FSCN1 (fascin actin-bundling protein 1) - Rat Genome Database
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Gene: FSCN1 (fascin actin-bundling protein 1) Canis lupus familiaris
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Symbol: FSCN1
Name: fascin actin-bundling protein 1
RGD ID: 12175284
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); drug binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); cell migration (ortholog); PARTICIPATES IN protein kinase C (PKC) signaling pathway; ASSOCIATED WITH Bile Duct Neoplasms (ortholog); cholangiocarcinoma (ortholog); common bile duct neoplasm (ortholog); FOUND IN actin cytoskeleton (ortholog); cell projection membrane (ortholog); cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: fascin; fascin homolog 1, actin-bundling protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl612,354,599 - 12,370,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1612,360,849 - 12,370,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22236355  


Genomics

Comparative Map Data
FSCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl612,354,599 - 12,370,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1612,360,849 - 12,370,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
FSCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl75,592,816 - 5,606,655 (+)EnsemblGRCh38hg38GRCh38
GRCh3875,592,816 - 5,606,655 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3775,632,436 - 5,646,287 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3775,632,447 - 5,646,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,598,980 - 5,612,812 (+)NCBINCBI36hg18NCBI36
Build 3475,405,694 - 5,419,526NCBI
Celera75,592,071 - 5,605,904 (+)NCBI
Cytogenetic Map7p22.1NCBI
HuRef75,544,716 - 5,558,303 (+)NCBIHuRef
CHM1_175,632,035 - 5,645,887 (+)NCBICHM1_1
CRA_TCAGchr7v275,678,781 - 5,692,632 (+)NCBI
Fscn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395142,946,110 - 142,958,944 (+)NCBIGRCm39mm39
GRCm385142,960,355 - 142,973,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5142,960,343 - 142,973,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv375143,722,034 - 143,734,868 (+)NCBIGRCm37mm9NCBIm37
MGSCv365143,225,511 - 143,238,323 (+)NCBImm8
Celera5140,008,743 - 140,021,597 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map581.84NCBI
Fscn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21211,597,042 - 11,610,183 (-)NCBI
Rnor_6.0 Ensembl1213,656,554 - 13,668,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,655,459 - 13,668,595 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01215,688,989 - 15,702,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1213,390,657 - 13,403,285 (-)NCBICelera
Cytogenetic Map12p11NCBI
Fscn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546010,402,855 - 10,412,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546010,402,855 - 10,412,459 (+)NCBIChiLan1.0ChiLan1.0
FSCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.175,865,307 - 5,877,366 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v075,848,902 - 5,862,756 (+)NCBIMhudiblu_PPA_v0panPan3
Fscn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936765609,894 - 619,417 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,134,170 - 4,145,394 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,134,173 - 4,143,275 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.234,776,501 - 4,785,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSCN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12816,127,033 - 16,142,285 (-)NCBI
ChlSab1.1 Ensembl2816,127,015 - 16,142,337 (-)Ensembl
Fscn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474028,038,216 - 28,047,252 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1 15 6 6 12 9 6
Low 4 4 7 6 6 6 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025402   ⟹   ENSCAFP00000023586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl612,360,854 - 12,370,808 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076284   ⟹   ENSCAFP00000052074
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl612,354,599 - 12,370,808 (-)Ensembl
RefSeq Acc Id: XM_546998   ⟹   XP_546998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1612,360,849 - 12,370,906 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038334228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038395483 (Get FASTA)   NCBI Sequence Viewer  
  XP_038459565 (Get FASTA)   NCBI Sequence Viewer  
  XP_038524268 (Get FASTA)   NCBI Sequence Viewer  
  XP_546998 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_546998   ⟸   XM_546998
- UniProtKB: F1PYU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023586   ⟸   ENSCAFT00000025402
RefSeq Acc Id: ENSCAFP00000052074   ⟸   ENSCAFT00000076284
Protein Domains
ABC transmembrane type-1   Fascin

Promoters
RGD ID:13683570
Promoter ID:EPDNEW_C1638
Type:single initiation site
Name:FSCN1_1
Description:fascin actin-bundling protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C1639  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1612,370,935 - 12,370,995EPDNEW
RGD ID:13683573
Promoter ID:EPDNEW_C1639
Type:single initiation site
Name:FSCN1_2
Description:fascin actin-bundling protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C1638  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1612,371,108 - 12,371,168EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016010 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000023586 UniProtKB/TrEMBL
  ENSCAFP00000052074 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025402 UniProtKB/TrEMBL
  ENSCAFT00000076284 UniProtKB/TrEMBL
InterPro ABC1_TM_dom UniProtKB/TrEMBL
  Actin_cross-linking UniProtKB/TrEMBL
  Fascin UniProtKB/TrEMBL
  Fascin-domain UniProtKB/TrEMBL
  FSCN1 UniProtKB/TrEMBL
NCBI Gene FSCN1 ENTREZGENE
PANTHER PTHR10551 UniProtKB/TrEMBL
  PTHR10551:SF23 UniProtKB/TrEMBL
Pfam Fascin UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
Superfamily-SCOP SSF50405 UniProtKB/TrEMBL
UniProt A0A5F4CGS5_CANLF UniProtKB/TrEMBL
  F1PYU3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40990 ENTREZGENE