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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-cotinine
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Accession:CHEBI:68641 term browser browse the term
Definition:An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
Synonyms:related_synonym: (5S)-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one;   (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone;   (S)-Cotinine;   Formula=C10H12N2O;   InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1;   InChIKey=UIKROCXWUNQSPJ-VIFPVBQESA-N;   SMILES=[H][C@]1(CCC(=O)N1C)c1cccnc1;   cotinina;   cotininum
 xref: CAS:486-56-6;   Drug_Central:737;   HMDB:HMDB0001046;   KNApSAcK:C00034470;   LINCS:LSM-5986
 xref_mesh: MESH:D003367
 xref: MetaCyc:CPD-2742;   PMID:14700346;   PMID:21655912;   PMID:21953524;   PMID:22027507;   PMID:22137886;   PMID:22169225;   PMID:22180597;   PMID:22200307;   PMID:22244928;   PMID:22253001;   PMID:22434216;   PMID:22460317;   PMID:22487419;   PMID:22489581;   PMID:22574797;   PMID:22608097;   PMID:22678157;   PMID:22687995;   PMID:22770225;   PMID:22809871;   PMID:22871902;   PMID:22878732;   PMID:22899265;   PMID:22919158;   PMID:23000417;   PMID:23011941;   PMID:23087643;   Reaxys:5736575;   Reaxys:83099;   Wikipedia:Cotinine


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(-)-cotinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahrr aryl-hydrocarbon receptor repressor affects methylation ISO Cotinine affects the methylation of AHRR gene CTD PMID:22851337 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Cotinine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]
CTD PMID:22687995 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:22687995 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein] CTD PMID:22687995 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Cotinine results in increased expression of CCND1 protein CTD PMID:31678612 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein CTD PMID:29617909 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA CTD PMID:29617909 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
multiple interactions
ISO CHRNA7 protein mutant form results in increased susceptibility to Cotinine
Cotinine binds to and results in increased activity of CHRNA7 protein
CTD PMID:10082212 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cntnap2 contactin associated protein 2 affects methylation ISO Cotinine affects the methylation of CNTNAP2 gene CTD PMID:22851337 NCBI chr 4:74,700,539...77,025,463 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects methylation ISO Cotinine affects the methylation of CYP1A1 gene CTD PMID:22851337 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
decreases activity
ISO Cotinine results in increased activity of CYP1A2 protein
Cotinine results in decreased activity of CYP1A2 protein
CTD PMID:15916432, PMID:16203240 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases abundance
multiple interactions
EXP CYP2B1 protein results in increased abundance of Cotinine
[Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine
CTD PMID:10799646 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of Cotinine CTD PMID:12488541 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Ext1 exostosin glycosyltransferase 1 affects methylation ISO Cotinine affects the methylation of EXT1 gene CTD PMID:22851337 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor affects methylation ISO Cotinine affects the methylation of GFI1 gene CTD PMID:22851337 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA CTD PMID:29617909 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA CTD PMID:29617909 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK1 protein CTD PMID:31678612 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Cotinine results in decreased phosphorylation of MAPK3 protein CTD PMID:31678612 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Cotinine results in increased expression of MKI67 protein CTD PMID:31678612 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Myo1g myosin IG affects methylation ISO Cotinine affects the methylation of MYO1G gene CTD PMID:22851337 NCBI chr14:86,781,243...86,796,393
Ensembl chr14:86,781,202...86,796,378
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects abundance
ISO NAT1 gene polymorphism affects the reaction [Tobacco Smoke Pollution results in increased abundance of Cotinine]
NAT1 gene polymorphism affects the abundance of Cotinine
CTD PMID:25156213 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein CTD PMID:29617909 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Runx1 RUNX family transcription factor 1 affects methylation ISO Cotinine affects the methylation of RUNX1 gene CTD PMID:22851337 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein CTD PMID:29617909 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein CTD PMID:29617909 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA CTD PMID:29617909 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cotinine results in increased phosphorylation of STAT3 protein CTD PMID:31678612 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA CTD PMID:29617909 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ttc7b tetratricopeptide repeat domain 7B affects methylation ISO Cotinine affects the methylation of TTC7B gene CTD PMID:22851337 NCBI chr 6:124,316,444...124,528,058
Ensembl chr 6:124,316,445...124,429,701
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768, PMID:16141602 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Cotinine CTD PMID:16141602 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        indicator 8649
          biomarker 6423
            (-)-cotinine 33
              trans-3-hydroxycotinine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  gamma-lactam 6266
                                                    pyrrolidin-2-ones 140
                                                      (-)-cotinine 33
                                                        trans-3-hydroxycotinine + 0
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