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ONTOLOGY REPORT - ANNOTATIONS


Term:(-)-cotinine
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Accession:CHEBI:68641 term browser browse the term
Definition:An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
Synonyms:related_synonym: (5S)-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one;   (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone;   (S)-Cotinine;   Formula=C10H12N2O;   InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1;   InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N;   SMILES=[H][C@]1(CCC(=O)N1C)c1cccnc1;   cotinina;   cotininum
 xref: CAS:486-56-6 "ChemIDplus";   Drug_Central:737 "DrugCentral";   HMDB:HMDB0001046;   KNApSAcK:C00034470;   LINCS:LSM-5986
 xref_mesh: MESH:D003367
 xref: MetaCyc:CPD-2742;   PMID:14700346 "Europe PMC";   PMID:21655912 "Europe PMC";   PMID:21953524 "Europe PMC";   PMID:22027507 "Europe PMC";   PMID:22137886 "Europe PMC";   PMID:22169225 "Europe PMC";   PMID:22180597 "Europe PMC";   PMID:22200307 "Europe PMC";   PMID:22244928 "Europe PMC";   PMID:22253001 "Europe PMC";   PMID:22434216 "Europe PMC";   PMID:22460317 "Europe PMC";   PMID:22487419 "Europe PMC";   PMID:22489581 "Europe PMC";   PMID:22574797 "Europe PMC";   PMID:22608097 "Europe PMC";   PMID:22678157 "Europe PMC";   PMID:22687995 "Europe PMC";   PMID:22770225 "Europe PMC";   PMID:22809871 "Europe PMC";   PMID:22871902 "Europe PMC";   PMID:22878732 "Europe PMC";   PMID:22899265 "Europe PMC";   PMID:22919158 "Europe PMC";   PMID:23000417 "Europe PMC";   PMID:23011941 "Europe PMC";   PMID:23087643 "Europe PMC";   Reaxys:5736575 "Reaxys";   Reaxys:83099 "Reaxys";   Wikipedia:Cotinine


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(-)-cotinine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahrr aryl-hydrocarbon receptor repressor JBrowse link 1 31,603,297 31,698,329 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Cd68 Cd68 molecule JBrowse link 10 56,268,726 56,270,605 RGD:6480464
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Cntnap2 contactin associated protein-like 2 JBrowse link 4 74,700,539 77,025,463 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:6480464
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Myo1g myosin IG JBrowse link 14 86,781,243 86,796,393 RGD:6480464
G Nat1 N-acetyltransferase 1 JBrowse link 16 23,970,742 23,991,573 RGD:6480464
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 1 214,434,638 214,439,720 RGD:6480464
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ttc7b tetratricopeptide repeat domain 7B JBrowse link 6 124,316,444 124,528,058 RGD:6480464
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        indicator 8519
          biomarker 6271
            (-)-cotinine 28
              trans-3-hydroxycotinine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                lactam 2855
                                                  gamma-lactam 346
                                                    pyrrolidin-2-ones 131
                                                      (-)-cotinine 28
                                                        trans-3-hydroxycotinine + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.