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ONTOLOGY REPORT - ANNOTATIONS


Term:rolipram
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Accession:CHEBI:104872 term browser browse the term
Definition:A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.
Synonyms:exact_synonym: 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
 related_synonym: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone;   Formula=C16H21NO3;   InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18);   InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1;   ZK 62711;   rolipramum
 alt_id: CHEBI:32104
 xref: Beilstein:1588548;   CAS:61413-54-5;   DrugBank:DB01954;   KEGG:D01783;   LINCS:LSM-1471
 xref_mesh: MESH:D020889
 xref: PMID:11163637;   PMID:11239354;   PMID:11408555;   PMID:11555183;   PMID:11737051;   PMID:11739553;   PMID:11959789;   PMID:11978843;   PMID:11992650;   PMID:12003795;   PMID:12065724;   PMID:12191588;   PMID:12447004;   PMID:12508846;   PMID:15114341;   PMID:15277469;   PMID:15374348;   PMID:15646801;   PMID:15744818;   PMID:15790951;   PMID:15839805;   PMID:15986861;   PMID:16010295;   PMID:16022866;   PMID:16077397;   PMID:16129118;   PMID:16190900;   PMID:16242629;   PMID:16250839;   PMID:16253125;   PMID:16254133;   PMID:16442096;   PMID:16455619;   PMID:16962789;   PMID:16968783;   PMID:17081698;   PMID:17097801;   PMID:17390056;   PMID:17489366;   PMID:18311187;   PMID:18347080;   PMID:18424161;   PMID:18437099;   PMID:18554698;   PMID:19554392;   PMID:19569465;   Patent:US4193926;   Patent:US6337325;   Patent:WO2011143607;   Reaxys:1588548;   Wikipedia:Rolipram


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rolipram term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcyap1 adenylate cyclase activating polypeptide 1 JBrowse link 9 121,705,897 121,725,736 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ap2m1 adaptor related protein complex 2 subunit mu 1 JBrowse link 11 84,041,184 84,047,542 RGD:6480464
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Epx eosinophil peroxidase JBrowse link 10 75,160,690 75,171,774 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Pde4a phosphodiesterase 4A JBrowse link 8 22,189,533 22,234,036 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6480464
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6480464
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        pharmaceutical 19254
          drug 19254
            central nervous system drug 16445
              psychotropic drug 15064
                antidepressant 3069
                  rolipram 39
                    (+)-rolipram 0
                    (-)-rolipram 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        carboacyl group 17190
                                          univalent carboacyl group 17190
                                            carbamoyl group 16928
                                              carboxamide 16928
                                                lactam 7829
                                                  gamma-lactam 6063
                                                    pyrrolidin-2-ones 140
                                                      rolipram 39
                                                        (+)-rolipram 0
                                                        (-)-rolipram 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.