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Accession:CHEBI:681848 term browser browse the term
Definition:A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Synonyms:exact_synonym: 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
 related_synonym: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone;   Formula=C24H30N2O2;   InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3;   InChIKey=XFDJYSQDBULQSI-UHFFFAOYSA-N;   SMILES=CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
 xref: Beilstein:628691 "Beilstein";   CAS:309-29-5 "ChemIDplus";   CAS:309-29-5 "KEGG DRUG";   DrugBank:DB00561;   Drug_Central:953 "DrugCentral";   KEGG:D07873;   LINCS:LSM-5058
 xref_mesh: MESH:D004315
 xref: PMID:19663568 "Europe PMC";   PMID:20140700 "Europe PMC";   PMID:25819170 "Europe PMC";   PMID:26896538 "Europe PMC";   PMID:4122029 "Europe PMC";   PMID:4126096 "Europe PMC";   PMID:527638 "Europe PMC";   Patent:BE613734;   Patent:US3192206;   Reaxys:628691 "Reaxys";   VSDB:1819;   Wikipedia:Doxapram

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doxapram term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      application 19350
        pharmaceutical 19224
          drug 19224
            central nervous system drug 16424
              central nervous system stimulant 6614
                doxapram 2
                  (R)-doxapram 0
                  (S)-doxapram 0
                  doxapram hydrochloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic group 18426
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18306
                                    carbonyl compound 18306
                                      carboxylic acid 17973
                                        carboacyl group 17082
                                          univalent carboacyl group 17082
                                            carbamoyl group 16811
                                              carboxamide 16811
                                                lactam 7820
                                                  gamma-lactam 6059
                                                    pyrrolidin-2-ones 131
                                                      doxapram 2
                                                        (R)-doxapram 0
                                                        (S)-doxapram 0
                                                        doxapram hydrochloride (anhydrous) + 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.