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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glp1r
Name: glucagon-like peptide 1 receptor
Acc ID: CHEBI:75431
Term: ghrelin
Definition: A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser(octanoyl), Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence. The O-n-octanoylation of the side-chain hydroxy group of serine-3 (Ser3) is essential for ghrelin's activity.
Chemical ID: MESH:D054439
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glp1rmultiple interactionsEXP 6480464CTDGhrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA]PMID:31468622
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