Dcx (doublecortin) - Rat Genome Database

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Gene: Dcx (doublecortin) Rattus norvegicus
Analyze
Symbol: Dcx
Name: doublecortin
RGD ID: 620670
Description: Predicted to enable microtubule binding activity and protein kinase binding activity. Involved in nervous system development; positive regulation of cellular component organization; and response to electrical stimulus. Located in dendrite; growth cone; and neuronal cell body. Colocalizes with microtubule. Used to study visual epilepsy. Biomarker of brain infarction; hypothyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in X-linked lissencephaly 1 and subcortical band heterotopia. Orthologous to human DCX (doublecortin); INTERACTS WITH 2,6-di-tert-butyl-4-methylphenol; 5-fluorouracil; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: neuronal migration protein doublecortin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,430,767 - 107,573,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,430,767 - 107,507,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,568,465 - 109,645,129 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X113,068,174 - 113,144,836 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X110,621,867 - 110,698,568 (-)NCBIRnor_WKY
Rnor_6.0X115,098,675 - 115,175,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX115,098,675 - 115,175,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,596,262 - 34,672,383 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,649,730 - 34,718,439NCBI
CeleraX106,829,783 - 106,906,206 (-)NCBICelera
Cytogenetic MapXq33-q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbofuran  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
Citreoviridin  (ISO)
clonazepam  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (EXP)
folic acid  (ISO)
glucose  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
LY294002  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
ochratoxin A  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
PCB138  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (EXP,ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (EXP)
thifluzamide  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
axoneme  (IBA)
cell projection  (IEA)
cytoplasm  (IEA,ISO)
dendrite  (IDA)
growth cone  (IDA)
microtubule  (IDA)
neuron projection  (IEA,ISO,ISS)
neuronal cell body  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Isolated lissencephaly sequence and double-cortex syndrome in a German family with a novel doublecortin mutation. Aigner L, etal., Neuropediatrics. 2000 Aug;31(4):195-8.
2. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
3. RNAi reveals doublecortin is required for radial migration in rat neocortex. Bai J, etal., Nat Neurosci 2003 Dec;6(12):1277-83. Epub 2003 Nov 16.
4. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. Corbo JC, etal., J Neurosci 2002 Sep 1;22(17):7548-57.
5. Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis. D'Alessio L, etal., Seizure. 2010 Nov;19(9):567-72. doi: 10.1016/j.seizure.2010.09.004.
6. doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). des Portes V, etal., Hum Mol Genet. 1998 Jul;7(7):1063-70.
7. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Fournier NM, etal., Hippocampus. 2009 Jun 4.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations. Guerrini R, etal., Ann Neurol. 2003 Jul;54(1):30-7.
11. Intragenic deletions and duplications of the LIS1 and DCX genes: a major disease-causing mechanism in lissencephaly and subcortical band heterotopia. Haverfield EV, etal., Eur J Hum Genet. 2009 Jul;17(7):911-8. doi: 10.1038/ejhg.2008.213. Epub 2008 Dec 3.
12. Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies. Juhasova J, etal., Cell Mol Neurobiol. 2015 Jan;35(1):57-70. doi: 10.1007/s10571-014-0145-7. Epub 2014 Dec 9.
13. A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia. Kato M, etal., Hum Genet. 1999 Apr;104(4):341-4.
14. Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain. Kremer T, etal., PLoS One. 2013 May 14;8(5):e59269. doi: 10.1371/journal.pone.0059269. Print 2013.
15. Spontaneous epileptic manifestations in a DCX knockdown model of human double cortex. Lapray D, etal., Cereb Cortex. 2010 Nov;20(11):2694-701. doi: 10.1093/cercor/bhq014. Epub 2010 Feb 17.
16. Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Manent JB, etal., Nat Med. 2009 Jan;15(1):84-90. doi: 10.1038/nm.1897. Epub 2008 Dec 21.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus. Nosten-Bertrand M, etal., PLoS One. 2008 Jun 25;3(6):e2473. doi: 10.1371/journal.pone.0002473.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Santra M, etal., Cancer Res. 2006 Dec 15;66(24):11726-35.
25. Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Santra M, etal., Cancer Sci. 2011 Jul;102(7):1350-7. doi: 10.1111/j.1349-7006.2011.01952.x. Epub 2011 May 10.
26. Single doublecortin gene therapy significantly reduces glioma tumor volume. Santra M, etal., J Neurosci Res. 2010 Feb 1;88(2):304-14. doi: 10.1002/jnr.22207.
27. Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structures. Tint I, etal., J Neurosci. 2009 Sep 2;29(35):10995-1010. doi: 10.1523/JNEUROSCI.3399-09.2009.
28. A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies. Tsai MH, etal., Eur J Paediatr Neurol. 2016 Sep;20(5):788-94. doi: 10.1016/j.ejpn.2016.05.010. Epub 2016 May 30.
29. Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum. Wang Y, etal., Arch Med Res. 2012 May;43(4):255-64. doi: 10.1016/j.arcmed.2012.05.002. Epub 2012 May 15.
30. [Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage]. Xu X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1437-41.
31. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding. Yap CC, etal., J Neurosci. 2012 May 30;32(22):7439-53. doi: 10.1523/JNEUROSCI.5318-11.2012.
32. Effects of treadmill exercise on cell proliferation and differentiation in the subgranular zone of the dentate gyrus in a rat model of type II diabetes. Yi SS, etal., Neurochem Res. 2009 Jun;34(6):1039-46. doi: 10.1007/s11064-008-9870-y. Epub 2008 Nov 4.
Additional References at PubMed
PMID:12223548   PMID:14741102   PMID:15632090   PMID:15804431   PMID:16387638   PMID:16387639   PMID:17026970   PMID:17161913   PMID:17409252   PMID:18075265   PMID:18177494   PMID:18647639  
PMID:18803236   PMID:18854839   PMID:19342486   PMID:20857512   PMID:21689730   PMID:22038821   PMID:22197046   PMID:22198017   PMID:22198688   PMID:23001563   PMID:23447615   PMID:23852478  
PMID:23861879   PMID:24367100   PMID:25209608   PMID:27487661   PMID:29476059   PMID:32236698   PMID:32783282   PMID:33843023  


Genomics

Comparative Map Data
Dcx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,430,767 - 107,573,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,430,767 - 107,507,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,568,465 - 109,645,129 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X113,068,174 - 113,144,836 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X110,621,867 - 110,698,568 (-)NCBIRnor_WKY
Rnor_6.0X115,098,675 - 115,175,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX115,098,675 - 115,175,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,596,262 - 34,672,383 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,649,730 - 34,718,439NCBI
CeleraX106,829,783 - 106,906,206 (-)NCBICelera
Cytogenetic MapXq33-q34NCBI
DCX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X111,293,779 - 111,412,192 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX111,293,779 - 111,412,429 (-)EnsemblGRCh38hg38GRCh38
GRCh37X110,537,007 - 110,655,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,423,663 - 110,542,062 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X110,343,151 - 110,461,551NCBI
CeleraX111,016,623 - 111,134,992 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX100,159,414 - 100,278,099 (-)NCBIHuRef
CHM1_1X110,448,522 - 110,566,950 (-)NCBICHM1_1
T2T-CHM13v2.0X109,741,985 - 109,860,408 (-)NCBIT2T-CHM13v2.0
Dcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X142,638,838 - 142,716,392 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX142,638,838 - 142,716,307 (-)EnsemblGRCm39 Ensembl
GRCm38X143,855,842 - 143,933,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX143,855,842 - 143,933,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X140,290,385 - 140,367,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X139,102,210 - 139,179,587 (-)NCBIMGSCv36mm8
CeleraX127,810,174 - 127,886,575 (-)NCBICelera
Cytogenetic MapXF2NCBI
Dcx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554904,354,307 - 4,469,055 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554904,354,307 - 4,469,055 (+)NCBIChiLan1.0ChiLan1.0
DCX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X110,878,060 - 110,988,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX110,875,032 - 110,988,582 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X100,411,871 - 100,529,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DCX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,408,762 - 84,541,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,408,895 - 84,517,827 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,501,790 - 70,641,477 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X86,062,412 - 86,202,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX86,062,955 - 86,179,258 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X83,553,159 - 83,685,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X85,222,965 - 85,362,879 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X85,051,446 - 85,192,159 (-)NCBIUU_Cfam_GSD_1.0
Dcx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X83,645,350 - 83,761,221 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364993,903,376 - 4,005,508 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364993,905,262 - 4,004,457 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX91,323,764 - 91,644,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X91,317,671 - 91,644,572 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X105,739,468 - 106,059,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X99,106,291 - 99,220,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX99,120,505 - 99,220,237 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606524,340,271 - 24,459,762 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248034,168,556 - 4,299,979 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248034,168,556 - 4,304,642 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dcx
1116 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1949
Count of miRNA genes:396
Interacting mature miRNAs:604
Transcripts:ENSRNOT00000074322
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 69 12
Low 21 15 7 7 5 5 5 18 27 4 5
Below cutoff 3 20 32 24 19 24 3 6 11 2 6 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF155959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074322   ⟹   ENSRNOP00000065381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,430,767 - 107,507,476 (-)Ensembl
Rnor_6.0 EnsemblX115,098,675 - 115,175,299 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103733   ⟹   ENSRNOP00000083258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,445,120 - 107,507,476 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107008   ⟹   ENSRNOP00000095915
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,433,107 - 107,507,476 (-)Ensembl
RefSeq Acc Id: NM_053379   ⟹   NP_445831
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,476 (-)NCBI
Rnor_6.0X115,098,675 - 115,175,299 (-)NCBI
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBI
RGSC_v3.4X34,596,262 - 34,672,383 (+)RGD
CeleraX106,829,783 - 106,906,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257382   ⟹   XP_006257444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,424 (-)NCBI
Rnor_6.0X115,098,675 - 115,175,248 (-)NCBI
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257385   ⟹   XP_006257447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,744 (-)NCBI
Rnor_6.0X115,098,675 - 115,175,514 (-)NCBI
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257386   ⟹   XP_006257448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,584 (-)NCBI
Rnor_6.0X115,098,675 - 115,175,515 (-)NCBI
Rnor_5.0X113,551,874 - 113,628,283 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602167   ⟹   XP_017457656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,165 (-)NCBI
Rnor_6.0X115,098,675 - 115,175,070 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100106   ⟹   XP_038956034
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,573,612 (-)NCBI
RefSeq Acc Id: XM_039100107   ⟹   XP_038956035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,424 (-)NCBI
RefSeq Acc Id: XM_039100108   ⟹   XP_038956036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,425 (-)NCBI
RefSeq Acc Id: XM_039100109   ⟹   XP_038956037
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,425 (-)NCBI
RefSeq Acc Id: XM_039100110   ⟹   XP_038956038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,424 (-)NCBI
RefSeq Acc Id: XM_039100112   ⟹   XP_038956040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,430,767 - 107,507,425 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_445831   ⟸   NM_053379
- UniProtKB: G3V997 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257448   ⟸   XM_006257386
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006257447   ⟸   XM_006257385
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006257444   ⟸   XM_006257382
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457656   ⟸   XM_017602167
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000065381   ⟸   ENSRNOT00000074322
RefSeq Acc Id: XP_038956034   ⟸   XM_039100106
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038956040   ⟸   XM_039100112
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GLD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956037   ⟸   XM_039100109
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038956036   ⟸   XM_039100108
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038956038   ⟸   XM_039100110
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038956035   ⟸   XM_039100107
- Peptide Label: isoform X2
- UniProtKB: G3V997 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083258   ⟸   ENSRNOT00000103733
RefSeq Acc Id: ENSRNOP00000095915   ⟸   ENSRNOT00000107008
Protein Domains
Doublecortin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESI7-F1-model_v2 AlphaFold Q9ESI7 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620670 AgrOrtholog
BioCyc Gene G2FUF-1499 BioCyc
Ensembl Genes ENSRNOG00000047712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065381 ENTREZGENE
  ENSRNOP00000065381.1 UniProtKB/TrEMBL
  ENSRNOP00000083258.1 UniProtKB/TrEMBL
  ENSRNOP00000095915 ENTREZGENE
  ENSRNOP00000095915.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074322 ENTREZGENE
  ENSRNOT00000074322.2 UniProtKB/TrEMBL
  ENSRNOT00000103733.1 UniProtKB/TrEMBL
  ENSRNOT00000107008 ENTREZGENE
  ENSRNOT00000107008.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Doublecortin_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doublecortin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doublecortin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RP1/RP1L1/DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84394 UniProtKB/TrEMBL
NCBI Gene 84394 ENTREZGENE
PANTHER PTHR23005 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dcx PhenoGen
PIRSF Doublin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF89837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZ19_RAT UniProtKB/TrEMBL
  A0A8I6GLD6 ENTREZGENE, UniProtKB/TrEMBL
  DCX_RAT UniProtKB/Swiss-Prot
  G3V997 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESI7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Dcx  doublecortin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dcx  doublecortin      Symbol and Name status set to provisional 70820 PROVISIONAL