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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-oxo-L-proline
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Accession:CHEBI:18183 term browser browse the term
Definition:An optically active form of 5-oxoproline having L-configuration.
Synonyms:exact_synonym: (2S)-5-oxopyrrolidine-2-carboxylic acid
 related_synonym: (S)-(-)-2-pyrrolidone-5-carboxylic acid;   (S)-pyroglutamic acid;   5-Pyrrolidone-2-carboxylic acid;   Formula=C5H7NO3;   InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1;   InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N;   L-5-Pyrrolidone-2-carboxylic acid;   L-Pyroglutamic acid;   PYROGLUTAMIC ACID;   Pyroglutamate;   SMILES=OC(=O)[C@@H]1CCC(=O)N1;   pidolic acid
 alt_id: CHEBI:12153;   CHEBI:20619;   CHEBI:2113;   CHEBI:44704
 xref: Beilstein:5251861;   Beilstein:82132;   CAS:98-79-3;   DrugBank:DB03088;   Gmelin:1125330;   HMDB:HMDB0000267;   KEGG:C01879;   KNApSAcK:C00007403
 xref_mesh: MESH:D011761
 xref: MetaCyc:5-OXOPROLINE;   PDBeChem:PCA;   PMID:17439666;   PMID:22560249;   PMID:22619187;   Reaxys:82132;   Wikipedia:Pyroglutamic_acid;   YMDB:YMDB00107
 cyclic_relationship: is_conjugate_acid_of CHEBI:58402;   is_enantiomer_of CHEBI:16924



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5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        osmolyte 2074
          compatible osmolytes 360
            L-proline 280
              L-proline derivative 263
                5-oxo-L-proline 2
                  5-oxo-L-proline residue 0
                  N-terminal 5-oxo-L-proline residue 0
                  pyroglutamylglycine 0
                  pyroglutamylvaline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        carboacyl group 17713
                                          univalent carboacyl group 17713
                                            carbamoyl group 17552
                                              carboxamide 17552
                                                lactam 8351
                                                  gamma-lactam 6615
                                                    pyrrolidin-2-ones 140
                                                      5-oxoproline 2
                                                        5-oxo-L-proline 2
                                                          5-oxo-L-proline residue 0
                                                          N-terminal 5-oxo-L-proline residue 0
                                                          pyroglutamylglycine 0
                                                          pyroglutamylvaline 0
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