RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Neoplasm Metastasis
Accession: DOID:9000965
browse the term
Definition: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Synonyms: exact_synonym: Metastases; Metastasis; Neoplasm Metastases
primary_id: MESH:D009362
xref: EFO:0009708 ; EFO:0009709 ; EFO:0010941
G
ABCB1
ATP binding cassette subfamily B member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12015757
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
G
ABCC4
ATP binding cassette subfamily C member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17003774
NCBI chr22:45,767,033...46,013,577
Ensembl chr22:45,765,835...46,013,505
G
ACE
angiotensin I converting enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18059164
NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
G
ACKR3
atypical chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22180778
NCBI chr25:47,327,921...47,339,632
Ensembl chr25:47,327,963...47,339,622
G
ACSBG1
acyl-CoA synthetase bubblegum family member 1
ISO
associated with pheochromocytoma
RGD
PMID:29067245
RGD:13831131
NCBI chr 3:58,319,222...58,367,087
Ensembl chr 3:58,319,376...58,366,854
G
ACVR2A
activin A receptor type 2A
exacerbates
ISO
associated with colon cancer;mRNA,protein:decreased expression:colon (human)
RGD
PMID:30310521
RGD:151361136
NCBI chr19:49,642,429...49,726,720
Ensembl chr19:49,641,219...49,723,420
G
ADGRB1
adhesion G protein-coupled receptor B1
ISO
associated with colorectal cancer
RGD
PMID:9772287
RGD:13831353
NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936
G
ADORA2B
adenosine A2b receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27590504
NCBI chr 5:39,884,375...39,908,214
G
AGTR1
angiotensin II receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18059164
NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238
G
AGTR2
angiotensin II receptor type 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18059164
NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853
G
AHR
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21948867
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
G
AKIRIN2
akirin 2
ISO
RGD
PMID:18460465
RGD:2306009
NCBI chr12:47,113,856...47,132,800
Ensembl chr12:47,113,857...47,132,555
G
AKT2
AKT serine/threonine kinase 2
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:19491266
RGD:2315599
NCBI chr 1:113,359,038...113,407,119
Ensembl chr 1:113,359,575...113,407,131
G
ALDOA
aldolase, fructose-bisphosphate A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr 6:18,077,241...18,083,053
G
ALK
ALK receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22986231 PMID:22999080
NCBI chr17:23,010,308...23,688,841
Ensembl chr17:23,010,308...23,688,841
G
ALOX5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20061081
NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
G
AMIGO2
adhesion molecule with Ig like domain 2
ISO
Liver Metastasis
RGD
PMID:28272394
RGD:14394499
NCBI chr27:7,507,426...7,510,015
Ensembl chr27:7,507,489...7,509,054
G
ANGPTL4
angiopoietin like 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17130448
NCBI chr20:52,942,090...52,948,126
Ensembl chr20:52,942,259...52,947,475
G
ANTXR1
ANTXR cell adhesion molecule 1
ISO
associated with Mammary Neoplasms, Experimental;
RGD
PMID:22085271
RGD:9684855
NCBI chr10:67,829,573...68,021,368
Ensembl chr10:67,829,225...68,019,127
G
ANXA1
annexin A1
treatment
ISO
associated with Mammary Neoplasms, Experimental associated with Mammary Neoplasms, Experimental;protein:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9514092 PMID:20308542 PMID:20821804
RGD:2306939 RGD:7421541 RGD:7421563
NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
G
ANXA4
annexin A4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr10:68,418,678...68,466,181
Ensembl chr10:68,431,056...68,466,174
G
ANXA7
annexin A7
ISO
associated with Breast Neoplasms;protein:increased expression:breast associated with Prostatic Neoplasms;protein:decreased expression:prostate gland
RGD
PMID:11287641 PMID:15073110
RGD:2292655 RGD:2292656
NCBI chr 4:23,933,959...23,961,968
Ensembl chr 4:23,934,234...23,961,880
G
APOE
apolipoprotein E
ISO
RGD
PMID:22469977
RGD:7771597
NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
G
ARHGDIA
Rho GDP dissociation inhibitor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr 9:419,350...422,284
Ensembl chr 9:419,413...423,252
G
ARID1A
AT-rich interaction domain 1A
disease_progression
ISO
in lung; associated with hepatocellular carcinoma
RGD
PMID:25975202
RGD:125097495
NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102
G
ATP6V1C1
ATPase H+ transporting V1 subunit C1
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:24155661
RGD:14700647
NCBI chr13:4,509,699...4,569,500
Ensembl chr13:4,510,003...4,579,846
G
AXL
AXL receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26206560
NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960
G
AZIN1
antizyme inhibitor 1
ISO
associated with stomach cancer;RNA:increased editing:stomach associated with colorectal cancer;RNA:increased editing:colorectum
RGD
PMID:29925690 PMID:30563560
RGD:14700703 RGD:14700704
NCBI chr13:4,363,996...4,396,069
Ensembl chr13:4,361,340...4,396,040
G
B9D2
B9 domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23146760 PMID:23992306 PMID:26896736 PMID:31381904
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
G
BAX
BCL2 associated X, apoptosis regulator
ISO
associated with Carcinoma, Infiltrating Duct
RGD
PMID:17288732
RGD:1643356
NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
G
BCL2
BCL2 apoptosis regulator
ISO
associated with Carcinoma, Renal Cell associated with Breast Neoplasms
RGD
PMID:12810203 PMID:16826579
RGD:2293020 RGD:2293021
NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
G
BMP6
bone morphogenetic protein 6
severity
ISO
associated with Prostatic Neoplasms;protein:increased expression:bone
RGD
PMID:16166304
RGD:2289018
NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845
G
BMP7
bone morphogenetic protein 7
disease_progression
ISO
associated with Prostatic Neoplasms;mRNA:increased expression:bone associated with Breast Neoplasms;protein:increased expression:breast
RGD
PMID:12539225 PMID:17895257
RGD:2289029 RGD:2289033
NCBI chr24:42,203,183...42,294,105
Ensembl chr24:42,204,823...42,294,653
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
onset
ISO
associated with Melanoma; DNA:mutations: :
RGD
PMID:25623140
RGD:11567259
NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906
G
BRD4
bromodomain containing 4
ISO
RGD
PMID:23950209
RGD:9586346
NCBI chr20:46,844,795...46,927,620
Ensembl chr20:46,891,514...46,927,608
G
BRMS1
BRMS1 transcriptional repressor and anoikis regulator
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27501413
NCBI chr18:50,967,175...50,974,816
Ensembl chr18:50,967,270...50,974,321
G
BSG
basigin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21956400
NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061
G
CAB39
calcium binding protein 39
ISO
associated with hepatocellular carcinoma;
RGD
PMID:28605041
RGD:14398832
NCBI chr25:42,752,798...42,801,257
Ensembl chr25:42,703,332...42,799,279
G
CACYBP
calcyclin binding protein
ISO
associated with pancreatic neoplasms
RGD
PMID:18765951
RGD:2326146
NCBI chr 7:24,372,599...24,384,084
Ensembl chr 7:24,372,596...24,383,926
G
CAP1
cyclase associated actin cytoskeleton regulatory protein 1
ISO
associated with Pancreatic Neoplasms; mRNA, protein:increased expression:pancreas
RGD
PMID:19188911
RGD:2326238
NCBI chr15:2,886,661...2,913,975
G
CASP3
caspase 3
ISO
associated with Breast Neoplasms
RGD
PMID:18064531
RGD:2293306
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
G
CAT
catalase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12538496 PMID:22580338 PMID:23518002
NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
G
CAV1
caveolin 1
treatment
ISO
associated with Mammary Neoplasms, Experimental CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15334058 PMID:15355971 PMID:20562527
RGD:2289106 RGD:8661780
NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935
G
CBX4
chromobox 4
ISO
associated with Carcinoma, Hepatocellular;
RGD
PMID:24838576
RGD:9586738
NCBI chr 9:1,799,847...1,807,500
Ensembl chr 9:1,802,047...1,807,690
G
CBX5
chromobox 5
ISO
associated with Lung Neoplasms;
RGD
PMID:22900142
RGD:9586743
NCBI chr27:1,020,500...1,058,027
Ensembl chr27:1,039,594...1,049,788
G
CCL2
C-C motif chemokine ligand 2
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:19629725
RGD:4891450
NCBI chr 9:39,008,187...39,009,932
G
CCL20
C-C motif chemokine ligand 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30603057
NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709
G
CCL5
C-C motif chemokine ligand 5
treatment
ISO
associated with Animal Mammary Neoplasms;
RGD
PMID:15692764
RGD:14995455
NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
G
CCN4
cellular communication network factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30723155
NCBI chr13:29,648,720...29,683,822
Ensembl chr13:29,648,639...29,679,732
G
CCNA2
cyclin A2
ISO
associated with Seminoma;protein:increased expression:testis
RGD
PMID:14696091
RGD:2293346
NCBI chr19:18,317,866...18,324,592
Ensembl chr19:18,318,004...18,323,691
G
CCND1
cyclin D1
treatment
ISO
associated with Carcinoma, Non-Small-Cell Lung;mRNA:splice variant associated with stomach cancer; human cells in mouse model
RGD
PMID:18715616 PMID:27431311
RGD:13434926 RGD:152995400
NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005
G
CCND2
cyclin D2
ISO
associated with Breast Neoplasms;DNA:hypermethylated:brain
RGD
PMID:15131050
RGD:2289155
NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255
G
CCNE1
cyclin E1
disease_progression
ISO
associated with non-small cell lung carcinoma protein:altered processing
RGD
PMID:11212263 PMID:17671189
RGD:13673913 RGD:2289229
NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
G
CCR5
C-C motif chemokine receptor 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35072892
NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
G
CD274
CD274 molecule
disease_progression
ISO
associated with ovarian cancer
RGD
PMID:23340297
RGD:41410797
NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
G
CD44
CD44 molecule
ISO
CTD Direct Evidence: marker/mechanism associated with Carcinoma, Renal Cell;protein:increased expression:kidney
CTD RGD
PMID:18026989 PMID:23098472
RGD:2289347
NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
G
CD82
CD82 molecule
ISO
associated with Prostatic Neoplasms;mRNA:decreased expression associated with Carcinoma, Infiltrating Duct;mRNA:decreased expression:brain associated with Prostatic Neoplasms;DNA:loss of heterozygosity CTD Direct Evidence: therapeutic associated with Carcinoma, Hepatocellular;mRNA:decreased expression associated with Prostatic Neoplasms;mRNA:decreased expression:bone
RGD CTD
PMID:9254900 PMID:9831222 PMID:11275982 PMID:12806379 PMID:15592684 PMID:20075392 More...
RGD:2289400 RGD:2289402 RGD:2289407 RGD:2289425 RGD:68869
NCBI chr18:44,658,414...44,707,897
Ensembl chr18:44,659,180...44,706,768
G
CD86
CD86 molecule
ISO
mRNA:decreased expression:mediastinal lymph node (rat)
RGD
PMID:18360875
RGD:4892237
NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087
G
CDH1
cadherin 1
treatment
ISO
associated with Prostatic Neoplasms associated with stomach cancer; human cells in mouse model CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17520682 PMID:18008331 PMID:22580338 PMID:27431311
RGD:152995400 RGD:2289488
NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878
G
CDH2
cadherin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23876460
NCBI chr 7:60,736,760...60,950,477
Ensembl chr 7:60,736,760...60,951,034
G
CDKL2
cyclin dependent kinase like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25333262
NCBI chr32:158,140...206,860
Ensembl chr32:159,332...202,617
G
CDKN1A
cyclin dependent kinase inhibitor 1A
ISO
associated with Melanoma;
RGD
PMID:9194578
RGD:8662817
NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
G
CDKN2A
cyclin dependent kinase inhibitor 2A
ISO
associated with Paraganglioma, Extra-Adrenal;DNA:hypermethylation
RGD
PMID:18509008
RGD:8552280
NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379
G
CFL1
cofilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr18:51,404,649...51,408,240
Ensembl chr18:51,401,659...51,408,212
G
CGA
glycoprotein hormones, alpha polypeptide
ISO
associated with Breast Neoplasms;protein:increased expression:serum
RGD
PMID:6768680
RGD:2293637
NCBI chr12:46,610,801...46,629,322
Ensembl chr12:46,610,973...46,636,640
G
CHEK1
checkpoint kinase 1
ISO
associated with Pancreatic Neoplasms
RGD
PMID:15448002
RGD:2317235
NCBI chr 5:8,878,511...8,910,626
Ensembl chr 5:8,879,147...8,907,669
G
CHUK
component of inhibitor of nuclear factor kappa B kinase complex
ISO
associated with prostate adenocarcinoma
RGD
PMID:17377533
RGD:2298657
NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512
G
CIC
capicua transcriptional repressor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869830
NCBI chr 1:112,081,775...112,105,093
Ensembl chr 1:112,082,265...112,105,082
G
CLDN7
claudin 7
ISO
RGD
PMID:23390083
RGD:9685143
NCBI chr 5:32,223,985...32,225,795
Ensembl chr 5:32,224,040...32,226,168
G
CLIC1
chloride intracellular channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr12:1,209,777...1,215,229
Ensembl chr12:1,209,780...1,215,229
G
CLU
clusterin
ISO
associated with Breast Neoplasms
RGD
PMID:20307318
RGD:8883512
NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
G
CREB1
cAMP responsive element binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29179997
NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556
G
CSF1
colony stimulating factor 1
ISO
associated with Prostatic Neoplasms
RGD
PMID:18510570
RGD:2293638
NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371
G
CSF1R
colony stimulating factor 1 receptor
exacerbates
ISO
associated with Prostatic Neoplasms associated with breast cancer CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:1390197 PMID:18510570 PMID:25005824
RGD:150524287 RGD:2293638
NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510
G
CSF3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:7543699 PMID:9018096
NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108
G
CSTA
cystatin A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20461718
NCBI chr33:25,477,789...25,489,123
Ensembl chr33:25,478,055...25,489,121
G
CTLA4
cytotoxic T-lymphocyte associated protein 4
disease_progression
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:15701862 PMID:18049334
RGD:4891518 RGD:7204722
NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874
G
CTNNB1
catenin beta 1
ISO
associated with Prostatic Neoplasms CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18008331 PMID:29106415
RGD:2289488
NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
G
CTSB
cathepsin B
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:12589965
RGD:5686394
NCBI chr25:26,048,237...26,056,570
Ensembl chr25:26,048,253...26,055,801
G
CTSD
cathepsin D
ISO
protein:increased expression:oral cavity, oropharynx, hypopharynx (human)
RGD
PMID:10562684
RGD:1547892
NCBI chr18:46,010,440...46,019,457
Ensembl chr18:46,010,440...46,019,457
G
CTSH
cathepsin H
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:12589965
RGD:5686394
NCBI chr 3:58,103,284...58,113,958
Ensembl chr 3:58,103,291...58,113,718
G
CTU1
cytosolic thiouridylase subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 1:105,795,273...105,800,722
G
CTU2
cytosolic thiouridylase subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr 5:64,640,389...64,647,298
Ensembl chr 5:64,640,389...64,647,215
G
CX3CR1
C-X3-C motif chemokine receptor 1
susceptibility
ISO
associated with Breast Neoplasms
RGD
PMID:16627550
RGD:4892015
NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
G
CXCL12
C-X-C motif chemokine ligand 12
treatment
ISO
associated with Pancreatic Carcinoma CTD Direct Evidence: marker/mechanism associated with Pancreatic Neoplasms
RGD CTD
PMID:12761880 PMID:21312072 PMID:23743303 PMID:26330165
RGD:10398726 RGD:2317610
NCBI chr28:2,895,916...2,903,543
G
CXCR3
C-X-C motif chemokine receptor 3
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:16885372
RGD:5135487
NCBI chr X:55,882,433...55,884,582
Ensembl chr X:55,882,433...55,884,582
G
CXCR4
C-X-C motif chemokine receptor 4
ameliorates disease_progression severity
ISO
associated with lung cancer; human cells in mouse model associated with lung non-small cell carcinoma; protein:increased expression:lung (human) associated with lung non-small cell carcinoma;mRNA,protein:increased expression:lung (human) associated with Otorhinolaryngologic Neoplasms;mRNA,protein:increased expression:Laryngeal and hypopharyngeal tissue (human) associated with oral squamous cell carcinoma human cells in mouse model;associated with lung cancer CTD Direct Evidence: marker/mechanism associated with osteosarcoma;protein:increased expression:bone (human) associated with pancreatic cancer
RGD CTD
PMID:16230077 PMID:16322285 PMID:17634424 PMID:18487224 PMID:21312072 PMID:23743303 PMID:24932250 PMID:25504108 PMID:26546437 PMID:28000861 PMID:32037613 More...
RGD:151708730 RGD:152023741 RGD:152023745 RGD:152023746 RGD:152025556 RGD:152177475 RGD:152177476 RGD:152177478 RGD:152177479
NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
G
CYP19A1
cytochrome P450 family 19 subfamily A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28112739
NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353
G
DAB2IP
DAB2 interacting protein
severity
ISO
associated with colorectal cancer;protein:decreased expression:colorectum (human)
RGD
PMID:26336990
RGD:11531913
NCBI chr 9:60,725,887...60,918,242
Ensembl chr 9:60,726,809...60,918,139
G
DAPK1
death associated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17319784
NCBI chr 1:72,278,939...72,448,907
Ensembl chr 1:72,280,103...72,447,822
G
DAXX
death domain associated protein
ISO
RGD
PMID:23539629
RGD:9587820
NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
G
DCN
decorin
ISO
associated with Breast Neoplasms
RGD
PMID:18688028
RGD:2311418
NCBI chr15:31,833,492...31,887,699
Ensembl chr15:31,833,746...31,877,417
G
DDR1
discoidin domain receptor tyrosine kinase 1
severity
ISO
mRNA:increased expression:ovary (human) protein:increased expression:bone (human)
RGD
PMID:28743276 PMID:29039472
RGD:151347541 RGD:151347601
NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543
G
DDR2
discoidin domain receptor tyrosine kinase 2
ameliorates
ISO
associated with melanoma;
RGD
PMID:24293323
RGD:150429711
NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275
G
DDX3X
DEAD-box helicase 3 X-linked
ISO
human cells in mouse model
RGD
PMID:26087195
RGD:11096798
NCBI chr X:35,759,367...35,789,759
Ensembl chr X:35,759,416...35,789,774
G
DEK
DEK proto-oncogene
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr35:17,014,802...17,045,308
Ensembl chr35:17,016,231...17,044,749
G
DHFR
dihydrofolate reductase
disease_progression
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:8149482 PMID:19159907
RGD:11040442
NCBI chr 3:26,521,214...26,556,065
G
DIO3
iodothyronine deiodinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26825960
NCBI chr 8:69,696,779...69,698,880
G
DMD
dystrophin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24793134
NCBI chr X:26,290,903...28,444,635
Ensembl chr X:26,290,910...28,333,576
G
DNMT3B
DNA methyltransferase 3 beta
ISO
associated with Uterine Cervical Neoplasms;
RGD
PMID:22330137
RGD:9589117
NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900
G
DPYD
dihydropyrimidine dehydrogenase
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Colonic Neoplasms
CTD RGD
PMID:11383214 PMID:17611699
RGD:11251755
NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923
G
E2F8
E2F transcription factor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27683099
NCBI chr21:41,340,410...41,358,261
Ensembl chr21:41,340,969...41,357,206
G
EDN1
endothelin 1
ISO
RGD
PMID:12941866
RGD:734914
NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
G
EDNRA
endothelin receptor type A
ISO
associated with Bladder Neoplasms
RGD
PMID:21183790
RGD:4892282
NCBI chr15:45,823,472...45,878,527
Ensembl chr15:45,823,560...45,876,463
G
EEF1B2
eukaryotic translation elongation factor 1 beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005 PMID:20562527
NCBI chr37:14,713,927...14,716,894
Ensembl chr37:14,714,017...14,716,850
G
EEF2
eukaryotic translation elongation factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126
G
EFNB2
ephrin B2
ISO
associated with cholangiocarcinoma;protein:increased expression:biliary ductule (human)
RGD
PMID:25012246
RGD:153305948
NCBI chr22:55,567,992...55,609,210
Ensembl chr22:55,566,039...55,609,443
G
EGF
epidermal growth factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21942447 PMID:23064031
NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295
G
EGFR
epidermal growth factor receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17369752 PMID:17575224 PMID:23867902
NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
G
EHMT2
euchromatic histone lysine methyltransferase 2
ISO
associated with lung neoplasms; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20940408 PMID:25115793
RGD:9589170
NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584
G
EIF1AX
eukaryotic translation initiation factor 1A X-linked
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr X:16,081,335...16,102,627
Ensembl chr X:16,081,392...16,099,142
G
EIF4A2
eukaryotic translation initiation factor 4A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr34:19,354,739...19,361,021
Ensembl chr34:19,354,825...19,409,844
G
ELP3
elongator acetyltransferase complex subunit 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27811057
NCBI chr25:29,415,229...29,507,159
Ensembl chr25:29,415,924...29,507,098
G
EML4
EMAP like 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22986231 PMID:22999080
NCBI chr17:33,774,478...33,935,478
Ensembl chr17:33,774,140...33,934,147
G
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26037280
NCBI chr13:18,586,886...18,697,339
Ensembl chr13:18,587,129...18,697,324
G
EPCAM
epithelial cell adhesion molecule
ISO
RGD
PMID:23390083
RGD:9685143
NCBI chr10:49,446,165...49,498,690
Ensembl chr10:49,485,746...49,498,475
G
EPO
erythropoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16699298
NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144
G
EPOR
erythropoietin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16699298
NCBI chr20:49,945,777...49,950,856
Ensembl chr20:49,945,777...49,950,856
G
ERBB2
erb-b2 receptor tyrosine kinase 2
ISO
CTD Direct Evidence: marker/mechanism rat gene in a mouse model
CTD RGD
PMID:11238891 PMID:16984552
RGD:734938
NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294
G
ERBB3
erb-b2 receptor tyrosine kinase 3
disease_progression
ISO
CTD Direct Evidence: marker/mechanism associated with lung adenocarcinoma associated with Prostatic Neoplasms;protein:increased expression, altered localization:bone, nucleus associated with Prostatic Neoplasms;protein:alternative form
CTD RGD
PMID:17634423 PMID:18559590 PMID:26254096 PMID:28114269
RGD:126790470 RGD:2289944 RGD:2298500
NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264
G
ERBB4
erb-b2 receptor tyrosine kinase 4
disease_progression
ISO
associated with lung adenocarcinoma
RGD
PMID:26254096
RGD:126790470
NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426
G
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
disease_progression
ISO
CTD Direct Evidence: marker/mechanism associated with Melanoma
CTD RGD
PMID:20801905 PMID:26202595
RGD:11252177
NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602
G
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20372803
NCBI chr 6:29,193,192...29,226,935
Ensembl chr 6:29,196,421...29,226,887
G
ERP29
endoplasmic reticulum protein 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr26:9,608,352...9,616,711
Ensembl chr26:9,608,399...9,616,338
G
ESR1
estrogen receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20104649 PMID:35044086
NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
G
ETV4
ETS variant transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869830
NCBI chr 9:19,715,259...19,731,085
Ensembl chr 9:19,715,535...19,730,456
G
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
ISO
associated with osteosarcoma associated with lung non-small cell carcinoma associated with stomach cancer;protein:increased expression:stomach
RGD
PMID:20132185 PMID:24097870 PMID:26265454
RGD:11532507 RGD:126779607 RGD:126781716
NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838
G
EZR
ezrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27137931
NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036
G
F2
coagulation factor II, thrombin
ISO
associated with Carcinoma, Small cell;protein:increased expression:brain
RGD
PMID:22065054
RGD:6893520
NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
G
FADD
Fas associated via death domain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16450001
NCBI chr18:48,087,447...48,094,497
G
FAS
Fas cell surface death receptor
ISO
associated with Breast Neoplasms;protein:decreased expression:breast associated with Mammary Neoplasms;protein:decreased expression:lung
RGD
PMID:17352235 PMID:17918178
RGD:2290048 RGD:2290053
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
G
FASLG
Fas ligand
ISO
associated with Breast Neoplasms;protein:decreased expression:breast
RGD
PMID:17352235
RGD:2290053
NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
G
FGF13
fibroblast growth factor 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19917848
NCBI chr X:108,658,113...109,156,096
Ensembl chr X:108,658,941...109,156,594
G
FGFR1
fibroblast growth factor receptor 1
ISO
associated with prostate adenocarcinoma
RGD
PMID:23576558
RGD:13504748
NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261
G
FLT1
fms related receptor tyrosine kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21975929
NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621
G
FN1
fibronectin 1
treatment
ISO
associated with stomach cancer; human cells in mouse model
RGD
PMID:27431311
RGD:152995400
NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
G
FSCN1
fascin actin-bundling protein 1
ISO
associated with Pancreatic Neoplasms
RGD
PMID:15626919
RGD:2317788
NCBI chr 6:12,360,849...12,370,906
Ensembl chr 6:12,354,599...12,370,808
G
FTL
ferritin light chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 1:107,418,457...107,419,923
Ensembl chr 1:107,418,458...107,419,923
G
GAB2
GRB2 associated binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21996746
NCBI chr21:20,414,903...20,605,807
Ensembl chr21:20,277,507...20,606,736
G
GDF15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23996089
NCBI chr20:44,633,131...44,636,842
Ensembl chr20:44,634,588...44,636,821
G
GJB1
gap junction protein beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17978847
NCBI chr X:55,565,995...55,575,332
Ensembl chr X:55,573,808...55,574,659
G
GP1BA
glycoprotein Ib platelet subunit alpha
ISO
associated with Melanoma, Experimental
RGD
PMID:19727118
RGD:10450866
NCBI chr 5:31,681,605...31,683,261
G
GPCPD1
glycerophosphocholine phosphodiesterase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25482527
NCBI chr24:16,153,622...16,203,155
Ensembl chr24:16,148,035...16,220,757
G
GPI
glucose-6-phosphate isomerase
ISO
RGD
PMID:20978190
RGD:11051956
NCBI chr 1:117,922,380...117,948,325
Ensembl chr 1:117,922,635...117,948,316
G
GPX2
glutathione peroxidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23867582
NCBI chr 8:39,322,040...39,325,833
Ensembl chr 8:39,322,034...39,325,817
G
HABP2
hyaluronan binding protein 2
treatment
ISO
associated with Thyroid Neoplasms
RGD
PMID:22715430
RGD:11353856
NCBI chr28:24,489,665...24,522,336
Ensembl chr28:24,489,773...24,522,263
G
HAVCR2
hepatitis A virus cellular receptor 2
disease_progression
ISO
DNA:polymorphisms: : +4259T>G (human)
RGD
PMID:22472081
RGD:7245505
NCBI chr 4:53,018,990...53,032,035
Ensembl chr 4:53,012,234...53,033,393
G
HDAC3
histone deacetylase 3
ISO
associated with Anaphylaxis; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:24619412 PMID:34973135
RGD:9590165
NCBI chr 2:36,583,283...36,598,121
Ensembl chr 2:36,583,283...36,597,682
G
HGF
hepatocyte growth factor
ISO
CTD Direct Evidence: marker/mechanism associated with Melanoma; associated with Mammary Neoplasms, Experimental; associated with Pancreatic Neoplasms
CTD RGD
PMID:10688652 PMID:11893931 PMID:16459153 PMID:25971889
RGD:2317904 RGD:8548538 RGD:8548625
NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263
G
HPSE
heparanase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22240343
NCBI chr32:7,166,437...7,199,659
Ensembl chr32:7,167,856...7,199,665
G
HRH2
histamine receptor H2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6224980
NCBI chr 4:37,333,843...37,407,146
Ensembl chr 4:37,275,852...37,386,072
G
HSP90AA1
heat shock protein 90 alpha family class A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20562527
NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243
G
IBSP
integrin binding sialoprotein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22407340 PMID:24980816
NCBI chr32:11,187,188...11,200,860
Ensembl chr32:11,187,160...11,200,846
G
ICAM1
intercellular adhesion molecule 1
ISO
associated with Pancreatic Neoplasms;protein:increased expression:serum associated with Melanoma, Cutaneous Malignant
RGD
PMID:10465581 PMID:12923961
RGD:2325163 RGD:8547593
NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
G
ID1
inhibitor of DNA binding 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24910342
NCBI chr24:21,094,339...21,096,276
Ensembl chr24:21,094,755...21,096,276
G
IGF1
insulin like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism associated with Uveal Melanoma;protein:increased expression:serum: associated with Pancreatic Neoplasms
CTD RGD
PMID:18398872 PMID:19375852 PMID:23197685
RGD:2317643 RGD:8548834
NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
G
IGF1R
insulin like growth factor 1 receptor
ISO
associated with Pancreatic Neoplasms
RGD
PMID:16575403
RGD:2317645
NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
G
IGF2
insulin like growth factor 2
ISO
associated with Arthritis, Experimental; protein:increased expression:lung, bone, serum:
RGD
PMID:21859454
RGD:5510000
NCBI chr18:46,294,036...46,311,982
Ensembl chr18:46,294,019...46,311,982
G
IKZF1
IKAROS family zinc finger 1
ISO
associated with colorectal cancer;DNA:polymorphisms:
RGD
PMID:31320627
RGD:150540328
NCBI chr18:1,661,851...1,750,987
Ensembl chr18:1,661,690...1,770,768
G
IL10
interleukin 10
ISO
RGD
PMID:16035616
RGD:1598627
NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
G
IL18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum associated with breast cancer;DNA:SNP:promoter:-137G>C (rs187238) (human) associated with breast cancer;protein:increased expression:serum
CTD RGD
PMID:11215816 PMID:12209760 PMID:12748951 PMID:19152241
RGD:4889862 RGD:8655866 RGD:8655899
NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
G
IL2
interleukin 2
treatment
ISO
associated with neuroblastoma. CTD Direct Evidence: therapeutic associated with melanoma associated with melanoma;
RGD CTD
PMID:8610104 PMID:8642346 PMID:9362156 PMID:17105418
RGD:14747043 RGD:14865005 RGD:8663438
NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
G
IL6
interleukin 6
treatment
ISO
associated with stomach cancer, human cells in mouse model CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21937440 PMID:26101800 PMID:28186964
RGD:127229952
NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
G
ITGA6
integrin subunit alpha 6
ISO
RGD
PMID:13130099
RGD:1302259
NCBI chr36:16,777,363...16,858,725
Ensembl chr36:16,776,863...16,855,449
G
ITGB1
integrin subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23562787
NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961
G
ITGB3
integrin subunit beta 3
ISO
mRNA, protein:increased expression:lung associated with renal cell carcinoma;DNA:missense mutation:cds:p.L33P (human)
RGD
PMID:16831169 PMID:21107114
RGD:5037225 RGD:6907406
NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451
G
JAK2
Janus kinase 2
treatment
ISO
associated with stomach cancer, human cells in mouse model
RGD
PMID:28186964
RGD:127229952
NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
G
JUP
junction plakoglobin
ISO
associated with Ovarian Neoplasms
RGD
PMID:15619205
RGD:2301746
NCBI chr 9:21,028,773...21,053,071
Ensembl chr 9:21,028,828...21,053,071
G
KDM6A
lysine demethylase 6A
disease_progression
ISO
associated with lung adenocarcinoma;protein:increased expression:brain (human)
RGD
PMID:33291558
RGD:150429741
NCBI chr X:38,745,854...38,964,029
Ensembl chr X:38,745,854...38,959,842
G
KDR
kinase insert domain receptor
ISO
associated with Carcinoma, Renal Cell
RGD
PMID:17465216
RGD:2301757
NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
G
KIF2C
kinesin family member 2C
disease_progression
ISO
associated with colorectal cancer
RGD
PMID:18506187
RGD:27372891
NCBI chr15:15,558,024...15,579,371
Ensembl chr15:15,558,021...15,579,217
G
KISS1
KiSS-1 metastasis suppressor
ISO
associated with Ovarian Neoplasms
RGD
PMID:16283480
RGD:2298668
NCBI chr38:768,333...774,328
Ensembl chr38:768,585...773,382
G
KMT2B
lysine methyltransferase 2B
ISO
associated with lung adenocarcinoma
RGD
PMID:33291558
RGD:150429741
NCBI chr 1:116,894,024...116,913,464
Ensembl chr 1:116,893,074...116,913,472
G
KMT2D
lysine methyltransferase 2D
disease_progression
ISO
associated with colorectal cancer;DNA:mutations::
RGD
PMID:27875625
RGD:155582219
NCBI chr27:5,516,866...5,556,303
Ensembl chr27:5,521,804...5,553,490
G
KRAS
KRAS proto-oncogene, GTPase
treatment disease_progression
ISO
associated with colorectal cancer; DNA:mutation:cds: associated with stomach cancer; human cells in mouse model associated with colorectal cancer;DNA:mutation: : associated with Fibrosarcoma;mRNA,protein:decreased expression:: CTD Direct Evidence: marker/mechanism associated with colorectal cancer;DNA:mutations: :
RGD CTD
PMID:3552201 PMID:8635384 PMID:26210240 PMID:27264476 PMID:27431311 PMID:29032374 More...
RGD:11086960 RGD:11570402 RGD:14398745 RGD:14398751 RGD:152995400
NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369
G
KRT14
keratin 14
ISO
mRNA:decreased expression:epithelial cell
RGD
PMID:9876218
RGD:1600180
NCBI chr 9:21,190,672...21,195,060
Ensembl chr 9:21,156,045...21,265,564
G
KRT20
keratin 20
ISO
associated with Colorectal Neoplasms
RGD
PMID:10931219
RGD:2317676
NCBI chr 9:21,808,171...21,818,301
Ensembl chr 9:21,808,548...21,817,387
G
L1CAM
L1 cell adhesion molecule
treatment
ISO
associated with Lung Neoplasms; associated with Pancreatic Neoplasms;
RGD
PMID:22095073 PMID:22307136
RGD:11570404 RGD:11570503
NCBI chr X:121,708,695...121,722,819
Ensembl chr X:121,708,894...121,733,365
G
LAMC2
laminin subunit gamma 2
ISO
associated with lung adenocarcinoma;
RGD
PMID:25591736
RGD:11075980
NCBI chr 7:16,543,541...16,625,304
Ensembl chr 7:16,569,086...16,624,085
G
LCN2
lipocalin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24570342
NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038
G
LECT2
leukocyte cell derived chemotaxin 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30453282
NCBI chr11:23,864,062...23,873,720
Ensembl chr11:23,864,064...23,886,226
G
LEF1
lymphoid enhancer binding factor 1
ISO
CTD Direct Evidence: marker/mechanism associated with prostate cancer
CTD RGD
PMID:27067790 PMID:27811057
RGD:11531513
NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019
G
LGALS3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25882088
NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705
G
LLGL2
LLGL scribble cell polarity complex component 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28114269
NCBI chr 9:4,975,309...5,008,383
Ensembl chr 9:4,975,660...4,996,775
G
LOC100687127
thioredoxin-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30396169
NCBI chr X:82,986,288...82,986,753
G
LOC100855904
mucin-6
disease_progression
ISO
associated with cholangiocarcinoma
RGD
PMID:18410610
RGD:2325159
NCBI chr18:45,359,412...45,376,678
G
LOC100856339
phosphatidylinositol 3-kinase regulatory subunit gamma
ISO
associated with Adenocarcinoma, Colon
RGD
PMID:24837077
RGD:13432045
NCBI chr15:14,222,059...14,357,200
Ensembl chr15:14,235,824...14,353,832
G
LOC102153034
calmodulin-like protein 3
ameliorates
ISO
associated with hepatocellular carcinoma; protein:decreased expression:liver (human) associated with hepatocellular carcinoma; human cells in mouse model
RGD
PMID:29445139
RGD:151665319
NCBI chr 2:30,410,830...30,411,981
G
LOC403581
peptidylprolyl isomerase A (cyclophilin A) pseudogene
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21956400
NCBI chr 7:80,937,433...80,938,175
G
LOC480600
chemokine (C-C motif) ligand 3
ISO
RGD
PMID:18941229
RGD:7241810
NCBI chr 9:37,708,561...37,710,209
Ensembl chr 9:37,676,966...37,710,209
G
LOC482182
sulfotransferase 1E1
ISO
associated with Colonic Neoplasms;protein:increased expression:liver
RGD
PMID:16895976
RGD:2302565
NCBI chr13:59,323,430...59,343,745
G
LOC607874
cystatin-C-like
ISO
protein:decreased expression:cerebrospinal fluid
RGD
PMID:12589965
RGD:5686394
NCBI chr23:49,562...53,618
G
LY96
lymphocyte antigen 96
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22180778
NCBI chr29:22,493,757...22,515,147
Ensembl chr29:22,493,896...22,515,117
G
MACC1
MET transcriptional regulator MACC1
treatment
ISO
associated with stomach cancer; human cells in mouse model CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:27431311 PMID:36008464
RGD:152995400
NCBI chr14:34,189,983...34,271,998
Ensembl chr14:34,075,463...34,251,330
G
MAP2K4
mitogen-activated protein kinase kinase 4
disease_progression
ISO
associated with oral squamous cell carcinoma;mRNA, protein:increased expression:lymph node (human)
RGD
PMID:22165133
RGD:150429749
NCBI chr 5:36,142,610...36,243,673
Ensembl chr 5:36,118,388...36,241,296
G
MAPK1
mitogen-activated protein kinase 1
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with prostate adenocarcinoma
CTD RGD
PMID:22139534 PMID:22580338
RGD:13504820
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
G
MAPK3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
G
MAPK9
mitogen-activated protein kinase 9
ISO
CTD Direct Evidence: therapeutic associated with Colorectal Neoplasms
CTD RGD
PMID:21779479 PMID:25205654
RGD:13217416
NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
G
MED28
mediator complex subunit 28
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21942447
NCBI chr 3:62,887,095...62,895,588
Ensembl chr 3:62,890,515...62,895,562
G
MET
MET proto-oncogene, receptor tyrosine kinase
disease_progression
ISO
associated with Squamous Cell Carcinoma of the Tongue; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20080979 PMID:21225626 PMID:22704061
RGD:8548616
NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
G
MIR125A
microRNA mir-125a
ISO
CTD Direct Evidence: marker/mechanism associated with stomach cancer;
CTD RGD
PMID:19487542 PMID:30117667
RGD:21403678
NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337
G
MIR130A
microRNA mir-130a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr18:38,543,618...38,543,679
Ensembl chr18:38,543,618...38,543,681
G
MIR136
microRNA mir-136
ameliorates
ISO
associated with stomach cancer;human cells in mouse model
RGD
PMID:28656883
RGD:153344628
NCBI chr 8:69,106,615...69,106,670
Ensembl chr 8:69,106,598...69,106,687
G
MIR148B
microRNA mir-148b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr27:975,146...975,206
Ensembl chr27:975,131...975,220
G
MIR152
microRNA mir-152
ISO
associated with Castration-Resistant Prostatic Neoplasms
RGD
PMID:23574937
RGD:19165145
NCBI chr 9:24,335,161...24,335,219
Ensembl chr 9:24,335,146...24,335,225
G
MIR155
microRNA mir-155
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19487542 PMID:27692344 PMID:27856635
RGD:21079446
NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833
G
MIR181C
microRNA mir-181c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr20:48,593,343...48,593,403
Ensembl chr20:48,593,325...48,593,421
G
MIR193A
microRNA mir-193a
exacerbates
ISO
associated with colorectal cancer; miRNA:decreased expression:colorectum (human) associated with lung non-small cell carcinoma; human cells in mouse model
RGD
PMID:24469061 PMID:25232258 PMID:30685413
RGD:153344566 RGD:153344592 RGD:153344599
NCBI chr 9:41,316,481...41,316,536
Ensembl chr 9:41,316,474...41,316,542
G
MIR197
microRNA mir-197
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 6:42,271,719...42,271,779
Ensembl chr 6:42,271,708...42,271,797
G
MIR19A
microRNA mir-19a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr22:42,478,298...42,478,355
Ensembl chr22:42,478,285...42,478,366
G
MIR205
microRNA mir-205
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 7:8,090,511...8,090,579
Ensembl chr 7:8,090,511...8,090,579
G
MIR20A
microRNA mir-20a
ISO
associated with colorectal cancer
RGD
PMID:27286257
RGD:25823157
NCBI chr22:42,478,462...42,478,520
Ensembl chr22:42,478,462...42,478,520
G
MIR20B
microRNA mir-20b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr X:104,896,091...104,896,158
Ensembl chr X:104,896,091...104,896,158
G
MIR21
microRNA mir-21
treatment ameliorates
ISO
associated with prostate carcinoma; human cells in mouse model CTD Direct Evidence: marker/mechanism human cells in mouse model;associated with breast cancer
RGD CTD
PMID:18270520 PMID:26101800 PMID:32736696
RGD:152998873 RGD:152998897
NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624
G
MIR221
microRNA mir-221
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr X:39,523,890...39,523,951
Ensembl chr X:39,523,885...39,523,954
G
MIR222
microRNA mir-222
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr X:39,524,519...39,524,608
Ensembl chr X:39,524,519...39,524,608
G
MIR224
microRNA mir-224
ISO
CTD Direct Evidence: marker/mechanism associated with colorectal cancer; mRNA:increased expression:colorectal mucosa:
CTD RGD
PMID:19487542 PMID:25919696
RGD:14398749
NCBI chr X:119,925,345...119,925,413
Ensembl chr X:119,925,345...119,925,413
G
MIR30A
microRNA mir-30a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961
G
MIR30E
microRNA mir-30e
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr15:2,283,306...2,283,369
Ensembl chr15:2,283,306...2,283,369
G
MIR31
microRNA mir-31
disease_progression treatment
ISO
CTD Direct Evidence: marker/mechanism associated with colorectal cancer;RNA:increased expression:colorectum (human) associated with stomach cancer;human cells in mouse model
CTD RGD
PMID:19487542 PMID:26497852 PMID:27174918 PMID:30108104
RGD:153297776 RGD:153297806 RGD:153297811
NCBI chr11:40,904,438...40,904,496
Ensembl chr11:40,904,437...40,904,503
G
MIR335
microRNA mir-335
ISO
lung metastasis
RGD
PMID:21822301
RGD:14394425
NCBI chr14:6,444,861...6,444,918
Ensembl chr14:6,444,847...6,444,932
G
MIR342
microRNA mir-342
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 8:68,424,656...68,424,718
G
MIR346
microRNA mir-346
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27501413 PMID:27777383
NCBI chr 4:34,073,335...34,073,429
Ensembl chr 4:34,073,335...34,073,429
G
MIR34B
microRNA mir-34b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 5:21,558,685...21,558,768
Ensembl chr 5:21,558,685...21,558,768
G
MIR34C
microRNA mir-34c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 5:21,558,106...21,558,160
G
MIR370
microRNA mir-370
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 8:69,132,786...69,132,864
Ensembl chr 8:69,132,786...69,132,864
G
MIR494
microRNA mir-494
ISO
associated with osteosarcoma; RNA:decreased expression:bone, serum
RGD
PMID:30314946 PMID:35117781
RGD:156420141 RGD:156430319
NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465
G
MIR532
microRNA mir-532
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr X:42,774,680...42,774,738
Ensembl chr X:42,774,680...42,774,738
G
MIR885
microRNA mir-885
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27738331
NCBI chr20:7,968,529...7,968,602
Ensembl chr20:7,968,529...7,968,602
G
MIR96
microRNA mir-96
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr14:7,068,754...7,068,842
Ensembl chr14:7,068,754...7,068,842
G
MIR99A-1
microRNA mir-99a-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr31:13,258,782...13,258,840
Ensembl chr31:13,258,782...13,258,840
G
MIR99A-2
microRNA mir-99a-2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 5:12,047,369...12,047,425
Ensembl chr 5:12,047,369...12,047,425
G
MIR99B
microRNA mir-99b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19487542
NCBI chr 1:105,400,925...105,400,984
Ensembl chr 1:105,400,925...105,400,984
G
MKI67
marker of proliferation Ki-67
ISO
associated with Pancreatic Neoplasms
RGD
PMID:20388395
RGD:2317702
NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486
G
MLH1
mutL homolog 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17717427
NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
G
MMP1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12538496 PMID:19487542 PMID:22580338 PMID:23548910
NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648
G
MMP13
matrix metallopeptidase 13
ISO
associated with Carcinoma, Renal Cell;mRNA, protein:increased expression:bone
RGD
PMID:18709334
RGD:2306080
NCBI chr 5:28,793,568...28,864,832
Ensembl chr 5:28,850,522...28,864,121
G
MMP2
matrix metallopeptidase 2
disease_progression
ISO
associated with Gallbladder Neoplasms; protein:increased expression:gallbladder associated with pancreatic cancer; protein:increased expression, increased activity:pancreas associated with Mammary Neoplasms, Animal;protein:increased expression:brain CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12173379 PMID:16158251 PMID:16475674 PMID:18398872 PMID:18665467 PMID:21209944 PMID:22321834 PMID:23707804 PMID:30603057 More...
RGD:2325743 RGD:2325749 RGD:8547884
NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
G
MMP24
matrix metallopeptidase 24
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27869830
NCBI chr24:24,223,049...24,258,082
Ensembl chr24:24,232,833...24,255,725
G
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
ISO
associated with Mammary Neoplasms, Animal;protein:increased expression:brain
RGD
PMID:16158251
RGD:8547884
NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222
G
MMP9
matrix metallopeptidase 9
severity disease_progression
ISO
associated with Mammary Neoplasms, Animal; associated with Arthritis, Experimental CTD Direct Evidence: marker/mechanism associated with osteosarcoma;protein:increased expression:bone (human) associated with skin melanoma;DNA:missense mutation:cds:p.Q279R (human) associated with Melanoma associated with Mammary Neoplasms, Animal;protein:increased expression:brain associated with carcinoma, pancreatic ductal; protein:increased expression:pancreas associated with pancreatic cancer; protein:increased expression, increased activity:pancreas
RGD CTD
PMID:8912869 PMID:12173379 PMID:15659795 PMID:16033831 PMID:16158251 PMID:16475674 PMID:17346338 PMID:17378244 PMID:18676849 PMID:18930813 PMID:21209944 PMID:21859454 PMID:21942447 PMID:26546437 PMID:34626302 More...
RGD:152023746 RGD:2325749 RGD:2325855 RGD:5510000 RGD:8547861 RGD:8547878 RGD:8547884 RGD:8547886 RGD:8547928
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
G
MSH2
mutS homolog 2
ISO
associated with Breast Neoplasms
RGD
PMID:17390069
RGD:2293506
NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
G
MST1
macrophage stimulating 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28114269
NCBI chr20:39,582,237...39,586,958
Ensembl chr20:39,582,282...39,586,908
G
MTDH
metadherin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19111877
NCBI chr29:41,675,601...41,732,389
Ensembl chr29:41,640,035...41,729,949
G
MTHFR
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17704422
NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
G
MTOR
mechanistic target of rapamycin kinase
ISO
associated with Pancreatic Neoplasms
RGD
PMID:23149918
RGD:10040959
NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114
G
MUC1
mucin 1, cell surface associated
disease_progression
ISO
associated with Pancreatic Neoplasms associated with Carcinoma, Renal Cell;
RGD
PMID:10390012 PMID:12941828 PMID:16707592
RGD:2324648 RGD:2324652 RGD:7245968
NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
G
MUC4
mucin 4, cell surface associated
ISO
associated with Melanoma
RGD
PMID:10918186
RGD:2303746
NCBI chr33:29,061,372...29,084,938
Ensembl chr33:29,063,096...29,111,802
G
MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
associated with chloangiocarcinoma;protein:increased expression:bile duct
RGD
PMID:16124042
RGD:2324987
NCBI chr18:45,471,232...45,498,961
G
MYC
MYC proto-oncogene, bHLH transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22321834
NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
G
MYLK
myosin light chain kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12970723 PMID:18710790
NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181
G
NAGK
N-acetylglucosamine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr17:51,367,477...51,376,461
G
NCOA1
nuclear receptor coactivator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21080969
NCBI chr17:18,880,676...19,124,300
Ensembl chr17:18,880,383...19,122,258
G
NDC80
NDC80 kinetochore complex component
disease_progression
ISO
associated with melanoma
RGD
PMID:31173190
RGD:40822820
NCBI chr 7:69,268,218...69,317,126
Ensembl chr 7:69,268,242...69,317,072
G
NDRG1
N-myc downstream regulated 1
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:15867226 PMID:22972152
NCBI chr13:29,689,294...29,745,964
Ensembl chr13:29,650,444...29,746,382
G
NECAB3
N-terminal EF-hand calcium binding protein 3
severity
ISO
protein:increased expression:bone (human)
RGD
PMID:29039472
RGD:151347601
NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656
G
NECTIN2
nectin cell adhesion molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29321541
NCBI chr 1:110,543,140...110,569,168
Ensembl chr 1:110,543,247...110,569,143
G
NFE2L2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32682831
NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
G
NFKB1
nuclear factor kappa B subunit 1
ISO
associated with prostate cancer
RGD
PMID:17974971
RGD:13506764
NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
G
NFKBIA
NFKB inhibitor alpha
ISO
associated with prostate cancer;protein:increased serine phosphorylation
RGD
PMID:23093296
RGD:13506767
NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433
G
NME1
non-metastatic cells 1, protein (NM23A) expressed in
ISO
CTD Direct Evidence: marker/mechanism associated with Ovarian Neoplasms
CTD RGD
PMID:7622307 PMID:15928304
RGD:2299069
NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955
G
NME2
non-metastatic cells 2, protein (NM23B) expressed in
resistance
ISO
RGD
PMID:8621239
RGD:2299081
NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934
G
NOS2
nitric oxide synthase 2
disease_progression
ISO
associated with Carcinoma, Pancreatic Ductal; protein:increased expression:pancreas associated with Gallbladder Neoplasms: protein:increased expression:gallbladder
RGD
PMID:12660813 PMID:14991947 PMID:15222037
RGD:2325242 RGD:2325250 RGD:2325254
NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
G
NOS3
nitric oxide synthase 3
susceptibility
ISO
protein:increased expression:blood vessel endothelial cell associated with Prostatic Neoplasms;DNA:polymorphism associated with Breast Neoplasms;DNA:polymorphism:promoter:-786T>C (human)
RGD
PMID:12445681 PMID:14623178 PMID:14672505
RGD:2292080 RGD:2292081 RGD:2292087
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
G
NPPA
natriuretic peptide A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18717826
NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
G
NSUN6
NOP2/Sun RNA methyltransferase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28114269
NCBI chr 2:18,477,150...18,534,716
Ensembl chr 2:18,477,211...18,534,710
G
OGN
osteoglycin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 1:98,939,374...98,959,173
Ensembl chr 1:98,939,429...98,957,543
G
OLIG2
oligodendrocyte transcription factor 2
ISO
associated with breast cancer
RGD
PMID:27340107
RGD:40902824
NCBI chr31:27,674,112...27,677,521
Ensembl chr31:27,674,107...27,676,822
G
ORAI1
ORAI calcium release-activated calcium modulator 1
treatment
ISO
associated with stomach cancer; human cells in mouse model
RGD
PMID:27431311
RGD:152995400
NCBI chr26:7,584,276...7,599,667
Ensembl chr26:7,584,880...7,599,401
G
OSM
oncostatin M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21937440
NCBI chr26:23,421,787...23,439,332
Ensembl chr26:23,421,787...23,426,036
G
PCNA
proliferating cell nuclear antigen
ISO
associated with Seminoma
RGD
PMID:9143022
RGD:2315011
NCBI chr24:16,478,774...16,485,992
Ensembl chr24:16,478,769...16,484,992
G
PDE5A
phosphodiesterase 5A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12972520
NCBI chr32:38,272,573...38,407,517
Ensembl chr32:38,244,338...38,407,522
G
PDGFB
platelet derived growth factor subunit B
ISO
associated with Breast Neoplasms;mRNA, protein:increased expression:breast
RGD
PMID:16596190
RGD:2292179
NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
G
PDGFRB
platelet derived growth factor receptor beta
ISO
mRNA,protein:increased expression: : associated with Carcinoma, Renal Cell
RGD
PMID:14593398 PMID:15994946
RGD:13703041 RGD:2292198
NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283
G
PEBP1
phosphatidylethanolamine binding protein 1
ISO
associated with Prostatic Neoplasms;protein:decreased expression:
RGD
PMID:12813171
RGD:2302862
NCBI chr26:14,522,124...14,526,370
Ensembl chr26:14,500,074...14,529,354
G
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21986133
NCBI chr38:974,248...1,016,226
Ensembl chr38:975,749...1,027,679
G
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
treatment
ISO
associated with colorectal cancer;DNA:mutations:: CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23302486 PMID:29106415
RGD:14402409
NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
G
PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16475674
NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851
G
PLAUR
plasminogen activator, urokinase receptor
ISO
associated with Ovarian Neoplasms CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15659795 PMID:22577342
RGD:6483788
NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880
G
PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
ameliorates
ISO
associated with lung non-small cell carcinoma
RGD
PMID:29072684
RGD:151665822
NCBI chr23:41,290,183...41,382,917
Ensembl chr23:41,290,567...41,382,807
G
PML
PML nuclear body scaffold
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29335545
NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
G
PMS2
PMS1 homolog 2, mismatch repair system component
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17717427
NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940
G
PRNP
prion protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17387271
NCBI chr24:16,845,224...16,862,319
Ensembl chr24:16,846,207...16,859,815
G
PROX1
prospero homeobox 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17415710
NCBI chr 7:11,996,282...12,047,693
Ensembl chr 7:11,996,703...12,044,036
G
PRSS8
serine protease 8
ISO
associated with Prostatic Neoplasms;mRNA:decreased expression:prostate gland, bone
RGD
PMID:12518323
RGD:2292484
NCBI chr 6:17,110,251...17,114,564
Ensembl chr 6:17,110,300...17,114,816
G
PTCH1
patched 1
ISO
associated with colorectal cancer
RGD
PMID:20230186
RGD:150523835
NCBI chr 1:71,246,750...71,309,036
Ensembl chr 1:71,238,195...71,305,662
G
PTEN
phosphatase and tensin homolog
ISO
CTD Direct Evidence: marker/mechanism associated with Mammary Neoplasms, Experimental
CTD RGD
PMID:10978354 PMID:18381417
RGD:2292496
NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
G
PTGIS
prostaglandin I2 synthase
exacerbates
ISO
associated with colorectal cancer; protein:increased expression:colorectum (human)
RGD
PMID:22109564
RGD:151347833
NCBI chr24:36,129,091...36,162,525
Ensembl chr24:36,132,173...36,162,509
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
associated with Mammary Neoplasms, Experimental associated with lung neoplasm associated with Breast Neoplasms CTD Direct Evidence: marker/mechanism associated with osteosarcoma; associated with breast neoplasm;
RGD CTD
PMID:16489006 PMID:18398660 PMID:18509974 PMID:18663571 PMID:18797196 PMID:19421193 PMID:21238650 More...
RGD:2300119 RGD:2300249 RGD:5135282 RGD:5135498 RGD:5135500
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
G
PTK2
protein tyrosine kinase 2
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:15930288 PMID:16547501
RGD:2292557 RGD:2292560
NCBI chr13:35,302,439...35,541,336
Ensembl chr13:35,303,380...35,541,294
G
PXN
paxillin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18492274
NCBI chr26:16,157,231...16,224,028
Ensembl chr26:16,159,025...16,184,820
G
RAC1
Rac family small GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18506888
NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216
G
RAD52
RAD52 homolog, DNA repair protein
susceptibility
ISO
associated with colorectal cancer; DNA:SNP:3'utr: (rs7963551) (human)
RGD
PMID:29245274
RGD:151361161
NCBI chr27:42,915,334...43,032,293
Ensembl chr27:42,915,634...42,951,323
G
RAMP2
receptor activity modifying protein 2
ISO
RGD
PMID:31754214
RGD:152985691
NCBI chr 9:20,250,711...20,252,485
G
RB1
RB transcriptional corepressor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27137931
NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726
G
RECK
reversion inducing cysteine rich protein with kazal motifs
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17233834
NCBI chr11:52,519,303...52,607,753
Ensembl chr11:52,519,317...52,607,217
G
RHOA
ras homolog family member A
ISO
associated with Ovarian Neoplasms
RGD
PMID:12808121
RGD:2298873
NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215
G
RHOC
ras homolog family member C
ISO
CTD Direct Evidence: marker/mechanism associated with Ovarian Neoplasms
CTD RGD
PMID:12808121 PMID:18230616
RGD:2298873
NCBI chr17:62,868,373...62,872,322
G
RIT1
Ras like without CAAX 1
ameliorates
ISO
associated with esophagus squamous cell carcinoma; human cells in mouse model
RGD
PMID:30348939
RGD:152999018
NCBI chr 7:41,894,726...41,903,450
Ensembl chr 7:41,895,330...41,901,173
G
ROR1
receptor tyrosine kinase like orphan receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28114269
NCBI chr 5:46,010,097...46,477,882
Ensembl chr 5:46,013,195...46,190,880
G
RPS6KA3
ribosomal protein S6 kinase A3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21488662
NCBI chr X:15,991,623...16,079,689
Ensembl chr X:15,998,172...16,074,749
G
RXRA
retinoid X receptor alpha
ISO
associated with Prostatic Neoplasms
RGD
PMID:15318950
RGD:1643115
NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119
G
S100A4
S100 calcium binding protein A4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21636539 PMID:21685359 PMID:36008464
NCBI chr 7:43,494,007...43,496,021
G
SERPINA1
serpin family A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435
G
SERPINB5
serpin family B member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19514085
NCBI chr 1:13,566,982...13,638,839
Ensembl chr 1:13,568,376...13,638,781
G
SERPINC1
serpin family C member 1
treatment
ISO
associated with Adenocarcinoma, Colon associated with Melanoma
RGD
PMID:16440418
RGD:1599327
NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987
G
SERPINF1
serpin family F member 1
ISO
associated with Prostatic Neoplasms
RGD
PMID:15313905
RGD:2312355
NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765
G
SIRT1
sirtuin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27793039
NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
G
SIX1
SIX homeobox 1
ISO
human gene in a mouse model
RGD
PMID:23435380
RGD:11561950
NCBI chr 8:35,676,705...35,679,534
Ensembl chr 8:35,676,479...35,679,534
G
SLC39A4
solute carrier family 39 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20957146
NCBI chr13:37,833,073...37,838,304
Ensembl chr13:37,833,156...37,838,522
G
SLC39A6
solute carrier family 39 member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12839489
NCBI chr 7:54,059,193...54,080,582
Ensembl chr 7:54,059,193...54,080,582
G
SLC3A2
solute carrier family 3 member 2
ISO
RGD
PMID:19018776
RGD:151361278
NCBI chr18:53,810,468...53,819,021
Ensembl chr18:53,810,398...53,819,021
G
SLC7A11
solute carrier family 7 member 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19015640
NCBI chr19:4,289,792...4,379,060
Ensembl chr19:4,289,850...4,389,048
G
SLC7A5
solute carrier family 7 member 5
ISO
RGD
PMID:19018776
RGD:151361278
NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858
G
SLCO1B2
solute carrier organic anion transporter family member 1B2
ISO
associated with Colonic Neoplasms;protein:decreased expression:liver
RGD
PMID:16895976
RGD:2302565
NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
G
SMAD4
SMAD family member 4
disease_progression
ISO
associated with colorectal carcinoma;DNA:mutation:cds:
RGD
PMID:10340381
RGD:21066333
NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405
G
SMO
smoothened, frizzled class receptor
ISO
associated with colon cancer
RGD
PMID:23098507
RGD:150340555
NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033
G
SNAI1
snail family transcriptional repressor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338 PMID:23219715
NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628
G
SNAI2
snail family transcriptional repressor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22580338
NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653
G
SNCG
synuclein gamma
ISO
protein:increased expression:breast DNA:hypomethylation: :
RGD
PMID:16140929 PMID:16821081
RGD:6478795 RGD:6478797
NCBI chr 4:34,604,867...34,608,851
Ensembl chr 4:34,605,091...34,608,842
G
SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12538496 PMID:18930813 PMID:19487542 PMID:22580338
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
G
SOX30
SRY-box transcription factor 30
ISO
associated with lung non-small cell carcinoma;mRNA, protein:decreased expression: :
RGD
PMID:29739711
RGD:151660333
NCBI chr 4:52,587,163...52,615,945
Ensembl chr 4:52,587,355...52,615,945
G
SOX9
SRY-box transcription factor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32682831
NCBI chr 9:8,275,049...8,278,172
Ensembl chr 9:8,275,049...8,278,172
G
SP1
Sp1 transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12538496 PMID:35072892
NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
G
SPA17
sperm autoantigenic protein 17
ISO
associated with ovarian carcinoma;proetin:increased expression:epithelium:
RGD
PMID:19744347
RGD:27226802
NCBI chr 5:9,719,222...9,731,521
Ensembl chr 5:9,719,241...9,730,913
G
SPP1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16474180 PMID:22407340
RGD:1581330
NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
associated with colorectal carcinoma;protein:increased activity:colorectum:
RGD
PMID:7687314 PMID:15486073
RGD:150521537 RGD:1581401
NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
G
SREBF2
sterol regulatory element binding transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30394316
NCBI chr10:23,451,923...23,532,765
Ensembl chr10:23,452,561...23,518,689 Ensembl chr10:23,452,561...23,518,689
G
SRSF1
serine and arginine rich splicing factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 9:32,692,517...32,696,325
Ensembl chr 9:32,694,073...32,696,285
G
SRSF2
serine and arginine rich splicing factor 2
severity
ISO
associated with hepatocellular carcinoma
RGD
PMID:29278882
RGD:150429692
NCBI chr 9:4,028,414...4,032,371
Ensembl chr 9:4,028,482...4,030,793
G
SRSF5
serine and arginine rich splicing factor 5
ISO
associated with Ovarian Neoplasms;mRNA:increased expression:epithelium of female gonad (human)
RGD
PMID:23748175
RGD:11039469
NCBI chr 8:43,514,048...43,519,019
Ensembl chr 8:43,514,076...43,518,481
G
SRSF6
serine and arginine rich splicing factor 6
ISO
associated with Ovarian Neoplasms;mRNA:increased expression:epithelium of female gonad (human)
RGD
PMID:23748175
RGD:11039469
NCBI chr24:31,217,190...31,222,852
Ensembl chr24:31,217,184...31,218,618
G
ST14
ST14 transmembrane serine protease matriptase
ISO
associated with Breast Neoplasms associated with Prostatic Neoplasms
RGD
PMID:17456594 PMID:18813126
RGD:2315088 RGD:2315092
NCBI chr 5:4,652,493...4,666,728
Ensembl chr 5:4,651,863...4,691,069
G
STAT1
signal transducer and activator of transcription 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29147627
NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178
G
STAT3
signal transducer and activator of transcription 3
treatment
ISO
associated with Melanoma CTD Direct Evidence: marker/mechanism associated with Prostatic Neoplasms;protein:decreased activity associated with Carcinoma, Renal Cell;protein:increased phosphorylation
RGD CTD
PMID:12131365 PMID:16540670 PMID:17382154 PMID:21937440 PMID:23382965 PMID:26101800 More...
RGD:2291915 RGD:2291917 RGD:8694303
NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672
G
STAT5A
signal transducer and activator of transcription 5A
disease_progression
ISO
DNA:CNV: :prostate (human)
RGD
PMID:23660011
RGD:151667415
NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103
G
STIM1
stromal interaction molecule 1
ameliorates exacerbates treatment
ISO
associated with hepatocellular carcinoma; human cells in mouse model associated with nasopharynx carcinoma; human cells in mouse model associated with hepatocellular carcinoma;protein:decreased expression:liver (human) associated with stomach cancer; human cells in mouse model human cells in mouse model;associated with lung cancer
RGD
PMID:27431311 PMID:28713917 PMID:32165272 PMID:32483465
RGD:152995357 RGD:152995361 RGD:152995387 RGD:152995400
NCBI chr21:26,394,592...26,594,764
Ensembl chr21:26,394,811...26,593,375
G
TBCB
tubulin folding cofactor B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 1:116,576,222...116,585,788
Ensembl chr 1:116,576,219...116,586,021
G
TCF3
transcription factor 3
disease_progression
ISO
associated with colon cancer
RGD
PMID:26212009
RGD:11533019
NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981
G
TCL1B
TCL1 family AKT coactivator B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20228224
NCBI chr 8:64,497,560...64,500,412
Ensembl chr 8:64,497,560...64,500,412
G
TET2
tet methylcytosine dioxygenase 2
ISO
associated with colorectal cancer; protein:decreased expression:colorectum (human)
RGD
PMID:33552282
RGD:150429609
NCBI chr32:26,021,745...26,145,109
Ensembl chr32:26,059,693...26,143,536
G
TFPI2
tissue factor pathway inhibitor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17372906
NCBI chr14:19,399,259...19,403,890
Ensembl chr14:19,399,720...19,403,708
G
TGFBR1
transforming growth factor beta receptor 1
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:12808151
RGD:737735
NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594
G
TGFBR2
transforming growth factor beta receptor 2
ISO
CTD Direct Evidence: therapeutic associated with Mammary Neoplasms, Experimental
CTD RGD
PMID:12808151 PMID:16489006
RGD:737735
NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636
G
TGIF1
TGFB induced factor homeobox 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29746904
NCBI chr 7:70,040,376...70,048,346
Ensembl chr 7:70,040,508...70,047,912
G
TIMP1
TIMP metallopeptidase inhibitor 1
ISO
associated with Breast Neoplasms;protein:increased expression:plasma
RGD
PMID:17407159
RGD:2290346
NCBI chr X:41,201,623...41,205,314
Ensembl chr X:41,201,638...41,205,310
G
TIMP2
TIMP metallopeptidase inhibitor 2
ISO
associated with Breast Neoplasms
RGD
PMID:17505812
RGD:2290394
NCBI chr 9:2,521,882...2,533,883
Ensembl chr 9:2,521,882...2,533,989
G
TLR4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22180778
NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
G
TNC
tenascin C
ISO
associated with Carcinoma, Renal Cell;protein:increased expression:lung
RGD
PMID:16928692
RGD:4889612
NCBI chr11:69,077,532...69,169,673
Ensembl chr11:69,077,535...69,170,281
G
TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8032535 PMID:23431386
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
G
TNFAIP8
TNF alpha induced protein 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21969086
NCBI chr11:8,624,106...8,685,389
Ensembl chr11:8,660,557...8,684,374
G
TNFRSF11A
TNF receptor superfamily member 11a
ISO
associated with Prostatic Neoplasms;protein:increased expression:bone, lymph node
RGD
PMID:16752412
RGD:2302322
NCBI chr 1:14,504,595...14,555,956
Ensembl chr 1:14,503,033...14,556,041
G
TNFRSF11B
TNF receptor superfamily member 11b
ISO
associated with Breast Neoplasms;protein:increased expression:serum
RGD
PMID:23167338
RGD:7205479
NCBI chr13:18,155,765...18,183,263
Ensembl chr13:18,156,367...18,183,444
G
TNFSF10
TNF superfamily member 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21209944
NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060
G
TP53
tumor protein p53
ISO
associated with Sarcoma; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17949449 PMID:21854749 PMID:22009531 PMID:23873029 PMID:27137931
RGD:11075090
NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
G
TP63
tumor protein p63
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15875781
NCBI chr34:21,766,861...21,985,095
Ensembl chr34:21,766,496...21,983,046
G
TPM4
tropomyosin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr20:46,354,808...46,376,489
Ensembl chr20:46,355,736...46,376,425
G
TTR
transthyretin
treatment
ISO
associated with oral squamous cell carcinoma;protein:decreased expression:blood serum, saliva (human) associated with colorectal cancer associated with colorectal adenocarcinoma;protein:decreased expression:colorectum (human)
RGD
PMID:20957082 PMID:28730771 PMID:33739034
RGD:151660505 RGD:151665158 RGD:151665163
NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
G
TWIST1
twist family bHLH transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19806464
G
TXNDC5
thioredoxin domain containing 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr35:7,834,135...7,854,836
Ensembl chr35:7,834,331...7,854,852
G
TYMS
thymidylate synthetase
disease_progression
ISO
associated with Gastrointestinal Neoplasms;DNA:SNPs: :
RGD
PMID:25677447
RGD:11081002
NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747
G
TYR
tyrosinase
no_association
ISO
associated with melanoma;
RGD
PMID:11092039
RGD:8694395
NCBI chr21:10,799,940...10,894,187
Ensembl chr21:10,799,940...10,894,191
G
UCHL3
ubiquitin C-terminal hydrolase L3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr22:29,348,962...29,397,944
Ensembl chr22:29,348,706...29,407,965
G
VCAM1
vascular cell adhesion molecule 1
ISO
associated with Pancreatic Neoplasms;protein:increased expression:serum
RGD
PMID:12923961
RGD:2325163
NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933
G
VDR
vitamin D receptor
ISO
associated with breast cancer;DNA:SNP:intron: (rs1544410) (human)
RGD
PMID:9613456
RGD:8158057
NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
G
VEGFA
vascular endothelial growth factor A
ISO
associated with Carcinoma, Renal Cell CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15659795 PMID:18930813 PMID:19064974 PMID:20158913
RGD:2315468
NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
G
VIM
vimentin
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with stomach cancer; human cells in mouse model
CTD RGD
PMID:17085005 PMID:27431311
RGD:152995400
NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466
G
VIP
vasoactive intestinal peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19189304
NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
G
XPC
XPC complex subunit, DNA damage recognition and repair factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27777383
NCBI chr20:4,299,644...4,328,826
Ensembl chr20:4,300,386...4,328,768
G
XRCC1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Neoplasms, Germ Cell and Embryonal;DNA:polymorphism: :p.R399Q
RGD
PMID:16596238
RGD:2302576
NCBI chr 1:111,548,719...111,571,816
Ensembl chr 1:111,548,719...111,571,816
G
YAP1
Yes1 associated transcriptional regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28114269
NCBI chr 5:29,394,760...29,495,977
Ensembl chr 5:29,394,541...29,496,251
G
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085005
NCBI chr 9:45,506,830...45,562,081
Ensembl chr 9:45,507,282...45,562,086
G
ZFHX3
zinc finger homeobox 3
exacerbates
ISO
brain metastasis associated with lung adenocarcinoma;DNA:mutations:multiple (human)
RGD
PMID:33479213
RGD:151361170
NCBI chr 5:78,450,963...78,635,615
Ensembl chr 5:78,455,005...78,610,033
G
ALOX12
arachidonate 12-lipoxygenase, 12S type
ISO
associated with Prostatic Neoplasms;
RGD
PMID:14669797
RGD:1578303
NCBI chr 5:32,026,193...32,038,698
Ensembl chr 5:31,882,501...32,038,119
G
BRIP1
BRCA1 interacting helicase 1
ISO
associated with Breast Neoplasms; human gene in a mouse model
RGD
PMID:22875853
RGD:11252149
NCBI chr 9:34,804,285...34,984,640
Ensembl chr 9:34,806,535...34,983,788
G
CXCR4
C-X-C motif chemokine receptor 4
disease_progression
ISO
associated with hepatocellular carcinoma;protein:increased expression:liver (human)
RGD
PMID:19508713
RGD:152023653
NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
G
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
ISO
associated with Breast Neoplasms;mRNA:increased expression:bone element (human)
RGD
PMID:23861746
RGD:13204736
NCBI chr 1:251,985...322,081
Ensembl chr 1:252,103...322,718
G
MIR34A
microRNA mir-34a
susceptibility
ISO
associated with hepatocellular carcinoma;miRNA:decreased expression:serum, bone
RGD
PMID:27893432
RGD:14694837
NCBI chr 5:62,485,832...62,485,897
Ensembl chr 5:62,485,832...62,485,897
G
MMP13
matrix metallopeptidase 13
ISO
associated with Carcinoma, Renal Cell; mRNA, protein:increased expression:bone (human)
RGD
PMID:18709334
RGD:2306080
NCBI chr 5:28,793,568...28,864,832
Ensembl chr 5:28,850,522...28,864,121
G
PDGFD
platelet derived growth factor D
ISO
associated with prostate carcinoma
RGD
PMID:22158043
RGD:13506772
NCBI chr 5:27,863,739...28,092,376
Ensembl chr 5:27,863,591...28,089,936
G
ERBB2
erb-b2 receptor tyrosine kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29044505
NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294
G
ACE
angiotensin I converting enzyme
ISO
associated with colorectal cancer;mRNA:increased expression:liver (mouse)
RGD
PMID:20380732
RGD:25671446
NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
severity
ISO
associated with skin melanoma;DNA:missense mutations:cds: associated with colorectal cancer;DNA:missense mutation:cds:p.V600E (human) associated with colorectal cancer;DNA:mutations:multiple associated with colorectal cancer;DNA:mutation:cds: associated with colorectal cancer;DNA:missense mutations:cds:pV599E,p.V600E (human)
RGD
PMID:22331825 PMID:23010994 PMID:26775732 PMID:27737491 PMID:28787433
RGD:11554843 RGD:14696791 RGD:15039394 RGD:18337264 RGD:18337265
NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906
G
CCL2
C-C motif chemokine ligand 2
disease_progression
ISO
associated with colorectal cancer
RGD
PMID:27058904
RGD:14995463
NCBI chr 9:39,008,187...39,009,932
G
CCL5
C-C motif chemokine ligand 5
treatment
ISO
associated with Animal Mammary Neoplasms;
RGD
PMID:15692764
RGD:14995455
NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
G
CCND2
cyclin D2
ISO
associated with colorectal cancer;protein:increased expression:colorectum
RGD
PMID:19508551
RGD:151665111
NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255
G
CCNG1
cyclin G1
treatment
ISO
human cells in mouse model
RGD
PMID:10910035
RGD:151356987
NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211
G
CD44
CD44 molecule
ISO
associated with Breast Neoplasm;protein:increased expression:liver
RGD
PMID:17991717
RGD:2289349
NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
G
CHD4
chromodomain helicase DNA binding protein 4
ameliorates
ISO
associated with human colon adenocarcinoma cells in a mouse model
RGD
PMID:28486105
RGD:153323299
NCBI chr27:38,411,009...38,440,367
Ensembl chr27:38,411,075...38,439,958
G
CXCL10
C-X-C motif chemokine ligand 10
treatment
ISO
associated with colon carcinoma;
RGD
PMID:30381616
RGD:27095891
NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979
G
CXCL12
C-X-C motif chemokine ligand 12
ameliorates
ISO
associated with colorectal cancer; human cells in mouse model
RGD
PMID:30789971
RGD:151893289
NCBI chr28:2,895,916...2,903,543
G
CXCL8
C-X-C motif chemokine ligand 8
ISO
associated with colorectal cancer; human colon adenocarcinoma cells in a mouse model
RGD
PMID:29679563
RGD:26884358
NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
G
CXCR4
C-X-C motif chemokine receptor 4
ameliorates
ISO
associated with colorectal cancer; human cells in mouse model human cells in mouse model; associated with colorectal cancer
RGD
PMID:29436696 PMID:30789971
RGD:151893289 RGD:152023643
NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
G
DAXX
death domain associated protein
exacerbates
ISO
associated with neuroendocrine tumor;DNA:mutations:CDS:multiple (human) associated with colon cancer; mRNA:decreased expression:liver (human) associated with pancreatic endocrine carcinoma;DNA:mutations:CDS:multiple (human)
RGD
PMID:30339629 PMID:30342802 PMID:31942198
RGD:152025194 RGD:152025199 RGD:152025203
NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340
G
DDR1
discoidin domain receptor tyrosine kinase 1
treatment
ISO
human cells in mouse model; nilotinib mRNA:increased expression:liver (mouse)
RGD
PMID:29438985 PMID:30666650 PMID:33110221
RGD:151347537 RGD:151347685 RGD:151347840
NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543
G
DDR2
discoidin domain receptor tyrosine kinase 2
ameliorates
ISO
associated with colon carcinoma associated with melanoma;
RGD
PMID:21701781 PMID:22071959
RGD:150429701 RGD:150429713
NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275
G
DOCK6
dedicator of cytokinesis 6
ameliorates
ISO
associated with stomach cancer;
RGD
PMID:29587866
RGD:155791564
NCBI chr20:50,029,354...50,066,829
Ensembl chr20:50,029,369...50,066,829
G
FBXW7
F-box and WD repeat domain containing 7
disease_progression
ISO
associated with colorectal cancer;
RGD
PMID:28846828
RGD:21408566
NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195
G
FGFR1
fibroblast growth factor receptor 1
ISO
associated with colorectal cancer;mRNA:increased expression:colorectal mucosa:
RGD
PMID:19082464
RGD:25330357
NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261
G
FOSL2
FOS like 2, AP-1 transcription factor subunit
ISO
human cells in mouse model
RGD
PMID:30114390
RGD:153344554
NCBI chr17:22,340,469...22,364,994
Ensembl chr17:22,341,322...22,361,772
G
GPC3
glypican 3
ISO
protein:increased expression:blood serum (human)
RGD
PMID:28801286
RGD:243065135
NCBI chr X:104,313,426...104,751,215
Ensembl chr X:104,313,591...104,751,756
G
HMBS
hydroxymethylbilane synthase
ISO
associated with colon adenocarcinoma;protein:decreased activity:liver(rat)
RGD
PMID:1386052
RGD:25440496
NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082
G
IL2
interleukin 2
treatment
ISO
associated with colon carcinoma associated with Colorectal Neoplasms, Carcinoma, Hepatocellular;
RGD
PMID:9354462 PMID:11591892
RGD:14928215 RGD:8663446
NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
G
IQSEC1
IQ motif and Sec7 domain ArfGEF 1
ISO
human cells in mouse model
RGD
PMID:22662237
RGD:153344589
NCBI chr20:3,241,058...3,403,394
Ensembl chr20:3,241,052...3,522,859
G
MAP2K7
mitogen-activated protein kinase kinase 7
ISO
associated with colon cancer;protein:increased expression:colon (human)
RGD
PMID:24533778
RGD:155259116
NCBI chr20:52,594,450...52,604,236
Ensembl chr20:52,594,536...52,602,150
G
MIR148B
microRNA mir-148b
exacerbates
ISO
associated with stomach cancer;
RGD
PMID:29587866
RGD:155791564
NCBI chr27:975,146...975,206
Ensembl chr27:975,131...975,220
G
MIR155
microRNA mir-155
ISO
RGD
PMID:26885061
RGD:21079444
NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833
G
MIR200B
microRNA mir-200b
ISO
associated with colorectal cancer;RNA:increased expression:liver:
RGD
PMID:28617555
RGD:14928321
NCBI chr 5:56,368,400...56,368,479
Ensembl chr 5:56,368,400...56,368,479
G
MIR200C
microRNA mir-200c
ISO
associated with colorectal cancer;RNA:increased expression:liver:
RGD
PMID:28617555
RGD:14928321
NCBI chr27:38,082,097...38,082,159
Ensembl chr27:38,082,091...38,082,169
G
MIR223
microRNA mir-223
disease_progression
ISO
associated with colorectal cancer;
RGD
PMID:28846828
RGD:21408566
NCBI chr X:50,838,131...50,838,233
Ensembl chr X:50,838,131...50,838,233
G
MIR494
microRNA mir-494
exacerbates
ISO
associated with pancreatic ductal adenocarcinoma;
RGD
PMID:24859161
RGD:156430321
NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465
G
MPL
MPL proto-oncogene, thrombopoietin receptor
exacerbates severity
ISO
associated with pancreatic cancer; protein:increased expression:liver, pancreas (human) associated with colorectal carcinoma;protein:increased expression:colorectum (human) associated with pancreatic ductal adenocarcinoma; human cells in mouse model
RGD
PMID:23747337 PMID:30770989
RGD:126925751 RGD:126925752
NCBI chr15:16,815,102...16,825,321
Ensembl chr15:16,815,294...16,825,350
G
NRAS
NRAS proto-oncogene, GTPase
susceptibility
ISO
associated with colorectal cancer;DNA:mutations:exons (human) associated with melanoma;DNA:mutations: exons (human) human gene in a mouse model;DNA:missense mutations:cds:p.G12V, p.Q61K (human)
RGD
PMID:26799184 PMID:28011498 PMID:28787433
RGD:14696774 RGD:14696791 RGD:14696792
NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788
G
PTPRB
protein tyrosine phosphatase receptor type B
treatment
ISO
mouse tumor cells in mouse recipient
RGD
PMID:31348125
RGD:151660353
NCBI chr10:12,267,891...12,384,522
Ensembl chr10:12,241,716...12,384,435
G
RICTOR
RPTOR independent companion of MTOR complex 2
disease_progression
ISO
mRNA:increased expression:liver (human)
RGD
PMID:30404068
RGD:152995463
NCBI chr 4:69,903,393...70,013,168
Ensembl chr 4:69,936,379...70,010,566
G
RNF43
ring finger protein 43
ISO
associated with colorectal adenocarcinoma;mRNA:increased expression:liver (human)
RGD
PMID:28789449
RGD:151361221
NCBI chr 9:32,996,668...33,061,781
Ensembl chr 9:32,997,937...33,060,313
G
SLC3A2
solute carrier family 3 member 2
severity
ISO
associated with colon adenocarcinoma
RGD
PMID:11745822
RGD:151361130
NCBI chr18:53,810,468...53,819,021
Ensembl chr18:53,810,398...53,819,021
G
SLC7A5
solute carrier family 7 member 5
severity
ISO
associated with colon adenocarcinoma associated with colon cancer
RGD
PMID:11718450 PMID:11745822
RGD:151361129 RGD:151361130
NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858
G
SMAD4
SMAD family member 4
treatment
ISO
associated with colorectal carcinoma;protein:decreased expression:colorectum: associated with colorectal carcinoma; DNA:mutations: :
RGD
PMID:17390050 PMID:29551247
RGD:18937000 RGD:21066338
NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405
G
SOX30
SRY-box transcription factor 30
ameliorates
ISO
RGD
PMID:29739711
RGD:151660333
NCBI chr 4:52,587,163...52,615,945
Ensembl chr 4:52,587,355...52,615,945
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
disease_progression
ISO
associated with colon cancer;protein:increased activity:colon
RGD
PMID:7678609
RGD:150521542
NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
G
VEGFA
vascular endothelial growth factor A
ISO
associated with colorectal carcinoma;mRNA,protein:increased expression:liver:
RGD
PMID:22156924
RGD:15014782
NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
G
ADAM28
ADAM metallopeptidase domain 28
ameliorates
ISO
associated with lung adenocarcinoma; associated with lung carcinoma, breast carcinoma
RGD
PMID:22636800 PMID:26800504
RGD:11531771 RGD:153297785
NCBI chr25:33,092,645...33,147,791
Ensembl chr25:33,092,628...33,264,710
G
ARHGAP5
Rho GTPase activating protein 5
ISO
associated with Mammary Neoplasms, Experimental
RGD
PMID:20860838
RGD:126848767
NCBI chr 8:11,190,663...11,269,353
Ensembl chr 8:11,204,696...11,267,086
G
ARID2
AT-rich interaction domain 2
exacerbates
ISO
associated with hepatocellular carcinoma,
RGD
PMID:32071245
RGD:150340708
NCBI chr27:8,411,092...8,579,735
Ensembl chr27:8,412,377...8,579,882
G
AZGP1
alpha-2-glycoprotein 1, zinc-binding
ameliorates
ISO
associated with hepatocellular carcinoma;
RGD
PMID:26902423 PMID:27993894
RGD:153350132 RGD:153350133
NCBI chr 6:9,622,991...9,629,154
Ensembl chr 6:9,622,992...9,629,154
G
CA12
carbonic anhydrase 12
ameliorates
ISO
associated with breast cancer;
RGD
PMID:29786141
RGD:155226861
NCBI chr30:27,903,460...27,957,162
Ensembl chr30:27,905,837...27,957,742
G
CBLB
Cbl proto-oncogene B
severity
ISO
associated with stomach carcinoma;
RGD
PMID:28334634
RGD:150540337
NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810
G
CCNG1
cyclin G1
ISO
RGD
PMID:30565428
RGD:151361205
NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211
G
CHD4
chromodomain helicase DNA binding protein 4
ameliorates
ISO
associated with human colon adenocarcinoma cells in a mouse model
RGD
PMID:28486105
RGD:153323299
NCBI chr27:38,411,009...38,440,367
Ensembl chr27:38,411,075...38,439,958
G
COL10A1
collagen type X alpha 1 chain
ameliorates
ISO
associated with H1299 cell
RGD
PMID:33324550
RGD:150429752
NCBI chr12:71,803,372...71,810,049
Ensembl chr12:71,798,692...71,809,399
G
CXCR4
C-X-C motif chemokine receptor 4
ameliorates
ISO
associated with nasopharynx carcinoma; human cells in mouse model associated with colorectal cancer; human cells in mouse model associated with osteosarcoma and melanoma
RGD
PMID:16000558 PMID:18071913 PMID:26498029 PMID:31938138
RGD:151665329 RGD:151893515 RGD:152023752 RGD:152177473
NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
G
DDR1
discoidin domain receptor tyrosine kinase 1
ISO
RGD
PMID:29483153
RGD:151347599
NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543
G
DDR2
discoidin domain receptor tyrosine kinase 2
exacerbates
ISO
associated with tongue squamous cell carcinoma;
RGD
PMID:24556606
RGD:150429746
NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275
G
FASN
fatty acid synthase
ISO
associated with head and neck squamous cell carcinoma
RGD
PMID:20604875
RGD:126790467
NCBI chr 9:233,105...249,573
Ensembl chr 9:232,963...249,092
G
FOSL2
FOS like 2, AP-1 transcription factor subunit
ISO
human cells in mouse model
RGD
PMID:30326930
RGD:153344557
NCBI chr17:22,340,469...22,364,994
Ensembl chr17:22,341,322...22,361,772
G
HILPDA
hypoxia inducible lipid droplet associated
ISO
human cells in mouse model
RGD
PMID:31142329
RGD:153344574
NCBI chr14:7,957,811...7,959,878
G
IQSEC1
IQ motif and Sec7 domain ArfGEF 1
ISO
human cells in mouse model
RGD
PMID:18084281
RGD:153344604
NCBI chr20:3,241,058...3,403,394
Ensembl chr20:3,241,052...3,522,859
G
ITGAV
integrin subunit alpha V
treatment
ISO
human cells in rat model
RGD
PMID:20841470
RGD:152998949
NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
G
MAP3K1
mitogen-activated protein kinase kinase kinase 1
ameliorates
ISO
associated with breast carcinoma
RGD
PMID:16568086
RGD:150573808
NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209
G
MAP3K8
mitogen-activated protein kinase kinase kinase 8
ameliorates
ISO
associated with clear cell renal cell carcinoma
RGD
PMID:23982215
RGD:151356974
NCBI chr 2:16,717,845...16,740,816
Ensembl chr 2:16,720,596...16,740,515
G
MIR423A
microRNA mir-423a
ISO
human cells in mouse model
RGD
PMID:30326930
RGD:153344557
NCBI chr 9:44,155,913...44,155,971
G
MIR494
microRNA mir-494
ameliorates
ISO
associated with hepatocellular carcinoma
RGD
PMID:25820676 PMID:28055013
RGD:155900754 RGD:156430322
NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465
G
NF2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
ISO
associated with hepatocellular carcinoma
RGD
PMID:26443326
RGD:11076529
NCBI chr26:22,816,869...22,896,103
Ensembl chr26:22,816,551...22,894,196
G
NTRK3
neurotrophic receptor tyrosine kinase 3
ameliorates
ISO
associated with mammary carcinoma
RGD
PMID:20802235
RGD:150520014
NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024
G
PAGR1
PAXIP1 associated glutamate rich protein 1
ISO
human cells in mouse model
RGD
PMID:33833989
RGD:153344568
NCBI chr 6:17,876,740...17,879,546
G
PTPRB
protein tyrosine phosphatase receptor type B
treatment
ISO
RGD
PMID:23899555
RGD:151660352
NCBI chr10:12,267,891...12,384,522
Ensembl chr10:12,241,716...12,384,435
G
RICTOR
RPTOR independent companion of MTOR complex 2
ISO
human cells in mouse model
RGD
PMID:20978191 PMID:29809146
RGD:152995469 RGD:152995516
NCBI chr 4:69,903,393...70,013,168
Ensembl chr 4:69,936,379...70,010,566
G
RPTOR
regulatory associated protein of MTOR complex 1
ISO
RGD
PMID:29809146
RGD:152995516
NCBI chr 9:1,012,512...1,345,872
Ensembl chr 9:1,013,603...1,344,148
G
SF3B4
splicing factor 3b subunit 4
ISO
human cells in mouse model
RGD
PMID:30391496
RGD:155804298
NCBI chr17:59,208,989...59,214,643
Ensembl chr17:59,208,990...59,213,991
G
SOX30
SRY-box transcription factor 30
ameliorates
ISO
RGD
PMID:29739711
RGD:151660333
NCBI chr 4:52,587,163...52,615,945
Ensembl chr 4:52,587,355...52,615,945
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
treatment ameliorates
ISO
associated with breast cancer; associated with nasopharynx carcinoma;
RGD
PMID:15753384 PMID:27078847
RGD:150521726 RGD:1581400
NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
G
ABCA13
ATP binding cassette subfamily A member 13
susceptibility
ISO
DNA:amplification:cds: (human, male)
RGD
PMID:27366209
RGD:152995256
NCBI chr18:136,338...353,974
Ensembl chr18:135,690...352,871
G
ADAM28
ADAM metallopeptidase domain 28
ISO
associated with breast cancer;DNA:hypermethylation:
RGD
PMID:25620615
RGD:153298970
NCBI chr25:33,092,645...33,147,791
Ensembl chr25:33,092,628...33,264,710
G
ADGRB1
adhesion G protein-coupled receptor B1
disease_progression
ISO
associated with stomach cancer;
RGD
PMID:11172604
RGD:13831357
NCBI chr13:36,627,791...36,649,013
Ensembl chr13:36,614,498...36,690,936
G
AICDA
activation induced cytidine deaminase
ISO
associated with stomach cancer;protein:increased expression:stomach (human)
RGD
PMID:21538122
RGD:127285638
NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789
G
ANGPTL4
angiopoietin like 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17130448
NCBI chr20:52,942,090...52,948,126
Ensembl chr20:52,942,259...52,947,475
G
ANXA1
annexin A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19381893
NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
G
AQP3
aquaporin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21401805
NCBI chr11:50,517,509...50,524,565
G
ARHGAP5
Rho GTPase activating protein 5
ISO
associated with nasopharynx carcinoma;mRNA, protein:increased expression: epithelium of nasopharynx
RGD
PMID:25961434
RGD:11056278
NCBI chr 8:11,190,663...11,269,353
Ensembl chr 8:11,204,696...11,267,086
G
ASXL1
ASXL transcriptional regulator 1
ISO
associated with colorectal cancer
RGD
PMID:32317519
RGD:126779580
NCBI chr24:21,725,126...21,804,745
Ensembl chr24:21,661,059...21,802,815
G
AXL
AXL receptor tyrosine kinase
ISO
associated Pancreatic Neoplasms
RGD
PMID:19252414
RGD:2325833
NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960
G
BAG1
BAG cochaperone 1
disease_progression
ISO
associated with Breast Neoplasms:protein:increased expression:breast
RGD
PMID:18430249
RGD:2292908
NCBI chr11:50,348,833...50,363,532
Ensembl chr11:50,350,999...50,363,581
G
BAMBI
BMP and activin membrane bound inhibitor
ISO
associated with stomach cancer; protein:increased expression: :
RGD
PMID:24752577
RGD:14390158
NCBI chr 2:17,453,628...17,459,812
Ensembl chr 2:17,455,243...17,462,346
G
BARHL2
BarH like homeobox 2
ISO
associated with oral squamous cell carcinoma; mRNA:decreased expression:mouth mucosa
RGD
PMID:27542258
RGD:14390167
NCBI chr 6:57,971,077...57,977,197
Ensembl chr 6:57,971,018...57,977,211
G
BCL2
BCL2 apoptosis regulator
ISO
associated with Breast Neoplasms;protein:increased expression:lymph node
RGD
PMID:18217456
RGD:2293013
NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
G
BIK
BCL2 interacting killer
ISO
associated with cholangiocarcinoma;DNA:CNV::
RGD
PMID:16865775
RGD:14394820
NCBI chr10:22,417,374...22,433,055
G
BIRC5
baculoviral IAP repeat containing 5
disease_progression
ISO
associated with Breast Neoplasms associated with Cervix Neoplasms;mRNA:splice variant
RGD
PMID:17285241 PMID:17877643
RGD:2293098 RGD:2293103
NCBI chr 9:2,930,308...2,959,307
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906
G
BRD7
bromodomain containing 7
severity
ISO
protein:increased expression:lung:
RGD
PMID:22008115
RGD:9586442
NCBI chr 2:64,966,636...65,002,800
Ensembl chr 2:64,966,392...65,002,799
G
BSG
basigin
disease_progression
ISO
associated with Breast Neoplasms
RGD
PMID:16004819
RGD:2289055
NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061
G
BTK
Bruton tyrosine kinase
disease_progression
ISO
associated with lung adenocarcinoma;protein:increased expression:lung (human)
RGD
PMID:31200752
RGD:151347847
NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562
G
CA9
carbonic anhydrase 9
ISO
associated with Cervix Neoplasms
RGD
PMID:17233814
RGD:2293196
NCBI chr11:52,205,619...52,211,281
Ensembl chr11:52,205,668...52,211,267
G
CAB39
calcium binding protein 39
ISO
associated with pancreatic cancer;RNA:increased expression:pancreas
RGD
PMID:28197410
RGD:14398834
NCBI chr25:42,752,798...42,801,257
Ensembl chr25:42,703,332...42,799,279
G
CASP9
caspase 9
ISO
associated with Carcinoma, Non-Small-Cell Lung;DNA:SNP:exon:rs1052576 (human)
RGD
PMID:17285546
RGD:13434907
NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
G
CAV1
caveolin 1
disease_progression
ISO
associated with Melanoma
RGD
PMID:22134245
RGD:8661767
NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935
G
CBL
Cbl proto-oncogene
ISO
associated with stomach carcinoma;protein:increased expression:stomach
RGD
PMID:31611438
RGD:126925223
NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956
G
CBLB
Cbl proto-oncogene B
ISO
associated with stomach carcinoma;
RGD
PMID:20038312
RGD:150540338
NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810
G
CCND2
cyclin D2
ISO
associated with colorectal cancer;protein:increased expression:colorectum
RGD
PMID:19508551
RGD:151665111
NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255
G
CCNE1
cyclin E1
ISO
associated with Carcinoma, Transitional Cell;protein:decreased expression
RGD
PMID:16949911
RGD:2289266
NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
G
CCNH
cyclin H
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 3:21,046,477...21,067,305
Ensembl chr 3:21,046,472...21,178,315
G
CCR5
C-C motif chemokine receptor 5
ISO
associated with Breast Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:24301790
RGD:8551816
NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
G
CD274
CD274 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16530813
NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
G
CD40
CD40 molecule
ISO
associated with breast cancer;DNA:snps:5' utr, intron:c.-1T>C, c.51+914T>G (rs1883832, rs4810485) (human)
RGD
PMID:21912605
RGD:8547780
NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301
G
CD44
CD44 molecule
ISO
associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach
RGD
PMID:16425351
RGD:2289356
NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
G
CDH1
cadherin 1
ISO
associated with Breast Neoplasms associated with Cervix Neoplasms
RGD
PMID:17649807 PMID:18097581
RGD:2289498 RGD:2296046
NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878
G
CDKN1A
cyclin dependent kinase inhibitor 1A
ISO
associated with Eyelid Neoplasms; associated with Oral Squamous Cell Carcinoma;
RGD
PMID:15817070 PMID:19628749
RGD:8661799 RGD:8662374
NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
G
CDKN1B
cyclin dependent kinase inhibitor 1B
ISO
associated with Breast Neoplasms associated with non-small cell lung carcinoma
RGD
PMID:12015771 PMID:28601655
RGD:13673921 RGD:2293607
NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906
G
CDKN2A
cyclin dependent kinase inhibitor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379
G
CLDN1
claudin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33665778
NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033
G
CLPTM1L
CLPTM1 like
ISO
associated with esophagus squamous cell carcinoma; mRNA:increased expression:esophagus
RGD
PMID:25480402
RGD:150530497
NCBI chr34:11,263,274...11,277,666
Ensembl chr34:11,263,162...11,277,436
G
CLU
clusterin
ISO
associated with breast cancer;DNA:snp:promoter:g.27611345C>G (rs9331888) (human)
RGD
PMID:22037783
RGD:8963167
NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563
G
COMT
catechol-O-methyltransferase
ISO
associated with breast cancer;DNA:missense mutation:cds:p.V108/158M (human)
RGD
PMID:10755383
RGD:8662330
NCBI chr26:29,359,930...29,381,854
Ensembl chr26:29,360,356...29,366,008
G
CRP
C-reactive protein
susceptibility
ISO
associated with Breast Neoplasm; DNA:polymorphism: :1846C>T(rs1205)(human)
RGD
PMID:24633920
RGD:9580226
NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
G
CSF1R
colony stimulating factor 1 receptor
ISO
associated with Breast Neoplasms
RGD
PMID:14734466
RGD:2293711
NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510
G
CTLA4
cytotoxic T-lymphocyte associated protein 4
ISO
associated with Prostatic Neoplasms
RGD
PMID:10611340
RGD:4891523
NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874
G
CTNNA1
catenin alpha 1
ISO
associated with Breast Neoplasms
RGD
PMID:12047765
RGD:2289795
NCBI chr11:26,273,322...26,459,497
Ensembl chr11:26,143,013...26,459,091
G
CTNNB1
catenin beta 1
ISO
associated with Breast Neoplasms;protein:decreased expression
RGD
PMID:17908479
RGD:2289813
NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
G
CXCL12
C-X-C motif chemokine ligand 12
disease_progression
ISO
associated with stomach cancer;mRNA:increased expression:stomach (human)
RGD
PMID:21633638
RGD:152023624
NCBI chr28:2,895,916...2,903,543
G
CXCR4
C-X-C motif chemokine receptor 4
ISO
associated with nasopharynx carcinoma; protein:increased expression:lymph node (human)
RGD
PMID:16000558
RGD:151893515
NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
G
CYCS
cytochrome c, somatic
ISO
associated with non-small cell lung carcinoma; protein:decreased expression:serum
RGD
PMID:25578497
RGD:13792769
NCBI chr14:38,579,446...38,581,983
Ensembl chr14:38,579,446...38,581,983
G
DDR1
discoidin domain receptor tyrosine kinase 1
severity
ISO
mRNA, protein:increased expression:mouth (human) mRNA:increased expression:kidney, lymph nodes (human)
RGD
PMID:27020590 PMID:31253192
RGD:151347620 RGD:151347863
NCBI chr12:653,800...671,190
Ensembl chr12:653,807...670,543
G
DDR2
discoidin domain receptor tyrosine kinase 2
disease_progression
ISO
associated with oral squamous cell carcinoma
RGD
PMID:29945346
RGD:150429700
NCBI chr38:20,002,984...20,152,930
Ensembl chr38:20,008,057...20,152,275
G
DNMT3B
DNA methyltransferase 3 beta
ISO
associated with Carcinoma, Pancreatic Ductal;
RGD
PMID:22919364
RGD:9589121
NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900
G
EBAG9
estrogen receptor binding site associated antigen 9
ISO
associated with Breast Neoplasms;protein:increased expression:breast associated with Prostatic Neoplasm;protein:increased expression:prostate gland, lymph node
RGD
PMID:12054692 PMID:12845666 PMID:17187007
RGD:2289847 RGD:2289856 RGD:2298489
NCBI chr13:10,081,700...10,099,737
Ensembl chr13:10,081,695...10,099,501
G
EGFR
epidermal growth factor receptor
treatment
ISO
associated with Squamous Cell Carcinoma of the Tongue
RGD
PMID:19380367
RGD:8551769
NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
G
EHMT2
euchromatic histone lysine methyltransferase 2
ISO
associated with Esophageal Squamous Cell Carcinoma; associated with Melanoma;
RGD
PMID:24658378 PMID:24805087
RGD:9590069 RGD:9590071
NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584
G
EPHA2
EPH receptor A2
ISO
protein:increased expression:esophagus (human)
RGD
PMID:33833989
RGD:153344568
NCBI chr 2:81,534,130...81,561,722
Ensembl chr 2:81,534,125...81,561,725
G
ERBB2
erb-b2 receptor tyrosine kinase 2
disease_progression
ISO
associated with Breast Neoplasms;DNA, protein:polymorphism, increased expression:serum:p.I655V associated with lung adenocarcinoma; protein:increased expression:lung (human) CTD Direct Evidence: marker/mechanism associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder
RGD CTD
PMID:18097576 PMID:18237248 PMID:21532492 PMID:21966491
RGD:153344600 RGD:2289925 RGD:2289926
NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294
G
ERBB3
erb-b2 receptor tyrosine kinase 3
ISO
associated with Prostatic Neoplasms;protein:increased expression, altered localization:lymph node, nucleus associated with head and neck squamous cell carcinoma
RGD
PMID:17634423 PMID:20604875
RGD:126790467 RGD:2289944
NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264
G
ERBB4
erb-b2 receptor tyrosine kinase 4
disease_progression severity
ISO
associated with oral squamous cell carcinoma associated with lung non-small cell carcinoma associated with colorectal adenocarcinoma
RGD
PMID:16507107 PMID:21324275 PMID:27444519
RGD:126781762 RGD:126781766 RGD:126790471
NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426
G
FAS
Fas cell surface death receptor
susceptibility
ISO
associated with Cervix Neoplasms;DNA:polymorphism:promoter:-1377G>A
RGD
PMID:18068525
RGD:2298509
NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
G
FGF1
fibroblast growth factor 1
ISO
associated with Cervix Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:17242701
RGD:2290286
NCBI chr 2:37,467,431...37,554,770
Ensembl chr 2:37,470,985...37,554,619
G
FGFR2
fibroblast growth factor receptor 2
ISO
associated with breast cancer;DNA:snp:intron:c.109+7033T>A (rs1219648) (human)
RGD
PMID:20640597
RGD:7394846
NCBI chr28:31,303,882...31,411,015
Ensembl chr28:31,303,894...31,411,621
G
FLT3
fms related receptor tyrosine kinase 3
disease_progression
ISO
associated with Prostatic Neoplasms
RGD
PMID:14566827
RGD:2302210
NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284
G
FOXA1
forkhead box A1
ISO
associated with lung non-small cell carcinoma; mRNA:increased expression: :
RGD
PMID:29115441
RGD:151665751
NCBI chr 8:16,072,629...16,083,105
Ensembl chr 8:16,079,140...16,083,807
G
FOXP1
forkhead box P1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25485836
NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397
G
GPX3
glutathione peroxidase 3
ISO
associated with stomach carcinoma; DNA:hypermethylation:promoter
RGD
PMID:23071548
RGD:151665353
NCBI chr 4:58,200,671...58,209,010
Ensembl chr 4:58,200,672...58,209,010
G
GRIK2
glutamate ionotropic receptor kainate type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr12:58,932,754...59,991,305
Ensembl chr12:59,355,017...59,990,408
G
HMGB1
high mobility group box 1
ISO
associated with Adenocarcinoma, Colon
RGD
PMID:20616616
RGD:10402080
NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165
G
ICAM1
intercellular adhesion molecule 1
ISO
associated with Breast Neoplasms
RGD
PMID:21590495
RGD:8547712
NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
G
IER2
immediate early response 2
ISO
RGD
PMID:22120713
RGD:153323322
NCBI chr20:49,071,243...49,074,184
Ensembl chr20:49,072,234...49,072,902
G
IL13
interleukin 13
ISO
associated with Melanoma, Cutaneous Malignant;mRNA:increased expression:lymph node
RGD
PMID:17545514
RGD:8549587
NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
G
IL18
interleukin 18
ISO
associated with Breast Neoplasms;protein:increased expression:serum
RGD
PMID:12902898
RGD:8655867
NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
G
ING4
inhibitor of growth family member 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27806345
NCBI chr27:38,371,656...38,379,251
Ensembl chr27:38,371,766...38,379,029
G
IQSEC1
IQ motif and Sec7 domain ArfGEF 1
disease_progression
ISO
associated with lung adenocarcinoma; protein:increased expression:lung (human)
RGD
PMID:21966491
RGD:153344600
NCBI chr20:3,241,058...3,403,394
Ensembl chr20:3,241,052...3,522,859
G
ITGB1
integrin subunit beta 1
ISO
associated with non-small cell lung carcinoma,
RGD
PMID:28537888
RGD:13792830
NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961
G
KCNJ12
potassium inwardly rectifying channel subfamily J member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34755307
NCBI chr 5:42,819,412...42,860,916
Ensembl chr 5:42,850,372...42,860,899
G
KDR
kinase insert domain receptor
treatment
ISO
associated with Squamous Cell Carcinoma of the Tongue
RGD
PMID:19380367
RGD:8551769
NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
G
KISS1
KiSS-1 metastasis suppressor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21383688
NCBI chr38:768,333...774,328
Ensembl chr38:768,585...773,382
G
KLF7
KLF transcription factor 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:37734194
NCBI chr37:15,515,563...15,607,345
Ensembl chr37:15,521,622...15,605,824
G
KMT2D
lysine methyltransferase 2D
ISO
associated with stomach cancer
RGD
PMID:30177394
RGD:150521710
NCBI chr27:5,516,866...5,556,303
Ensembl chr27:5,521,804...5,553,490
G
LAMC2
laminin subunit gamma 2
ISO
associated with lung squamous cell carcinoma;
RGD
PMID:23124251
RGD:13793371
NCBI chr 7:16,543,541...16,625,304
Ensembl chr 7:16,569,086...16,624,085
G
LOC611363
mesothelin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22644300
NCBI chr 6:39,827,985...39,834,945
G
LRRC59
leucine rich repeat containing 59
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 9:26,350,300...26,364,021
Ensembl chr 9:26,351,734...26,364,082
G
MACIR
macrophage immunometabolism regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 3:7,956,865...7,968,964
G
MET
MET proto-oncogene, receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29426936
NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
G
MIR125A
microRNA mir-125a
ISO
associated with stomach cancer;
RGD
PMID:22322911
RGD:21408544
NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337
G
MIR152
microRNA mir-152
ISO
associated with breast cancer
RGD
PMID:22935141
RGD:19165152
NCBI chr 9:24,335,161...24,335,219
Ensembl chr 9:24,335,146...24,335,225
G
MIR155
microRNA mir-155
disease_progression
ISO
associated with colon cancer
RGD
PMID:26885061 PMID:27856635 PMID:29893326
RGD:21079444 RGD:21079446 RGD:21409756
NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833
G
MIR187
microRNA mir-187
ISO
associated with oral squamous cell carcinoma; RNA:increased expression:plasma
RGD
PMID:27542258
RGD:14390167
NCBI chr 7:54,261,943...54,262,010
Ensembl chr 7:54,261,943...54,262,010
G
MIR224
microRNA mir-224
ISO
associated with colorectal cancer; mRNA:decreased expression:colorectal mucosa:
RGD
PMID:25919696
RGD:14398749
NCBI chr X:119,925,345...119,925,413
Ensembl chr X:119,925,345...119,925,413
G
MIR30A
microRNA mir-30a
ISO
associated with Colorectal Neoplasms
RGD
PMID:23486085
RGD:13432035
NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961
G
MIR335
microRNA mir-335
ISO
associated with stomach cancer; RNA:decreased expression:stomach
RGD
PMID:21822301
RGD:14394425
NCBI chr14:6,444,861...6,444,918
Ensembl chr14:6,444,847...6,444,932
G
MIR432
microRNA mir-432
disease_progression
ISO
mRNA:decreased expression:colon (human)
RGD
PMID:33717244
RGD:152999433
NCBI chr 8:69,106,415...69,106,501
Ensembl chr 8:69,106,415...69,106,501
G
MMP2
matrix metallopeptidase 2
disease_progression
ISO
associated with Carcinoma, Ductal, Breast associated with Tongue Neoplasms
RGD
PMID:23107277 PMID:23280016
RGD:8547824 RGD:8655998
NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
G
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
ISO
associated with breast cancer;DNA:deletion:promoter:-1170_-1172delA (human)
RGD
PMID:15161710
RGD:8662937
NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222
G
MMP9
matrix metallopeptidase 9
disease_progression
ISO
associated with Endometrial Neoplasms;protein:increased expression:endometrium associated with Tongue Neoplasms associated with Carcinoma, Non-Small-Cell Lung;protein:increased expression:serum
RGD
PMID:12487935 PMID:20704821 PMID:23107277
RGD:2298523 RGD:5129215 RGD:8547824
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
G
MSH2
mutS homolog 2
ISO
associated with laryngeal squamous cell carcinoma
RGD
PMID:24459922
RGD:126848797
NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
G
MTA1
metastasis associated 1
ISO
associated with Carcinoma, Non-Small-Cell Lung;mRNA:increased expression:lung
RGD
PMID:11804687
RGD:9588220
NCBI chr 8:72,752,894...72,772,236
Ensembl chr 8:72,753,178...72,772,762
G
MTOR
mechanistic target of rapamycin kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114
G
MUC1
mucin 1, cell surface associated
ISO
associated with Common Bile Duct Neoplasms associated with Esophageal Neoplasms associated with Gallbladder Neoplasms;protein:altered localization:gallbladder associated with Carcinoma, Renal Cell;
RGD
PMID:10390012 PMID:11295067 PMID:16222735 PMID:21339746
RGD:2324649 RGD:2324860 RGD:7245968 RGD:7349383
NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
G
MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
associated with chloangiocarcinoma;protein:increased expression:bile duct
RGD
PMID:16842244
RGD:2325168
NCBI chr18:45,471,232...45,498,961
G
NCAM1
neural cell adhesion molecule 1
ISO
RGD
PMID:10086383
RGD:2326067
NCBI chr 5:19,895,587...20,192,334
Ensembl chr 5:19,895,613...20,191,995
G
NME1
non-metastatic cells 1, protein (NM23A) expressed in
ISO
associated with Cervix Neoplasms; associated with Endometrial Neoplasms associated with Breast Neoplasms
RGD
PMID:8102131 PMID:8855975 PMID:9036878
RGD:2299061 RGD:2299062 RGD:2299077
NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955
G
NME2
non-metastatic cells 2, protein (NM23B) expressed in
ISO
associated with Cervix Neoplasms; associated with Endometrial Neoplasms
RGD
PMID:8855975
RGD:2299062
NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934
G
NOS3
nitric oxide synthase 3
susceptibility
ISO
associated with Breast Neoplasms;DNA:polymorphisms:promoter, exon:-786T>C,p.E298D (human)
RGD
PMID:17262178
RGD:2292070
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
G
OGG1
8-oxoguanine DNA glycosylase
ISO
associated with breast cancer;DNA:missense mutation:cds:p.S326C (rs1052133) (human)
RGD
PMID:18977234
RGD:8657156
NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264
G
PAGR1
PAXIP1 associated glutamate rich protein 1
disease_progression
ISO
protein:decreased expression:esophagus (human)
RGD
PMID:33833989
RGD:153344568
NCBI chr 6:17,876,740...17,879,546
G
PDGFA
platelet derived growth factor subunit A
ISO
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:8619189
RGD:2292155
NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396
G
PDGFB
platelet derived growth factor subunit B
ISO
associated with Breast Neoplasms;mRNA:increased expression:lymph node
RGD
PMID:17674348
RGD:2292173
NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
G
PDPK1
3-phosphoinositide dependent protein kinase 1
ISO
associated with non-small cell lung carcinoma;mRNA:increased expression:blood serum
RGD
PMID:25064732
RGD:13503320
NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295
G
PDPN
podoplanin
ISO
associated with Breast Neoplasms associated with Cervix Neoplasms
RGD
PMID:16528371 PMID:18165897
RGD:2292231 RGD:2292237
NCBI chr 2:83,552,735...83,581,375
Ensembl chr 2:83,552,830...83,581,375
G
PEBP1
phosphatidylethanolamine binding protein 1
ISO
associated with Cervix Neoplasms associated with Breast Neoplasms
RGD
PMID:16243812 PMID:18191186
RGD:2302867 RGD:2302868
NCBI chr26:14,522,124...14,526,370
Ensembl chr26:14,500,074...14,529,354
G
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
ISO
associated with Colorectal Neoplasms
RGD
PMID:25550888
RGD:13432030
NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
G
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
ISO
associated with Colorectal Neoplasms
RGD
PMID:25550888
RGD:13432030
NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939
G
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34755307
NCBI chr17:60,257,017...60,295,866
Ensembl chr17:60,257,332...60,295,866
G
POU5F1
POU class 5 homeobox 1
ISO
associated with Seminoma; associated with Carcinoma, Embryonal
RGD
PMID:15386301
RGD:2292442
G
PPARG
peroxisome proliferator activated receptor gamma
ISO
associated with Cholangiocarcinoma;protein:increased expression:bile duct epithelium
RGD
PMID:20021832
RGD:2317459
NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
G
PREX1
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
ISO
associated with Prostatic Neoplasms
RGD
PMID:19305425
RGD:2314605
NCBI chr24:35,403,078...35,503,428
Ensembl chr24:35,404,564...35,582,041
G
PTEN
phosphatase and tensin homolog
ISO
associated with Breast Neoplasms associated with Prostatic Neoplasms;protein:decreased expression:prostate
RGD
PMID:17163422 PMID:17919877
RGD:2292499 RGD:2292507
NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
associated with Breast Neoplasms associated with Biliary Tract Neoplasms associated with carcinoma, non-small-cell lung; DNA:SNP: :929G>C(human)
RGD
PMID:18159174 PMID:18353210 PMID:20016751
RGD:2300128 RGD:2317165 RGD:5135471
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
G
PTK2
protein tyrosine kinase 2
ISO
associated with lung squamous cell carcinoma; protein:increased tyrosine phosphorylation:lymph node
RGD
PMID:23906871
RGD:152176664
NCBI chr13:35,302,439...35,541,336
Ensembl chr13:35,303,380...35,541,294
G
PTPN13
protein tyrosine phosphatase non-receptor type 13
ISO
associated with lung squamous cell carcinoma; protein:decreased expression:lymph node
RGD
PMID:23906871
RGD:152176664
NCBI chr32:10,125,447...10,328,764
Ensembl chr32:10,125,441...10,328,757
G
RAMP2
receptor activity modifying protein 2
disease_progression
ISO
associated with colorectal cancer; protein:increased expression:lymph node (human)
RGD
PMID:23634287
RGD:151708733
NCBI chr 9:20,250,711...20,252,485
G
RAMP3
receptor activity modifying protein 3
ISO
associated with colorectal cancer; protein:increased expression:lymph node (human)
RGD
PMID:23634287
RGD:151708733
G
RASSF2
Ras association domain family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17013896
NCBI chr24:16,736,786...16,779,910
Ensembl chr24:16,736,962...16,781,569
G
RBM10
RNA binding motif protein 10
ISO
associated with lung adenocarcinoma;DNA:missense mutation:exon:p.R241C (c.763C>T) (human)
RGD
PMID:30405763
RGD:151356993
NCBI chr X:40,746,959...40,776,764
Ensembl chr X:40,747,178...40,776,742
G
RELA
RELA proto-oncogene, NF-kB subunit
ISO
associated with Prostatic Neoplasms;protein:altered localization:nucleus, prostate gland
RGD
PMID:17020979
RGD:2298757
NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
G
RET
ret proto-oncogene
ISO
associated with Pancreatic Neoplasms
RGD
PMID:18652760
RGD:2324925
NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210
G
RHOA
ras homolog family member A
ISO
associated with Bladder Neoplasms;protein:increased expression:lymph node associated with colorectal cancer
RGD
PMID:12855641 PMID:17597401
RGD:13432052 RGD:2298872
NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215
G
RICTOR
RPTOR independent companion of MTOR complex 2
ISO
associated with breast ductal carcinoma; protein:increased expression:breast tumor, lymph node (human)
RGD
PMID:20978191
RGD:152995469
NCBI chr 4:69,903,393...70,013,168
Ensembl chr 4:69,936,379...70,010,566
G
RUNX1
RUNX family transcription factor 1
ISO
associated with Carcinoid Tumor
RGD
PMID:21636701
RGD:126779567
NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839
G
SFN
stratifin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19381893
NCBI chr 2:73,268,289...73,269,663
Ensembl chr 2:73,268,791...73,269,537
G
SKP2
S-phase kinase associated protein 2
ISO
associated with Endometrial Neoplasms;protein:increased expression:endometrium
RGD
PMID:16080017
RGD:2315043
NCBI chr 4:72,352,966...72,386,469
Ensembl chr 4:72,352,986...72,386,307
G
SLC22A10
solute carrier family 22 member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr18:53,597,148...53,628,569
Ensembl chr18:53,597,533...53,628,165
G
SLC7A5
solute carrier family 7 member 5
severity
ISO
associated with gastric adenocarcinoma;protein:increased expression: : associated with stomach carcinoma
RGD
PMID:21501294 PMID:25908107
RGD:11052781 RGD:151361203
NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858
G
SMAD4
SMAD family member 4
ISO
associated with Breast Neoplasms
RGD
PMID:11809701
RGD:2300007
NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405
G
SMO
smoothened, frizzled class receptor
ISO
associated with colorectal cancer
RGD
PMID:30784110
RGD:150520177
NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033
G
SNCG
synuclein gamma
ISO
RGD
PMID:15221989
RGD:6478801
NCBI chr 4:34,604,867...34,608,851
Ensembl chr 4:34,605,091...34,608,842
G
SOCS2
suppressor of cytokine signaling 2
ISO
associated with Prostatic Neoplasms
RGD
PMID:16707422
RGD:2298925
NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869
G
SOCS3
suppressor of cytokine signaling 3
ISO
associated with Breast Neoplasms
RGD
PMID:18097573
RGD:2298901
NCBI chr 9:2,859,267...2,859,944
G
SOD2
superoxide dismutase 2
disease_progression
ISO
CTD Direct Evidence: marker/mechanism associated with tongue neoplasms;
CTD RGD
PMID:10853026 PMID:19381893 PMID:20618948
RGD:8547519
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
G
SOX2
SRY-box transcription factor 2
disease_progression
ISO
associated with Breast Neoplasms
RGD
PMID:24382260
RGD:8661670
NCBI chr34:14,853,000...14,855,153
G
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
associated with colon adenocarcinoma,
RGD
PMID:21282564
RGD:150520218
NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
G
ST14
ST14 transmembrane serine protease matriptase
ISO
associated with Endometrial Neoplasms
RGD
PMID:19443387
RGD:2315087
NCBI chr 5:4,652,493...4,666,728
Ensembl chr 5:4,651,863...4,691,069
G
STAT3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549414
NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672
G
STK11
serine/threonine kinase 11
ISO
associated with Breast Neoplasms;protein:decreased expression
RGD
PMID:12114407
RGD:2291948
NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118
G
TERT
telomerase reverse transcriptase
disease_progression
ISO
associated with lung non-small cell carcinoma;
RGD
PMID:11679180
RGD:152977755
NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
G
TIMP1
TIMP metallopeptidase inhibitor 1
ISO
associated with Endometrial Neoplasms;protein:increased expression:endometrium
RGD
PMID:12487935
RGD:2298523
NCBI chr X:41,201,623...41,205,314
Ensembl chr X:41,201,638...41,205,310
G
TIMP3
TIMP metallopeptidase inhibitor 3
ISO
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:12828172
RGD:2290437
NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288
G
TIMP4
TIMP metallopeptidase inhibitor 4
ISO
associated with Breast Neoplasms;mRNA:increased expression:breast
RGD
PMID:12828172
RGD:2290437
NCBI chr20:6,399,522...6,405,089
Ensembl chr20:6,399,522...6,405,089
G
TLR4
toll like receptor 4
ISO
associated with Carcinoma, Ductal, Breast;
RGD
PMID:23338716
RGD:7794684
NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
G
TP53
tumor protein p53
ISO
associated with Breast Neoplasms;DNA:missense mutation, duplication:cds, intron:p.R72P associated with Penile Neoplasms associated with Carcinoma, Squamous Cell;
RGD
PMID:18059331 PMID:18230179 PMID:18268397
RGD:2290533 RGD:2290534 RGD:8547790
NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
G
TP53BP1
tumor protein p53 binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134
G
TRMT11
tRNA methyltransferase 11 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30705370
NCBI chr 1:64,861,404...64,917,449
Ensembl chr 1:64,834,770...65,064,562
G
TSC2
TSC complex subunit 2
ISO
associated with Breast Neoplasms
RGD
PMID:15951164
RGD:11568707
NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960
G
TSHR
thyroid stimulating hormone receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9062474
NCBI chr 8:53,327,280...53,482,898
Ensembl chr 8:53,326,655...53,482,898
G
TTR
transthyretin
ISO
associated with colorectal cancer;protein:decreased expresion:blood serum (human)
RGD
PMID:21074777
RGD:151665155
NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
G
VEGFA
vascular endothelial growth factor A
ISO
associated with Breast neoplasms; associated with Cervix Neoplasms
RGD
PMID:17597103 PMID:19783962
RGD:2315454 RGD:7421574
NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
G
VEGFC
vascular endothelial growth factor C
exacerbates disease_progression
ISO
associated with Lymphatic Metastasis; associated with pancreatic adenocarcinoma;protein:increased expression:pancreas (human) associated with Breast Neoplasms associated with Carcinoma, Transitional Cell;protein:increased expression:urinary bladder associated with Prostatic Neoplasms associated with thyroid diseases;mRNA:increased expression:thyroid gland: associated with Cervix Neoplasms
RGD
PMID:12203051 PMID:15289890 PMID:17034609 PMID:18061373 PMID:19589137 PMID:19608016 PMID:19923084 More...
RGD:155630642 RGD:2315469 RGD:2315474 RGD:2315475 RGD:2315484 RGD:7483611 RGD:7488946
NCBI chr16:52,883,242...52,987,684
Ensembl chr16:52,883,139...52,987,563
G
VEGFD
vascular endothelial growth factor D
ISO
associated with Breast Neoplasms associated with Cervix Neoplasms
RGD
PMID:17951197 PMID:19589137
RGD:2315475 RGD:2315480
NCBI chr X:11,590,097...11,627,199
Ensembl chr X:11,590,089...11,626,486
G
WRAP53
WD repeat containing antisense to TP53
ISO
associated with esophagus squamous cell carcinoma; associated with lung non-small cell carcinoma;
RGD
PMID:24626331 PMID:31281482
RGD:21081513 RGD:21081532
NCBI chr 5:32,574,153...32,586,222
Ensembl chr 5:32,574,134...32,594,333
G
CYCS
cytochrome c, somatic
ISO
associated with non-small cell lung carcinoma; protein:decreased expression:serum
RGD
PMID:25578497
RGD:13792769
NCBI chr14:38,579,446...38,581,983
Ensembl chr14:38,579,446...38,581,983
G
CDH1
cadherin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27224422
NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all