BCL2 (BCL2 apoptosis regulator) - Rat Genome Database

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Gene: BCL2 (BCL2 apoptosis regulator) Canis lupus familiaris
Analyze
Symbol: BCL2
Name: BCL2 apoptosis regulator
RGD ID: 12074886
Description: ENCODES a protein that exhibits BH domain binding (ortholog); molecular adaptor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin filament organization (ortholog); aging (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; erythropoietin signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN BAD-BCL-2 complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH calcitriol; spironolactone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; BCL-2; BCL2, apoptosis regulator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,733,849 - 13,900,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,595,394 - 13,762,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adrenal Insufficiency  (ISO)
AIDS-Related Kaposi Sarcoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
azoospermia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-Cell CLL/Lymphoma 2  (ISO)
bilirubin metabolic disorder  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 18q deletion syndrome  (ISO)
Chronic Intermittent Hypoxia  (ISO)
clear cell adenocarcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
dementia  (ISO)
Diabetic Cardiomyopathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fetal Growth Retardation  (ISO)
follicular lymphoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
Head and Neck Neoplasms  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypothermia  (ISO)
impotence  (ISO)
intestinal disease  (ISO)
Intestinal Neoplasms  (ISO)
intracranial aneurysm  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
learning disability  (ISO)
leiomyoma  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
mesenchymal chondrosarcoma  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multi-Infarct Dementia  (ISO)
multiple congenital anomalies-hypotonia-seizures syndrome 1  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
oligomeganephronia  (ISO)
Optic Nerve Injuries  (ISO)
oral mucosa leukoplakia  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
Ovarian Neoplasms  (ISO)
plasmacytoma  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
Premature Aging  (ISO)
priapism  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Sarcopenia  (ISO)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (ISO)
synovial sarcoma  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Testis Reperfusion Injury  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO)
aging  (ISO)
animal organ morphogenesis  (IEA,ISO)
apoptotic mitochondrial changes  (IEA,ISO)
apoptotic process  (IEA,ISO)
axon regeneration  (IEA,ISO)
axonogenesis  (IEA,ISO)
B cell apoptotic process  (IEA,ISO)
B cell differentiation  (IEA,ISO)
B cell homeostasis  (IEA,ISO)
B cell lineage commitment  (IEA,ISO)
B cell proliferation  (IEA,ISO)
B cell receptor signaling pathway  (IEA)
behavioral fear response  (IEA,ISO)
brain development  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
calcium ion transport into cytosol  (IEA,ISO)
CD8-positive, alpha-beta T cell lineage commitment  (IEA,ISO)
cell migration  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell adhesion  (IEA,ISO)
cellular response to DNA damage stimulus  (IEA)
cellular response to fluoride  (ISO)
cellular response to glucose starvation  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (IEA,ISO)
cerebral cortex development  (ISO)
cochlear nucleus development  (IEA,ISO)
defense response to virus  (IEA)
dendritic cell apoptotic process  (IEA,ISO)
developmental growth  (IEA,ISO)
developmental pigmentation  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
ear development  (IEA,ISO)
endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
focal adhesion assembly  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
gland morphogenesis  (IEA,ISO)
glial cell apoptotic process  (ISO)
glomerulus development  (IEA,ISO)
hair follicle morphogenesis  (IEA)
hematopoietic stem cell differentiation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
immune system development  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
kidney development  (IEA,ISO)
leukocyte homeostasis  (IEA,ISO)
liver regeneration  (ISO)
lymphocyte apoptotic process  (IEA,ISO)
lymphocyte homeostasis  (IEA,ISO)
lymphoid progenitor cell differentiation  (IEA,ISO)
male gonad development  (IEA,ISO)
melanin metabolic process  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
mesenchymal cell development  (IEA,ISO)
metanephros development  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
motor neuron apoptotic process  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
negative regulation of anoikis  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of autophagy  (IEA,ISS)
negative regulation of B cell apoptotic process  (IEA,ISO)
negative regulation of calcium ion transport into cytosol  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cellular pH reduction  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,IEA)
negative regulation of lymphocyte apoptotic process  (IEA,ISO)
negative regulation of mitotic cell cycle  (IEA,ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of neuron death  (IEA,ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA)
negative regulation of retinal cell programmed cell death  (IEA,ISO)
negative regulation of T cell apoptotic process  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron death  (IEA,ISO)
neuron maturation  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
oocyte development  (IEA,ISO)
organ growth  (IEA,ISO)
ossification  (IEA,ISO)
osteoblast proliferation  (IEA,ISO)
ovarian follicle development  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA,ISO)
pigment granule organization  (IEA,ISO)
pigmentation  (IEA)
positive regulation of B cell proliferation  (IEA)
positive regulation of catalytic activity  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of developmental pigmentation  (IEA,ISO)
positive regulation of melanocyte differentiation  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of neuron maturation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of skeletal muscle fiber development  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein dephosphorylation  (IEA,ISO)
protein polyubiquitination  (IEA,ISO)
reactive oxygen species metabolic process  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (IEA)
regulation of calcium ion transport  (IEA,ISO)
regulation of catalytic activity  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell-matrix adhesion  (IEA,ISO)
regulation of developmental pigmentation  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of glycoprotein biosynthetic process  (IEA,ISO)
regulation of growth  (IEA,ISO)
regulation of mitochondrial membrane permeability  (IEA)
regulation of mitochondrial membrane potential  (IEA)
regulation of nitrogen utilization  (IEA,ISO)
regulation of programmed cell death  (IEA,ISO)
regulation of protein localization  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of transmembrane transporter activity  (IEA)
regulation of viral genome replication  (IEA)
release of cytochrome c from mitochondria  (IEA)
renal system process  (IEA,ISO)
response to aluminum ion  (ISO)
response to amino acid  (IEA,ISO)
response to amyloid-beta  (ISO)
response to caffeine  (ISO)
response to cAMP  (ISO)
response to copper ion  (ISO)
response to corticosterone  (ISO)
response to cytokine  (IEA,ISO)
response to electrical stimulus  (ISO)
response to erythropoietin  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to gamma radiation  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to heat  (ISO)
response to hydrogen peroxide  (IEA,ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to iron ion  (IEA)
response to ischemia  (IEA,ISO)
response to L-ascorbic acid  (ISO)
response to monosaccharide  (ISO)
response to nicotine  (IEA,ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to organic substance  (ISO)
response to oxidative stress  (IEA,ISO)
response to peptide hormone  (ISO)
response to phenylpropanoid  (ISO)
response to steroid hormone  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to UV-B  (IEA,ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
retinal cell programmed cell death  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
smooth muscle cell migration  (IEA,ISO)
spleen development  (IEA,ISO)
stem cell development  (IEA,ISO)
T cell apoptotic process  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T cell lineage commitment  (IEA,ISO)
thymus development  (IEA,ISO)
ureteric bud development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15563927   PMID:16714293   PMID:17537469   PMID:17565996   PMID:18479697   PMID:20198571   PMID:24495616   PMID:27033900   PMID:34111022  


Genomics

Comparative Map Data
BCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,733,849 - 13,900,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,595,394 - 13,762,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBIUU_Cfam_GSD_1.0
BCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,123,346 - 63,320,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1863,123,346 - 63,320,128 (-)EnsemblGRCh38hg38GRCh38
GRCh371860,790,579 - 60,987,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,941,559 - 59,137,593 (-)NCBINCBI36Build 36hg18NCBI36
Build 341858,941,558 - 59,136,910NCBI
Celera1857,509,356 - 57,706,116 (-)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,487,199 - 57,684,751 (-)NCBIHuRef
CHM1_11860,786,149 - 60,982,536 (-)NCBICHM1_1
T2T-CHM13v2.01863,326,497 - 63,524,830 (-)NCBIT2T-CHM13v2.0
Bcl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,465,906 - 106,642,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,465,908 - 106,642,004 (-)EnsemblGRCm39 Ensembl
GRCm381106,538,176 - 106,714,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,538,178 - 106,714,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,434,756 - 108,610,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,365,740 - 108,541,849 (-)NCBIMGSCv36mm8
Celera1109,386,734 - 109,563,656 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.76NCBI
Bcl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21322,689,783 - 22,853,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,013,354 - 23,175,038 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01324,297,817 - 24,459,509 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01322,983,528 - 23,145,223 (-)NCBIRnor_WKY
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
Bcl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBIChiLan1.0ChiLan1.0
BCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11859,797,184 - 59,993,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1859,802,443 - 59,992,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01856,481,212 - 56,679,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Bcl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,970,171 - 27,134,608 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,210,334 - 2,210,921 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364972,209,136 - 2,373,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,337,522 - 158,518,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,337,403 - 158,518,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,824,218 - 175,994,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,440,560 - 16,643,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1816,441,733 - 16,637,895 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,049,043 - 9,247,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247928,859,522 - 9,031,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247928,854,345 - 9,032,727 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BCL2
1498 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 12 6 1 6 6 6
Low 5 5 10 6 6 5 6 6 8 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000118   ⟹   ENSCAFP00000000102
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl113,734,504 - 13,900,658 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046240   ⟹   ENSCAFP00000037976
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004846   ⟹   ENSCAFP00845003877
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl113,595,394 - 13,762,292 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004852   ⟹   ENSCAFP00845003883
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl113,595,767 - 13,597,610 (+)Ensembl
RefSeq Acc Id: NM_001002949   ⟹   NP_001002949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1113,733,849 - 13,900,653 (+)NCBI
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBI
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBI
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBI
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBI
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR92491 (Get FASTA)   NCBI Sequence Viewer  
  BAC81344 (Get FASTA)   NCBI Sequence Viewer  
  BAD05044 (Get FASTA)   NCBI Sequence Viewer  
  Q6R755 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002949   ⟸   NM_001002949
- UniProtKB: Q75SV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000102   ⟸   ENSCAFT00000000118
RefSeq Acc Id: ENSCAFP00000037976   ⟸   ENSCAFT00000046240
RefSeq Acc Id: ENSCAFP00845003883   ⟸   ENSCAFT00845004852
RefSeq Acc Id: ENSCAFP00845003877   ⟸   ENSCAFT00845004846
Protein Domains
BH4_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000068 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013211 UniProtKB/TrEMBL
  ENSCAFG00040001807 UniProtKB/TrEMBL
  ENSCAFG00845002725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000037976.3 UniProtKB/TrEMBL
  ENSCAFP00000071519.1 UniProtKB/TrEMBL
  ENSCAFP00030021344.1 UniProtKB/TrEMBL
  ENSCAFP00030021374.1 UniProtKB/TrEMBL
  ENSCAFP00030021417.1 UniProtKB/TrEMBL
  ENSCAFP00040002915 UniProtKB/TrEMBL
  ENSCAFP00845003877 ENTREZGENE
  ENSCAFP00845003877.1 UniProtKB/TrEMBL
  ENSCAFP00845003883.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046240.4 UniProtKB/TrEMBL
  ENSCAFT00000102167.1 UniProtKB/TrEMBL
  ENSCAFT00030024455.1 UniProtKB/TrEMBL
  ENSCAFT00030024486.1 UniProtKB/TrEMBL
  ENSCAFT00030024532.1 UniProtKB/TrEMBL
  ENSCAFT00040003404 UniProtKB/TrEMBL
  ENSCAFT00845004846 ENTREZGENE
  ENSCAFT00845004846.1 UniProtKB/TrEMBL
  ENSCAFT00845004852.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apop_reg_Bcl2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2/BclX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH4_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403416 UniProtKB/TrEMBL
NCBI Gene BCL2 ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11256:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS APOPREGBCL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NC28_CANLF UniProtKB/TrEMBL
  A0A8C0RJ94_CANLF UniProtKB/TrEMBL
  A0A8C0RJA5_CANLF UniProtKB/TrEMBL
  A0A8C0RVL3_CANLF UniProtKB/TrEMBL
  A0A8I3MLT5_CANLF UniProtKB/TrEMBL
  A0A8I3RSE6_CANLF UniProtKB/TrEMBL
  BCL2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q75SV7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54274 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-30 BCL2  BCL2 apoptosis regulator    BCL2, apoptosis regulator  Symbol and/or name change 5135510 APPROVED