CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ghrelin
Accession: CHEBI:75431
Definition: A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser(octanoyl), Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence. The O-n-octanoylation of the side-chain hydroxy group of serine-3 (Ser3) is essential for ghrelin's activity.
Synonyms: exact_synonym: glycyl-L-seryl-O-octanoyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine related_synonym: Formula=C149H249N47O42; GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR; GSS(octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR; Gastric MLTRP; Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg; H-Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH; Human ghrelin; InChI=1S/C149H249N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h13-15,32-33,74,79-83,86-110,119,197-199H,9-12,16-31,34-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1; InChIKey=GNKDKYIHGQKHHM-RJKLHVOGSA-N; Motilin-related peptide; SMILES=C(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N1[C@@H](CCC1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N4[C@@H](CCC4)C(=O)N[C@H](C(=O)O)CCCNC(=N)N)=O)CCC(=O)N)CC(C)C)CCCCN)C)=O)=O)CCCCN)CCCCN)CO)CCC(=O)O)CCCCN)CCCNC(N)=N)CCC(=O)N)CCC(=O)N)C(C)C)CCCNC(N)=N)CCC(=O)N)CC=5N=CNC5)CCC(=O)O)=O)CO)CC(C)C)CC=6C=CC=CC6)COC(=O)CCCCCCC)CO)N; lenomorelin; lenomorelina; lenomoreline; lenomorelinum xref: CAS:258279-04-8; CAS:304853-26-7; KEGG:C16025 xref_mesh: MESH:D054439 xref: PMID:15788704; PMID:23159561; PMID:23178701; PMID:23278489; PMID:23307791; PMID:23316086; PMID:23317782; PMID:23359315; PMID:23428971; PMID:23481295; PMID:23524619; PMID:23624808; PMID:23631903; PMID:23652386; PMID:23652399; PMID:23652420; PMID:23698230; PMID:23704134; PMID:23778458; PMID:23804489; PMID:23808302; PMID:23843943; PMID:23847595; PMID:23965296; PMID:23982275; PMID:23989358; PMID:28538835; PMID:28542403; PMID:28547758; PMID:28590260; PMID:28621678; PMID:28704966; Reaxys:24715767; Wikipedia:Ghrelin
G
Cnr1 cannabinoid receptor 1
multiple interactions
EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA]
CTD PMID:31468622
NCBI chr 5:48,408,543...48,436,099
G
Glp1r glucagon-like peptide 1 receptor
multiple interactions
EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA]
CTD PMID:31468622
NCBI chr20:8,972,004...9,010,241
G
Il1b interleukin 1 beta
multiple interactions
ISO ghrelin inhibits the reaction [High fat diet increases expression of IL1b mRNA in heart]
RGD
PMID:32084395 RGD:242905211
NCBI chr 3:116,577,005...116,583,386
G
Il6 interleukin 6
multiple interactions
ISO ghrelin inhibits the reaction [High fat diet increases expression of Il6 mRNA in heart]
RGD
PMID:32084395 RGD:242905211
NCBI chr 4:5,214,602...5,219,178
G
Mir33 microRNA 33
multiple interactions
EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA]
CTD PMID:31468622
NCBI chr 7:113,713,855...113,713,923
G
Tgfb1 transforming growth factor, beta 1
multiple interactions
ISO ghrelin inhibits the reaction [High fat diet increases expression of Tgfb1 mRNA in heart]
RGD
PMID:32084395 RGD:242905211
NCBI chr 1:81,196,532...81,212,848
G
Tnf tumor necrosis factor
multiple interactions
ISO ghrelin inhibits the reaction [high fat diet increases expression of TNF mRNA in heart]
RGD
PMID:32084395 RGD:242905211
NCBI chr20:3,622,011...3,624,629
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