ALOX12 (arachidonate 12-lipoxygenase, 12S type) - Rat Genome Database

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Gene: ALOX12 (arachidonate 12-lipoxygenase, 12S type) Canis lupus familiaris
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Symbol: ALOX12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 12179236
Description: ENCODES a protein that exhibits arachidonate 12(S)-lipoxygenase activity (inferred); arachidonate 15-lipoxygenase activity (inferred); dioxygenase activity (inferred); INVOLVED IN cellular response to lipid (ortholog); hepoxilin biosynthetic process (ortholog); leukotriene A4 metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Albuminuria (ortholog); autism spectrum disorder (ortholog); Bone Metastasis (ortholog); FOUND IN sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arachidonate 12-lipoxygenase, 12S-type; LOC479476; polyunsaturated fatty acid lipoxygenase ALOX12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
sarcolemma  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,589,497 - 14,604,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,555,472 - 16,571,790 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALOX12
96 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845030117   ⟹   ENSCAFP00845023621
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)Ensembl
RefSeq Acc Id: XM_038475425   ⟹   XP_038331353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBI
RefSeq Acc Id: XM_038536594   ⟹   XP_038392522
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBI
RefSeq Acc Id: XM_038600787   ⟹   XP_038456715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBI
RefSeq Acc Id: XM_038665321   ⟹   XP_038521249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBI
RefSeq Acc Id: XM_536613   ⟹   XP_536613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,026,193 - 32,038,698 (+)NCBI
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBI
Sequence:
RefSeq Acc Id: XP_536613   ⟸   XM_536613
- UniProtKB: A0A8C0K9S4 (UniProtKB/TrEMBL),   A0A8C0MY34 (UniProtKB/TrEMBL),   A0A8P0NHJ0 (UniProtKB/TrEMBL),   A0A8C0KCN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038331353   ⟸   XM_038475425
RefSeq Acc Id: XP_038456715   ⟸   XM_038600787
RefSeq Acc Id: XP_038521249   ⟸   XM_038665321
- UniProtKB: A0A8I3S2E8 (UniProtKB/TrEMBL),   A0A8C0KCN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392522   ⟸   XM_038536594
- UniProtKB: A0A8C0K9S4 (UniProtKB/TrEMBL),   A0A8C0KCN8 (UniProtKB/TrEMBL),   A0A8C0MY34 (UniProtKB/TrEMBL),   A0A8P0NHJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845023621   ⟸   ENSCAFT00845030117
Protein Domains
Lipoxygenase   PLAT

Promoters
RGD ID:13683215
Promoter ID:EPDNEW_C1281
Type:single initiation site
Name:ALOX12_1
Description:arachidonate 12-lipoxygenase, 12S type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,026,367 - 32,026,427EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015949 Ensembl
  ENSCAFG00000053695 UniProtKB/TrEMBL
  ENSCAFG00030009683 UniProtKB/TrEMBL
  ENSCAFG00040003004 UniProtKB/TrEMBL
  ENSCAFG00845017004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025298.5 UniProtKB/TrEMBL
  ENSCAFT00030017903.1 UniProtKB/TrEMBL
  ENSCAFT00040005702.1 UniProtKB/TrEMBL
  ENSCAFT00845030117 ENTREZGENE
  ENSCAFT00845030117.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:479476 UniProtKB/TrEMBL
NCBI Gene LOC479476 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 UniProtKB/TrEMBL
  PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A8C0K9S4 ENTREZGENE
  A0A8C0KCN8 ENTREZGENE
  A0A8C0MY34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S2E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NHJ0 ENTREZGENE
UniProt Secondary A0A8P0NHJ0 UniProtKB/TrEMBL
VGNC ID VGNC:49900 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 ALOX12  arachidonate 12-lipoxygenase, 12S type  LOC479476  arachidonate 12-lipoxygenase, 12S-type  Symbol and/or name change 5135510 APPROVED