CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: levetiracetam
Accession: CHEBI:6437
browse the term
Definition: A pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine.
Synonyms: exact_synonym: (2S)-2-(2-oxopyrrolidin-1-yl)butanamide
related_synonym: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide; Formula=C8H14N2O2; InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1; InChIKey=HPHUVLMMVZITSG-LURJTMIESA-N; Keppra; SMILES=CC[C@H](N1CCCC1=O)C(N)=O; UCB-L 059; levetiracetamum
xref: CAS:102767-28-2; DrugBank:DB01202; Drug_Central:1563; KEGG:C07841; KEGG:D00709; LINCS:LSM-5603
xref_mesh: MESH:D000077287
xref: PMID:22119754; PMID:22321334; Reaxys:8407472; VSDB:2979; Wikipedia:Levetiracetam
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases activity increases transport increases expression
EXP ISO
Amino Acids, Peptides, and Proteins inhibits the reaction [Levetiracetam results in increased expression of ABCB1 protein] Levetiracetam results in decreased activity of ABCB1 protein ABCB1A protein results in increased transport of Levetiracetam
CTD
PMID:17045309 PMID:18408562 PMID:18473823
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc1
ATP binding cassette subfamily C member 1
increases expression
EXP
Levetiracetam results in increased expression of ABCC1 protein
CTD
PMID:18473823
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
Abcc2
ATP binding cassette subfamily C member 2
increases expression
EXP
Levetiracetam results in increased expression of ABCC2 protein
CTD
PMID:18473823
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Acvrl1
activin A receptor like type 1
decreases expression
EXP
Levetiracetam results in decreased expression of ACVRL1 mRNA
CTD
PMID:20345932
NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
G
Arhgef1
Rho guanine nucleotide exchange factor 1
decreases expression
EXP
Levetiracetam results in decreased expression of ARHGEF1 mRNA
CTD
PMID:20345932
NCBI chr 1:80,499,026...80,520,954
Ensembl chr 1:80,499,131...80,520,953
G
Atg7
autophagy related 7
decreases expression multiple interactions
EXP
Levetiracetam results in decreased expression of ATG7 protein Quercetin inhibits the reaction [Levetiracetam results in decreased expression of ATG7 protein]
CTD
PMID:37098359
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
EXP
Levetiracetam results in decreased expression of BCL2 protein Quercetin inhibits the reaction [Levetiracetam results in decreased expression of BCL2 protein]
CTD
PMID:37098359
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
decreases expression
EXP
Levetiracetam results in decreased expression of CACNB1 mRNA
CTD
PMID:20345932
NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
G
Casp3
caspase 3
increases activity multiple interactions
EXP
Levetiracetam results in increased activity of CASP3 protein Quercetin inhibits the reaction [Levetiracetam results in increased activity of CASP3 protein]
CTD
PMID:37098359
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions decreases expression
ISO EXP
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein] Levetiracetam results in decreased expression of CAT protein Quercetin inhibits the reaction [Levetiracetam results in decreased expression of CAT protein]
CTD
PMID:17205390 PMID:37098359
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccnh
cyclin H
increases expression
EXP
Levetiracetam results in increased expression of CCNH mRNA
CTD
PMID:20345932
NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
G
Chrm2
cholinergic receptor, muscarinic 2
increases activity decreases expression
ISO
Levetiracetam results in increased activity of CHRM2 protein Levetiracetam results in decreased expression of CHRM2 protein
CTD
PMID:15967574
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Cxcr3
C-X-C motif chemokine receptor 3
increases expression
EXP
Levetiracetam results in increased expression of CXCR3 mRNA
CTD
PMID:20345932
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
G
Cycs
cytochrome c, somatic
increases expression multiple interactions
EXP
Levetiracetam results in increased expression of CYCS protein Quercetin inhibits the reaction [Levetiracetam results in increased expression of CYCS protein]
CTD
PMID:37098359
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Levetiracetam results in decreased expression of CYP17A1 mRNA
CTD
PMID:19566492
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
ISO
Levetiracetam results in decreased expression of CYP19A1 mRNA
CTD
PMID:19566492
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Dao
D-amino-acid oxidase
increases expression
EXP
Levetiracetam results in increased expression of DAO mRNA
CTD
PMID:20345932
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
G
Dbp
D-box binding PAR bZIP transcription factor
decreases expression
EXP
Levetiracetam results in decreased expression of DBP mRNA
CTD
PMID:20345932
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
G
Des
desmin
increases expression
EXP
Levetiracetam results in increased expression of DES mRNA
CTD
PMID:20345932
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
G
Gja1
gap junction protein, alpha 1
multiple interactions increases expression
EXP
Quercetin inhibits the reaction [Levetiracetam results in increased expression of GJA1 protein]
CTD
PMID:37098359
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gle1
GLE1 RNA export mediator
increases expression
EXP
Levetiracetam results in increased expression of GLE1 mRNA
CTD
PMID:20345932
NCBI chr 3:13,209,312...13,237,018
Ensembl chr 3:13,209,322...13,237,379
G
Got1
glutamic-oxaloacetic transaminase 1
increases activity
EXP
Levetiracetam results in increased activity of GOT1 protein
CTD
PMID:37572749
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Levetiracetam results in increased activity of GPT protein
CTD
PMID:37572749
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
decreases activity multiple interactions decreases expression
EXP
Levetiracetam results in decreased activity of GPX1 protein Quercetin inhibits the reaction [Levetiracetam results in decreased expression of GPX1 protein]
CTD
PMID:37098359 PMID:37572749
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Hcn2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
decreases expression
EXP
Levetiracetam results in decreased expression of HCN2 mRNA
CTD
PMID:20345932
NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
G
Hdac10
histone deacetylase 10
decreases expression
EXP
Levetiracetam results in decreased expression of HDAC10 mRNA
CTD
PMID:20345932
NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228
G
Hmox1
heme oxygenase 1
decreases expression
EXP
Levetiracetam results in decreased expression of HMOX1 protein
CTD
PMID:37098359
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hmox2
heme oxygenase 2
multiple interactions
EXP
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of HMOX2 protein]
CTD
PMID:37098359
NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases expression
ISO
Levetiracetam results in decreased expression of HSD3B2 mRNA
CTD
PMID:19566492
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Il1b
interleukin 1 beta
multiple interactions increases activity
EXP
Quercetin inhibits the reaction [Levetiracetam results in increased activity of IL1B protein]
CTD
PMID:37098359
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Kcna4
potassium voltage-gated channel subfamily A member 4
increases expression
EXP
Levetiracetam results in increased expression of KCNA4 mRNA
CTD
PMID:20345932
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
G
Kctd3
potassium channel tetramerization domain containing 3
increases expression
EXP
Levetiracetam results in increased expression of KCTD3 mRNA
CTD
PMID:20345932
NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718
G
Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases expression
EXP
Levetiracetam results in increased expression of KHDRBS2 mRNA
CTD
PMID:20345932
NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530
G
Lap3
leucine aminopeptidase 3
increases expression
EXP
Levetiracetam results in increased expression of LAP3 mRNA
CTD
PMID:20345932
NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
G
Lsm1
LSM1 homolog, mRNA degradation associated
increases expression
EXP
Levetiracetam results in increased expression of LSM1 mRNA
CTD
PMID:20345932
NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852
G
Mettl7b
methyltransferase like 7B
increases expression
EXP
Levetiracetam results in increased expression of METTL7B mRNA
CTD
PMID:20345932
NCBI chr 7:1,388,876...1,391,526
Ensembl chr 7:1,388,879...1,391,526
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases expression
EXP
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of MTOR protein]
CTD
PMID:37098359
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Nap1l2
nucleosome assembly protein 1-like 2
increases expression
EXP
Levetiracetam results in increased expression of NAP1L2 mRNA
CTD
PMID:20345932
NCBI chr X:68,174,051...68,176,449
Ensembl chr X:68,173,987...68,176,666
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions decreases expression
EXP
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NFE2L2 protein]
CTD
PMID:37098359
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Ngly1
N-glycanase 1
increases expression
EXP
Levetiracetam results in increased expression of NGLY1 mRNA
CTD
PMID:20345932
NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630
G
Nox1
NADPH oxidase 1
multiple interactions decreases expression
EXP
Quercetin inhibits the reaction [Levetiracetam results in decreased expression of NOX1 protein]
CTD
PMID:37098359
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
G
Phldb1
pleckstrin homology-like domain, family B, member 1
decreases expression
EXP
Levetiracetam results in decreased expression of PHLDB1 mRNA
CTD
PMID:20345932
NCBI chr 8:45,003,543...45,051,541
Ensembl chr 8:45,003,538...45,051,522
G
Pon1
paraoxonase 1
affects activity
ISO
Levetiracetam affects the activity of PON1 protein
CTD
PMID:28032682
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Prkx
protein kinase cAMP-dependent X-linked catalytic subunit
increases expression
EXP
Levetiracetam results in increased expression of PRKX mRNA
CTD
PMID:20345932
NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669
G
Psip1
PC4 and SRSF1 interacting protein 1
increases expression
EXP
Levetiracetam results in increased expression of PSIP1 mRNA
CTD
PMID:20345932
NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
G
Serinc1
serine incorporator 1
increases expression
EXP
Levetiracetam results in increased expression of SERINC1 mRNA
CTD
PMID:20345932
NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691
G
Slc23a2
solute carrier family 23 member 2
increases expression
EXP
Levetiracetam results in increased expression of SLC23A2 mRNA
CTD
PMID:20345932
NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
G
Slc4a7
solute carrier family 4 member 7
increases expression
EXP
Levetiracetam results in increased expression of SLC4A7 mRNA
CTD
PMID:20345932
NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781
G
Smc2
structural maintenance of chromosomes 2
increases expression
EXP
Levetiracetam results in increased expression of SMC2 mRNA
CTD
PMID:20345932
NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
G
Sod1
superoxide dismutase 1
decreases activity decreases expression multiple interactions
EXP
Levetiracetam results in decreased activity of SOD1 protein Levetiracetam results in decreased expression of SOD1 protein Quercetin inhibits the reaction [Levetiracetam results in decreased expression of SOD1 protein]
CTD
PMID:37098359 PMID:37572749
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Star
steroidogenic acute regulatory protein
decreases expression
ISO
Levetiracetam results in decreased expression of STAR mRNA
CTD
PMID:19566492
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Tent2
terminal nucleotidyltransferase 2
increases expression
EXP
Levetiracetam results in increased expression of TENT2 mRNA
CTD
PMID:20345932
NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099
G
Tnf
tumor necrosis factor
increases activity multiple interactions
EXP
Levetiracetam results in increased activity of TNF protein Quercetin inhibits the reaction [Levetiracetam results in increased activity of TNF protein]
CTD
PMID:37098359
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases activity multiple interactions
EXP
Levetiracetam results in increased activity of TP53 protein Quercetin inhibits the reaction [Levetiracetam results in increased activity of TP53 protein]
CTD
PMID:37098359
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Trdmt1
tRNA aspartic acid methyltransferase 1
decreases expression
EXP
Levetiracetam results in decreased expression of TRDMT1 mRNA
CTD
PMID:20345932
NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
G
Vars2
valyl-tRNA synthetase 2, mitochondrial
decreases expression
EXP
Levetiracetam results in decreased expression of VARS2 mRNA
CTD
PMID:20345932
NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994
G
Xrcc1
X-ray repair cross complementing 1
decreases expression
EXP
Levetiracetam results in decreased expression of XRCC1 mRNA
CTD
PMID:20345932
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
G
Zfp266
zinc finger protein 266
increases expression
EXP
Levetiracetam results in increased expression of ZFP266 mRNA
CTD
PMID:20345932
NCBI chr 8:19,030,766...19,061,381
Ensembl chr 8:19,030,768...19,060,937
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all