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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-cotinine
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Accession:CHEBI:68641 term browser browse the term
Definition:An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
Synonyms:related_synonym: (5S)-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one;   (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone;   (S)-Cotinine;   Formula=C10H12N2O;   InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1;   InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N;   SMILES=[H][C@]1(CCC(=O)N1C)c1cccnc1;   cotinina;   cotininum
 xref: CAS:486-56-6;   Drug_Central:737;   HMDB:HMDB0001046;   KNApSAcK:C00034470;   LINCS:LSM-5986
 xref_mesh: MESH:D003367
 xref: MetaCyc:CPD-2742;   PMID:14700346;   PMID:21655912;   PMID:21953524;   PMID:22027507;   PMID:22137886;   PMID:22169225;   PMID:22180597;   PMID:22200307;   PMID:22244928;   PMID:22253001;   PMID:22434216;   PMID:22460317;   PMID:22487419;   PMID:22489581;   PMID:22574797;   PMID:22608097;   PMID:22678157;   PMID:22687995;   PMID:22770225;   PMID:22809871;   PMID:22871902;   PMID:22878732;   PMID:22899265;   PMID:22919158;   PMID:23000417;   PMID:23011941;   PMID:23087643;   Reaxys:5736575;   Reaxys:83099;   Wikipedia:Cotinine


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(-)-cotinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahrr aryl-hydrocarbon receptor repressor affects methylation ISO Cotinine affects the methylation of AHRR gene CTD PMID:22851337 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Cotinine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]
CTD PMID:22687995 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:22687995 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein] CTD PMID:22687995 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Cotinine results in increased expression of CCND1 protein CTD PMID:31678612 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein CTD PMID:29617909 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA CTD PMID:29617909 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
multiple interactions
ISO CHRNA7 protein mutant form results in increased susceptibility to Cotinine
Cotinine binds to and results in increased activity of CHRNA7 protein
CTD PMID:10082212 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cntnap2 contactin associated protein 2 affects methylation ISO Cotinine affects the methylation of CNTNAP2 gene CTD PMID:22851337 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects methylation ISO Cotinine affects the methylation of CYP1A1 gene CTD PMID:22851337 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
decreases activity
ISO Cotinine results in increased activity of CYP1A2 protein
Cotinine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:16203240 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases abundance
multiple interactions
EXP CYP2B1 protein results in increased abundance of Cotinine
[Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine
CTD PMID:10799646 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of Cotinine CTD PMID:12488541 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Ext1 exostosin glycosyltransferase 1 affects methylation ISO Cotinine affects the methylation of EXT1 gene CTD PMID:22851337 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor affects methylation ISO Cotinine affects the methylation of GFI1 gene CTD PMID:22851337 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA CTD PMID:29617909 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA CTD PMID:29617909 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK1 protein CTD PMID:31678612 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK3 protein CTD PMID:31678612 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Cotinine results in increased expression of MKI67 protein CTD PMID:31678612 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Myo1g myosin IG affects methylation ISO Cotinine affects the methylation of MYO1G gene CTD PMID:22851337 NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects abundance
ISO NAT1 gene polymorphism affects the reaction [Tobacco Smoke Pollution results in increased abundance of Cotinine]
NAT1 gene polymorphism affects the abundance of Cotinine
CTD PMID:25156213 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein CTD PMID:29617909 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Runx1 RUNX family transcription factor 1 affects methylation ISO Cotinine affects the methylation of RUNX1 gene CTD PMID:22851337 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein CTD PMID:29617909 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein CTD PMID:29617909 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA CTD PMID:29617909 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cotinine results in increased phosphorylation of STAT3 protein CTD PMID:31678612 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA CTD PMID:29617909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ttc7b tetratricopeptide repeat domain 7B affects methylation ISO Cotinine affects the methylation of TTC7B gene CTD PMID:22851337 NCBI chr 6:119,587,389...119,799,155
Ensembl chr 6:119,587,390...119,799,330
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768 PMID:16141602 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Cotinine CTD PMID:16141602 NCBI chr 9:88,696,981...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        indicator 8689
          biomarker 6470
            (-)-cotinine 33
              trans-3-hydroxycotinine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                lactam 8302
                                                  gamma-lactam 6585
                                                    pyrrolidin-2-ones 140
                                                      (-)-cotinine 33
                                                        trans-3-hydroxycotinine + 0
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