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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:angiotensin II
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Accession:CHEBI:48432 term browser browse the term
Synonyms:related_synonym: 1-8-angiotensin I;   ang II;   angiotensina II;   angiotensinum II
 xref: CAS:11128-99-7
 xref_mesh: MESH:D000804


show annotations for term's descendants           Sort by:
angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II CTD PMID:27649628 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II CTD PMID:27649628 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] CTD PMID:38230784 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA] CTD PMID:38230784 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA] CTD PMID:33746155 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Angiotensin II results in increased expression of COL3A1 mRNA CTD PMID:33746155 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]] CTD PMID:37269933 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of ESRRA protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]		 CTD PMID:37269933 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein] CTD PMID:38230784 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of IL1B mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA]		 CTD PMID:38230784 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein] CTD PMID:38230784 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Angiotensin II increases phosphorylation of JAK2 protein in liver RGD PMID:22613986 RGD:127285667 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Klf4 KLF transcription factor 4 increases expression ISO angiotensin II increases expression of KLF4 mRNA and protein in vascular smooth muscle cells RGD PMID:29127880 RGD:155230825 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO Angiotensin II increases expression of MAP3K7 mRNA in cardiomyocytes RGD PMID:30854566 RGD:155791647 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Angiotensin II results in decreased expression of MCL1 protein
naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein]		 CTD PMID:38230784 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir143 microRNA 143 decreases expression ISO Angiotensin II decreases expression of miRNA143 RNA in vascular smooth muscle cells RGD PMID:28167124 RGD:155260287 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir145 microRNA 145 decreases expression ISO angiotensin II decreases expression of MIR145a RNA in vascular smooth muscle cell
Angiotensin II decreases expression of miRNA145 RNA in vascular smooth muscle cells		 RGD PMID:29127880 PMID:28167124 RGD:155230825, RGD:155260287 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form] CTD PMID:37269933 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myocd myocardin decreases expression ISO angiotensin II decreases expression of MYOCD mRNA and protein in vascular smooth muscle cell RGD PMID:29127880 RGD:155230825 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] CTD PMID:33746155 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]		 CTD PMID:33746155 PMID:38230784 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO angiotensin II inhibits reaction [fluvastatin increases expression of Nphs1 protein in kidney] RGD PMID:19188342 RGD:38596324 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions		 ISO
EXP		 angiotensin II increases expression of mRNA in mouse heart
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA]		 CTD
RGD		 PMID:37269933 PMID:26873969 RGD:11526363 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 ISO
EXP		 angiotensin II increases expression of mRNA in mouse heart
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA]		 CTD
RGD		 PMID:37269933 PMID:26873969 RGD:11526363 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Angiotensin II decreases expression of NR1H3 mRNA and protein in macrophages RGD PMID:25225013 RGD:401827926 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Angiotensin II CTD PMID:33746155 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]] CTD PMID:37269933 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pfkm phosphofructokinase, muscle increases expression
multiple interactions		 EXP Angiotensin II results in increased expression of PFKM mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]		 CTD PMID:37269933 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Postn periostin increases expression ISO Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein CTD PMID:33746155 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein] CTD PMID:37269933 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PPARGC1B protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein]		 CTD PMID:37269933 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Prkd1 protein kinase D1 affects localization EXP Angiotensin II affects localization of Prkd1 protein in cardiomyocytes RGD PMID:15652511 RGD:288084581 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression EXP Angiotensin II increases expression of Ptpn1 protein in cardiac microvascular endothelial cells RGD PMID:31502193 RGD:401976382 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 decreases expression EXP Angiotensin II decreases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells RGD PMID:28993448 RGD:329848961 NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691 		JBrowse link
G Sox17 SRY-box transcription factor 17 increases expression
decreases expression 		ISO Angiotensin II increases expression of SOX17 mRNA and protein in retinal microvascular endothelial cells
Angiotensin II decreases expression of SOX17 protein in retinal endothelial cells		 RGD PMID:36200131 PMID:32078435 RGD:329853320, RGD:329853329 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Angiotensin II increases expression of Spp1 protein in vascular smooth muscle cells RGD PMID:28167124 RGD:155260287 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]		 CTD PMID:37269933 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of TNF mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA]		 CTD PMID:38230784 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression EXP Angiotensin II increases expression of Traf6 protein in rat neonatal cardiomyocytes RGD PMID:27249171 RGD:155646134 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression EXP Angiotensin II decreases expression of Zeb2 mRNA and protein in rat renal artery endothelial cells RGD PMID:31881206 RGD:155882533 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
Ile(5)-angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II CTD PMID:27649628 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II CTD PMID:27649628 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] CTD PMID:38230784 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of CCL2 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA]		 CTD PMID:38230784 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of COL1A1 mRNA
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]		 CTD PMID:33746155 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Angiotensin II results in increased expression of COL3A1 mRNA CTD PMID:33746155 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of CPT1A mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]		 CTD PMID:37269933 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]] CTD PMID:37269933 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of FIS1 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein]		 CTD PMID:38230784 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA] CTD PMID:38230784 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of IL6 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein]		 CTD PMID:38230784 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein] CTD PMID:38230784 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of MYH6 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form]		 CTD PMID:37269933 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] CTD PMID:33746155 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of NOX4 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]		 CTD PMID:33746155 PMID:38230784 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA] CTD PMID:37269933 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA] CTD PMID:37269933 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Angiotensin II CTD PMID:33746155 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PDHA1 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]		 CTD PMID:37269933 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Postn periostin increases expression ISO Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein CTD PMID:33746155 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PPARGC1A protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein]		 CTD PMID:37269933 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein] CTD PMID:37269933 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]		 CTD PMID:37269933 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA] CTD PMID:38230784 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        molecular messenger 18650
          hormone 18457
            peptide hormone 152
              angiotensin 46
                angiotensin II 46
                  Ile(5)-angiotensin II 28
                  Val(5)-angiotensin II 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              peptide 11120
                                                peptide hormone 152
                                                  angiotensin 46
                                                    angiotensin II 46
                                                      Ile(5)-angiotensin II 28
                                                      Val(5)-angiotensin II 0
paths to the root