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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:neurotensin
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Accession:CHEBI:7542 term browser browse the term
Definition:A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
 related_synonym: 5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu;   5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu-OH;  
 xref: CAS:39379-15-2;   CAS:55508-42-4;   CAS:58889-67-1;   KEGG:C01836
 xref_mesh: MESH:D009496
 xref: PMID:17000667;   PMID:21124211;   PMID:21549161;   PMID:23526754;   PMID:25189338;   PMID:25215420;   PMID:26453765;   PMID:27173113;   PMID:28316623;   PMID:28341345;   PMID:28887225;   PMID:29333632;   PMID:29938867;   PMID:30279001;   PMID:31079844;   PMID:31204518;   PMID:32057800;   PMID:32151680;   PMID:32168264;   PMID:32275927;   Wikipedia:Neurotensin
 cyclic_relationship: is_conjugate_base_of CHEBI:147362


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neurotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases activity
multiple interactions
ISO Neurotensin results in increased activity of FOS protein
[Neurotensin results in increased activity of FOS protein] which results in increased expression of CXCL8 protein
CTD PMID:17000667 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases activity
multiple interactions
ISO Neurotensin results in increased activity of FOSL1 protein
[Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 protein
CTD PMID:17000667 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases activity
ISO [Neurotensin results in increased activity of JUNB protein] which results in increased expression of CXCL8 protein CTD PMID:17000667 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
ISO Neurotensin results in increased activity of NFKB1 protein
[Neurotensin results in increased activity of NFKB1 protein] which results in increased expression of CXCL8 mRNA
CTD PMID:17000667 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ntsr1 neurotensin receptor 1 affects binding ISO Neurotensin binds to NTSR1 protein CTD PMID:19874804 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Ntsr2 neurotensin receptor 2 affects binding ISO Neurotensin binds to NTSR2 protein CTD PMID:19874804 NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO [Neurotensin results in increased activity of RELA protein] which results in increased expression of CXCL8 mRNA CTD PMID:17000667 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link

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Path 1
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        mitogen 3448
          neurotensin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                peptide 9444
                                                  peptide hormone 101
                                                    neurotensin 7
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