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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:16010 term browser browse the term
Definition:An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.
Synonyms:exact_synonym: 5-oxopyrrolidine-2-carboxylic acid
 related_synonym: 2-pyrrolidone-5-carboxylic acid;   5-oxo-DL-proline;   Formula=C5H7NO3;   Glp;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9);   InChIKey=ODHCTXKNWHHXJC-UHFFFAOYSA-N;   Pyroglutamate;   Pyroglutamic acid;   SMILES=OC(=O)C1CCC(=O)N1
 alt_id: CHEBI:12157;   CHEBI:20624;   CHEBI:2116;   CHEBI:44943
 xref: Beilstein:82131;   CAS:149-87-1;   PMID:17439666;   PMID:22770225;   PMID:23217740;   Reaxys:82131;   Wikipedia:Pyroglutamic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:57606

show annotations for term's descendants           Sort by:
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              animal metabolite 18712
                mammalian metabolite 18711
                  human metabolite 18214
                    5-oxoproline 2
                      5-oxo-D-proline 0
                      5-oxo-L-proline + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  gamma-lactam 6265
                                                    pyrrolidin-2-ones 140
                                                      5-oxoproline 2
                                                        5-oxo-D-proline 0
                                                        5-oxo-L-proline + 2
paths to the root


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