CXCL10 (C-X-C motif chemokine ligand 10) - Rat Genome Database

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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Canis lupus familiaris
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Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
RGD ID: 12109165
Description: ENCODES a protein that exhibits chemokine activity (ortholog); CXCR3 chemokine receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to heat (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; CXC chemokine ligand 10; small-inducible cytokine B10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia areata  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
Carrington Syndrome  (ISO)
celiac disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cryoglobulinemia  (ISO)
Cytomegalovirus Infections  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
encephalitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
fatty liver disease  (ISO)
Foot Ulcer  (ISO)
Graft vs Host Disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hypothermia  (ISO)
inhalation anthrax  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
ischemia  (ISO)
Kabuki Syndrome 1  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (ISO)
progressive myoclonus epilepsy  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
Thyroid Neoplasms  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISS)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
antiviral innate immune response  (IEA)
cellular response to heat  (ISO)
cellular response to interleukin-17  (IEA)
cellular response to lipopolysaccharide  (IBA,IEA,ISO)
cellular response to virus  (IEA)
chemokine-mediated signaling pathway  (IBA,IEA)
chemotaxis  (IEA,ISS)
defense response  (IEA)
defense response to virus  (IEA,ISO)
endothelial cell activation  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISS)
immune response  (IEA,ISO)
inflammatory response  (IBA,IEA)
killing of cells of another organism  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myoblast fusion  (IEA,ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of leukocyte chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISS)
positive regulation of T cell migration  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of cell population proliferation  (IEA,ISS)
regulation of endothelial tube morphogenesis  (IEA)
regulation of T cell chemotaxis  (IEA)
response to auditory stimulus  (ISO)
response to bacterium  (IEA,ISO)
response to cold  (ISO)
response to gamma radiation  (ISO)
response to lipopolysaccharide  (ISO)
response to virus  (ISO)
response to vitamin D  (ISO)
T cell chemotaxis  (IEA)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
T2T-CHM13v2.0479,361,779 - 79,364,158 (-)NCBI
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)Ensembl
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBI
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBIVero_WHO_p1.0
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475714,989,084 - 14,991,910 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 2 1 6 1 2 2
Low 4 5 20 5 5 4 3 10 5 8 4
Below cutoff 3 2 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000036612   ⟹   ENSCAFP00000032015
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl32597,987 - 599,979 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845052887   ⟹   ENSCAFP00845041528
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
RefSeq Acc Id: NM_001010949   ⟹   NP_001010949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.132598,406 - 599,925 (-)NCBI
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001010949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD83839 (Get FASTA)   NCBI Sequence Viewer  
  Q5KSV9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001010949   ⟸   NM_001010949
- Peptide Label: precursor
- UniProtKB: Q5KSV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000032015   ⟸   ENSCAFT00000036612
RefSeq Acc Id: ENSCAFP00845041528   ⟸   ENSCAFT00845052887

Promoters
RGD ID:13688678
Promoter ID:EPDNEW_C6746
Type:single initiation site
Name:CXCL10_1
Description:C-X-C motif chemokine ligand 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.132599,986 - 600,046EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008584 Ensembl
  ENSCAFG00030014095 UniProtKB/Swiss-Prot
  ENSCAFG00040023780 UniProtKB/Swiss-Prot
  ENSCAFG00845029862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00030022791 UniProtKB/Swiss-Prot
  ENSCAFP00040038650 UniProtKB/Swiss-Prot
  ENSCAFP00845041528 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00030026099 UniProtKB/Swiss-Prot
  ENSCAFT00040044270 UniProtKB/Swiss-Prot
  ENSCAFT00845052887 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report cfa:478432 UniProtKB/Swiss-Prot
NCBI Gene CXCL10 ENTREZGENE
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXL10_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:49645 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 CXCL10  C-X-C motif chemokine ligand 10    chemokine (C-X-C motif) ligand 10  Symbol and/or name change 5135510 APPROVED