CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: levetiracetam
Accession: CHEBI:6437
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Definition: A pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine.
Synonyms: exact_synonym: (2S)-2-(2-oxopyrrolidin-1-yl)butanamide
related_synonym: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide; Formula=C8H14N2O2; InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1; InChIKey=HPHUVLMMVZITSG-LURJTMIESA-N; Keppra; SMILES=CC[C@H](N1CCCC1=O)C(N)=O; UCB-L 059; levetiracetamum
xref: CAS:102767-28-2; DrugBank:DB01202; Drug_Central:1563; KEGG:C07841; KEGG:D00709; LINCS:LSM-5603
xref_mesh: MESH:D000077287
xref: PMID:22119754; PMID:22321334; Reaxys:8407472; VSDB:2979; Wikipedia:Levetiracetam
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases activity increases transport increases expression
EXP ISO
Amino Acids, Peptides, and Proteins inhibits the reaction [Levetiracetam results in increased expression of ABCB1 protein] Levetiracetam results in decreased activity of ABCB1 protein ABCB1A protein results in increased transport of Levetiracetam
CTD
PMID:17045309 PMID:18408562 PMID:18473823
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
EXP
Levetiracetam results in increased expression of ABCC1 protein
CTD
PMID:18473823
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
EXP
Levetiracetam results in increased expression of ABCC2 protein
CTD
PMID:18473823
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Acvrl1
activin A receptor like type 1
decreases expression
EXP
Levetiracetam results in decreased expression of ACVRL1 mRNA
CTD
PMID:20345932
NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
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Arhgef1
Rho guanine nucleotide exchange factor 1
decreases expression
EXP
Levetiracetam results in decreased expression of ARHGEF1 mRNA
CTD
PMID:20345932
NCBI chr 1:80,499,026...80,520,954
Ensembl chr 1:80,499,131...80,520,953
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
decreases expression
EXP
Levetiracetam results in decreased expression of CACNB1 mRNA
CTD
PMID:20345932
NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
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Cat
catalase
multiple interactions
ISO
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
CTD
PMID:17205390
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnh
cyclin H
increases expression
EXP
Levetiracetam results in increased expression of CCNH mRNA
CTD
PMID:20345932
NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819
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Chrm2
cholinergic receptor, muscarinic 2
increases activity decreases expression
ISO
Levetiracetam results in increased activity of CHRM2 protein Levetiracetam results in decreased expression of CHRM2 protein
CTD
PMID:15967574
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Cxcr3
C-X-C motif chemokine receptor 3
increases expression
EXP
Levetiracetam results in increased expression of CXCR3 mRNA
CTD
PMID:20345932
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Levetiracetam results in decreased expression of CYP17A1 mRNA
CTD
PMID:19566492
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
ISO
Levetiracetam results in decreased expression of CYP19A1 mRNA
CTD
PMID:19566492
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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Dao
D-amino-acid oxidase
increases expression
EXP
Levetiracetam results in increased expression of DAO mRNA
CTD
PMID:20345932
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
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Dbp
D-box binding PAR bZIP transcription factor
decreases expression
EXP
Levetiracetam results in decreased expression of DBP mRNA
CTD
PMID:20345932
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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Des
desmin
increases expression
EXP
Levetiracetam results in increased expression of DES mRNA
CTD
PMID:20345932
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Gle1
GLE1 RNA export mediator
increases expression
EXP
Levetiracetam results in increased expression of GLE1 mRNA
CTD
PMID:20345932
NCBI chr 3:13,209,312...13,237,018
Ensembl chr 3:13,209,322...13,237,379
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Hcn2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
decreases expression
EXP
Levetiracetam results in decreased expression of HCN2 mRNA
CTD
PMID:20345932
NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
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Hdac10
histone deacetylase 10
decreases expression
EXP
Levetiracetam results in decreased expression of HDAC10 mRNA
CTD
PMID:20345932
NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases expression
ISO
Levetiracetam results in decreased expression of HSD3B2 mRNA
CTD
PMID:19566492
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Kcna4
potassium voltage-gated channel subfamily A member 4
increases expression
EXP
Levetiracetam results in increased expression of KCNA4 mRNA
CTD
PMID:20345932
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
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Kctd3
potassium channel tetramerization domain containing 3
increases expression
EXP
Levetiracetam results in increased expression of KCTD3 mRNA
CTD
PMID:20345932
NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718
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Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases expression
EXP
Levetiracetam results in increased expression of KHDRBS2 mRNA
CTD
PMID:20345932
NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530
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Lap3
leucine aminopeptidase 3
increases expression
EXP
Levetiracetam results in increased expression of LAP3 mRNA
CTD
PMID:20345932
NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
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Lsm1
LSM1 homolog, mRNA degradation associated
increases expression
EXP
Levetiracetam results in increased expression of LSM1 mRNA
CTD
PMID:20345932
NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852
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Mettl7b
methyltransferase like 7B
increases expression
EXP
Levetiracetam results in increased expression of METTL7B mRNA
CTD
PMID:20345932
NCBI chr 7:1,388,876...1,391,526
Ensembl chr 7:1,388,879...1,391,526
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Nap1l2
nucleosome assembly protein 1-like 2
increases expression
EXP
Levetiracetam results in increased expression of NAP1L2 mRNA
CTD
PMID:20345932
NCBI chr X:68,174,051...68,176,449
Ensembl chr X:68,173,987...68,176,666
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Ngly1
N-glycanase 1
increases expression
EXP
Levetiracetam results in increased expression of NGLY1 mRNA
CTD
PMID:20345932
NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630
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Phldb1
pleckstrin homology-like domain, family B, member 1
decreases expression
EXP
Levetiracetam results in decreased expression of PHLDB1 mRNA
CTD
PMID:20345932
NCBI chr 8:45,003,538...45,051,541
Ensembl chr 8:45,003,538...45,051,522
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Pon1
paraoxonase 1
affects activity
ISO
Levetiracetam affects the activity of PON1 protein
CTD
PMID:28032682
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Prkx
protein kinase cAMP-dependent X-linked catalytic subunit
increases expression
EXP
Levetiracetam results in increased expression of PRKX mRNA
CTD
PMID:20345932
NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669
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Psip1
PC4 and SRSF1 interacting protein 1
increases expression
EXP
Levetiracetam results in increased expression of PSIP1 mRNA
CTD
PMID:20345932
NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
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Serinc1
serine incorporator 1
increases expression
EXP
Levetiracetam results in increased expression of SERINC1 mRNA
CTD
PMID:20345932
NCBI chr20:36,850,062...36,896,691
Ensembl chr20:36,850,076...36,896,691
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Slc23a2
solute carrier family 23 member 2
increases expression
EXP
Levetiracetam results in increased expression of SLC23A2 mRNA
CTD
PMID:20345932
NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
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Slc4a7
solute carrier family 4 member 7
increases expression
EXP
Levetiracetam results in increased expression of SLC4A7 mRNA
CTD
PMID:20345932
NCBI chr15:10,585,307...10,664,781
Ensembl chr15:10,588,979...10,664,781
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Smc2
structural maintenance of chromosomes 2
increases expression
EXP
Levetiracetam results in increased expression of SMC2 mRNA
CTD
PMID:20345932
NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
Levetiracetam results in decreased expression of STAR mRNA
CTD
PMID:19566492
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Tent2
terminal nucleotidyltransferase 2
increases expression
EXP
Levetiracetam results in increased expression of TENT2 mRNA
CTD
PMID:20345932
NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099
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Trdmt1
tRNA aspartic acid methyltransferase 1
decreases expression
EXP
Levetiracetam results in decreased expression of TRDMT1 mRNA
CTD
PMID:20345932
NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
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Vars2
valyl-tRNA synthetase 2, mitochondrial
decreases expression
EXP
Levetiracetam results in decreased expression of VARS2 mRNA
CTD
PMID:20345932
NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994
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Xrcc1
X-ray repair cross complementing 1
decreases expression
EXP
Levetiracetam results in decreased expression of XRCC1 mRNA
CTD
PMID:20345932
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Zfp266
zinc finger protein 266
increases expression
EXP
Levetiracetam results in increased expression of ZFP266 mRNA
CTD
PMID:20345932
NCBI chr 8:19,030,766...19,061,381
Ensembl chr 8:19,030,768...19,060,937
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