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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corticotropin-releasing hormone
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Accession:CHEBI:65311 term browser browse the term
Definition:A family of peptide hormones derived from a 191-membered prehormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The first full sequence was discovered in sheep, those in rats and humans differ from the ovine sequence by 7 amino acids.
Synonyms:related_synonym: CRH;   corticotropin-releasing factor
 xref_mesh: MESH:D003346
 xref: PMID:22494987;   PMID:6267699;   Wikipedia:Corticotropin-releasing_hormone



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corticotropin-releasing hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 increases expression
multiple interactions
decreases activity
EXP Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA
Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]
CTD PMID:12093084 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        molecular messenger 18313
          neurotransmitter 10940
            corticotropin-releasing hormone 1
              corticotropin-releasing hormone (human) 0
              corticotropin-releasing hormone (ovine) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                peptide 9461
                                                  polypeptide 198
                                                    corticotropin-releasing hormone 1
                                                      corticotropin-releasing hormone (human) 0
                                                      corticotropin-releasing hormone (ovine) 0
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