ALOX12 (arachidonate 12-lipoxygenase, 12S type) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ALOX12 (arachidonate 12-lipoxygenase, 12S type) Canis lupus familiaris
Analyze
Symbol: ALOX12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 12179236
Description: ENCODES a protein that exhibits dioxygenase activity (inferred); iron ion binding (inferred); metal ion binding (inferred); INVOLVED IN aging (ortholog); cellular response to lipid (ortholog); leukotriene A4 metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Albuminuria (ortholog); Bone Metastasis (ortholog); breast cancer (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arachidonate 12-lipoxygenase, 12S-type; LOC479476; polyunsaturated fatty acid lipoxygenase ALOX12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBI
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBI
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBI
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBI
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,ISO)
membrane  (ISO)
plasma membrane  (IBA)
sarcolemma  (IBA,ISO)

References

Genomics

Comparative Map Data
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBI
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBI
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBI
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBI
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBI
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBI
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBImm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)Ensembl
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0panPan3
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845030117   ⟹   ENSCAFP00845023621
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)Ensembl
RefSeq Acc Id: XM_038475425   ⟹   XP_038331353
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBI
RefSeq Acc Id: XM_038536594   ⟹   XP_038392522
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBI
RefSeq Acc Id: XM_038600787   ⟹   XP_038456715
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBI
RefSeq Acc Id: XM_038665321   ⟹   XP_038521249
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBI
RefSeq Acc Id: XM_536613   ⟹   XP_536613
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,026,193 - 32,038,698 (+)NCBI
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038331353 (Get FASTA)   NCBI Sequence Viewer  
  XP_038392522 (Get FASTA)   NCBI Sequence Viewer  
  XP_038456715 (Get FASTA)   NCBI Sequence Viewer  
  XP_038521249 (Get FASTA)   NCBI Sequence Viewer  
  XP_536613 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_536613   ⟸   XM_536613
- UniProtKB: F6Y0A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038331353   ⟸   XM_038475425
RefSeq Acc Id: XP_038456715   ⟸   XM_038600787
RefSeq Acc Id: XP_038521249   ⟸   XM_038665321
RefSeq Acc Id: XP_038392522   ⟸   XM_038536594
RefSeq Acc Id: ENSCAFP00845023621   ⟸   ENSCAFT00845030117
Protein Domains
Lipoxygenase   PLAT

Promoters
RGD ID:13683215
Promoter ID:EPDNEW_C1281
Type:single initiation site
Name:ALOX12_1
Description:arachidonate 12-lipoxygenase, 12S type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,026,367 - 32,026,427EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 32029999 32030000 T C snv Sloughi (SG008)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015949 Ensembl
  ENSCAFG00030009683 UniProtKB/TrEMBL
  ENSCAFG00040003004 UniProtKB/TrEMBL
  ENSCAFG00845017004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030015635.1 UniProtKB/TrEMBL
  ENSCAFP00040004908 UniProtKB/TrEMBL
  ENSCAFP00845023621 ENTREZGENE
  ENSCAFP00845023621.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030017903.1 UniProtKB/TrEMBL
  ENSCAFT00040005702 UniProtKB/TrEMBL
  ENSCAFT00845030117 ENTREZGENE
  ENSCAFT00845030117.1 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC479476 ENTREZGENE
PANTHER PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A8C0MY34_CANLF UniProtKB/TrEMBL
  A0A8I3S2E8_CANLF UniProtKB/TrEMBL
  F6Y0A9 ENTREZGENE
VGNC ID VGNC:49900 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 ALOX12  arachidonate 12-lipoxygenase, 12S type  LOC479476  arachidonate 12-lipoxygenase, 12S-type  Symbol and/or name change 5135510 APPROVED