SLCO1B3 (solute carrier organic anion transporter family member 1B3) - Rat Genome Database

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Gene: SLCO1B3 (solute carrier organic anion transporter family member 1B3) Canis lupus familiaris
Analyze
Symbol: SLCO1B3
Name: solute carrier organic anion transporter family member 1B3
RGD ID: 12097421
Description: ENCODES a protein that exhibits bile acid transmembrane transporter activity (ortholog); oligopeptide transmembrane transporter activity (ortholog); organic anion transmembrane transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); liver development (ortholog); oligopeptide transport (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; multispecific organic anion transporter mediated transport pathway; mycophenolic acid pharmacokinetics pathway; ASSOCIATED WITH Animal Hepatitis (ortholog); bilirubin metabolic disorder (ortholog); breast ductal carcinoma (ortholog); FOUND IN basolateral plasma membrane (ortholog); cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol 17-glucosiduronic acid; bromosulfophthalein; DPDPE
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Oatp1b4; OATPC; organic anion transporter polypeptide 1b4; organic anion transporting polypeptide C; Slco1b4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,411,008 - 26,496,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2719,984,815 - 20,045,585 (+)NCBI
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBI
ROS_Cfam_1.0 Ensembl2726,736,958 - 26,797,155 (-)Ensembl
UMICH_Zoey_3.12726,599,886 - 26,660,552 (-)NCBI
UNSW_CanFamBas_1.02726,578,617 - 26,645,709 (-)NCBI
UU_Cfam_GSD_1.02719,689,283 - 19,750,093 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12429346   PMID:20079461  


Genomics

Comparative Map Data
SLCO1B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,411,008 - 26,496,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2719,984,815 - 20,045,585 (+)NCBI
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBI
ROS_Cfam_1.0 Ensembl2726,736,958 - 26,797,155 (-)Ensembl
UMICH_Zoey_3.12726,599,886 - 26,660,552 (-)NCBI
UNSW_CanFamBas_1.02726,578,617 - 26,645,709 (-)NCBI
UU_Cfam_GSD_1.02719,689,283 - 19,750,093 (+)NCBI
SLCO1B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,810,705 - 20,916,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1220,810,702 - 20,916,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,963,639 - 21,069,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,854,905 - 20,960,925 (+)NCBINCBI36hg18NCBI36
Build 341220,859,894 - 20,960,921NCBI
Celera1226,119,013 - 26,224,987 (+)NCBI
Cytogenetic Map12p12.2NCBI
HuRef1220,736,680 - 20,842,844 (+)NCBIHuRef
CHM1_11220,929,128 - 21,035,317 (+)NCBICHM1_1
T2T-CHM13v2.01220,689,337 - 20,795,485 (+)NCBI
Slco1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396141,575,178 - 141,632,372 (+)NCBIGRCm39mm39
GRCm39 Ensembl6141,575,244 - 141,632,372 (+)Ensembl
GRCm386141,629,452 - 141,686,646 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6141,629,518 - 141,686,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv376141,578,039 - 141,635,156 (+)NCBIGRCm37mm9NCBIm37
MGSCv366141,591,924 - 141,649,041 (+)NCBImm8
Celera6144,691,211 - 144,748,787 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map672.57NCBI
Slco1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24174,551,463 - 174,619,988 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4174,551,480 - 174,619,981 (+)Ensembl
Rnor_6.04175,814,118 - 175,881,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,814,118 - 175,881,768 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,035,313 - 240,103,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,045,586 - 179,118,680 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14179,290,709 - 179,363,804 (+)NCBI
Celera4163,091,969 - 163,159,409 (+)NCBICelera
Cytogenetic Map4q44NCBI
SLCO1B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,987,635 - 68,016,792 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01265,386,042 - 65,492,240 (-)NCBIMhudiblu_PPA_v0panPan3
Slco1b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,670,986 - 87,759,281 (-)NCBI
SpeTri2.0NW_0049365485,593,908 - 5,682,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLCO1B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1552,137,454 - 52,206,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,411,801 - 55,475,930 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLCO1B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,637,429 - 20,760,577 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,648,582 - 20,761,161 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606914,391,434 - 14,498,674 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low
Below cutoff 5 5 16 6 6 6 12 8 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005636672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005636673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022410841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022410842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF403244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN753314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR105480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ497899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN833579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000019638   ⟹   ENSCAFP00000018215
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071555   ⟹   ENSCAFP00000055129
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077055   ⟹   ENSCAFP00000054212
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079821   ⟹   ENSCAFP00000056478
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,412,302 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086787   ⟹   ENSCAFP00000062358
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093915   ⟹   ENSCAFP00000049391
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2726,411,010 - 26,470,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027852   ⟹   ENSCAFP00845021923
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2726,736,958 - 26,797,155 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027915   ⟹   ENSCAFP00845021973
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2726,736,958 - 26,797,155 (-)Ensembl
RefSeq Acc Id: NM_001166047   ⟹   NP_001159519
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12726,411,008 - 26,471,775 (-)NCBI
Dog10K_Boxer_Tasha2719,984,815 - 20,045,585 (+)NCBI
ROS_Cfam_1.02726,736,956 - 26,797,938 (-)NCBI
UMICH_Zoey_3.12726,599,886 - 26,660,552 (-)NCBI
UNSW_CanFamBas_1.02726,578,617 - 26,645,709 (-)NCBI
UU_Cfam_GSD_1.02719,689,283 - 19,750,093 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038437729   ⟹   XP_038293657
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBI
RefSeq Acc Id: XM_038437730   ⟹   XP_038293658
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBI
RefSeq Acc Id: XM_038437731   ⟹   XP_038293659
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,189 (-)NCBI
RefSeq Acc Id: XM_038437732   ⟹   XP_038293660
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,160 (-)NCBI
RefSeq Acc Id: XM_038437733   ⟹   XP_038293661
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,188 (-)NCBI
RefSeq Acc Id: XM_038437734   ⟹   XP_038293662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,822,156 (-)NCBI
RefSeq Acc Id: XM_038437735   ⟹   XP_038293663
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02726,736,938 - 26,821,988 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001159519   ⟸   NM_001166047
- UniProtKB: C9EGT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049391   ⟸   ENSCAFT00000093915
RefSeq Acc Id: ENSCAFP00000054212   ⟸   ENSCAFT00000077055
RefSeq Acc Id: ENSCAFP00000018215   ⟸   ENSCAFT00000019638
RefSeq Acc Id: ENSCAFP00000062358   ⟸   ENSCAFT00000086787
RefSeq Acc Id: ENSCAFP00000056478   ⟸   ENSCAFT00000079821
RefSeq Acc Id: ENSCAFP00000055129   ⟸   ENSCAFT00000071555
RefSeq Acc Id: XP_038293659   ⟸   XM_038437731
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293658   ⟸   XM_038437730
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293657   ⟸   XM_038437729
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293661   ⟸   XM_038437733
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293660   ⟸   XM_038437732
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293662   ⟸   XM_038437734
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293663   ⟸   XM_038437735
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845021973   ⟸   ENSCAFT00845027915
RefSeq Acc Id: ENSCAFP00845021923   ⟸   ENSCAFT00845027852
Protein Domains
Kazal-like   MFS

Promoters
RGD ID:13688169
Promoter ID:EPDNEW_C6238
Type:single initiation site
Name:SLCO1B3_1
Description:solute carrier organic anion transporter family member 1B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12726,470,998 - 26,471,058EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
27 26427221 26427222 T G snv Lagotto Romagnolo (LR1030)
27 26432851 26432852 G A snv Yellowstone Wolf (SRS661496)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012373 Ensembl
  ENSCAFG00030023611 UniProtKB/TrEMBL
  ENSCAFG00040017525 UniProtKB/TrEMBL
  ENSCAFG00845015602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030037920.1 UniProtKB/TrEMBL
  ENSCAFP00030038007.1 UniProtKB/TrEMBL
  ENSCAFP00030038046.1 UniProtKB/TrEMBL
  ENSCAFP00040028211 UniProtKB/TrEMBL
  ENSCAFP00845021923 ENTREZGENE
  ENSCAFP00845021923.1 UniProtKB/TrEMBL
  ENSCAFP00845021973.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030043437.1 UniProtKB/TrEMBL
  ENSCAFT00030043535.1 UniProtKB/TrEMBL
  ENSCAFT00030043579.1 UniProtKB/TrEMBL
  ENSCAFT00040032426 UniProtKB/TrEMBL
  ENSCAFT00845027852 ENTREZGENE
  ENSCAFT00845027852.1 UniProtKB/TrEMBL
  ENSCAFT00845027915.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  OATP UniProtKB/TrEMBL
KEGG Report cfa:403519 UniProtKB/TrEMBL
NCBI Gene SLCO1B3 ENTREZGENE
PANTHER PTHR11388 UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/TrEMBL
  OATP UniProtKB/TrEMBL
PROSITE KAZAL_2 UniProtKB/TrEMBL
  MFS UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF103473 UniProtKB/TrEMBL
TIGRFAMs oat UniProtKB/TrEMBL
UniProt A0A8C0PAA4_CANLF UniProtKB/TrEMBL
  A0A8C0PEM4_CANLF UniProtKB/TrEMBL
  A0A8C0SWV8_CANLF UniProtKB/TrEMBL
  A0A8I3NUI6_CANLF UniProtKB/TrEMBL
  A0A8I3NXU8_CANLF UniProtKB/TrEMBL
  C9EGT7 ENTREZGENE, UniProtKB/TrEMBL