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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxytocin
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Accession:CHEBI:7872 term browser browse the term
Definition:A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.
Synonyms:exact_synonym: 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
 related_synonym: (1-Hemicystine)oxytocin;   3-Isoleucine-8-leucine vasopressin;   Endopituitrina;   Formula=C43H66N12O12S2;   InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1;   InChIKey=XNOPRXBHLZRZKH-DSZYJQQASA-N;   L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide;   OT;   OXT;   Ocytocin;   Orasthin;   Pitocin;   Piton S;   SMILES=[H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC;   Syntocinon;   oxitocina;   oxytocine;   oxytocinum
 xref: Beilstein:3586108;   CAS:50-56-6;   DrugBank:DB00107;   Drug_Central:2042;   HMDB:HMDB0002865;   KEGG:C00746;   KEGG:D00089
 xref_mesh: MESH:D010121
 xref: PMID:10027619;   PMID:10834934;   PMID:10949083;   PMID:10949750;   PMID:10983343;   PMID:11134819;   PMID:13305558;   PMID:15815422;   PMID:18593851;   PMID:18988842;   PMID:19104313;   PMID:19369205;   PMID:19482229;   PMID:24706799;   PMID:25209411;   PMID:32509991;   PMID:32683141;   PMID:32979349;   PMID:33192340;   Patent:US2938891;   Patent:US3076797;   Wikipedia:Oxytocin


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oxytocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression EXP Oxytocin results in increased expression of BCL2 protein CTD PMID:23707249 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Oxytocin results in increased expression of EGFR protein modified form CTD PMID:23707249 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Oxytocin results in increased expression of FOS protein
Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein]
CTD PMID:20731630 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression EXP Oxytocin results in increased expression of GDF9 protein CTD PMID:23707249 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940
JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Oxytocin results in increased expression of HAS2 protein CTD PMID:23707249 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
increases expression
ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]
Oxytocin results in increased expression of KLF4 mRNA; Oxytocin results in increased expression of KLF4 protein
CTD PMID:29104011 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP Oxytocin results in increased expression of MAPK1 protein modified form CTD PMID:23707249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression EXP Oxytocin results in increased expression of MAPK3 protein modified form CTD PMID:23707249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of MKNK2 mRNA] CTD PMID:21993003 NCBI chr 7:11,908,107...11,919,161
Ensembl chr 7:11,908,107...11,919,156
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases response to substance EXP MMP2 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance EXP MMP9 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of NOXO1 mRNA] CTD PMID:21993003 NCBI chr10:14,062,331...14,066,918
Ensembl chr10:14,062,331...14,066,918
JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression
EXP
ISO
Oxytocin analog binds to and results in decreased activity of OXTR protein
Oxytocin results in increased expression of OXTR protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of OXTR protein]
CTD PMID:9502799 PMID:27340106 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G Plcb1 phospholipase C beta 1 affects localization ISO Oxytocin affects the localization of PLCB1 protein CTD PMID:11579162 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb3 phospholipase C beta 3 affects localization ISO Oxytocin affects the localization of PLCB3 protein CTD PMID:11579162 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP
ISO
Oxytocin results in increased expression of PTGS2 protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of PTGS2 protein]
CTD PMID:23707249 PMID:27340106 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sele selectin E multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein] CTD PMID:29104011 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression EXP Oxytocin results in increased expression of TNFAIP6 protein CTD PMID:23707249 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein] CTD PMID:29104011 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        molecular messenger 18298
          hormone 18068
            peptide hormone 100
              oxytocin 21
                demoxytocin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                peptide 9420
                                                  cyclic peptide 8741
                                                    heterodetic cyclic peptide 1446
                                                      oxytocin 21
                                                        demoxytocin 0
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