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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrrolidin-2-ones
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Accession:CHEBI:74223 term browser browse the term
Definition:A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
Synonyms:related_synonym: 2-pyrrolidinones;   2-pyrrolidones;   Formula=C4NOR7;   SMILES=[*]N1C(=O)C([*])([*])C([*])([*])C1([*])[*];   pyrrolidine-2-ones


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(-)-cotinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of AGER gene CTD PMID:34009014 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor affects methylation ISO Cotinine affects the methylation of AHRR gene CTD PMID:22851337 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Cotinine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]		 CTD PMID:22687995 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bsg basigin multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of BSG gene CTD PMID:34009014 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:22687995 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein] CTD PMID:22687995 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Cotinine results in increased expression of CCND1 protein CTD PMID:31678612 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein CTD PMID:29617909 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA CTD PMID:29617909 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
multiple interactions		 ISO CHRNA7 protein mutant form results in increased susceptibility to Cotinine
Cotinine binds to and results in increased activity of CHRNA7 protein		 CTD PMID:10082212 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cntnap2 contactin associated protein 2 affects methylation ISO Cotinine affects the methylation of CNTNAP2 gene CTD PMID:22851337 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects methylation ISO Cotinine affects the methylation of CYP1A1 gene CTD PMID:22851337 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
decreases activity		 ISO Cotinine results in increased activity of CYP1A2 protein
Cotinine results in decreased activity of CYP1A2 protein		 CTD PMID:15916432 PMID:16203240 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases abundance
multiple interactions		 EXP CYP2B1 protein results in increased abundance of Cotinine
[Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine		 CTD PMID:10799646 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of Cotinine CTD PMID:12488541 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Dcx doublecortin multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of DCX mRNA CTD PMID:37914285 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of DLGAP2 gene CTD PMID:34009014 NCBI chr16:74,786,771...75,496,402
Ensembl chr16:74,791,509...75,496,407 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 affects methylation ISO Cotinine affects the methylation of EXT1 gene CTD PMID:22851337 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of FHIT gene CTD PMID:34009014 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor affects methylation ISO Cotinine affects the methylation of GFI1 gene CTD PMID:22851337 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA CTD PMID:29617909 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA CTD PMID:29617909 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of MAP2 mRNA CTD PMID:37914285 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK1 protein CTD PMID:31678612 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK3 protein CTD PMID:31678612 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Cotinine results in increased expression of MKI67 protein CTD PMID:31678612 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Myo1g myosin IG affects methylation ISO Cotinine affects the methylation of MYO1G gene CTD PMID:22851337 NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects abundance		 ISO NAT1 gene polymorphism affects the reaction [Tobacco Smoke Pollution results in increased abundance of Cotinine]
NAT1 gene polymorphism affects the abundance of Cotinine		 CTD PMID:25156213 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of PAX6 mRNA CTD PMID:37914285 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein CTD PMID:29617909 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of PRKG1 gene CTD PMID:34009014 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions ISO [diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of RBFOX3 mRNA CTD PMID:37914285 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935 		JBrowse link
G Runx1 RUNX family transcription factor 1 affects methylation ISO Cotinine affects the methylation of RUNX1 gene CTD PMID:22851337 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein CTD PMID:29617909 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein CTD PMID:29617909 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA CTD PMID:29617909 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cotinine results in increased phosphorylation of STAT3 protein CTD PMID:31678612 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA CTD PMID:29617909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ttc7b tetratricopeptide repeat domain 7B affects methylation ISO Cotinine affects the methylation of TTC7B gene CTD PMID:22851337 NCBI chr 6:119,587,389...119,799,167
Ensembl chr 6:119,587,390...119,799,330 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768 PMID:16141602 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Cotinine CTD PMID:16141602 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
aniracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of aniracetam CTD PMID:9300133 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of aniracetam CTD PMID:9300133 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
doxapram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone increases expression EXP Doxapram results in increased expression of CRH mRNA; Doxapram results in increased expression of CRH protein CTD PMID:16269353 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Prl prolactin increases expression ISO Doxapram results in increased expression of PRL protein CTD PMID:15741000 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
levetiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases transport
decreases activity		 EXP
ISO		 Amino Acids, Peptides, and Proteins inhibits the reaction [Levetiracetam results in increased expression of ABCB1 protein]
ABCB1A protein results in increased transport of Levetiracetam
Levetiracetam results in decreased activity of ABCB1 protein		 CTD PMID:17045309 PMID:18408562 PMID:18473823 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Levetiracetam results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Levetiracetam results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Levetiracetam results in decreased expression of ACVRL1 mRNA CTD PMID:20345932 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 decreases expression EXP Levetiracetam results in decreased expression of ARHGEF1 mRNA CTD PMID:20345932 NCBI chr 1:80,499,026...80,520,954
Ensembl chr 1:80,499,131...80,520,953 		JBrowse link
G Atg7 autophagy related 7 decreases expression
multiple interactions		 EXP Levetiracetam results in decreased expression of ATG7 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of ATG7 protein]		 CTD PMID:37098359 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Levetiracetam results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of BCL2 protein]		 CTD PMID:37098359 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 decreases expression EXP Levetiracetam results in decreased expression of CACNB1 mRNA CTD PMID:20345932 NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Levetiracetam results in increased activity of CASP3 protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of CASP3 protein]		 CTD PMID:37098359 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases expression		 ISO
EXP		 Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of CAT protein]		 CTD PMID:17205390 PMID:37098359 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnh cyclin H increases expression EXP Levetiracetam results in increased expression of CCNH mRNA CTD PMID:20345932 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases activity
decreases expression		 ISO Levetiracetam results in increased activity of CHRM2 protein
Levetiracetam results in decreased expression of CHRM2 protein		 CTD PMID:15967574 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression EXP Levetiracetam results in increased expression of CXCR3 mRNA CTD PMID:20345932 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions		 EXP Levetiracetam results in increased expression of CYCS protein
Quercetin inhibits the reaction [Levetiracetam results in increased expression of CYCS protein]		 CTD PMID:37098359 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP17A1 mRNA CTD PMID:19566492 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP19A1 mRNA CTD PMID:19566492 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Dao D-amino-acid oxidase increases expression EXP Levetiracetam results in increased expression of DAO mRNA CTD PMID:20345932 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Levetiracetam results in decreased expression of DBP mRNA CTD PMID:20345932 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Des desmin increases expression EXP Levetiracetam results in increased expression of DES mRNA CTD PMID:20345932 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression		 EXP Quercetin inhibits the reaction [Levetiracetam results in increased expression of GJA1 protein] CTD PMID:37098359 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gle1 GLE1 RNA export mediator increases expression EXP Levetiracetam results in increased expression of GLE1 mRNA CTD PMID:20345932 NCBI chr 3:13,209,312...13,237,018
Ensembl chr 3:13,209,322...13,237,379 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP Levetiracetam results in increased activity of GOT1 protein CTD PMID:37572749 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Levetiracetam results in increased activity of GPT protein CTD PMID:37572749 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression
multiple interactions		 EXP Levetiracetam results in decreased activity of GPX1 protein
Levetiracetam results in decreased expression of GPX1 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of GPX1 protein]		 CTD PMID:37098359 PMID:37572749 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases expression EXP Levetiracetam results in decreased expression of HCN2 mRNA CTD PMID:20345932 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hdac10 histone deacetylase 10 decreases expression EXP Levetiracetam results in decreased expression of HDAC10 mRNA CTD PMID:20345932 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Levetiracetam results in decreased expression of HMOX1 protein CTD PMID:37098359 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of HMOX2 protein] CTD PMID:37098359 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression ISO Levetiracetam results in decreased expression of HSD3B2 mRNA CTD PMID:19566492 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases activity		 EXP Quercetin inhibits the reaction [Levetiracetam results in increased activity of IL1B protein] CTD PMID:37098359 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 increases expression EXP Levetiracetam results in increased expression of KCNA4 mRNA CTD PMID:20345932 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162 		JBrowse link
G Kctd3 potassium channel tetramerization domain containing 3 increases expression EXP Levetiracetam results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718 		JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases expression EXP Levetiracetam results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530 		JBrowse link
G Lap3 leucine aminopeptidase 3 increases expression EXP Levetiracetam results in increased expression of LAP3 mRNA CTD PMID:20345932 NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359 		JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated increases expression EXP Levetiracetam results in increased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of MTOR protein] CTD PMID:37098359 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 increases expression EXP Levetiracetam results in increased expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:68,174,051...68,176,449
Ensembl chr  X:68,173,987...68,176,666 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NFE2L2 protein] CTD PMID:37098359 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngly1 N-glycanase 1 increases expression EXP Levetiracetam results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NOX1 protein] CTD PMID:37098359 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression EXP Levetiracetam results in decreased expression of PHLDB1 mRNA CTD PMID:20345932 NCBI chr 8:45,003,543...45,051,541
Ensembl chr 8:45,003,538...45,051,522 		JBrowse link
G Pon1 paraoxonase 1 affects activity ISO Levetiracetam affects the activity of PON1 protein CTD PMID:28032682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit increases expression EXP Levetiracetam results in increased expression of PRKX mRNA CTD PMID:20345932 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Psip1 PC4 and SRSF1 interacting protein 1 increases expression EXP Levetiracetam results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257 		JBrowse link
G Serinc1 serine incorporator 1 increases expression EXP Levetiracetam results in increased expression of SERINC1 mRNA CTD PMID:20345932 NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression EXP Levetiracetam results in increased expression of SLC23A2 mRNA CTD PMID:20345932 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 increases expression EXP Levetiracetam results in increased expression of SLC4A7 mRNA CTD PMID:20345932 NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP Levetiracetam results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions
decreases expression		 EXP Levetiracetam results in decreased activity of SOD1 protein
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of SOD1 protein]		 CTD PMID:37098359 PMID:37572749 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Levetiracetam results in decreased expression of STAR mRNA CTD PMID:19566492 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tent2 terminal nucleotidyltransferase 2 increases expression EXP Levetiracetam results in increased expression of TENT2 mRNA CTD PMID:20345932 NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099 		JBrowse link
G Tnf tumor necrosis factor increases activity
multiple interactions		 EXP Levetiracetam results in increased activity of TNF protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of TNF protein]		 CTD PMID:37098359 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions		 EXP Levetiracetam results in increased activity of TP53 protein
Quercetin inhibits the reaction [Levetiracetam results in increased activity of TP53 protein]		 CTD PMID:37098359 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP Levetiracetam results in decreased expression of TRDMT1 mRNA CTD PMID:20345932 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial decreases expression EXP Levetiracetam results in decreased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression EXP Levetiracetam results in decreased expression of XRCC1 mRNA CTD PMID:20345932 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Zfp266 zinc finger protein 266 increases expression EXP Levetiracetam results in increased expression of ZFP266 mRNA CTD PMID:20345932 NCBI chr 8:19,030,766...19,061,381
Ensembl chr 8:19,030,768...19,060,937 		JBrowse link
N-Vinyl-2-pyrrolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ABCC2 mRNA CTD PMID:22037397 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ABCC3 mRNA CTD PMID:22037397 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of AKT1 mRNA CTD PMID:22037397 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of AKT2 mRNA CTD PMID:22037397 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of BCAR1 mRNA CTD PMID:22037397 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Capn1 calpain 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CAPN1 mRNA CTD PMID:22037397 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CRK mRNA CTD PMID:22037397 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Csnk1d casein kinase 1, delta multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK1D mRNA CTD PMID:22037397 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614 		JBrowse link
G Csnk1e casein kinase 1, epsilon multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK1E mRNA CTD PMID:22037397 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK2A1 mRNA CTD PMID:22037397 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CSNK2A2 mRNA CTD PMID:22037397 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP2B1 mRNA CTD PMID:22037397 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP3A23-3A1 mRNA CTD PMID:22037397 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of CYP3A9 mRNA CTD PMID:22037397 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of DDR1 mRNA CTD PMID:22037397 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Foxg1 forkhead box G1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of FOXG1 mRNA CTD PMID:22037397 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of HDAC1 mRNA CTD PMID:22037397 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Ilk integrin-linked kinase multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of ILK mRNA CTD PMID:22037397 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of LEF1 mRNA CTD PMID:22037397 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of PIK3R2 mRNA CTD PMID:22037397 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of PPP2R1A mRNA CTD PMID:22037397 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of SLC5A5 mRNA CTD PMID:22037397 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tcf3 transcription factor 3 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TCF3 mRNA CTD PMID:22037397 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TGFB1 mRNA CTD PMID:22037397 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TGFBR2 mRNA CTD PMID:22037397 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TPO mRNA CTD PMID:22037397 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TSHB protein CTD PMID:22037397 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of UGT2B1 mRNA CTD PMID:22037397 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Wnt4 Wnt family member 4 multiple interactions EXP [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of WNT4 mRNA CTD PMID:22037397 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
rolipram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions ISO Rolipram promotes the reaction [ADCYAP1 protein affects the secretion of Acids] CTD PMID:20388963 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Rolipram results in increased phosphorylation of AKT1 protein]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Rolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Areg amphiregulin increases expression ISO Rolipram results in increased expression of AREG mRNA CTD PMID:15284208 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein] CTD PMID:31161640 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:31161640 PMID:37431890 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]; Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]
Rolipram results in increased expression of BDNF mRNA		 CTD PMID:8601816 PMID:31161640 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Rolipram inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein] CTD PMID:37431890 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein] CTD PMID:31161640 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Rolipram inhibits the reaction [Oxygen results in increased expression of CCL2 protein] CTD PMID:18941502 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:9863660 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO PDE4D protein inhibits the reaction [Rolipram results in increased expression of CDH1 protein]
Rolipram results in increased expression of CDH1 mRNA; Rolipram results in increased expression of CDH1 protein		 CTD PMID:37020384 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP Rolipram promotes the reaction [FSHB protein results in increased expression of CEBPB protein] CTD PMID:25253736 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
decreases activity		 ISO Rolipram promotes the reaction [CFTR protein affects the secretion of Chlorides]
Rolipram results in increased activity of CFTR protein
Rolipram results in decreased activity of CFTR protein		 CTD PMID:12714375 PMID:15611099 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
increases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Rolipram results in increased phosphorylation of CREB1 protein
Rolipram results in increased expression of CREB1 mRNA		 CTD PMID:8601816 PMID:10908723 PMID:18276108 PMID:31161640 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Rolipram results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]] CTD PMID:28859905 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Edn1 endothelin 1 increases activity EXP Rolipram results in increased activity of EDN1 protein CTD PMID:15464066 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Rolipram inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP
ISO		 Rolipram promotes the reaction [FSHB protein results in increased expression of CEBPB protein]; Rolipram promotes the reaction [FSHB protein results in increased expression of STAR mRNA]
Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]]; Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]		 CTD PMID:25253736 PMID:28859905 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Rolipram results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 decreases expression
decreases secretion		 ISO Rolipram results in decreased expression of IL13 mRNA
Rolipram results in decreased secretion of IL13 protein		 CTD PMID:16083514 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
Rolipram promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]
Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]		 CTD PMID:8904084 PMID:16442096 PMID:18710439 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]
Rolipram promotes the reaction [TNF protein results in increased expression of IL6 mRNA]		 CTD PMID:16442096 PMID:24771768 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein] CTD PMID:21457779 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rolipram results in decreased activity of KCNH2 protein CTD PMID:17146843 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Rolipram results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein] CTD PMID:35137321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein] CTD PMID:35137321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO PDE4D protein inhibits the reaction [Rolipram results in decreased expression of MMP9 protein]
Rolipram results in decreased expression of MMP9 mRNA; Rolipram results in decreased expression of MMP9 protein		 CTD PMID:37020384 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP		 Rolipram inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]
Rolipram inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Rolipram inhibits the reaction [Indomethacin results in increased activity of MPO protein]		 CTD PMID:14567935 PMID:16442096 PMID:18710439 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18710439 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions		 EXP
ISO		 Rolipram results in increased expression of NTRK2 mRNA
Rolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein]		 CTD PMID:8601816 PMID:31631060 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions
decreases activity		 ISO
EXP		 [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA
Rolipram results in decreased activity of PDE4A protein		 CTD PMID:10763856 PMID:15922051 PMID:31195342 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions
decreases activity		 ISO
EXP		 [Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA
Rolipram results in decreased activity of PDE4B protein
Rolipram inhibits the reaction [Manganese results in increased expression of PDE4B protein]
Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]		 CTD PMID:10763856 PMID:20384571 PMID:31161640 PMID:31195342 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4d phosphodiesterase 4D decreases expression
multiple interactions		 ISO Rolipram results in decreased expression of PDE4D protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of MMP9 protein]; PDE4D protein inhibits the reaction [Rolipram results in decreased expression of TIMP1 protein]; PDE4D protein inhibits the reaction [Rolipram results in decreased expression of VIM protein]; PDE4D protein inhibits the reaction [Rolipram results in increased expression of CDH1 protein]		 CTD PMID:37020384 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Rolipram affects the reaction [Colforsin results in increased activity of RAP1A protein] CTD PMID:10908723 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family multiple interactions EXP Rolipram affects the reaction [Colforsin results in increased activity of RAP1B protein] CTD PMID:10908723 NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression		 EXP RAPGEF3 mutant form inhibits the reaction [Rolipram results in increased phosphorylation of AKT1 protein]
Rolipram results in increased expression of RAPGEF3 protein		 CTD PMID:18276108 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521 		JBrowse link
G Sele selectin E multiple interactions ISO [Colforsin co-treated with Rolipram] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein] CTD PMID:8780174 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO Rolipram results in decreased expression of SMAD1 protein CTD PMID:37020384 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Rolipram results in decreased expression of SMAD4 protein CTD PMID:37020384 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression		 ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]; [[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein; dorsomorphin inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]
Rolipram results in increased expression of SOCS3 protein		 CTD PMID:23782265 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 mRNA]; Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 protein] CTD PMID:18941502 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO		 Rolipram promotes the reaction [FSHB protein results in increased expression of STAR mRNA]
Rolipram inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]		 CTD PMID:25253736 PMID:28859905 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion ISO Rolipram results in decreased secretion of TGFB1 protein CTD PMID:37020384 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions		 ISO Rolipram results in decreased expression of TIMP1 mRNA; Rolipram results in decreased expression of TIMP1 protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of TIMP1 protein]		 CTD PMID:37020384 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 Rolipram inhibits the reaction [[Lipopolysaccharides co-treated with deoxynivalenol] results in increased expression of TNF protein]
[Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Rolipram promotes the reaction [TNF protein results in increased expression of IL6 mRNA]
Rolipram results in decreased secretion of TNF protein
Rolipram results in decreased expression of TNF protein
Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of TNF mRNA]		 CTD PMID:8780174 PMID:8937731 PMID:9819297 PMID:11922776 PMID:15231041 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO Rolipram results in decreased expression of VIM protein
PDE4D protein inhibits the reaction [Rolipram results in decreased expression of VIM protein]		 CTD PMID:37020384 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    chemical entity 19846
      atom 19846
        nonmetal atom 19784
          nitrogen atom 18965
            nitrogen molecular entity 18965
              organonitrogen compound 18816
                organonitrogen heterocyclic compound 18155
                  pyrrolidines 2327
                    pyrrolidinone 190
                      pyrrolidin-2-ones 167
                        (-)-cotinine + 42
                        (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                        (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                        (2S)-2-[(3S)-3-\{[(6-chloronaphthalen-2-yl)sulfonyl]amino\}-2-oxopyrrolidin-1-yl]-N-(1-methylethyl)-N-\{2-[(methylsulfonyl)amino]ethyl\}propanamide 0
                        (2S)-N-((1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-\{[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]amino\}propyl)-3-methyl-2-(2-oxopyrrolidin-1-yl)butanamide 0
                        (3S)-1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-3-[(2S)-2-amino-3-hydroxybutyl]pyrrolidin-2-one 0
                        (3S)-3-[(2S)-2-amino-3-oxobutyl]pyrrolidin-2-one 0
                        (3S)-3-[(2S)-2-amino-4-hydroxy-3-oxobutyl]pyrrolidin-2-one 0
                        (3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3S)-N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                        (3Z)-ravenic acid 0
                        (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                        (beta-D-glucosyl)-O-mycofactocinone + 0
                        1,5,5-trimethylpyrrolidin-2-one 0
                        1-(4-carboxy-2-guanidinophenyl)-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                        1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                        1-dodecylpyrrolidin-2-one 0
                        2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid 0
                        2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                        3,3-diethyl-2-pyrrolidinone 0
                        3-(Dichloromethylene)-2,5-pyrrolidinedione 0
                        3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                        3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one 0
                        3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}-L-phenylalaninamide 0
                        3-nitro-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide 0
                        3-oxo-N-[(3S)-2-oxopyrrolidin-3-yl]dodecanamide 0
                        4-[(2R)-2-(aminomethyl)-2-(hydroxymethyl)-5-oxopyrrolidin-1-yl]-3-[(1-ethylpropyl)amino]benzoic acid 0
                        4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                        5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                        5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one 0
                        5-\{[(2-amino-9H-purin-6-yl)oxy]methyl\}pyrrolidin-2-one 0
                        5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                        5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-indole-2-sulfonamide 0
                        5-cyclohexylmethyl-2-Pyrrolidinone 0
                        5-oxoproline + 2
                        5-oxopyrrolidine-2-carbaldehyde 0
                        6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                        6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}naphthalene-2-sulfonamide 0
                        Clonostalactam 0
                        Fischerellin B 0
                        N-(3-acetamidopropyl)pyrrolidin-2-one 0
                        N-(3-furoyl)-D-valyl-L-valyl-N-((1R,2Z)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-D-leucinamide 0
                        N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-\{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                        N-Vinyl-2-pyrrolidone 30
                        N-[(2S)-3-cyclohexyl-1-oxo-1-(\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}amino)propan-2-yl]-1H-indole-2-carboxamide 0
                        N-[(3S,6R)-6-\{(S,E)-4-ethoxycarbonyl-1-[(S)-2-oxopyrrolidin-3-yl]but-3-en-2-ylcarbamoyl\}-2,9-dimethyl-4-oxodec-8-en-3-yl]-5-methylisoxazole-3-carboxamide 0
                        N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-\{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                        N-[(5-methylisoxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N(1)-((1S)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-L-leucinamide 0
                        N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-3-cyclohexyl-N-[(1S)-2-hydroxy-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}ethyl]-L-alaninamide 0
                        N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                        N-methylpyrrolidin-2-one 0
                        PF-00835231 + 0
                        PF-07304814 0
                        PHA-533533 0
                        Pericoannosin C 0
                        Pericoannosin D 0
                        Pericoannosin E 0
                        Pericoannosin F 0
                        Pterolactam 0
                        SG85 0
                        Salinazinone B 0
                        Spinoxazine A 0
                        Spinoxazine B 0
                        Sulfosuccinimidyl oleate 0
                        aniracetam 2
                        cotinine N-oxide 0
                        doxapram + 2
                        ethyl (2E,4S)-4-[((2R)-2-\{[N-(tert-butoxycarbonyl)-L-valyl]amino\}-2-phenylethanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
                        ethyl (4R)-4-[((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-\{[(5-methylisoxazol-3-yl)carbonyl]amino\}-4-oxoheptanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate 0
                        fradafiban + 0
                        gamma-Valerolactam 0
                        ivosidenib 0
                        lefradafiban 0
                        levetiracetam 57
                        lilaline 0
                        melophlin P 0
                        melophlin Q 0
                        melophlin R 0
                        melophlin S 0
                        nirmatrelvir + 0
                        premycofactocin + 0
                        pyranonigrin I 0
                        pyranonigrin J 0
                        pyrrolidin-2-one 0
                        rolapitant 0
                        rolipram + 51
                        sch 210971 0
                        sch 210972 + 0
                        sch 213766 0
                        tenuazonic acid 0
                        tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
                        trans-3-hydroxycotinine + 0
                        trans-3-hydroxycotinine beta-D-glucuronide 0
                        vibrioferrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17697
                                        univalent carboacyl group 17697
                                          carbamoyl group 17547
                                            carboxamide 17547
                                              lactam 8394
                                                gamma-lactam 6652
                                                  pyrrolidin-2-ones 167
                                                    (-)-cotinine + 42
                                                    (1E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}prop-1-ene-1-sulfonamide 0
                                                    (2R)-N-hydroxy-2-[(3S)-3-methyl-3-\{4-[(2-methylquinolin-4-yl)methoxy]phenyl\}-2-oxopyrrolidin-1-yl]propanamide 0
                                                    (2S)-2-[(3S)-3-\{[(6-chloronaphthalen-2-yl)sulfonyl]amino\}-2-oxopyrrolidin-1-yl]-N-(1-methylethyl)-N-\{2-[(methylsulfonyl)amino]ethyl\}propanamide 0
                                                    (2S)-N-((1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-\{[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]amino\}propyl)-3-methyl-2-(2-oxopyrrolidin-1-yl)butanamide 0
                                                    (3S)-1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-3-[(2S)-2-amino-3-hydroxybutyl]pyrrolidin-2-one 0
                                                    (3S)-3-[(2S)-2-amino-3-oxobutyl]pyrrolidin-2-one 0
                                                    (3S)-3-[(2S)-2-amino-4-hydroxy-3-oxobutyl]pyrrolidin-2-one 0
                                                    (3S)-N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-N-(3-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3S)-N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide 0
                                                    (3Z)-ravenic acid 0
                                                    (E)-2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethenesulfonamide 0
                                                    (beta-D-glucosyl)-O-mycofactocinone + 0
                                                    1,5,5-trimethylpyrrolidin-2-one 0
                                                    1-(4-carboxy-2-guanidinophenyl)-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                                                    1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one 0
                                                    1-dodecylpyrrolidin-2-one 0
                                                    2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid 0
                                                    2-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}ethanesulfonamide 0
                                                    3,3-diethyl-2-pyrrolidinone 0
                                                    3-(Dichloromethylene)-2,5-pyrrolidinedione 0
                                                    3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                                                    3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one 0
                                                    3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}-L-phenylalaninamide 0
                                                    3-nitro-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide 0
                                                    3-oxo-N-[(3S)-2-oxopyrrolidin-3-yl]dodecanamide 0
                                                    4-[(2R)-2-(aminomethyl)-2-(hydroxymethyl)-5-oxopyrrolidin-1-yl]-3-[(1-ethylpropyl)amino]benzoic acid 0
                                                    4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                                                    5-(5-chlorothiophen-2-yl)-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-1,2,4-triazole-3-sulfonamide 0
                                                    5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one 0
                                                    5-\{[(2-amino-9H-purin-6-yl)oxy]methyl\}pyrrolidin-2-one 0
                                                    5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                                                    5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1H-indole-2-sulfonamide 0
                                                    5-cyclohexylmethyl-2-Pyrrolidinone 0
                                                    5-oxoproline + 2
                                                    5-oxopyrrolidine-2-carbaldehyde 0
                                                    6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide 0
                                                    6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}naphthalene-2-sulfonamide 0
                                                    Clonostalactam 0
                                                    Fischerellin B 0
                                                    N-(3-acetamidopropyl)pyrrolidin-2-one 0
                                                    N-(3-furoyl)-D-valyl-L-valyl-N-((1R,2Z)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-D-leucinamide 0
                                                    N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-\{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                                                    N-Vinyl-2-pyrrolidone 30
                                                    N-[(2S)-3-cyclohexyl-1-oxo-1-(\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}amino)propan-2-yl]-1H-indole-2-carboxamide 0
                                                    N-[(3S,6R)-6-\{(S,E)-4-ethoxycarbonyl-1-[(S)-2-oxopyrrolidin-3-yl]but-3-en-2-ylcarbamoyl\}-2,9-dimethyl-4-oxodec-8-en-3-yl]-5-methylisoxazole-3-carboxamide 0
                                                    N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-\{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
                                                    N-[(5-methylisoxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N(1)-((1S)-4-ethoxy-4-oxo-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}but-2-enyl)-L-leucinamide 0
                                                    N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-3-cyclohexyl-N-[(1S)-2-hydroxy-1-\{[(3S)-2-oxopyrrolidin-3-yl]methyl\}ethyl]-L-alaninamide 0
                                                    N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                                                    N-methylpyrrolidin-2-one 0
                                                    PF-00835231 + 0
                                                    PF-07304814 0
                                                    PHA-533533 0
                                                    Pericoannosin C 0
                                                    Pericoannosin D 0
                                                    Pericoannosin E 0
                                                    Pericoannosin F 0
                                                    Pterolactam 0
                                                    SG85 0
                                                    Salinazinone B 0
                                                    Spinoxazine A 0
                                                    Spinoxazine B 0
                                                    Sulfosuccinimidyl oleate 0
                                                    aniracetam 2
                                                    cotinine N-oxide 0
                                                    doxapram + 2
                                                    ethyl (2E,4S)-4-[((2R)-2-\{[N-(tert-butoxycarbonyl)-L-valyl]amino\}-2-phenylethanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
                                                    ethyl (4R)-4-[((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-\{[(5-methylisoxazol-3-yl)carbonyl]amino\}-4-oxoheptanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate 0
                                                    fradafiban + 0
                                                    gamma-Valerolactam 0
                                                    ivosidenib 0
                                                    lefradafiban 0
                                                    levetiracetam 57
                                                    lilaline 0
                                                    melophlin P 0
                                                    melophlin Q 0
                                                    melophlin R 0
                                                    melophlin S 0
                                                    nirmatrelvir + 0
                                                    premycofactocin + 0
                                                    pyranonigrin I 0
                                                    pyranonigrin J 0
                                                    pyrrolidin-2-one 0
                                                    rolapitant 0
                                                    rolipram + 51
                                                    sch 210971 0
                                                    sch 210972 + 0
                                                    sch 213766 0
                                                    tenuazonic acid 0
                                                    tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
                                                    trans-3-hydroxycotinine + 0
                                                    trans-3-hydroxycotinine beta-D-glucuronide 0
                                                    vibrioferrin 0
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