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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:levetiracetam
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Accession:CHEBI:6437 term browser browse the term
Definition:A pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine.
Synonyms:exact_synonym: (2S)-2-(2-oxopyrrolidin-1-yl)butanamide
 related_synonym: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide;   Formula=C8H14N2O2;   InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1;   InChIKey=HPHUVLMMVZITSG-LURJTMIESA-N;   Keppra;   SMILES=CC[C@H](N1CCCC1=O)C(N)=O;   UCB-L 059;   levetiracetamum
 xref: CAS:102767-28-2;   DrugBank:DB01202;   Drug_Central:1563;   KEGG:C07841;   KEGG:D00709;   LINCS:LSM-5603
 xref_mesh: MESH:D000077287
 xref: PMID:22119754;   PMID:22321334;   Reaxys:8407472;   VSDB:2979;   Wikipedia:Levetiracetam

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levetiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases transport
decreases activity		 EXP
ISO		 Amino Acids, Peptides, and Proteins inhibits the reaction [Levetiracetam results in increased expression of ABCB1 protein]
ABCB1A protein results in increased transport of Levetiracetam
Levetiracetam results in decreased activity of ABCB1 protein		 CTD PMID:17045309, PMID:18408562, PMID:18473823 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Levetiracetam results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Levetiracetam results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Levetiracetam results in decreased expression of ACVRL1 mRNA CTD PMID:20345932 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335 		JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 decreases expression EXP Levetiracetam results in decreased expression of ARHGEF1 mRNA CTD PMID:20345932 NCBI chr 1:81,769,212...81,797,237
Ensembl chr 1:81,779,380...81,797,236 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 decreases expression EXP Levetiracetam results in decreased expression of CACNB1 mRNA CTD PMID:20345932 NCBI chr10:85,954,138...85,974,764
Ensembl chr10:85,954,138...85,974,651 		JBrowse link
G Cat catalase multiple interactions ISO Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein] CTD PMID:17205390 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnh cyclin H increases expression EXP Levetiracetam results in increased expression of CCNH mRNA CTD PMID:20345932 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases activity
decreases expression		 ISO Levetiracetam results in increased activity of CHRM2 protein
Levetiracetam results in decreased expression of CHRM2 protein		 CTD PMID:15967574 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression EXP Levetiracetam results in increased expression of CXCR3 mRNA CTD PMID:20345932 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP17A1 mRNA CTD PMID:19566492 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Levetiracetam results in decreased expression of CYP19A1 mRNA CTD PMID:19566492 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Dao D-amino-acid oxidase increases expression EXP Levetiracetam results in increased expression of DAO mRNA CTD PMID:20345932 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Levetiracetam results in decreased expression of DBP mRNA CTD PMID:20345932 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846 		JBrowse link
G Des desmin increases expression EXP Levetiracetam results in increased expression of DES mRNA CTD PMID:20345932 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Gle1 GLE1 RNA export mediator increases expression EXP Levetiracetam results in increased expression of GLE1 mRNA CTD PMID:20345932 NCBI chr 3:8,498,098...8,530,218
Ensembl chr 3:8,498,122...8,526,771 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases expression EXP Levetiracetam results in decreased expression of HCN2 mRNA CTD PMID:20345932 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215 		JBrowse link
G Hdac10 histone deacetylase 10 decreases expression EXP Levetiracetam results in decreased expression of HDAC10 mRNA CTD PMID:20345932 NCBI chr 7:130,102,335...130,109,036
Ensembl chr 7:130,102,347...130,107,437 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression ISO Levetiracetam results in decreased expression of HSD3B2 mRNA CTD PMID:19566492 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 increases expression EXP Levetiracetam results in increased expression of KCNA4 mRNA CTD PMID:20345932 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680 		JBrowse link
G Kctd3 potassium channel tetramerization domain containing 3 increases expression EXP Levetiracetam results in increased expression of KCTD3 mRNA CTD PMID:20345932 NCBI chr13:107,433,588...107,471,843
Ensembl chr13:107,433,588...107,471,843 		JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases expression EXP Levetiracetam results in increased expression of KHDRBS2 mRNA CTD PMID:20345932 NCBI chr 9:39,501,431...40,008,707
Ensembl chr 9:39,539,530...40,008,680 		JBrowse link
G Lap3 leucine aminopeptidase 3 increases expression EXP Levetiracetam results in increased expression of LAP3 mRNA CTD PMID:20345932 NCBI chr14:70,102,813...70,121,797
Ensembl chr14:70,102,814...70,121,797 		JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated increases expression EXP Levetiracetam results in increased expression of LSM1 mRNA CTD PMID:20345932 NCBI chr16:71,046,475...71,057,883
Ensembl chr16:71,046,475...71,057,883 		JBrowse link
G Mettl7b methyltransferase like 7B increases expression EXP Levetiracetam results in increased expression of METTL7B mRNA CTD PMID:20345932 NCBI chr 7:3,383,876...3,386,522
Ensembl chr 7:3,383,879...3,386,522 		JBrowse link
G Nap1l2 nucleosome assembly protein 1-like 2 increases expression EXP Levetiracetam results in increased expression of NAP1L2 mRNA CTD PMID:20345932 NCBI chr  X:73,997,274...73,999,677 JBrowse link
G Ngly1 N-glycanase 1 increases expression EXP Levetiracetam results in increased expression of NGLY1 mRNA CTD PMID:20345932 NCBI chr15:10,405,453...10,455,973
Ensembl chr15:10,405,164...10,455,956 		JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression EXP Levetiracetam results in decreased expression of PHLDB1 mRNA CTD PMID:20345932 NCBI chr 8:48,997,189...49,045,176
Ensembl chr 8:48,997,184...49,045,154 		JBrowse link
G Pon1 paraoxonase 1 affects activity ISO Levetiracetam affects the activity of PON1 protein CTD PMID:28032682 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Prkx protein kinase, X-linked increases expression EXP Levetiracetam results in increased expression of PRKX mRNA CTD PMID:20345932 NCBI chr  X:45,080,963...45,125,095
Ensembl chr  X:45,080,963...45,124,270 		JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 increases expression EXP Levetiracetam results in increased expression of PSIP1 mRNA CTD PMID:20345932 NCBI chr 5:101,555,691...101,588,659
Ensembl chr 5:101,555,694...101,588,598 		JBrowse link
G Serinc1 serine incorporator 1 increases expression EXP Levetiracetam results in increased expression of SERINC1 mRNA CTD PMID:20345932 NCBI chr20:38,966,016...38,985,056
Ensembl chr20:38,967,238...38,985,036 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression EXP Levetiracetam results in increased expression of SLC23A2 mRNA CTD PMID:20345932 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 increases expression EXP Levetiracetam results in increased expression of SLC4A7 mRNA CTD PMID:20345932 NCBI chr15:11,832,611...11,912,923
Ensembl chr15:11,836,286...11,912,916 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP Levetiracetam results in increased expression of SMC2 mRNA CTD PMID:20345932 NCBI chr 5:68,717,509...68,764,080
Ensembl chr 5:68,717,519...68,763,850 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Levetiracetam results in decreased expression of STAR mRNA CTD PMID:19566492 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Tent2 terminal nucleotidyltransferase 2 increases expression EXP Levetiracetam results in increased expression of TENT2 mRNA CTD PMID:20345932 NCBI chr 2:22,746,290...22,798,252
Ensembl chr 2:22,747,547...22,798,214 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP Levetiracetam results in decreased expression of TRDMT1 mRNA CTD PMID:20345932 NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195 		JBrowse link
G Vars2 valyl-tRNA synthetase 2, mitochondrial decreases expression EXP Levetiracetam results in decreased expression of VARS2 mRNA CTD PMID:20345932 NCBI chr20:3,588,462...3,599,514
Ensembl chr20:3,588,497...3,599,514 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression EXP Levetiracetam results in decreased expression of XRCC1 mRNA CTD PMID:20345932 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
G Zfp266 zinc finger protein 266 increases expression EXP Levetiracetam results in increased expression of ZFP266 mRNA CTD PMID:20345932 NCBI chr 8:21,511,831...21,543,275
Ensembl chr 8:21,511,839...21,523,540 		JBrowse link
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  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          levetiracetam 41
Path 2
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  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  gamma-lactam 6266
                                                    pyrrolidin-2-ones 140
                                                      levetiracetam 41
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