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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:681848 term browser browse the term
Definition:A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Synonyms:exact_synonym: 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
 related_synonym: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone;   Formula=C24H30N2O2;   InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3;   InChIKey=XFDJYSQDBULQSI-UHFFFAOYSA-N;   SMILES=CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
 xref: Beilstein:628691;   CAS:309-29-5;   DrugBank:DB00561;   Drug_Central:953;   KEGG:D07873;   LINCS:LSM-5058
 xref_mesh: MESH:D004315
 xref: PMID:19663568;   PMID:20140700;   PMID:25819170;   PMID:26896538;   PMID:4122029;   PMID:4126096;   PMID:527638;   Patent:BE613734;   Patent:US3192206;   Reaxys:628691;   VSDB:1819;   Wikipedia:Doxapram

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doxapram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone increases expression EXP Doxapram results in increased expression of CRH mRNA; Doxapram results in increased expression of CRH protein CTD PMID:16269353 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Prl prolactin increases expression ISO Doxapram results in increased expression of PRL protein CTD PMID:15741000 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            central nervous system drug 16522
              central nervous system stimulant 6864
                doxapram 2
                  (R)-doxapram 0
                  (S)-doxapram 0
                  doxapram hydrochloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                lactam 8307
                                                  gamma-lactam 6589
                                                    pyrrolidin-2-ones 140
                                                      doxapram 2
                                                        (R)-doxapram 0
                                                        (S)-doxapram 0
                                                        doxapram hydrochloride (anhydrous) + 0
paths to the root