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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2368
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Acc ID: CHEBI:3892
Term: corticotropin
Definition: A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.
Chemical ID: MESH:D000324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cnpdecreases activityEXP 6480464CTDAdrenocorticotropic Hormone results in decreased activity of CNP protein

PMID:3030154
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