The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells 2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits the reaction [insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells]
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]
[[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose
Insulin increases expression of Mir210 miRNA in myocardial cell LY294002 inhibits the reaction [Insulin increases expression of Mir210 miRNA in myocardial cell]
[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
insulin increases expression of Srebf1 mRNA in hepatoma cells cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in liver cancer cells] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in primary hepatocytes] cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in hepatoma cells]
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