA and protein in vascular smooth muscle cells |
RGD |
PMID:29127880 |
RGD:155230825 |
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
increases expression |
ISO |
Angiotensin II increases expression of MAP3K7 mRNA in cardiomyocytes |
RGD |
PMID:30854566 |
RGD:155791647 |
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
Angiotensin II results in decreased expression of MCL1 protein naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein] |
CTD |
PMID:38230784 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mir143 |
microRNA 143 |
decreases expression |
ISO |
Angiotensin II decreases expression of miRNA143 RNA in vascular smooth muscle cells |
RGD |
PMID:28167124 |
RGD:155260287 |
NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
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G |
Mir145 |
microRNA 145 |
decreases expression |
ISO |
angiotensin II decreases expression of MIR145a RNA in vascular smooth muscle cell Angiotensin II decreases expression of miRNA145 RNA in vascular smooth muscle cells |
RGD |
PMID:29127880 PMID:28167124 |
RGD:155230825, RGD:155260287 |
NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
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G |
Myh6 |
myosin heavy chain 6 |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form] |
CTD |
PMID:37269933 |
|
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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G |
Myocd |
myocardin |
decreases expression |
ISO |
angiotensin II decreases expression of MYOCD mRNA and protein in vascular smooth muscle cell |
RGD |
PMID:29127880 |
RGD:155230825 |
NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] |
CTD |
PMID:33746155 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] Angiotensin II results in increased expression of NOX4 mRNA naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA] |
CTD |
PMID:33746155 PMID:38230784 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO |
angiotensin II inhibits reaction [fluvastatin increases expression of Nphs1 protein in kidney] |
RGD |
PMID:19188342 |
RGD:38596324 |
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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G |
Nppa |
natriuretic peptide A |
increases expression multiple interactions |
ISO EXP |
angiotensin II increases expression of mRNA in mouse heart Angiotensin II results in increased expression of NPPA mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA] |
CTD RGD |
PMID:37269933 PMID:26873969 |
RGD:11526363 |
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
increases expression multiple interactions |
ISO EXP |
angiotensin II increases expression of mRNA in mouse heart Angiotensin II results in increased expression of NPPB mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA] |
CTD RGD |
PMID:37269933 PMID:26873969 |
RGD:11526363 |
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
ISO |
Angiotensin II decreases expression of NR1H3 mRNA and protein in macrophages |
RGD |
PMID:25225013 |
RGD:401827926 |
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
affects response to substance |
ISO |
NR1I2 protein affects the susceptibility to Angiotensin II |
CTD |
PMID:33746155 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pdha1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
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G |
Pfkm |
phosphofructokinase, muscle |
increases expression multiple interactions |
EXP |
Angiotensin II results in increased expression of PFKM mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] |
CTD |
PMID:37269933 |
|
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Postn |
periostin |
increases expression |
ISO |
Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein |
CTD |
PMID:33746155 |
|
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] |
CTD |
PMID:37269933 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein] |
CTD |
PMID:37269933 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppargc1b |
PPARG coactivator 1 beta |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of PPARGC1B protein celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein] |
CTD |
PMID:37269933 |
|
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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G |
Prkd1 |
protein kinase D1 |
affects localization |
EXP |
Angiotensin II affects localization of Prkd1 protein in cardiomyocytes |
RGD |
PMID:15652511 |
RGD:288084581 |
NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
increases expression |
EXP |
Angiotensin II increases expression of Ptpn1 protein in cardiac microvascular endothelial cells |
RGD |
PMID:31502193 |
RGD:401976382 |
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rbfox2 |
RNA binding fox-1 homolog 2 |
decreases expression |
EXP |
Angiotensin II decreases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells |
RGD |
PMID:28993448 |
RGD:329848961 |
NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691
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G |
Sox17 |
SRY-box transcription factor 17 |
increases expression decreases expression |
ISO |
Angiotensin II increases expression of SOX17 mRNA and protein in retinal microvascular endothelial cells Angiotensin II decreases expression of SOX17 protein in retinal endothelial cells |
RGD |
PMID:36200131 PMID:32078435 |
RGD:329853320, RGD:329853329 |
NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
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G |
Spp1 |
secreted phosphoprotein 1 |
increases expression |
ISO |
Angiotensin II increases expression of Spp1 protein in vascular smooth muscle cells |
RGD |
PMID:28167124 |
RGD:155260287 |
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Tfam |
transcription factor A, mitochondrial |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of TFAM protein celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]] |
CTD |
PMID:37269933 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of TNF mRNA naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA] |
CTD |
PMID:38230784 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Traf6 |
TNF receptor associated factor 6 |
increases expression |
EXP |
Angiotensin II increases expression of Traf6 protein in rat neonatal cardiomyocytes |
RGD |
PMID:27249171 |
RGD:155646134 |
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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G |
Zeb2 |
zinc finger E-box binding homeobox 2 |
decreases expression |
EXP |
Angiotensin II decreases expression of Zeb2 mRNA and protein in rat renal artery endothelial cells |
RGD |
PMID:31881206 |
RGD:155882533 |
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
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G |
Avpr1a |
arginine vasopressin receptor 1A |
multiple interactions increases activity |
ISO |
vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- inhibits the reaction [Arginine Vasopressin results in increased activity of AVPR1A protein] |
CTD |
PMID:31323226 |
|
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression multiple interactions |
EXP |
Arginine Vasopressin results in increased expression of HSPB1 mRNA; Arginine Vasopressin results in increased expression of HSPB1 protein Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]; Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein] |
CTD |
PMID:10839933 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Myl9 |
myosin light chain 9 |
increases phosphorylation |
EXP |
Arginine Vasopressin results in increased phosphorylation of MYL9 protein |
CTD |
PMID:15347643 |
|
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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G |
Nppa |
natriuretic peptide A |
decreases response to substance |
ISO |
NPPA protein results in decreased susceptibility to Arginine Vasopressin |
CTD |
PMID:8188982 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Hcrt |
hypocretin neuropeptide precursor |
decreases expression |
EXP |
salmon calcitonin results in decreased expression of HCRT mRNA |
CTD |
PMID:12686383 |
|
NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
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G |
Pmch |
pro-melanin-concentrating hormone |
decreases expression |
EXP |
salmon calcitonin results in decreased expression of PMCH mRNA |
CTD |
PMID:12686383 |
|
NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
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G |
Ada |
adenosine deaminase |
increases activity |
ISO |
Adrenocorticotropic Hormone results in increased activity of ADA protein |
CTD |
PMID:8868375 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Calca |
calcitonin-related polypeptide alpha |
increases abundance |
EXP |
CALCA protein results in increased abundance of Adrenocorticotropic Hormone |
CTD |
PMID:12639925 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
decreases activity |
EXP |
Adrenocorticotropic Hormone results in decreased activity of CNP protein |
CTD |
PMID:3030154 |
|
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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G |
Crh |
corticotropin releasing hormone |
multiple interactions increases secretion |
EXP |
Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]; E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone] |
CTD |
PMID:18835572 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
affects abundance |
ISO |
CYP17A1 protein affects the abundance of Adrenocorticotropic Hormone |
CTD |
PMID:18645707 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Gh1 |
growth hormone 1 |
multiple interactions |
ISO |
Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] |
CTD |
PMID:3008584 |
|
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions affects expression |
EXP |
Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA] |
CTD |
PMID:18239281 |
|
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] |
CTD |
PMID:3008584 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
affects abundance |
ISO |
NR3C1 gene polymorphism affects the abundance of Adrenocorticotropic Hormone |
CTD |
PMID:17716631 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions |
ISO |
Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone] |
CTD |
PMID:10516482 |
|
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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G |
Ucn2 |
urocortin 2 |
increases abundance |
ISO |
UCN2 protein results in increased abundance of Adrenocorticotropic Hormone |
CTD |
PMID:16330704 |
|
NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172
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G |
Crhr1 |
corticotropin releasing hormone receptor 1 |
increases expression decreases activity multiple interactions |
EXP |
Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA] |
CTD |
PMID:12093084 |
|
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2 |
CTD |
PMID:17704804 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3 |
CTD |
PMID:17704804 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Cckbr |
cholecystokinin B receptor |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2; [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3; [gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA |
CTD |
PMID:17704804 |
|
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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G |
Ier3 |
immediate early response 3 |
multiple interactions |
ISO |
[gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA |
CTD |
PMID:17704804 |
|
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases activity |
ISO |
gastrin 17 results in decreased activity of NFKB1 protein |
CTD |
PMID:15623601 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases activity |
ISO |
gastrin 17 results in decreased activity of RELA protein |
CTD |
PMID:15623601 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sele |
selectin E |
decreases expression |
ISO |
gastrin 17 results in decreased expression of SELE protein |
CTD |
PMID:15623601 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] |
CTD |
PMID:31468622 |
|
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] |
CTD |
PMID:31468622 |
|
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of IL1b mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of Il6 mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mir33 |
microRNA 33 |
multiple interactions |
EXP |
Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] |
CTD |
PMID:31468622 |
|
NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
ghrelin inhibits the reaction [High fat diet increases expression of Tgfb1 mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
ghrelin inhibits the reaction [high fat diet increases expression of TNF mRNA in heart] |
RGD |
PMID:32084395 |
RGD:242905211 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of ACTA2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of ACTA2 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of ADIPOQ protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of and results in decreased secretion of ADIPOQ protein] |
CTD |
PMID:29988851 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Cat |
catalase |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased activity of CAT protein] |
CTD |
PMID:29988851 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of COL1A1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of COL1A1 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CPT1A mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of CPT1A mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein |
CTD |
PMID:22676303 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FASN mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of FASN mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
Glucagon analog promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein]; Glucagon analog promotes the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of FGF21 protein] |
CTD |
PMID:29988851 |
|
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP |
[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC1 mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC1 mRNA] |
CTD |
PMID:22676303 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gcgr |
glucagon receptor |
multiple interactions |
ISO |
Glucagon analog binds to and results in increased activity of GCGR protein |
CTD |
PMID:29988851 |
|
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions |
ISO |
Glucagon analog binds to and results in increased activity of GLP1R protein |
CTD |
PMID:29988851 |
|
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of IL6 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of IL6 protein] |
CTD |
PMID:29988851 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of INS1 protein] |
CTD |
PMID:29988851 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Lep |
leptin |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] |
CTD |
PMID:29988851 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lepr |
leptin receptor |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[LEPR gene mutant form results in increased oxidation of Lipids] which results in increased abundance of Thiobarbituric Acid Reactive Substances]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased activity of CAT protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of and results in decreased secretion of ADIPOQ protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of CPT1A mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of PPARA mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased oxidation of and results in decreased metabolism of Fatty Acids]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Cholesterol]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Triglycerides]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Urea]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of ACTA2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of IL6 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of INS1 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of COL1A1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of FASN mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of MMP9 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SCD1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SREBF1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TGFB1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TNF mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased oxidation of Lipids]; Glucagon analog promotes the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of FGF21 protein] |
CTD |
PMID:29988851 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MMP9 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of MMP9 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
EXP |
[Glucagon co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA] |
CTD |
PMID:22676303 |
|
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of PPARA mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein] |
CTD |
PMID:22676303 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SCD1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SCD1 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SREBF1 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TGFB1 mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TNF mRNA] |
CTD |
PMID:29988851 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein]; Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein |
CTD |
PMID:16055746 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ube2d2 |
ubiquitin-conjugating enzyme E2D 2 |
increases expression |
ISO |
Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 mRNA; Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 protein |
CTD |
PMID:16055746 |
|
NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181
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G |
Ace2 |
angiotensin converting enzyme 2 |
affects abundance |
ISO |
[ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II |
CTD |
PMID:27649628 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II |
CTD |
PMID:27649628 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression |
EXP |
Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein |
CTD |
PMID:12969123 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] |
CTD |
PMID:38230784 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of CCL2 mRNA naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA] |
CTD |
PMID:38230784 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of COL1A1 mRNA NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA] |
CTD |
PMID:33746155 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression |
ISO |
Angiotensin II results in increased expression of COL3A1 mRNA |
CTD |
PMID:33746155 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of CPT1A mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
Angiotensin II results in increased expression of EDNRB protein |
CTD |
PMID:15007106 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Esrra |
estrogen related receptor, alpha |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]] |
CTD |
PMID:37269933 |
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NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of FIS1 protein naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein] |
CTD |
PMID:38230784 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA] |
CTD |
PMID:38230784 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of IL6 protein naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein] |
CTD |
PMID:38230784 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions decreases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein] |
CTD |
PMID:38230784 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Myh6 |
myosin heavy chain 6 |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of MYH6 mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form] |
CTD |
PMID:37269933 |
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NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] |
CTD |
PMID:33746155 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nox4 |
NADPH oxidase 4 |
increases expression multiple interactions |
ISO |
Angiotensin II results in increased expression of NOX4 protein naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA] NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] |
CTD |
PMID:33746155 PMID:38230784 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nppa |
natriuretic peptide A |
multiple interactions increases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA] |
CTD |
PMID:37269933 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions increases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA] |
CTD |
PMID:37269933 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
affects response to substance |
ISO |
NR1I2 protein affects the susceptibility to Angiotensin II |
CTD |
PMID:33746155 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pdha1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of PDHA1 mRNA celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
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G |
Pfkm |
phosphofructokinase, muscle |
multiple interactions increases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Postn |
periostin |
increases expression |
ISO |
Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein |
CTD |
PMID:33746155 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] |
CTD |
PMID:37269933 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of PPARGC1A protein celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein] |
CTD |
PMID:37269933 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppargc1b |
PPARG coactivator 1 beta |
multiple interactions decreases expression |
EXP |
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein] |
CTD |
PMID:37269933 |
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NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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G |
Tfam |
transcription factor A, mitochondrial |
decreases expression multiple interactions |
EXP |
Angiotensin II results in decreased expression of TFAM protein celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]] |
CTD |
PMID:37269933 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA] |
CTD |
PMID:38230784 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression |
ISO |
Angiotensin-(1-7) increases expression of NR1H3 mRNA and protein in macrophages |
RGD |
PMID:25225013 |
RGD:401827926 |
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:37005939 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein |
CTD |
PMID:37005939 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein |
CTD |
PMID:37005939 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP9 mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of HIF1A mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Insr |
insulin receptor |
decreases expression |
EXP |
insulin decreases expression of hepatic mRNA in streptozocin treated rats |
RGD |
PMID:1280238 |
RGD:15036814 |
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Kcnn4 |
potassium calcium-activated channel subfamily N member 4 |
increases expression multiple interactions |
EXP |
insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells 2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits the reaction [insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells] |
RGD |
PMID:21463632 PMID:21463632 |
RGD:401794561, RGD:401794561 |
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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G |
Lpl |
lipoprotein lipase |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA] |
CTD |
PMID:34575692 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose |
CTD |
PMID:36394833 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mir210 |
microRNA 210 |
increases expression multiple interactions |
EXP |
Insulin increases expression of Mir210 miRNA in myocardial cell LY294002 inhibits the reaction [Insulin increases expression of Mir210 miRNA in myocardial cell] |
RGD |
PMID:25968948 PMID:25968948 |
RGD:11086706, RGD:11086706 |
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] |
CTD |
PMID:34575692 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression multiple interactions |
EXP ISO |
insulin increases expression of Srebf1 mRNA in hepatoma cells cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in liver cancer cells] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in primary hepatocytes] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in hepatoma cells] |
RGD |
PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 More...
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RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379 |
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]] |
CTD |
PMID:26614261 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnf |
tumor necrosis factor |
increases secretion |
EXP |
Novorapid inhibits the reaction [Lipopolysaccharide increases secretion of Tnf protein in serum] |
RGD |
PMID:18078960 |
RGD:15023464 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases activity multiple interactions |
ISO |
Neurotensin results in increased activity of FOS protein [Neurotensin results in increased activity of FOS protein] which results in increased expression of CXCL8 protein |
CTD |
PMID:17000667 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases activity multiple interactions |
ISO |
Neurotensin results in increased activity of FOSL1 protein [Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 protein |
CTD |
PMID:17000667 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases activity |
ISO |
[Neurotensin results in increased activity of JUNB protein] which results in increased expression of CXCL8 protein |
CTD |
PMID:17000667 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
increases activity multiple interactions |
ISO |
Neurotensin results in increased activity of NFKB1 protein [Neurotensin results in increased activity of NFKB1 protein] which results in increased expression of CXCL8 mRNA |
CTD |
PMID:17000667 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Ntsr1 |
neurotensin receptor 1 |
affects binding |
ISO |
Neurotensin binds to NTSR1 protein |
CTD |
PMID:19874804 |
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NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377
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G |
Ntsr2 |
neurotensin receptor 2 |
affects binding |
ISO |
Neurotensin binds to NTSR2 protein |
CTD |
PMID:19874804 |
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NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases activity |
ISO |
[Neurotensin results in increased activity of RELA protein] which results in increased expression of CXCL8 mRNA |
CTD |
PMID:17000667 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Oxytocin results in increased expression of BCL2 protein |
CTD |
PMID:23707249 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
EXP |
Oxytocin results in increased expression of EGFR protein modified form |
CTD |
PMID:23707249 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Oxytocin results in increased expression of FOS protein Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein] |
CTD |
PMID:20731630 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gdf9 |
growth differentiation factor 9 |
increases expression |
EXP |
Oxytocin results in increased expression of GDF9 protein |
CTD |
PMID:23707249 |
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NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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G |
Has2 |
hyaluronan synthase 2 |
increases expression |
EXP |
Oxytocin results in increased expression of HAS2 protein |
CTD |
PMID:23707249 |
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NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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G |
Klf4 |
KLF transcription factor 4 |
multiple interactions increases expression |
ISO |
KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein] Oxytocin results in increased expression of KLF4 mRNA; Oxytocin results in increased expression of KLF4 protein |
CTD |
PMID:29104011 |
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NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
multiple interactions |
ISO |
MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] |
CTD |
PMID:29104011 |
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NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression |
EXP |
Oxytocin results in increased expression of MAPK1 protein modified form |
CTD |
PMID:23707249 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases expression |
EXP |
Oxytocin results in increased expression of MAPK3 protein modified form |
CTD |
PMID:23707249 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mef2a |
myocyte enhancer factor 2a |
multiple interactions |
ISO |
MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] |
CTD |
PMID:29104011 |
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NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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G |
Mknk2 |
MAPK interacting serine/threonine kinase 2 |
multiple interactions |
EXP |
Oxytocin inhibits the reaction [Cisplatin results in increased expression of MKNK2 mRNA] |
CTD |
PMID:21993003 |
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NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases response to substance |
EXP |
MMP2 protein results in decreased susceptibility to Oxytocin |
CTD |
PMID:22496348 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases response to substance |
EXP |
MMP9 protein results in decreased susceptibility to Oxytocin |
CTD |
PMID:22496348 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Noxo1 |
NADPH oxidase organizer 1 |
multiple interactions |
EXP |
Oxytocin inhibits the reaction [Cisplatin results in increased expression of NOXO1 mRNA] |
CTD |
PMID:21993003 |
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NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061
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G |
Oxtr |
oxytocin receptor |
multiple interactions increases expression |
EXP ISO |
Oxytocin analog binds to and results in decreased activity of OXTR protein Oxytocin results in increased expression of OXTR protein guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of OXTR protein] |
CTD |
PMID:9502799 PMID:27340106 |
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NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
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G |
Plcb1 |
phospholipase C beta 1 |
affects localization |
ISO |
Oxytocin affects the localization of PLCB1 protein |
CTD |
PMID:11579162 |
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NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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G |
Plcb3 |
phospholipase C beta 3 |
affects localization |
ISO |
Oxytocin affects the localization of PLCB3 protein |
CTD |
PMID:11579162 |
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NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP ISO |
Oxytocin results in increased expression of PTGS2 protein guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of PTGS2 protein] |
CTD |
PMID:23707249 PMID:27340106 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Sele |
selectin E |
multiple interactions |
ISO |
KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein] |
CTD |
PMID:29104011 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Tnfaip6 |
TNF alpha induced protein 6 |
increases expression |
EXP |
Oxytocin results in increased expression of TNFAIP6 protein |
CTD |
PMID:23707249 |
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NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein] |
CTD |
PMID:29104011 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
multiple interactions |
ISO |
pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
ISO |
pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Bmp7 |
bone morphogenetic protein 7 |
multiple interactions |
ISO |
pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
ISO EXP |
NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]] |
CTD |
PMID:23137853 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO EXP |
NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
ISO |
NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]] |
CTD |
PMID:23137853 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
EXP |
pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Id1 |
inhibitor of DNA binding 1 |
multiple interactions |
ISO |
pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] |
CTD |
PMID:23137853 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Nog |
noggin |
multiple interactions |
ISO |
NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] |
CTD |
PMID:23137853 |
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NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
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G |
Smad6 |
SMAD family member 6 |
decreases expression |
EXP |
pasireotide results in decreased expression of SMAD6 mRNA |
CTD |
PMID:23137853 |
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NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763
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G |
Smad7 |
SMAD family member 7 |
decreases expression |
EXP |
pasireotide results in decreased expression of SMAD7 mRNA |
CTD |
PMID:23137853 |
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NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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G |
Sstr1 |
somatostatin receptor 1 |
affects binding |
ISO |
pasireotide binds to SSTR1 protein |
CTD |
PMID:16625840 |
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NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
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G |
Sstr2 |
somatostatin receptor 2 |
affects binding |
ISO |
pasireotide binds to SSTR2 protein |
CTD |
PMID:16625840 |
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NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
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G |
Sstr3 |
somatostatin receptor 3 |
affects binding |
ISO |
pasireotide binds to SSTR3 protein |
CTD |
PMID:16625840 |
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NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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G |
Sstr4 |
somatostatin receptor 4 |
affects binding |
ISO |
pasireotide binds to SSTR4 protein |
CTD |
PMID:16625840 |
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NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689
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G |
Sstr5 |
somatostatin receptor 5 |
affects binding |
ISO |
pasireotide binds to SSTR5 protein |
CTD |
PMID:16625840 |
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NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO EXP |
NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] |
CTD |
PMID:23137853 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
multiple interactions |
EXP |
Somatostatin inhibits the reaction [Dexamethasone results in increased expression of KCNA5 mRNA] |
CTD |
PMID:15955845 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
Somatostatin inhibits the reaction [Glucose increases expression of Ptpn1 protein in photoreceptor cells] |
RGD |
PMID:28050125 |
RGD:401976377 |
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Sstr1 |
somatostatin receptor 1 |
increases expression |
ISO |
Somatostatin results in increased expression of SSTR1 mRNA |
CTD |
PMID:18575731 |
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NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
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G |
Sstr2 |
somatostatin receptor 2 |
increases expression |
ISO |
Somatostatin results in increased expression of SSTR2 mRNA |
CTD |
PMID:18575731 |
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NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
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G |
Sstr3 |
somatostatin receptor 3 |
increases expression |
ISO |
Somatostatin results in increased expression of SSTR3 mRNA |
CTD |
PMID:18575731 |
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NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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G |
Sstr4 |
somatostatin receptor 4 |
increases expression |
ISO |
Somatostatin results in increased expression of SSTR4 mRNA |
CTD |
PMID:18575731 |
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NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689
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G |
Sstr5 |
somatostatin receptor 5 |
increases expression |
ISO |
Somatostatin results in increased expression of SSTR5 mRNA |
CTD |
PMID:18575731 |
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NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
Vasopressins results in increased activity of CFTR protein |
CTD |
PMID:15513933 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Mylk |
myosin light chain kinase |
affects response to substance |
EXP |
MYLK protein affects the susceptibility to Vasopressins |
CTD |
PMID:15347643 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
Vasotocin results in increased activity of CFTR protein |
CTD |
PMID:15685210 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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