RGD Reference Report - CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. - Rat Genome Database

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CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice.

Authors: Shigihara, T  Shimada, A  Oikawa, Y  Yoneyama, H  Kanazawa, Y  Okubo, Y  Matsushima, K  Yamato, E  Miyazaki, J  Kasuga, A  Saruta, T  Narumi, S 
Citation: Shigihara T, etal., J Immunol. 2005 Dec 15;175(12):8401-8.
RGD ID: 2311362
Pubmed: PMID:16339582   (View Abstract at PubMed)

CXCL10, a chemokine for Th1 cells, is involved in the pathogenesis of various Th1-dominant autoimmune diseases. Type 1 diabetes is considered to be a Th1-dominant autoimmune disease, and a suppressive effect of CXCL10 neutralization on diabetes development has been reported in a cyclophosphamide-induced accelerated diabetes model through induction of beta cell proliferation. However, intervention in a diabetes model might bring about opposite effects, depending on the timing, amount, or method of treatment. In the present study, we examined the effect of CXCL10 neutralization in a "spontaneous diabetes" model of NOD mice, using CXCL10 DNA vaccination (pCAGGS-CXCL10). pCAGGS-CXCL10 treatment in young NOD mice induced the production of anti-CXCL10 Ab in vivo and suppressed the incidence of spontaneous diabetes, although this treatment did not inhibit insulitis or alter the immunological response. pCAGGS-CXCL10 treatment enhanced the proliferation of pancreatic beta cells, resulting in an increase of beta cell mass in this spontaneous diabetes model as well. Therefore, CXCL10 neutralization is suggested to be useful for maintaining beta cell mass at any stage of autoimmune diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  ISOCxcl10 (Rattus norvegicus)2311362; 2311362 RGD 
type 1 diabetes mellitus  IMP 2311362 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl10  (C-X-C motif chemokine ligand 10)

Genes (Mus musculus)
Cxcl10  (C-X-C motif chemokine ligand 10)

Genes (Homo sapiens)
CXCL10  (C-X-C motif chemokine ligand 10)


Additional Information