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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Liver Metastasis
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Accession:DOID:9006618 term browser browse the term
Definition:Transfer of a neoplasm from its primary site to the liver.
Synonyms:exact_synonym: liver metastases;   metastatic liver disease;   secondary liver cancer
For additional species annotation, visit the Alliance of Genome Resources.



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Liver Metastasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO associated with colorectal cancer;mRNA:increased expression:liver (mouse) RGD PMID:20380732 RGD:25671446 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase severity IAGP associated with colorectal cancer;DNA:mutation:cds:
associated with colorectal cancer;DNA:mutations:multiple
associated with skin melanoma;DNA:missense mutations:cds:
associated with colorectal cancer;DNA:missense mutations:cds:pV599E,p.V600E (human)
associated with colorectal cancer;DNA:missense mutation:cds:p.V600E (human)
RGD PMID:27737491 PMID:26775732 PMID:28787433 PMID:22331825 PMID:23010994 RGD:18337264, RGD:11554843, RGD:14696791, RGD:18337265, RGD:15039394 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 disease_progression ISO associated with colorectal cancer RGD PMID:27058904 RGD:14995463 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 treatment ISO associated with Animal Mammary Neoplasms; RGD PMID:15692764 RGD:14995455 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO associated with Breast Neoplasm;protein:increased expression:liver RGD PMID:17991717 RGD:2289349 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment ISO associated with colon carcinoma; RGD PMID:30381616 RGD:27095891 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 ameliorates ISO associated with colon carcinoma
associated with melanoma;
RGD PMID:22071959 PMID:21701781 RGD:150429701, RGD:150429713 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 disease_progression ISO associated with colorectal cancer; RGD PMID:28846828 RGD:21408566 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO associated with colorectal cancer;mRNA:increased expression:colorectal mucosa: RGD PMID:19082464 RGD:25330357 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Hmbs hydroxymethylbilane synthase IEP associated with colon adenocarcinoma;protein:decreased activity:liver(rat) RGD PMID:1386052 RGD:25440496 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Il2 interleukin 2 treatment ISO associated with Colorectal Neoplasms, Carcinoma, Hepatocellular;
associated with colon carcinoma
RGD PMID:11591892 PMID:9354462 RGD:8663446, RGD:14928215 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mir141 microRNA 141 ISO associated with colorectal cancer;RNA:increased expression:liver: RGD PMID:28617555 RGD:14928321 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:26885061 RGD:21079444 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir200b microRNA 200b ISO associated with colorectal cancer;RNA:increased expression:liver: RGD PMID:28617555 RGD:14928321 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
JBrowse link
G Mir200c microRNA 200c ISO associated with colorectal cancer;RNA:increased expression:liver: RGD PMID:28617555 RGD:14928321 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir223 microRNA 223 disease_progression ISO associated with colorectal cancer; RGD PMID:28846828 RGD:21408566 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor severity
exacerbates
ISO associated with pancreatic ductal adenocarcinoma; human cells in mouse model
associated with colorectal carcinoma;protein:increased expression:colorectum (human)
associated with pancreatic cancer; protein:increased expression:liver, pancreas (human)
RGD PMID:30770989 PMID:23747337 PMID:30770989 RGD:126925751, RGD:126925752, RGD:126925751 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Nras NRAS proto-oncogene, GTPase susceptibility ISO human gene in a mouse model;DNA:missense mutations:cds:p.G12V, p.Q61K (human)
associated with colorectal cancer;DNA:mutations:exons (human)
associated with melanoma;DNA:mutations: exons (human)
RGD PMID:26799184 PMID:28011498 PMID:28787433 RGD:14696774, RGD:14696792, RGD:14696791 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Smad4 SMAD family member 4 treatment ISO associated with colorectal carcinoma; DNA:mutations: :
associated with colorectal carcinoma;protein:decreased expression:colorectum:
RGD PMID:29551247 PMID:17390050 RGD:18937000, RGD:21066338 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase disease_progression ISO associated with colon cancer;protein:increased activity:colon RGD PMID:7678609 RGD:150521542 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with colorectal carcinoma;mRNA,protein:increased expression:liver: RGD PMID:22156924 RGD:15014782 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    disease of cellular proliferation 7054
      Neoplastic Processes 648
        Neoplasm Metastasis 434
          Liver Metastasis 22
Path 2
Term Annotations click to browse term
  disease 17289
    disease of cellular proliferation 7054
      Neoplasms by Site 6698
        Digestive System Neoplasms 3440
          Gastrointestinal Neoplasms 3319
            gastrointestinal system cancer 2539
              hepatobiliary system cancer 860
                liver cancer 793
                  Liver Metastasis 22
paths to the root