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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
Acc ID: CHEBI:65311
Term: corticotropin-releasing hormone
Definition: A family of peptide hormones derived from a 191-membered prehormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The first full sequence was discovered in sheep, those in rats and humans differ from the ovine sequence by 7 amino acids.
Chemical ID: MESH:D003346
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhr1decreases activityEXP 6480464CTDCorticotropin-Releasing Hormone results in decreased activity of CRHR1 proteinPMID:12093084
Crhr1increases expressionEXP 6480464CTDCorticotropin-Releasing Hormone results in increased expression of CRHR1 mRNAPMID:12093084
Crhr1multiple interactionsEXP 6480464CTDPentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]PMID:12093084
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