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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:neurotensin
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Accession:CHEBI:7542 term browser browse the term
Definition:A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
 related_synonym: 5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu;   5-oxo-L-Pro-L-Leu-L-Tyr-L-Glu-L-Asn-L-Lys-L-Pro-L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu-OH;  
 xref: CAS:39379-15-2;   CAS:55508-42-4;   CAS:58889-67-1;   KEGG:C01836
 xref_mesh: MESH:D009496
 xref: PMID:17000667;   PMID:21124211;   PMID:21549161;   PMID:23526754;   PMID:25189338;   PMID:25215420;   PMID:26453765;   PMID:27173113;   PMID:28316623;   PMID:28341345;   PMID:28887225;   PMID:29333632;   PMID:29938867;   PMID:30279001;   PMID:31079844;   PMID:31204518;   PMID:32057800;   PMID:32151680;   PMID:32168264;   PMID:32275927;   Wikipedia:Neurotensin
 cyclic_relationship: is_conjugate_base_of CHEBI:147362


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neurotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases activity
multiple interactions
ISO Neurotensin results in increased activity of FOS protein
[Neurotensin results in increased activity of FOS protein] which results in increased expression of CXCL8 protein
CTD PMID:17000667 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases activity
multiple interactions
ISO Neurotensin results in increased activity of FOSL1 protein
[Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 protein
CTD PMID:17000667 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases activity
ISO [Neurotensin results in increased activity of JUNB protein] which results in increased expression of CXCL8 protein CTD PMID:17000667 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
ISO Neurotensin results in increased activity of NFKB1 protein
[Neurotensin results in increased activity of NFKB1 protein] which results in increased expression of CXCL8 mRNA
CTD PMID:17000667 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ntsr1 neurotensin receptor 1 affects binding ISO Neurotensin binds to NTSR1 protein CTD PMID:19874804 NCBI chr 3:175,982,313...176,046,345
Ensembl chr 3:175,885,894...176,046,345
JBrowse link
G Ntsr2 neurotensin receptor 2 affects binding ISO Neurotensin binds to NTSR2 protein CTD PMID:19874804 NCBI chr 6:41,917,065...41,923,780
Ensembl chr 6:41,917,132...41,923,542
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO [Neurotensin results in increased activity of RELA protein] which results in increased expression of CXCL8 mRNA CTD PMID:17000667 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        mitogen 2916
          neurotensin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                peptide 9395
                                                  peptide hormone 99
                                                    neurotensin 7
paths to the root