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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:104872
Term: rolipram
Definition: A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.
Chemical ID: MESH:D020889
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:690086480464CTDRolipram results in decreased expression of IL13 mRNA

PMID:16083514
decreases secretionISORGD:690086480464CTDRolipram results in decreased secretion of IL13 protein

PMID:16083514
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.